PL2212283T3 - Podstawione karboksyamidy N-fenylobipirolidyny i ich zastosowanie terapeutyczne - Google Patents

Podstawione karboksyamidy N-fenylobipirolidyny i ich zastosowanie terapeutyczne

Info

Publication number
PL2212283T3
PL2212283T3 PL08839959T PL08839959T PL2212283T3 PL 2212283 T3 PL2212283 T3 PL 2212283T3 PL 08839959 T PL08839959 T PL 08839959T PL 08839959 T PL08839959 T PL 08839959T PL 2212283 T3 PL2212283 T3 PL 2212283T3
Authority
PL
Poland
Prior art keywords
phenyl
substituted
therapeutic use
bipyrrolidine carboxamides
bipyrrolidine
Prior art date
Application number
PL08839959T
Other languages
English (en)
Inventor
Werngard Czechtizky
Zhongli Gao
William J Hurst
Lothar Schwink
Siegfried Stengelin
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of PL2212283T3 publication Critical patent/PL2212283T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
PL08839959T 2007-10-17 2008-10-14 Podstawione karboksyamidy N-fenylobipirolidyny i ich zastosowanie terapeutyczne PL2212283T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98059907P 2007-10-17 2007-10-17
EP08839959A EP2212283B1 (en) 2007-10-17 2008-10-14 Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof
PCT/US2008/079757 WO2009052062A1 (en) 2007-10-17 2008-10-14 Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof

Publications (1)

Publication Number Publication Date
PL2212283T3 true PL2212283T3 (pl) 2012-01-31

Family

ID=40247942

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08839959T PL2212283T3 (pl) 2007-10-17 2008-10-14 Podstawione karboksyamidy N-fenylobipirolidyny i ich zastosowanie terapeutyczne

Country Status (26)

Country Link
US (2) US8088808B2 (pl)
EP (1) EP2212283B1 (pl)
JP (1) JP5377503B2 (pl)
KR (1) KR20100072077A (pl)
CN (1) CN101903340B (pl)
AT (1) ATE525351T1 (pl)
AU (1) AU2008312635B2 (pl)
BR (1) BRPI0818581A2 (pl)
CA (1) CA2702467C (pl)
CY (1) CY1112083T1 (pl)
DK (1) DK2212283T3 (pl)
ES (1) ES2372332T3 (pl)
HK (1) HK1146053A1 (pl)
HR (1) HRP20110762T1 (pl)
IL (1) IL205001A (pl)
MA (1) MA31858B1 (pl)
MX (1) MX2010003949A (pl)
MY (1) MY151348A (pl)
NZ (1) NZ584690A (pl)
PL (1) PL2212283T3 (pl)
PT (1) PT2212283E (pl)
RS (1) RS52235B (pl)
RU (1) RU2477720C2 (pl)
SI (1) SI2212283T1 (pl)
WO (1) WO2009052062A1 (pl)
ZA (1) ZA201002115B (pl)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2702467C (en) * 2007-10-17 2012-11-27 Sanofi-Aventis Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof
CA2702482C (en) * 2007-10-17 2012-11-27 Sanofi-Aventis Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof
DK2205558T3 (da) 2007-10-17 2012-11-05 Sanofi Sa Substituterede n-phenylpyrrolidinylmethylpyrrolidinamider og terapeutisk anvendelse deraf som histamin-h3- receptormodulatorer
DK2215058T3 (da) 2007-10-17 2012-03-12 Sanofi Sa Substituerede N-phenylbipyrrolidinureaer og terapeutisk anvendelse deraf
AR074466A1 (es) 2008-12-05 2011-01-19 Sanofi Aventis Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3.
AR074467A1 (es) * 2008-12-05 2011-01-19 Sanofi Aventis Tetrahidropiran espiro pirrolidinonas y piperidinonas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas en el tratamiento y/o prevencion de enfermedades del snc ,tales como alzheimer y parkinson, entre otras.
SA110310332B1 (ar) * 2009-05-01 2013-12-10 Astrazeneca Ab مركبات ميثانون (3 استبدال -ازيتيدين -1-يل )(5- فينيل -1، 3، 4- أوكساديازول -2-يل )
TW201206910A (en) 2010-05-11 2012-02-16 Sanofi Aventis Substituted N-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof
AR081383A1 (es) * 2010-05-11 2012-08-29 Sanofi Aventis N-heteroaril bipirrolidin carboxamidas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de enfermedades del sistema nervioso central.
TW201206939A (en) 2010-05-11 2012-02-16 Sanofi Aventis Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof
TW201206898A (en) * 2010-05-11 2012-02-16 Sanofi Aventis Substituted N-phenyl spirolactam bipyrrolidines, preparation and therapeutic use thereof
JP5784110B2 (ja) 2010-05-11 2015-09-24 サノフイ 置換されたｎ−ヘテロアリールテトラヒドロ−イソキノリン誘導体、その製造及び治療上の使用
TW201202251A (en) 2010-05-11 2012-01-16 Sanofi Aventis Substituted N-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof
JP5766278B2 (ja) 2010-05-11 2015-08-19 サノフイ 置換されたｎ−アルキルおよびｎ−アシルテトラヒドロ−イソキノリン誘導体、それらの製造および治療上の使用
JP5827683B2 (ja) * 2010-07-06 2015-12-02 アストラゼネカ アクチボラグ 療法薬９７６
UY34194A (es) 2011-07-15 2013-02-28 Astrazeneca Ab ?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad?
JP2013232564A (ja) * 2012-04-27 2013-11-14 National Institute Of Advanced Industrial & Technology 半導体装置および半導体装置の製造方法
CN108250128A (zh) * 2012-09-27 2018-07-06 江苏先声药业有限公司 作为钾通道调节剂的化合物
AU2014204978A1 (en) 2013-01-10 2015-08-20 Grünenthal GmbH Pyrazolyl-based carboxamides I as CRAC channel inhibitors
EP2943197A1 (en) 2013-01-10 2015-11-18 Grünenthal GmbH Pyrazolyl-based carboxamides ii as crac channel inhibitors
EP3366683A1 (en) 2017-02-28 2018-08-29 Acousia Therapeutics GmbH Cyclic amides, acteamides and ureas useful as potassium channel openers

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20020507A1 (es) * 2000-10-17 2002-06-25 Schering Corp Compuestos no-imidazoles como antagonistas del receptor histamina h3
AU2003287206A1 (en) * 2002-10-23 2004-05-13 Janssen Pharmaceutica, N.V. Phenylpiperidines and phenylpyrrolidines as histamine h3 receptor modulators
DE10306250A1 (de) * 2003-02-14 2004-09-09 Aventis Pharma Deutschland Gmbh Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US7223788B2 (en) * 2003-02-14 2007-05-29 Sanofi-Aventis Deutschland Gmbh Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
AU2006227815B2 (en) 2005-03-17 2011-09-22 Eli Lilly And Company Pyrrolidine derivatives as histamine H3 receptor antagonists
JP5072827B2 (ja) * 2005-04-01 2012-11-14 イーライ リリー アンド カンパニー ヒスタミンｈ３受容体薬剤、製剤及び治療的使用
ATE523488T1 (de) * 2005-07-01 2011-09-15 Lilly Co Eli Histamin-h3-rezeptor-mittel, deren herstellung und therapeutische verwendung
US7943605B2 (en) * 2005-10-27 2011-05-17 Ucb Pharma S.A. Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses
TW200800908A (en) * 2006-02-15 2008-01-01 Sanofi Aventis Novel azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
DK2205558T3 (da) 2007-10-17 2012-11-05 Sanofi Sa Substituterede n-phenylpyrrolidinylmethylpyrrolidinamider og terapeutisk anvendelse deraf som histamin-h3- receptormodulatorer
CA2702482C (en) * 2007-10-17 2012-11-27 Sanofi-Aventis Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof
DK2215058T3 (da) * 2007-10-17 2012-03-12 Sanofi Sa Substituerede N-phenylbipyrrolidinureaer og terapeutisk anvendelse deraf
CA2702467C (en) * 2007-10-17 2012-11-27 Sanofi-Aventis Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof

Also Published As

Publication number Publication date
AU2008312635A1 (en) 2009-04-23
KR20100072077A (ko) 2010-06-29
ATE525351T1 (de) 2011-10-15
RS52235B (en) 2012-10-31
MX2010003949A (es) 2010-04-30
CN101903340B (zh) 2013-03-27
EP2212283B1 (en) 2011-09-21
SI2212283T1 (sl) 2011-12-30
HRP20110762T1 (hr) 2011-11-30
CA2702467C (en) 2012-11-27
RU2010119528A (ru) 2011-11-27
NZ584690A (en) 2011-09-30
CN101903340A (zh) 2010-12-01
EP2212283A1 (en) 2010-08-04
IL205001A (en) 2014-06-30
AU2008312635B2 (en) 2013-05-16
US8252824B2 (en) 2012-08-28
US8088808B2 (en) 2012-01-03
MY151348A (en) 2014-05-15
US20120065234A1 (en) 2012-03-15
PT2212283E (pt) 2011-11-03
RU2477720C2 (ru) 2013-03-20
US20100173949A1 (en) 2010-07-08
JP5377503B2 (ja) 2013-12-25
JP2011500693A (ja) 2011-01-06
CY1112083T1 (el) 2015-11-04
DK2212283T3 (da) 2011-12-19
IL205001A0 (en) 2010-11-30
ES2372332T3 (es) 2012-01-18
ZA201002115B (en) 2010-12-29
HK1146053A1 (en) 2011-05-13
CA2702467A1 (en) 2009-04-23
WO2009052062A1 (en) 2009-04-23
MA31858B1 (fr) 2010-11-01
BRPI0818581A2 (pt) 2015-07-21

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