KR20100072077A - 치환된 ｎ페닐비피롤리딘 카복스아미드 및 이의 치료적 용도 - Google Patents
치환된 ｎ페닐비피롤리딘 카복스아미드 및 이의 치료적 용도 Download PDFInfo
- Publication number
- KR20100072077A KR20100072077A KR1020107010769A KR20107010769A KR20100072077A KR 20100072077 A KR20100072077 A KR 20100072077A KR 1020107010769 A KR1020107010769 A KR 1020107010769A KR 20107010769 A KR20107010769 A KR 20107010769A KR 20100072077 A KR20100072077 A KR 20100072077A
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- bipyrrolidinyl
- phenyl
- amide
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 *C(CCC1)N1C(CC1)CN1c(cc1)ccc1N Chemical compound *C(CCC1)N1C(CC1)CN1c(cc1)ccc1N 0.000 description 5
- HHAUFTJSDMPHKG-UHFFFAOYSA-N CC(CCC1)N1C(CC1)CN1c(cc1)cc(C)c1[N+]([O-])=O Chemical compound CC(CCC1)N1C(CC1)CN1c(cc1)cc(C)c1[N+]([O-])=O HHAUFTJSDMPHKG-UHFFFAOYSA-N 0.000 description 1
- BKJXXWZRHKJOAA-UHFFFAOYSA-N CC(CCC1)N1C(CC1)CN1c(cc1)ccc1NC(c1c[nH]nc1)=O Chemical compound CC(CCC1)N1C(CC1)CN1c(cc1)ccc1NC(c1c[nH]nc1)=O BKJXXWZRHKJOAA-UHFFFAOYSA-N 0.000 description 1
- LTXNFOYXSJWOGL-UHFFFAOYSA-N Cc1n[o]c(C(Nc(cc2)c(C)cc2N(CC2)CC2N2CCCC2)=O)c1 Chemical compound Cc1n[o]c(C(Nc(cc2)c(C)cc2N(CC2)CC2N2CCCC2)=O)c1 LTXNFOYXSJWOGL-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98059907P | 2007-10-17 | 2007-10-17 | |
| US60/980,599 | 2007-10-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20100072077A true KR20100072077A (ko) | 2010-06-29 |
Family
ID=40247942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020107010769A Ceased KR20100072077A (ko) | 2007-10-17 | 2008-10-14 | 치환된 ｎ페닐비피롤리딘 카복스아미드 및 이의 치료적 용도 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US8088808B2 (https=) |
| EP (1) | EP2212283B1 (https=) |
| JP (1) | JP5377503B2 (https=) |
| KR (1) | KR20100072077A (https=) |
| CN (1) | CN101903340B (https=) |
| AT (1) | ATE525351T1 (https=) |
| AU (1) | AU2008312635B2 (https=) |
| BR (1) | BRPI0818581A2 (https=) |
| CA (1) | CA2702467C (https=) |
| CY (1) | CY1112083T1 (https=) |
| DK (1) | DK2212283T3 (https=) |
| ES (1) | ES2372332T3 (https=) |
| HR (1) | HRP20110762T1 (https=) |
| IL (1) | IL205001A (https=) |
| MA (1) | MA31858B1 (https=) |
| MX (1) | MX2010003949A (https=) |
| MY (1) | MY151348A (https=) |
| NZ (1) | NZ584690A (https=) |
| PL (1) | PL2212283T3 (https=) |
| PT (1) | PT2212283E (https=) |
| RS (1) | RS52235B (https=) |
| RU (1) | RU2477720C2 (https=) |
| SI (1) | SI2212283T1 (https=) |
| WO (1) | WO2009052062A1 (https=) |
| ZA (1) | ZA201002115B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2212282T1 (sl) * | 2007-10-17 | 2012-01-31 | Sanofi Sa | Substituirani n-fenil-bipirolidin karboksamidi in njihova terapevtska uporaba |
| SI2215058T1 (sl) | 2007-10-17 | 2012-03-30 | Sanofi Sa | Substituirane N fenil bipirolidin sečnine in njihova terapevtska uporaba |
| EP2205558B1 (en) | 2007-10-17 | 2012-07-25 | Sanofi | Substituted n-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine h3 receptor modulators |
| ES2372332T3 (es) * | 2007-10-17 | 2012-01-18 | Sanofi | N-fenil-bipirrolidina carboxamidas sustituidas y su uso terapéutico. |
| AR074466A1 (es) | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3. |
| AR074467A1 (es) * | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Tetrahidropiran espiro pirrolidinonas y piperidinonas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas en el tratamiento y/o prevencion de enfermedades del snc ,tales como alzheimer y parkinson, entre otras. |
| SA110310332B1 (ar) | 2009-05-01 | 2013-12-10 | Astrazeneca Ab | مركبات ميثانون (3 استبدال -ازيتيدين -1-يل )(5- فينيل -1، 3، 4- أوكساديازول -2-يل ) |
| WO2011143148A1 (en) * | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
| TW201206444A (en) * | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
| EP2569280B1 (en) | 2010-05-11 | 2015-02-25 | Sanofi | Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof |
| TW201206898A (en) * | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-phenyl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
| EP2569294B1 (en) * | 2010-05-11 | 2015-03-11 | Sanofi | Substituted n-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof |
| AR081498A1 (es) | 2010-05-11 | 2012-09-19 | Sanofi Aventis | Derivados de n-alquil -y n-acil-tetrahidroisoquinolina sustituidos, preparacion y su uso terapeutico de los mismos |
| EP2569297A1 (en) | 2010-05-11 | 2013-03-20 | Sanofi | Substituted n-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof |
| AU2011275547B2 (en) * | 2010-07-06 | 2015-10-29 | Astrazeneca Ab | Therapeutic agents 976 |
| UY34194A (es) | 2011-07-15 | 2013-02-28 | Astrazeneca Ab | ?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad? |
| JP2013232564A (ja) * | 2012-04-27 | 2013-11-14 | National Institute Of Advanced Industrial & Technology | 半導体装置および半導体装置の製造方法 |
| CN108250128A (zh) * | 2012-09-27 | 2018-07-06 | 江苏先声药业有限公司 | 作为钾通道调节剂的化合物 |
| KR20150103752A (ko) | 2013-01-10 | 2015-09-11 | 그뤼넨탈 게엠베하 | Crac 채널 억제제로서의 피라졸릴계 카복스아미드 ⅱ |
| AR094412A1 (es) | 2013-01-10 | 2015-07-29 | Gruenenthal Gmbh | Carboxamidas basadas en pirazolilo i |
| EP3366683A1 (en) | 2017-02-28 | 2018-08-29 | Acousia Therapeutics GmbH | Cyclic amides, acteamides and ureas useful as potassium channel openers |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020507A1 (es) * | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
| EP1556046A1 (en) * | 2002-10-23 | 2005-07-27 | Janssen Pharmaceutica N.V. | Phenylpiperidines and phenylpyrrolidines as histamine h3 receptor modulators |
| DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7223788B2 (en) * | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
| BRPI0608523A2 (pt) | 2005-03-17 | 2010-11-16 | Lilly Co Eli | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos para inibir receptor de histamina h3 em um mamìfero, para tratar ou prevenir um distúrbio do sistema nervoso, para tratar ou prevenir obesidade e para tratar ou prevenir um distúrbio ou doença, e, uso de um composto ou um sal do mesmo |
| AU2006232871B9 (en) * | 2005-04-01 | 2011-11-24 | Eli Lilly And Company | Histamine H3 receptor agents, preparation and therapeutic uses |
| MX2007016216A (es) * | 2005-07-01 | 2008-03-11 | Lilly Co Eli | Agenes del receptor de histamina h3, preparacion y usos terapeuticos. |
| CA2627234A1 (en) * | 2005-10-27 | 2007-05-03 | Ucb Pharma, S.A. | Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses |
| WO2007093364A1 (en) * | 2006-02-15 | 2007-08-23 | Sanofi-Aventis | Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments |
| SI2212282T1 (sl) * | 2007-10-17 | 2012-01-31 | Sanofi Sa | Substituirani n-fenil-bipirolidin karboksamidi in njihova terapevtska uporaba |
| ES2372332T3 (es) * | 2007-10-17 | 2012-01-18 | Sanofi | N-fenil-bipirrolidina carboxamidas sustituidas y su uso terapéutico. |
| EP2205558B1 (en) | 2007-10-17 | 2012-07-25 | Sanofi | Substituted n-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine h3 receptor modulators |
| SI2215058T1 (sl) | 2007-10-17 | 2012-03-30 | Sanofi Sa | Substituirane N fenil bipirolidin sečnine in njihova terapevtska uporaba |
-
2008
- 2008-10-14 ES ES08839959T patent/ES2372332T3/es active Active
- 2008-10-14 SI SI200830416T patent/SI2212283T1/sl unknown
- 2008-10-14 MX MX2010003949A patent/MX2010003949A/es active IP Right Grant
- 2008-10-14 WO PCT/US2008/079757 patent/WO2009052062A1/en not_active Ceased
- 2008-10-14 PL PL08839959T patent/PL2212283T3/pl unknown
- 2008-10-14 RU RU2010119528/04A patent/RU2477720C2/ru not_active IP Right Cessation
- 2008-10-14 CA CA2702467A patent/CA2702467C/en not_active Expired - Fee Related
- 2008-10-14 EP EP08839959A patent/EP2212283B1/en active Active
- 2008-10-14 NZ NZ584690A patent/NZ584690A/en not_active IP Right Cessation
- 2008-10-14 CN CN2008801212081A patent/CN101903340B/zh not_active Expired - Fee Related
- 2008-10-14 AU AU2008312635A patent/AU2008312635B2/en not_active Ceased
- 2008-10-14 JP JP2010530049A patent/JP5377503B2/ja not_active Expired - Fee Related
- 2008-10-14 BR BRPI0818581-6A patent/BRPI0818581A2/pt not_active IP Right Cessation
- 2008-10-14 MY MYPI20101299 patent/MY151348A/en unknown
- 2008-10-14 HR HR20110762T patent/HRP20110762T1/hr unknown
- 2008-10-14 DK DK08839959.7T patent/DK2212283T3/da active
- 2008-10-14 PT PT08839959T patent/PT2212283E/pt unknown
- 2008-10-14 RS RS20110522A patent/RS52235B/sr unknown
- 2008-10-14 KR KR1020107010769A patent/KR20100072077A/ko not_active Ceased
- 2008-10-14 AT AT08839959T patent/ATE525351T1/de active
-
2010
- 2010-03-15 US US12/724,028 patent/US8088808B2/en not_active Expired - Fee Related
- 2010-03-25 ZA ZA2010/02115A patent/ZA201002115B/en unknown
- 2010-04-11 IL IL205001A patent/IL205001A/en not_active IP Right Cessation
- 2010-05-17 MA MA32850A patent/MA31858B1/fr unknown
-
2011
- 2011-11-18 US US13/299,574 patent/US8252824B2/en not_active Expired - Fee Related
- 2011-11-24 CY CY20111101151T patent/CY1112083T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5377503B2 (ja) | 置換されたｎ−フェニル−ビピロリジンカルボキサミド及びその治療上の使用 | |
| US8618159B2 (en) | Substituted N-phenyl-bipyrrolidine carboxamides and therapeutic use thereof | |
| US8222290B2 (en) | Substituted N-phenyl-bipyrrolidine ureas and therapeutic use thereof | |
| US8227504B2 (en) | Substituted N-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof | |
| US8383814B2 (en) | Substituted tetrahydropyran spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof | |
| US8859588B2 (en) | Substituted N-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof | |
| HK1146053B (en) | Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof | |
| HK1162515A (en) | Substituted tetrahydropyran spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof | |
| HK1162515B (en) | Substituted tetrahydropyran spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20100517 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20131014 Comment text: Request for Examination of Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20150223 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 20150521 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20150223 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |