CA2713394C - Anti-inflammatory quinic acid derivatives for oral administration - Google Patents

Anti-inflammatory quinic acid derivatives for oral administration Download PDF

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Publication number
CA2713394C
CA2713394C CA2713394A CA2713394A CA2713394C CA 2713394 C CA2713394 C CA 2713394C CA 2713394 A CA2713394 A CA 2713394A CA 2713394 A CA2713394 A CA 2713394A CA 2713394 C CA2713394 C CA 2713394C
Authority
CA
Canada
Prior art keywords
compound
inflammatory
compounds
quinic acid
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2713394A
Other languages
English (en)
French (fr)
Other versions
CA2713394A1 (en
Inventor
Charles Yates
Kui Zeng
Duane Miller
Karin Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Tennessee Research Foundation
Original Assignee
University of Tennessee Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Tennessee Research Foundation filed Critical University of Tennessee Research Foundation
Publication of CA2713394A1 publication Critical patent/CA2713394A1/en
Application granted granted Critical
Publication of CA2713394C publication Critical patent/CA2713394C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2713394A 2007-11-09 2008-11-10 Anti-inflammatory quinic acid derivatives for oral administration Expired - Fee Related CA2713394C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US261107P 2007-11-09 2007-11-09
US61/002,611 2007-11-09
PCT/US2008/083068 WO2009062200A1 (en) 2007-11-09 2008-11-10 Anti-inflammatory quinic acid derivatives for oral administration

Publications (2)

Publication Number Publication Date
CA2713394A1 CA2713394A1 (en) 2009-05-14
CA2713394C true CA2713394C (en) 2016-01-19

Family

ID=40626242

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2713394A Expired - Fee Related CA2713394C (en) 2007-11-09 2008-11-10 Anti-inflammatory quinic acid derivatives for oral administration

Country Status (6)

Country Link
US (1) US8115031B2 (enExample)
EP (1) EP2219445A4 (enExample)
JP (1) JP5660898B2 (enExample)
AU (1) AU2008323683B2 (enExample)
CA (1) CA2713394C (enExample)
WO (1) WO2009062200A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101284799B (zh) * 2007-03-23 2013-04-03 浙江医药股份有限公司新昌制药厂 咖啡酰奎宁酸含氮衍生物及其制备方法和其药物组合物及用途
WO2010132504A1 (en) 2009-05-11 2010-11-18 University Of Tennessee Research Foundation Anti-inflammatory quinic acid derivatives for radioprotection/radiomitigation
US10369133B2 (en) 2013-07-23 2019-08-06 The University Of Tennessee Research Foundation Immunosuppressive compounds and therapeutics
TWI481600B (zh) * 2013-07-24 2015-04-21 Nat Applied Res Laboratories 一種奎尼酸衍生物、其製程及其用途
US11883457B1 (en) 2022-09-06 2024-01-30 Optigenex Inc. Method of enhancing cognition in individuals with at least normal cognition
CN117547562A (zh) * 2023-05-09 2024-02-13 北京农学院 一种用于抗炎的虎耳草提取物及其制备方法和用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6017A (en) * 1849-01-09 Die for bending ttjbe-skelps
US7020A (en) * 1850-01-15 Improvement in harvesting-mac mines
US2918477A (en) * 1954-12-28 1959-12-22 Alberti Carlo Giuseppe Caffeic esters of quinic acid and quinic acid amide and syntheses thereof
US2866734A (en) * 1956-12-05 1958-12-30 Us Vitamin Corp 3-pyridylethyl 2, 4-oxazolidinediones and process
GB1460593A (en) * 1973-06-22 1977-01-06 Ici Ltd Ethanolamine derivatives
US3968211A (en) * 1974-02-11 1976-07-06 The Upjohn Company Compositions and methods of use of amidines for anti-arrhythmic purposes
GB1476351A (en) * 1974-04-17 1977-06-10 Wilkinson Sword Ltd Compounds having a physiological cooling effect and compo sitions containing them
US4582855A (en) * 1981-11-12 1986-04-15 American Hospital Supply Corporation Aromatic and esters of hydroxypropylamines
JPS61251616A (ja) * 1985-04-30 1986-11-08 Agency Of Ind Science & Technol 溶質の放出量の制御方法
HU906340D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Synthesis in solid phase for producing peptonic alcohols
US6964784B2 (en) * 2002-03-07 2005-11-15 Optigenex, Inc. Method of preparation and composition of a water soluble extract of the bioactive component of the plant species uncaria for enhancing immune, anti-inflammatory, anti-tumor and dna repair processes of warm blooded animals
WO2005035534A1 (ja) * 2003-10-08 2005-04-21 Ono Pharmaceutical Co., Ltd. 複素ビシクロ環および複素トリシクロ環化合物およびその医薬
US7482378B2 (en) * 2004-05-28 2009-01-27 Millenium Specialty Chemicals, Inc. Physiological cooling compositions
US8436006B2 (en) * 2004-08-06 2013-05-07 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
WO2007103719A2 (en) * 2006-03-03 2007-09-13 Incyte Corporation MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME
CN101400660A (zh) * 2006-03-16 2009-04-01 安斯泰来制药有限公司 三唑衍生物或其盐
CN101284799B (zh) * 2007-03-23 2013-04-03 浙江医药股份有限公司新昌制药厂 咖啡酰奎宁酸含氮衍生物及其制备方法和其药物组合物及用途

Also Published As

Publication number Publication date
EP2219445A4 (en) 2013-05-29
US20090234015A1 (en) 2009-09-17
JP5660898B2 (ja) 2015-01-28
WO2009062200A1 (en) 2009-05-14
CA2713394A1 (en) 2009-05-14
EP2219445A1 (en) 2010-08-25
AU2008323683A1 (en) 2009-05-14
JP2011503110A (ja) 2011-01-27
US8115031B2 (en) 2012-02-14
AU2008323683B2 (en) 2014-10-02

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Effective date: 20131028

MKLA Lapsed

Effective date: 20210831

MKLA Lapsed

Effective date: 20191112