JP2011500718A5 - - Google Patents

Info

Publication number

JP2011500718A5

JP2011500718A5 JP2010530124A JP2010530124A JP2011500718A5 JP 2011500718 A5 JP2011500718 A5 JP 2011500718A5 JP 2010530124 A JP2010530124 A JP 2010530124A JP 2010530124 A JP2010530124 A JP 2010530124A JP 2011500718 A5 JP2011500718 A5 JP 2011500718A5

Authority

JP

Japan

Prior art keywords

mva

antigen

polypeptide

pap

human

Prior art date

2008-10-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 241001183012 Modified Vaccinia Ankara virus Species 0.000 claims description 61
• 239000000427 antigen Substances 0.000 claims description 37
• 102000036639 antigens Human genes 0.000 claims description 37
• 108091007433 antigens Proteins 0.000 claims description 37
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 30
• 229920001184 polypeptide Polymers 0.000 claims description 29
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 29
• 229940123237 Taxane Drugs 0.000 claims description 16
• 239000000203 mixture Substances 0.000 claims description 16
• DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims description 16
• 230000028993 immune response Effects 0.000 claims description 14
• 230000002163 immunogen Effects 0.000 claims description 13
• 101001035654 Homo sapiens 28 kDa heat- and acid-stable phosphoprotein Proteins 0.000 claims description 12
• 101000785915 Homo sapiens Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 Proteins 0.000 claims description 12
• 101000735427 Homo sapiens Poly(A) RNA polymerase, mitochondrial Proteins 0.000 claims description 12
• 206010028980 Neoplasm Diseases 0.000 claims description 12
• 206010060862 Prostate cancer Diseases 0.000 claims description 11
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 11
• 230000002476 tumorcidal effect Effects 0.000 claims description 11
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 9
• 101000605534 Homo sapiens Prostate-specific antigen Proteins 0.000 claims description 9
• 101000592517 Homo sapiens Puromycin-sensitive aminopeptidase Proteins 0.000 claims description 9
• 210000001744 T-lymphocyte Anatomy 0.000 claims description 9
• 108010072866 Prostate-Specific Antigen Proteins 0.000 claims description 8
• 102000007066 Prostate-Specific Antigen Human genes 0.000 claims description 8
• 201000011510 cancer Diseases 0.000 claims description 7
• 210000003719 b-lymphocyte Anatomy 0.000 claims description 6
• 230000037452 priming Effects 0.000 claims description 6
• 239000002773 nucleotide Substances 0.000 claims description 5
• 125000003729 nucleotide group Chemical group 0.000 claims description 5
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims description 4
• 229930012538 Paclitaxel Natural products 0.000 claims description 4
• 229960003668 docetaxel Drugs 0.000 claims description 4
• 229960001592 paclitaxel Drugs 0.000 claims description 4
• 108010043671 prostatic acid phosphatase Proteins 0.000 claims description 4
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 4
• 108091029795 Intergenic region Proteins 0.000 claims description 2
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 2
• 108010071652 human kallikrein-related peptidase 3 Proteins 0.000 claims description 2
• 102000007579 human kallikrein-related peptidase 3 Human genes 0.000 claims description 2
• 230000001939 inductive effect Effects 0.000 claims description 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 13
• 238000001514 detection method Methods 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 208000010658 metastatic prostate carcinoma Diseases 0.000 claims 1
• 238000000034 method Methods 0.000 description 15
• 102100037850 Interferon gamma Human genes 0.000 description 3
• 108010074328 Interferon-gamma Proteins 0.000 description 3
• 230000005867 T cell response Effects 0.000 description 3
• 241000282412 Homo Species 0.000 description 2
• 230000006698 induction Effects 0.000 description 2
• 230000004044 response Effects 0.000 description 2
• 206010027476 Metastases Diseases 0.000 description 1
• 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
• 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
• 230000003321 amplification Effects 0.000 description 1
• 230000000259 anti-tumor effect Effects 0.000 description 1
• 230000006023 anti-tumor response Effects 0.000 description 1
• 230000030833 cell death Effects 0.000 description 1
• 230000001413 cellular effect Effects 0.000 description 1
• 230000036039 immunity Effects 0.000 description 1
• 238000009169 immunotherapy Methods 0.000 description 1
• 238000011534 incubation Methods 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1
• 230000009401 metastasis Effects 0.000 description 1
• 238000003199 nucleic acid amplification method Methods 0.000 description 1
• 230000001681 protective effect Effects 0.000 description 1
• 230000028327 secretion Effects 0.000 description 1
• 239000000758 substrate Substances 0.000 description 1
• 210000004881 tumor cell Anatomy 0.000 description 1
• 229960005486 vaccine Drugs 0.000 description 1