GB985970A - Diaminoanthraquinones - Google Patents

Abstract

The invention comprises compounds of the formula <FORM:0985970/C4-C5/1> wherein R4R3N.A2.NH- is in position 5 or 8, A1 and A2 are the same and are straight or branched alkylene chains of 2 to 12 carbon atoms, NR1R2 and NR3R4 are the same and are dimethylamino, N - ethyl - N - methylamino, diethylamino, pyrrolidino, piperidino, hexamethyleneimino, morpholino, piperazino or N-alkyl-piperazino groups, Z1 is hydrogen or alkyl and is in one of positions 2, 3 and 4, and the acid addition salts thereof. The compounds are made by condensing an amine of the formula R2R1NANH2 with an anthraquinone substituted in the 1 and 5 or 1 and 8 positions with a reactive atom or group such as halogen, hydroxy, nitro, alkoxy or a sulphonic acid or alkali-metal sulphonate group. The compounds are pharmaceutically active.ALSO:Pharmaceutical compositions comprise a carrier and an anthraquinone of the formula <FORM:0985970/A5-A6/1> wherein R4R3N.A2.NH- is in position 5 or 8, A1 and A2 are the same and are straight or branched alkylene chains of 2 to 12 carbon atoms, NR1R2 and NR3R4 are the same and are dimethylamino, N-ethyl-N-methylamino, diethylamino, pyrrolidino, piperidino, hexamethyleneimino, morpholino, piperazino, or N-alkylpiperazino groups, Z1 is hydrogen or alkyl and is in any of positions 2, 3 and 4, or an addition salt thereof such as the hydrochloric, sulphuric, citric, lactic, succinic, oxalic or p-toluenesulphonic acid salt. The compositions may contain a fine powder or granules of the anthraquinone with diluents and dispersing and surface-active agents in a draft or drench in water or in a syrup, in capsules or cachets in the dry state or in non-aqueous suspension when a suspending agent may be included, in tablets when binders and lubricants may be included, or in suspension in water or a syrup or an oil or in a water/oil emulsion when flavouring, preserving, suspending, thickening and emulsifying agents may be included. The granules or tablets may be coated.