ATE525351T1 - Substituierte n-phenyl- bipyrrolidincarbonsäureamide und deren therapeutische verwendung - Google Patents
Substituierte n-phenyl- bipyrrolidincarbonsäureamide und deren therapeutische verwendungInfo
- Publication number
- ATE525351T1 ATE525351T1 AT08839959T AT08839959T ATE525351T1 AT E525351 T1 ATE525351 T1 AT E525351T1 AT 08839959 T AT08839959 T AT 08839959T AT 08839959 T AT08839959 T AT 08839959T AT E525351 T1 ATE525351 T1 AT E525351T1
- Authority
- AT
- Austria
- Prior art keywords
- phenyl
- substituted
- bipyrrolidinecarbonic
- acid amides
- therapeutic use
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98059907P | 2007-10-17 | 2007-10-17 | |
| PCT/US2008/079757 WO2009052062A1 (en) | 2007-10-17 | 2008-10-14 | Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE525351T1 true ATE525351T1 (de) | 2011-10-15 |
Family
ID=40247942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08839959T ATE525351T1 (de) | 2007-10-17 | 2008-10-14 | Substituierte n-phenyl- bipyrrolidincarbonsäureamide und deren therapeutische verwendung |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US8088808B2 (de) |
| EP (1) | EP2212283B1 (de) |
| JP (1) | JP5377503B2 (de) |
| KR (1) | KR20100072077A (de) |
| CN (1) | CN101903340B (de) |
| AT (1) | ATE525351T1 (de) |
| AU (1) | AU2008312635B2 (de) |
| BR (1) | BRPI0818581A2 (de) |
| CA (1) | CA2702467C (de) |
| CY (1) | CY1112083T1 (de) |
| DK (1) | DK2212283T3 (de) |
| ES (1) | ES2372332T3 (de) |
| HK (1) | HK1146053A1 (de) |
| HR (1) | HRP20110762T1 (de) |
| IL (1) | IL205001A (de) |
| MA (1) | MA31858B1 (de) |
| MX (1) | MX2010003949A (de) |
| MY (1) | MY151348A (de) |
| NZ (1) | NZ584690A (de) |
| PL (1) | PL2212283T3 (de) |
| PT (1) | PT2212283E (de) |
| RS (1) | RS52235B (de) |
| RU (1) | RU2477720C2 (de) |
| SI (1) | SI2212283T1 (de) |
| WO (1) | WO2009052062A1 (de) |
| ZA (1) | ZA201002115B (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101903339B (zh) | 2007-10-17 | 2012-06-27 | 赛诺菲-安万特 | 取代的n-苯基-联吡咯烷羧酰胺及其治疗用途 |
| MX2010003949A (es) * | 2007-10-17 | 2010-04-30 | Sanofi Aventis | N-fenil-bipirrolidina carboxamidas sustituidas y uso terapeutico de las mismas. |
| PT2205558E (pt) | 2007-10-17 | 2012-11-02 | Sanofi Sa | Amidas de n-fenil-pirrolidinilmetilpirrolidina substituídas e sua utilização terapêutica como moduladores do receptor h3 da histamina |
| MX2010003948A (es) | 2007-10-17 | 2010-04-30 | Sanofi Aventis | N-fenil-birrolidin ureas sustituidas y uso terapeutico de las mismas. |
| AR074467A1 (es) | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Tetrahidropiran espiro pirrolidinonas y piperidinonas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas en el tratamiento y/o prevencion de enfermedades del snc ,tales como alzheimer y parkinson, entre otras. |
| AR074466A1 (es) | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3. |
| SA110310332B1 (ar) | 2009-05-01 | 2013-12-10 | Astrazeneca Ab | مركبات ميثانون (3 استبدال -ازيتيدين -1-يل )(5- فينيل -1، 3، 4- أوكساديازول -2-يل ) |
| AR081498A1 (es) | 2010-05-11 | 2012-09-19 | Sanofi Aventis | Derivados de n-alquil -y n-acil-tetrahidroisoquinolina sustituidos, preparacion y su uso terapeutico de los mismos |
| WO2011143162A1 (en) * | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof |
| JP5784110B2 (ja) | 2010-05-11 | 2015-09-24 | サノフイ | 置換されたｎ−ヘテロアリールテトラヒドロ−イソキノリン誘導体、その製造及び治療上の使用 |
| EP2569296A1 (de) * | 2010-05-11 | 2013-03-20 | Sanofi | Substituierte n-phenyl-spirolactam-bipyrrolidine, ihre zubereitung und therapeutische verwendung |
| TW201206910A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof |
| TW201206939A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof |
| WO2011143148A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
| CN103209979B (zh) | 2010-07-06 | 2016-02-10 | 阿斯利康(瑞典)有限公司 | 治疗剂976 |
| UY34194A (es) | 2011-07-15 | 2013-02-28 | Astrazeneca Ab | ?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad? |
| JP2013232564A (ja) * | 2012-04-27 | 2013-11-14 | National Institute Of Advanced Industrial & Technology | 半導体装置および半導体装置の製造方法 |
| CN108250128A (zh) * | 2012-09-27 | 2018-07-06 | 江苏先声药业有限公司 | 作为钾通道调节剂的化合物 |
| AR094412A1 (es) | 2013-01-10 | 2015-07-29 | Gruenenthal Gmbh | Carboxamidas basadas en pirazolilo i |
| AU2014204977A1 (en) | 2013-01-10 | 2015-08-20 | Grunenthal Gmbh | Pyrazolyl-based carboxamides II as CRAC channel inhibitors |
| EP3366683A1 (de) | 2017-02-28 | 2018-08-29 | Acousia Therapeutics GmbH | Zyklische amide, acetamide und harnstoffe als kalium kanal öffner |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020507A1 (es) * | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
| US7279491B2 (en) * | 2002-10-23 | 2007-10-09 | Janssen Pharmaceutica N.V. | Phenylpiperidines and phenylpyrrolidines |
| US7223788B2 (en) * | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
| DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| JP5052497B2 (ja) | 2005-03-17 | 2012-10-17 | イーライ リリー アンド カンパニー | ヒスタミンｈ３受容体アンタゴニストとしてのピロリジン誘導体 |
| ES2510490T3 (es) * | 2005-04-01 | 2014-10-21 | Eli Lilly And Company | Agentes receptores de la histamina H3, preparación y usos terapéuticos |
| JP5193033B2 (ja) * | 2005-07-01 | 2013-05-08 | イーライ リリー アンド カンパニー | ヒスタミンｈ３受容体薬剤、製剤及び治療的使用 |
| AU2006308167A1 (en) * | 2005-10-27 | 2007-05-03 | Ucb Pharma, S.A. | Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses |
| WO2007093364A1 (en) * | 2006-02-15 | 2007-08-23 | Sanofi-Aventis | Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments |
| MX2010003948A (es) * | 2007-10-17 | 2010-04-30 | Sanofi Aventis | N-fenil-birrolidin ureas sustituidas y uso terapeutico de las mismas. |
| PT2205558E (pt) | 2007-10-17 | 2012-11-02 | Sanofi Sa | Amidas de n-fenil-pirrolidinilmetilpirrolidina substituídas e sua utilização terapêutica como moduladores do receptor h3 da histamina |
| CN101903339B (zh) * | 2007-10-17 | 2012-06-27 | 赛诺菲-安万特 | 取代的n-苯基-联吡咯烷羧酰胺及其治疗用途 |
| MX2010003949A (es) * | 2007-10-17 | 2010-04-30 | Sanofi Aventis | N-fenil-bipirrolidina carboxamidas sustituidas y uso terapeutico de las mismas. |
-
2008
- 2008-10-14 MX MX2010003949A patent/MX2010003949A/es active IP Right Grant
- 2008-10-14 WO PCT/US2008/079757 patent/WO2009052062A1/en active Application Filing
- 2008-10-14 AU AU2008312635A patent/AU2008312635B2/en not_active Ceased
- 2008-10-14 PL PL08839959T patent/PL2212283T3/pl unknown
- 2008-10-14 CN CN2008801212081A patent/CN101903340B/zh not_active Expired - Fee Related
- 2008-10-14 DK DK08839959.7T patent/DK2212283T3/da active
- 2008-10-14 AT AT08839959T patent/ATE525351T1/de active
- 2008-10-14 MY MYPI20101299 patent/MY151348A/en unknown
- 2008-10-14 ES ES08839959T patent/ES2372332T3/es active Active
- 2008-10-14 RS RS20110522A patent/RS52235B/en unknown
- 2008-10-14 RU RU2010119528/04A patent/RU2477720C2/ru not_active IP Right Cessation
- 2008-10-14 EP EP08839959A patent/EP2212283B1/de active Active
- 2008-10-14 JP JP2010530049A patent/JP5377503B2/ja not_active Expired - Fee Related
- 2008-10-14 CA CA2702467A patent/CA2702467C/en not_active Expired - Fee Related
- 2008-10-14 SI SI200830416T patent/SI2212283T1/sl unknown
- 2008-10-14 BR BRPI0818581-6A patent/BRPI0818581A2/pt not_active IP Right Cessation
- 2008-10-14 KR KR1020107010769A patent/KR20100072077A/ko not_active Application Discontinuation
- 2008-10-14 PT PT08839959T patent/PT2212283E/pt unknown
- 2008-10-14 NZ NZ584690A patent/NZ584690A/en not_active IP Right Cessation
-
2010
- 2010-03-15 US US12/724,028 patent/US8088808B2/en not_active Expired - Fee Related
- 2010-03-25 ZA ZA2010/02115A patent/ZA201002115B/en unknown
- 2010-04-11 IL IL205001A patent/IL205001A/en not_active IP Right Cessation
- 2010-05-17 MA MA32850A patent/MA31858B1/fr unknown
-
2011
- 2011-01-12 HK HK11100254.8A patent/HK1146053A1/xx not_active IP Right Cessation
- 2011-10-19 HR HR20110762T patent/HRP20110762T1/hr unknown
- 2011-11-18 US US13/299,574 patent/US8252824B2/en active Active
- 2011-11-24 CY CY20111101151T patent/CY1112083T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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