JP2011500562A5 - - Google Patents
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- JP2011500562A5 JP2011500562A5 JP2010528867A JP2010528867A JP2011500562A5 JP 2011500562 A5 JP2011500562 A5 JP 2011500562A5 JP 2010528867 A JP2010528867 A JP 2010528867A JP 2010528867 A JP2010528867 A JP 2010528867A JP 2011500562 A5 JP2011500562 A5 JP 2011500562A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkenyl
- compound according
- compound
- ring members
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 55
- 125000000217 alkyl group Chemical group 0.000 claims 51
- 125000003342 alkenyl group Chemical group 0.000 claims 36
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 30
- 125000000623 heterocyclic group Chemical group 0.000 claims 16
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 14
- 125000005842 heteroatom Chemical group 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 229910052721 tungsten Inorganic materials 0.000 claims 7
- 229910052727 yttrium Inorganic materials 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 125000006526 (C1-C2) alkyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 229910052723 transition metal Inorganic materials 0.000 claims 4
- 150000003624 transition metals Chemical class 0.000 claims 4
- -1 —OH Chemical group 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 2
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims 2
- 125000002877 alkyl aryl group Chemical group 0.000 claims 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- 125000006709 (C5-C7) cycloalkenyl group Chemical group 0.000 claims 1
- 125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 102100025101 GATA-type zinc finger protein 1 Human genes 0.000 claims 1
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims 1
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 1
- 125000004946 alkenylalkyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004948 alkyl aryl alkyl group Chemical group 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 125000004106 butoxy group Chemical group [*]OC([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 229910052759 nickel Inorganic materials 0.000 claims 1
- 229910052763 palladium Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 229910052703 rhodium Inorganic materials 0.000 claims 1
- 239000010948 rhodium Substances 0.000 claims 1
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 229910052720 vanadium Inorganic materials 0.000 claims 1
- 0 C*1C=C(*)C(C)(C)CC1 Chemical compound C*1C=C(*)C(C)(C)CC1 0.000 description 3
- ZRVYMRHQWZKLKY-UHFFFAOYSA-N CC1(COC)CCCC1 Chemical compound CC1(COC)CCCC1 ZRVYMRHQWZKLKY-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99878607P | 2007-10-10 | 2007-10-10 | |
| US60/998,786 | 2007-10-10 | ||
| US6872408P | 2008-03-06 | 2008-03-06 | |
| US61/068,724 | 2008-03-06 | ||
| PCT/US2008/011422 WO2009048527A1 (en) | 2007-10-10 | 2008-10-03 | Substituted biphenyl gpr40 modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011500562A JP2011500562A (ja) | 2011-01-06 |
| JP2011500562A5 true JP2011500562A5 (OSRAM) | 2011-11-17 |
| JP5591706B2 JP5591706B2 (ja) | 2014-09-17 |
Family
ID=40338063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010528867A Expired - Fee Related JP5591706B2 (ja) | 2007-10-10 | 2008-10-03 | 置換ビフェニルｇｐｒ４０調節因子 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8030354B2 (OSRAM) |
| EP (1) | EP2205548A1 (OSRAM) |
| JP (1) | JP5591706B2 (OSRAM) |
| KR (1) | KR20100090249A (OSRAM) |
| CN (1) | CN102083783A (OSRAM) |
| AR (1) | AR068840A1 (OSRAM) |
| AU (1) | AU2008311355B2 (OSRAM) |
| BR (1) | BRPI0818253A2 (OSRAM) |
| CA (1) | CA2702047C (OSRAM) |
| CL (1) | CL2008002997A1 (OSRAM) |
| CO (1) | CO6270312A2 (OSRAM) |
| CR (1) | CR11420A (OSRAM) |
| IL (1) | IL204635A0 (OSRAM) |
| MA (1) | MA31841B1 (OSRAM) |
| MX (1) | MX2010003876A (OSRAM) |
| PE (1) | PE20091222A1 (OSRAM) |
| TN (1) | TN2010000125A1 (OSRAM) |
| TW (1) | TW200927091A (OSRAM) |
| WO (1) | WO2009048527A1 (OSRAM) |
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| AU2008309589B2 (en) | 2007-10-10 | 2012-07-05 | Novartis Ag | Spiropyrrolidines and their use against HCV and HIV infection |
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| AR074760A1 (es) | 2008-12-18 | 2011-02-09 | Metabolex Inc | Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico. |
| RU2567755C2 (ru) | 2009-12-25 | 2015-11-10 | Мотида Фармасьютикал Ко., Лтд. | Новое производное 3-гидрокси-5-арилизотиазола |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8299117B2 (en) | 2010-06-16 | 2012-10-30 | Metabolex Inc. | GPR120 receptor agonists and uses thereof |
| CA2801182A1 (en) * | 2010-06-16 | 2011-12-22 | Metabolex, Inc. | Gpr120 receptor agonists and uses thereof |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
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| US9040525B2 (en) | 2010-10-08 | 2015-05-26 | Mochida Pharmaceutical Co., Ltd. | Cyclic amide derivative |
| CN102617501A (zh) * | 2011-01-31 | 2012-08-01 | 中国科学院上海药物研究所 | 取代正戊酰胺类化合物、其制备方法及用途 |
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| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
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| KR20150036245A (ko) | 2012-08-02 | 2015-04-07 | 머크 샤프 앤드 돔 코포레이션 | 항당뇨병 트리시클릭 화합물 |
| WO2014064215A1 (en) | 2012-10-24 | 2014-05-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING β-CELL SURVIVAL |
| KR101942752B1 (ko) * | 2012-11-05 | 2019-01-28 | 주식회사 엘지화학 | Ｇｐｒ120 효능제로서의 티오아릴 유도체 |
| CA2891574A1 (en) | 2012-11-16 | 2014-05-22 | Bristol-Myers Squibb Company | Dihydropyrazole gpr40 modulators |
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| KR101569522B1 (ko) * | 2013-04-18 | 2015-11-17 | 현대약품 주식회사 | 신규한 3-(4-(벤질옥시)페닐)헥스-4-이노익 산 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물 |
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| EP3551176A4 (en) | 2016-12-06 | 2020-06-24 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| EP3558298A4 (en) | 2016-12-20 | 2020-08-05 | Merck Sharp & Dohme Corp. | ANTIDIABETIC SPIROCHROMAN COMPOUNDS |
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| US11186565B2 (en) | 2017-03-31 | 2021-11-30 | Takeda Pharmaceutical Company Limited | Aromatic compound |
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| MY196582A (en) | 2018-02-13 | 2023-04-19 | Gilead Sciences Inc | PD-1/PD-L1 Inhibitors |
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| PT3820572T (pt) | 2018-07-13 | 2023-11-10 | Gilead Sciences Inc | Inibidores pd-1/pd-l1 |
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-
2008
- 2008-10-03 MX MX2010003876A patent/MX2010003876A/es active IP Right Grant
- 2008-10-03 US US12/287,036 patent/US8030354B2/en active Active
- 2008-10-03 KR KR1020107010209A patent/KR20100090249A/ko not_active Withdrawn
- 2008-10-03 JP JP2010528867A patent/JP5591706B2/ja not_active Expired - Fee Related
- 2008-10-03 CA CA2702047A patent/CA2702047C/en not_active Expired - Fee Related
- 2008-10-03 AU AU2008311355A patent/AU2008311355B2/en not_active Ceased
- 2008-10-03 CN CN2008801199462A patent/CN102083783A/zh active Pending
- 2008-10-03 WO PCT/US2008/011422 patent/WO2009048527A1/en not_active Ceased
- 2008-10-03 EP EP08837085A patent/EP2205548A1/en not_active Withdrawn
- 2008-10-03 BR BRPI0818253-1A patent/BRPI0818253A2/pt not_active Application Discontinuation
- 2008-10-09 CL CL2008002997A patent/CL2008002997A1/es unknown
- 2008-10-09 TW TW097139006A patent/TW200927091A/zh unknown
- 2008-10-09 AR ARP080104409A patent/AR068840A1/es not_active Application Discontinuation
- 2008-10-09 PE PE2008001746A patent/PE20091222A1/es not_active Application Discontinuation
-
2010
- 2010-03-21 IL IL204635A patent/IL204635A0/en unknown
- 2010-03-22 TN TNP2010000125A patent/TN2010000125A1/fr unknown
- 2010-05-06 CO CO10054070A patent/CO6270312A2/es not_active Application Discontinuation
- 2010-05-10 CR CR11420A patent/CR11420A/es not_active Application Discontinuation
- 2010-05-10 MA MA32826A patent/MA31841B1/fr unknown
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