JP2011500594A5 - - Google Patents
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- Publication number
- JP2011500594A5 JP2011500594A5 JP2010529081A JP2010529081A JP2011500594A5 JP 2011500594 A5 JP2011500594 A5 JP 2011500594A5 JP 2010529081 A JP2010529081 A JP 2010529081A JP 2010529081 A JP2010529081 A JP 2010529081A JP 2011500594 A5 JP2011500594 A5 JP 2011500594A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- phenyl
- amino
- triazin
- methylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 50
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 49
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 34
- 125000005843 halogen group Chemical group 0.000 claims 16
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 15
- 125000001424 substituent group Chemical group 0.000 claims 15
- PNZXMIKHJXIPEK-UHFFFAOYSA-N cyclohexanecarboxamide Chemical compound NC(=O)C1CCCCC1 PNZXMIKHJXIPEK-UHFFFAOYSA-N 0.000 claims 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000001188 haloalkyl group Chemical group 0.000 claims 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 7
- 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- -1 2-chloro-4-cyanophenyl Chemical group 0.000 claims 6
- 125000004429 atom Chemical group 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- AHFINSWGYAZBOZ-UHFFFAOYSA-N 4-chloro-2-(trifluoromethyl)benzaldehyde Chemical group FC(F)(F)C1=CC(Cl)=CC=C1C=O AHFINSWGYAZBOZ-UHFFFAOYSA-N 0.000 claims 5
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims 3
- 125000002950 monocyclic group Chemical group 0.000 claims 3
- 125000006578 monocyclic heterocycloalkyl group Chemical group 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 125000001544 thienyl group Chemical group 0.000 claims 3
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 2
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 2
- 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 claims 2
- RNOVGJWJVRESAA-UHFFFAOYSA-N 4-fluoro-2-(trifluoromethyl)phenol Chemical group OC1=CC=C(F)C=C1C(F)(F)F RNOVGJWJVRESAA-UHFFFAOYSA-N 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 239000000470 constituent Substances 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 2
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- OQHJGUWJDONURE-DZGCQCFKSA-N (1s,3r)-n-[[4-methoxy-2-(trifluoromethyl)phenyl]methyl]-3-[[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]amino]cyclohexane-1-carboxamide Chemical compound CNC1=NC(C)=NC(N[C@H]2C[C@H](CCC2)C(=O)NCC=2C(=CC(OC)=CC=2)C(F)(F)F)=N1 OQHJGUWJDONURE-DZGCQCFKSA-N 0.000 claims 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- LSGZQCYLTSNCCS-AVCGJXAMSA-N C1([C@@H](C)CNC=2N=C(N=C(N[C@@H]3CC[C@@H](CC3)C(=O)NCC=3C=CC(=CC=3)C(O)=O)N=2)SC)=CC=CC=C1 Chemical compound C1([C@@H](C)CNC=2N=C(N=C(N[C@@H]3CC[C@@H](CC3)C(=O)NCC=3C=CC(=CC=3)C(O)=O)N=2)SC)=CC=CC=C1 LSGZQCYLTSNCCS-AVCGJXAMSA-N 0.000 claims 1
- PDTHSKKHEIUPIT-UHFFFAOYSA-N CC1=NC(=NC(=N1)N(CC2=C(C=C(C=C2)Cl)C(F)(F)F)C3CCCCC3)NC Chemical compound CC1=NC(=NC(=N1)N(CC2=C(C=C(C=C2)Cl)C(F)(F)F)C3CCCCC3)NC PDTHSKKHEIUPIT-UHFFFAOYSA-N 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 1
- LNOJNKJACUHNMD-MOBUCQHHSA-N O=C([C@@H]1CC[C@@H](CC1)NC=1N=C(N=C(N=1)C=1C=C(C=CC=1)C(O)=O)NC)NCC1=CC=C(C#N)C=C1Cl Chemical compound O=C([C@@H]1CC[C@@H](CC1)NC=1N=C(N=C(N=1)C=1C=C(C=CC=1)C(O)=O)NC)NCC1=CC=C(C#N)C=C1Cl LNOJNKJACUHNMD-MOBUCQHHSA-N 0.000 claims 1
- JBBOFHPJZWVAMN-GLRZTSSQSA-N O=C([C@@H]1CC[C@@H](CC1)NC=1N=C(N=C(N=1)C=1C=C(C=CC=1)C(O)=O)NC)NCC1=CC=C(OC)C=C1C(F)(F)F Chemical compound O=C([C@@H]1CC[C@@H](CC1)NC=1N=C(N=C(N=1)C=1C=C(C=CC=1)C(O)=O)NC)NCC1=CC=C(OC)C=C1C(F)(F)F JBBOFHPJZWVAMN-GLRZTSSQSA-N 0.000 claims 1
- XQFRVIOBINNUGV-GLRZTSSQSA-N O=C([C@@H]1CC[C@@H](CC1)NC=1N=C(N=C(N=1)C=1C=C(C=CC=1)C(O)=O)NC)NCC1=CC=CC=C1OC(F)(F)F Chemical compound O=C([C@@H]1CC[C@@H](CC1)NC=1N=C(N=C(N=1)C=1C=C(C=CC=1)C(O)=O)NC)NCC1=CC=CC=C1OC(F)(F)F XQFRVIOBINNUGV-GLRZTSSQSA-N 0.000 claims 1
- SACCTTIRYCKSTH-UJKQEGAGSA-N O=C([C@@H]1CC[C@@H](CC1)NC=1N=C(N=C(N=1)C=1C=C(C=CC=1)C(O)=O)NC)NCC1=CN=CC=C1C(F)(F)F Chemical compound O=C([C@@H]1CC[C@@H](CC1)NC=1N=C(N=C(N=1)C=1C=C(C=CC=1)C(O)=O)NC)NCC1=CN=CC=C1C(F)(F)F SACCTTIRYCKSTH-UJKQEGAGSA-N 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97915407P | 2007-10-11 | 2007-10-11 | |
| US60/979,154 | 2007-10-11 | ||
| PCT/US2008/079517 WO2009049157A1 (en) | 2007-10-11 | 2008-10-10 | Novel seh inhibitors and their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011500594A JP2011500594A (ja) | 2011-01-06 |
| JP2011500594A5 true JP2011500594A5 (https=) | 2011-11-24 |
| JP5372943B2 JP5372943B2 (ja) | 2013-12-18 |
Family
ID=40549589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010529081A Active JP5372943B2 (ja) | 2007-10-11 | 2008-10-10 | 新規ｓＥＨ阻害剤およびそれらの使用 |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US8173805B2 (https=) |
| EP (1) | EP2214487B1 (https=) |
| JP (1) | JP5372943B2 (https=) |
| KR (1) | KR101546111B1 (https=) |
| CN (1) | CN101896065B (https=) |
| AU (1) | AU2008310732B2 (https=) |
| BR (1) | BRPI0817542A2 (https=) |
| CA (1) | CA2702265C (https=) |
| CO (1) | CO6270285A2 (https=) |
| CR (1) | CR11423A (https=) |
| CY (1) | CY1114865T1 (https=) |
| DK (1) | DK2214487T3 (https=) |
| DO (1) | DOP2010000101A (https=) |
| EA (1) | EA018414B1 (https=) |
| ES (1) | ES2445444T3 (https=) |
| HR (1) | HRP20140105T1 (https=) |
| IL (1) | IL204889A (https=) |
| MA (1) | MA31761B1 (https=) |
| MX (1) | MX2010003942A (https=) |
| MY (1) | MY157116A (https=) |
| NZ (1) | NZ584471A (https=) |
| PL (1) | PL2214487T3 (https=) |
| PT (1) | PT2214487E (https=) |
| RS (1) | RS53180B (https=) |
| SI (1) | SI2214487T1 (https=) |
| UA (1) | UA107444C2 (https=) |
| WO (1) | WO2009049157A1 (https=) |
| ZA (1) | ZA201002465B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7994317B2 (en) | 2006-11-03 | 2011-08-09 | GlaxoSmithKline, LLC | sEH inhibitors and their use |
| WO2009049165A1 (en) | 2007-10-11 | 2009-04-16 | Smithkline Beecham Corporation | Novel seh inhibitors and their use |
| JP5372943B2 (ja) | 2007-10-11 | 2013-12-18 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 新規ｓＥＨ阻害剤およびそれらの使用 |
| FR2948027A1 (fr) | 2009-07-17 | 2011-01-21 | Merck Sante Sas | Derives amines de dihydro-1,3,5-triazine pour leur utilisation dans le traitement des maladies associees a une ischemie et/ou une reperfusion |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US8809552B2 (en) * | 2011-11-01 | 2014-08-19 | Hoffmann-La Roche Inc. | Azetidine compounds, compositions and methods of use |
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| WO2015104422A1 (en) | 2014-01-13 | 2015-07-16 | Basf Se | Dihydrothiophene compounds for controlling invertebrate pests |
| WO2015155129A1 (en) * | 2014-04-07 | 2015-10-15 | Basf Se | Diaminotriazine compound |
| WO2016058544A1 (en) | 2014-10-16 | 2016-04-21 | Syros Pharmaceuticals, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
| WO2020074549A1 (en) * | 2018-10-10 | 2020-04-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and topical pharmaceutical compositions for the treatment of skin microvascular dysfunction |
| EP4618985A1 (en) | 2022-11-18 | 2025-09-24 | Universitat De Barcelona | Dual inhibitors of sigma-1 receptor and soluble epoxide hydrolase and their use in the treatment of pain |
| WO2024105225A1 (en) | 2022-11-18 | 2024-05-23 | Universitat De Barcelona | Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain |
| WO2026058000A2 (en) | 2024-09-13 | 2026-03-19 | Ucl Business Ltd | Methods |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5420283A (en) * | 1993-08-02 | 1995-05-30 | Pfizer Inc. | Resolution of (R)-2-benzylsuccinic acid 4-[4-(N-t-butoxycarbonylmethylamino)-piperidine] amide |
| WO2000038683A1 (en) * | 1998-12-23 | 2000-07-06 | Du Pont Pharmaceuticals Company | THROMBIN OR FACTOR Xa INHIBITORS |
| EP1790344B1 (en) * | 2000-07-07 | 2011-02-23 | Spectrum Pharmaceuticals, Inc. | Methods for treatment of disease-induced peripheral neuropathy and related conditions |
| US6451814B1 (en) * | 2000-07-17 | 2002-09-17 | Wyeth | Heterocyclic β-3 adrenergic receptor agonists |
| DE60137273D1 (de) | 2000-10-20 | 2009-02-12 | Eisai R&D Man Co Ltd | Verfahren zur Herstellung von 4-Phenoxy chinolin Derivaten |
| US20020091133A1 (en) * | 2000-12-12 | 2002-07-11 | Eve M. Taylor | Use of 9-substituted purine analogues and other molecules to stimulate neurogenesis |
| NZ526472A (en) * | 2000-12-21 | 2004-04-30 | Vertex Pharma | Pyrazole compounds useful as protein kinase inhibitors |
| CA2449486A1 (en) * | 2001-06-29 | 2003-01-09 | Boehringer Ingelheim Pharmaceuticals Inc. | Methods of using soluble epoxide hydrolase inhibitors |
| US20030055249A1 (en) | 2001-07-17 | 2003-03-20 | Fick David B. | Synthesis and methods of use of pyrimidine analogues and derivatives |
| TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| KR100875362B1 (ko) * | 2002-02-05 | 2008-12-22 | 아스텔라스세이야쿠 가부시키가이샤 | 2,4,6-트리아미노-1,3,5-트리아진 유도체 |
| EP1505972A2 (en) | 2002-05-16 | 2005-02-16 | Pharmacia Corporation | A selective inos inhibitor and a pde inhibitor in combination for the treatment of respiratory diseases |
| US20050197350A1 (en) * | 2003-03-31 | 2005-09-08 | Taisho Pharmaceutical Co., Ltd. | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof |
| EP1638955A2 (en) * | 2003-07-02 | 2006-03-29 | Vertex Pharmaceuticals Incorporated | Pyrimidines useful as modulators of voltage-gated ion channels |
| WO2005028467A1 (en) | 2003-09-15 | 2005-03-31 | Anadys Pharmaceuticals, Inc. | Antibacterial 3,5-diaminopiperidine-substitute aromatic and heteroaromatic compounds |
| AU2004274309B2 (en) * | 2003-09-22 | 2010-04-08 | Msd K.K. | Novel piperidine derivative |
| GB0401269D0 (en) | 2004-01-21 | 2004-02-25 | Astrazeneca Ab | Compounds |
| WO2006037117A1 (en) * | 2004-09-27 | 2006-04-06 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
| WO2006053109A1 (en) | 2004-11-10 | 2006-05-18 | Synta Pharmaceuticals Corp. | Heteroaryl compounds |
| EP1831181A2 (en) | 2004-12-14 | 2007-09-12 | Vertex Pharmaceuticals Incorporated | Pyrimidine inhibitors of erk protein kinase and uses thereof |
| WO2006121719A2 (en) * | 2005-05-06 | 2006-11-16 | Boehringer Ingelheim International, Gmbh | Soluble epoxide hydrolase inhibitors and methods of using same |
| CA2622754A1 (en) * | 2005-10-07 | 2007-04-19 | Boehringer Ingelheim International Gmbh | N-substituted pyridinone or pyrimidinone compounds useful as soluble epoxide hydrolase inhibitors |
| WO2007098352A2 (en) * | 2006-02-16 | 2007-08-30 | Boehringer Ingelheim International Gmbh | Substituted pyridineamide compounds useful as soluble epoxide hydrolase inhibitors |
| AR059826A1 (es) | 2006-03-13 | 2008-04-30 | Univ California | Inhibidores de urea conformacionalmente restringidos de epoxido hidrolasa soluble |
| US7994317B2 (en) * | 2006-11-03 | 2011-08-09 | GlaxoSmithKline, LLC | sEH inhibitors and their use |
| WO2009049154A1 (en) | 2007-10-11 | 2009-04-16 | Smithkline Beecham Corporation | NOVEL sEH INHIBITORS AND THEIR USE |
| JP5372943B2 (ja) | 2007-10-11 | 2013-12-18 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 新規ｓＥＨ阻害剤およびそれらの使用 |
| WO2009049165A1 (en) | 2007-10-11 | 2009-04-16 | Smithkline Beecham Corporation | Novel seh inhibitors and their use |
| JPWO2009048154A1 (ja) | 2007-10-12 | 2011-02-24 | 日本電気株式会社 | 半導体装置及びその設計方法 |
| WO2009070497A1 (en) | 2007-11-28 | 2009-06-04 | Smithkline Beecham Corporation | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE |
| EP2224928A4 (en) | 2007-12-06 | 2012-02-15 | Glaxosmithkline Llc | NOVEL INHIBITORS OF SEH AND THEIR USE |
| WO2009097474A1 (en) | 2008-01-30 | 2009-08-06 | Smithkline Beecham Corporation | Novel seh inhibitors and their use |
| EP2240025A4 (en) * | 2008-01-30 | 2012-03-28 | Glaxosmithkline Llc | NEW SEE INHIBITORS AND THEIR USE |
| WO2009097476A1 (en) | 2008-01-30 | 2009-08-06 | Smithkline Beecham Corporation | NOVEL sEH INHIBITORS AND THEIR USE |
| WO2010011917A1 (en) | 2008-07-25 | 2010-01-28 | Glaxosmithkline Llc | SEH AND 11β-HSD1 DUAL INHIBITORS |
-
2008
- 2008-10-10 JP JP2010529081A patent/JP5372943B2/ja active Active
- 2008-10-10 CA CA2702265A patent/CA2702265C/en active Active
- 2008-10-10 WO PCT/US2008/079517 patent/WO2009049157A1/en not_active Ceased
- 2008-10-10 PT PT88383146T patent/PT2214487E/pt unknown
- 2008-10-10 DK DK08838314.6T patent/DK2214487T3/da active
- 2008-10-10 SI SI200831142T patent/SI2214487T1/sl unknown
- 2008-10-10 BR BRPI0817542-0A2A patent/BRPI0817542A2/pt active Search and Examination
- 2008-10-10 CN CN200880120430XA patent/CN101896065B/zh active Active
- 2008-10-10 ES ES08838314.6T patent/ES2445444T3/es active Active
- 2008-10-10 AU AU2008310732A patent/AU2008310732B2/en not_active Ceased
- 2008-10-10 KR KR1020107010233A patent/KR101546111B1/ko active Active
- 2008-10-10 RS RS20140078A patent/RS53180B/sr unknown
- 2008-10-10 HR HRP20140105AT patent/HRP20140105T1/hr unknown
- 2008-10-10 NZ NZ584471A patent/NZ584471A/en unknown
- 2008-10-10 MX MX2010003942A patent/MX2010003942A/es active IP Right Grant
- 2008-10-10 MY MYPI2010001613A patent/MY157116A/en unknown
- 2008-10-10 EA EA201070442A patent/EA018414B1/ru not_active IP Right Cessation
- 2008-10-10 UA UAA201005720A patent/UA107444C2/uk unknown
- 2008-10-10 PL PL08838314T patent/PL2214487T3/pl unknown
- 2008-10-10 US US12/682,073 patent/US8173805B2/en active Active
- 2008-10-10 EP EP08838314.6A patent/EP2214487B1/en active Active
-
2010
- 2010-04-06 IL IL204889A patent/IL204889A/en active IP Right Grant
- 2010-04-08 MA MA32751A patent/MA31761B1/fr unknown
- 2010-04-08 ZA ZA2010/02465A patent/ZA201002465B/en unknown
- 2010-04-09 DO DO2010000101A patent/DOP2010000101A/es unknown
- 2010-04-09 US US12/757,089 patent/US8212032B2/en active Active
- 2010-05-06 CO CO10054262A patent/CO6270285A2/es active IP Right Grant
- 2010-05-11 CR CR11423A patent/CR11423A/es unknown
-
2014
- 2014-02-18 CY CY20141100122T patent/CY1114865T1/el unknown
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