JP2011500693A5 - - Google Patents

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Publication number
JP2011500693A5
JP2011500693A5 JP2010530049A JP2010530049A JP2011500693A5 JP 2011500693 A5 JP2011500693 A5 JP 2011500693A5 JP 2010530049 A JP2010530049 A JP 2010530049A JP 2010530049 A JP2010530049 A JP 2010530049A JP 2011500693 A5 JP2011500693 A5 JP 2011500693A5
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JP
Japan
Prior art keywords
methyl
bipyrrolidinyl
phenyl
amide
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010530049A
Other languages
English (en)
Japanese (ja)
Other versions
JP5377503B2 (ja
JP2011500693A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2008/079757 external-priority patent/WO2009052062A1/en
Publication of JP2011500693A publication Critical patent/JP2011500693A/ja
Publication of JP2011500693A5 publication Critical patent/JP2011500693A5/ja
Application granted granted Critical
Publication of JP5377503B2 publication Critical patent/JP5377503B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2010530049A 2007-10-17 2008-10-14 置換されたｎ−フェニル−ビピロリジンカルボキサミド及びその治療上の使用 Expired - Fee Related JP5377503B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98059907P 2007-10-17 2007-10-17
US60/980,599 2007-10-17
PCT/US2008/079757 WO2009052062A1 (en) 2007-10-17 2008-10-14 Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof

Publications (3)

Publication Number Publication Date
JP2011500693A JP2011500693A (ja) 2011-01-06
JP2011500693A5 true JP2011500693A5 (https=) 2011-12-01
JP5377503B2 JP5377503B2 (ja) 2013-12-25

Family

ID=40247942

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010530049A Expired - Fee Related JP5377503B2 (ja) 2007-10-17 2008-10-14 置換されたｎ−フェニル−ビピロリジンカルボキサミド及びその治療上の使用

Country Status (25)

Country Link
US (2) US8088808B2 (https=)
EP (1) EP2212283B1 (https=)
JP (1) JP5377503B2 (https=)
KR (1) KR20100072077A (https=)
CN (1) CN101903340B (https=)
AT (1) ATE525351T1 (https=)
AU (1) AU2008312635B2 (https=)
BR (1) BRPI0818581A2 (https=)
CA (1) CA2702467C (https=)
CY (1) CY1112083T1 (https=)
DK (1) DK2212283T3 (https=)
ES (1) ES2372332T3 (https=)
HR (1) HRP20110762T1 (https=)
IL (1) IL205001A (https=)
MA (1) MA31858B1 (https=)
MX (1) MX2010003949A (https=)
MY (1) MY151348A (https=)
NZ (1) NZ584690A (https=)
PL (1) PL2212283T3 (https=)
PT (1) PT2212283E (https=)
RS (1) RS52235B (https=)
RU (1) RU2477720C2 (https=)
SI (1) SI2212283T1 (https=)
WO (1) WO2009052062A1 (https=)
ZA (1) ZA201002115B (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2212282T1 (sl) * 2007-10-17 2012-01-31 Sanofi Sa Substituirani n-fenil-bipirolidin karboksamidi in njihova terapevtska uporaba
SI2215058T1 (sl) 2007-10-17 2012-03-30 Sanofi Sa Substituirane N fenil bipirolidin sečnine in njihova terapevtska uporaba
EP2205558B1 (en) 2007-10-17 2012-07-25 Sanofi Substituted n-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine h3 receptor modulators
ES2372332T3 (es) * 2007-10-17 2012-01-18 Sanofi N-fenil-bipirrolidina carboxamidas sustituidas y su uso terapéutico.
AR074466A1 (es) 2008-12-05 2011-01-19 Sanofi Aventis Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3.
AR074467A1 (es) * 2008-12-05 2011-01-19 Sanofi Aventis Tetrahidropiran espiro pirrolidinonas y piperidinonas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas en el tratamiento y/o prevencion de enfermedades del snc ,tales como alzheimer y parkinson, entre otras.
SA110310332B1 (ar) 2009-05-01 2013-12-10 Astrazeneca Ab مركبات ميثانون (3 استبدال -ازيتيدين -1-يل )(5- فينيل -1، 3، 4- أوكساديازول -2-يل )
WO2011143148A1 (en) * 2010-05-11 2011-11-17 Sanofi Substituted n-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof
TW201206444A (en) * 2010-05-11 2012-02-16 Sanofi Aventis Substituted N-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof
EP2569280B1 (en) 2010-05-11 2015-02-25 Sanofi Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof
TW201206898A (en) * 2010-05-11 2012-02-16 Sanofi Aventis Substituted N-phenyl spirolactam bipyrrolidines, preparation and therapeutic use thereof
EP2569294B1 (en) * 2010-05-11 2015-03-11 Sanofi Substituted n-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof
AR081498A1 (es) 2010-05-11 2012-09-19 Sanofi Aventis Derivados de n-alquil -y n-acil-tetrahidroisoquinolina sustituidos, preparacion y su uso terapeutico de los mismos
EP2569297A1 (en) 2010-05-11 2013-03-20 Sanofi Substituted n-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof
AU2011275547B2 (en) * 2010-07-06 2015-10-29 Astrazeneca Ab Therapeutic agents 976
UY34194A (es) 2011-07-15 2013-02-28 Astrazeneca Ab ?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad?
JP2013232564A (ja) * 2012-04-27 2013-11-14 National Institute Of Advanced Industrial & Technology 半導体装置および半導体装置の製造方法
CN108250128A (zh) * 2012-09-27 2018-07-06 江苏先声药业有限公司 作为钾通道调节剂的化合物
KR20150103752A (ko) 2013-01-10 2015-09-11 그뤼넨탈 게엠베하 Crac 채널 억제제로서의 피라졸릴계 카복스아미드 ⅱ
AR094412A1 (es) 2013-01-10 2015-07-29 Gruenenthal Gmbh Carboxamidas basadas en pirazolilo i
EP3366683A1 (en) 2017-02-28 2018-08-29 Acousia Therapeutics GmbH Cyclic amides, acteamides and ureas useful as potassium channel openers

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20020507A1 (es) * 2000-10-17 2002-06-25 Schering Corp Compuestos no-imidazoles como antagonistas del receptor histamina h3
EP1556046A1 (en) * 2002-10-23 2005-07-27 Janssen Pharmaceutica N.V. Phenylpiperidines and phenylpyrrolidines as histamine h3 receptor modulators
DE10306250A1 (de) * 2003-02-14 2004-09-09 Aventis Pharma Deutschland Gmbh Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US7223788B2 (en) * 2003-02-14 2007-05-29 Sanofi-Aventis Deutschland Gmbh Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
BRPI0608523A2 (pt) 2005-03-17 2010-11-16 Lilly Co Eli composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos para inibir receptor de histamina h3 em um mamìfero, para tratar ou prevenir um distúrbio do sistema nervoso, para tratar ou prevenir obesidade e para tratar ou prevenir um distúrbio ou doença, e, uso de um composto ou um sal do mesmo
AU2006232871B9 (en) * 2005-04-01 2011-11-24 Eli Lilly And Company Histamine H3 receptor agents, preparation and therapeutic uses
MX2007016216A (es) * 2005-07-01 2008-03-11 Lilly Co Eli Agenes del receptor de histamina h3, preparacion y usos terapeuticos.
CA2627234A1 (en) * 2005-10-27 2007-05-03 Ucb Pharma, S.A. Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses
WO2007093364A1 (en) * 2006-02-15 2007-08-23 Sanofi-Aventis Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
SI2212282T1 (sl) * 2007-10-17 2012-01-31 Sanofi Sa Substituirani n-fenil-bipirolidin karboksamidi in njihova terapevtska uporaba
ES2372332T3 (es) * 2007-10-17 2012-01-18 Sanofi N-fenil-bipirrolidina carboxamidas sustituidas y su uso terapéutico.
EP2205558B1 (en) 2007-10-17 2012-07-25 Sanofi Substituted n-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine h3 receptor modulators
SI2215058T1 (sl) 2007-10-17 2012-03-30 Sanofi Sa Substituirane N fenil bipirolidin sečnine in njihova terapevtska uporaba

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