JP2009543792A5 - - Google Patents
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- Publication number
- JP2009543792A5 JP2009543792A5 JP2009519586A JP2009519586A JP2009543792A5 JP 2009543792 A5 JP2009543792 A5 JP 2009543792A5 JP 2009519586 A JP2009519586 A JP 2009519586A JP 2009519586 A JP2009519586 A JP 2009519586A JP 2009543792 A5 JP2009543792 A5 JP 2009543792A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- carbon atoms
- prodrug
- alkyl
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 150000001875 compounds Chemical class 0.000 claims 14
- 125000004432 carbon atom Chemical group C* 0.000 claims 9
- 239000000651 prodrug Substances 0.000 claims 7
- 229940002612 prodrug Drugs 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 206010030043 Ocular hypertension Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical class C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 150000007524 organic acids Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80697206P | 2006-07-11 | 2006-07-11 | |
| US80694606P | 2006-07-11 | 2006-07-11 | |
| PCT/US2007/072632 WO2008008660A2 (en) | 2006-07-11 | 2007-07-02 | Cyclopentane derivatives as antiglaucoma agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009543792A JP2009543792A (ja) | 2009-12-10 |
| JP2009543792A5 true JP2009543792A5 (OSRAM) | 2010-08-19 |
Family
ID=38716351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009519586A Withdrawn JP2009543792A (ja) | 2006-07-11 | 2007-07-02 | 抗緑内障薬としてのシクロペンタン誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20080015219A1 (OSRAM) |
| EP (1) | EP2066615A2 (OSRAM) |
| JP (1) | JP2009543792A (OSRAM) |
| AU (1) | AU2007272730B2 (OSRAM) |
| BR (1) | BRPI0714286A2 (OSRAM) |
| CA (1) | CA2659121A1 (OSRAM) |
| WO (1) | WO2008008660A2 (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2069295B1 (en) * | 2006-07-10 | 2013-12-18 | Allergan, Inc. | Substituted cyclopentane derivatives as therapeutic agents |
| AU2007272617B2 (en) * | 2006-07-11 | 2012-11-01 | Allergan, Inc. | Cyclopentane derivatives as antiglaucoma agents |
| US9591935B2 (en) * | 2007-07-03 | 2017-03-14 | Allergen, Inc. | Therapeutic substituted cyclopentanes |
| BRPI0819707A2 (pt) * | 2007-11-29 | 2015-06-16 | Allergan Inc | Ciclopentanos substituídas tendo atividade de prostaglandina |
| US8569349B2 (en) * | 2008-05-09 | 2013-10-29 | Allergan, Inc. | Therapeutic compounds |
| AU2009246573B2 (en) * | 2008-05-15 | 2014-04-24 | Allergan, Inc. | Therapeutic substituted cyclopentanes |
| US8867820B2 (en) * | 2009-10-07 | 2014-10-21 | Microsoft Corporation | Systems and methods for removing a background of an image |
| DK3107906T3 (en) * | 2014-02-20 | 2019-03-18 | Allergan Inc | REDUCED CENTRAL CORNER MAP THICKNESS USING HYDROFILE ESTER PRODRUGS OF BETA-CHLORCYCLOPENTANE |
| WO2015129782A1 (ja) * | 2014-02-27 | 2015-09-03 | 小野薬品工業株式会社 | 選択的ｅｐ２アゴニスト活性を有する化合物 |
| TR201905436T4 (tr) | 2014-06-06 | 2019-05-21 | Allergan Inc | Terapötik bileşikler olarak yeni ep4 agonistleri. |
| EP3327018B1 (en) | 2015-07-23 | 2020-11-25 | ONO Pharmaceutical Co., Ltd. | 2-(octahydrocyclopenta[b]pyran-2-yl)1,3-thiazole-4-carboxylic acid derivatives and related compounds as ep2 agonists with intraocular pressure lowering activity |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3980700A (en) * | 1971-10-07 | 1976-09-14 | G. D. Searle & Co. | Prostaglandin intermediates and optically active isomers thereof |
| DE2346706A1 (de) * | 1973-09-17 | 1975-04-03 | Hoechst Ag | Neue, nicht natuerlich vorkommende analoga von prostansaeuren und verfahren zu ihrer herstellung |
| US5688819A (en) * | 1992-09-21 | 1997-11-18 | Allergan | Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| US5352708A (en) * | 1992-09-21 | 1994-10-04 | Allergan, Inc. | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| JPH07238068A (ja) * | 1994-02-24 | 1995-09-12 | Taisho Pharmaceut Co Ltd | プロスタグランジンｅ１類縁体 |
| JP2001527063A (ja) * | 1998-12-24 | 2001-12-25 | 小野薬品工業株式会社 | ω−シクロアルキル−プロスタグランジンＥ２誘導体 |
| JP2004538306A (ja) * | 2001-07-31 | 2004-12-24 | スキャンポ・アーゲー | 高眼圧症および緑内障の処置 |
| BRPI0605926A2 (pt) * | 2005-01-14 | 2009-05-26 | Allergan Inc | ciclopentanos substituìdos ou ciclopentanonas como agentes terapêuticos |
| AU2007272617B2 (en) * | 2006-07-11 | 2012-11-01 | Allergan, Inc. | Cyclopentane derivatives as antiglaucoma agents |
-
2007
- 2007-05-14 US US11/748,168 patent/US20080015219A1/en not_active Abandoned
- 2007-07-02 EP EP07812546A patent/EP2066615A2/en not_active Withdrawn
- 2007-07-02 CA CA002659121A patent/CA2659121A1/en not_active Abandoned
- 2007-07-02 BR BRPI0714286-2A patent/BRPI0714286A2/pt not_active IP Right Cessation
- 2007-07-02 JP JP2009519586A patent/JP2009543792A/ja not_active Withdrawn
- 2007-07-02 WO PCT/US2007/072632 patent/WO2008008660A2/en not_active Ceased
- 2007-07-02 AU AU2007272730A patent/AU2007272730B2/en not_active Ceased
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