JP2010500416A5 - - Google Patents
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- Publication number
- JP2010500416A5 JP2010500416A5 JP2009524741A JP2009524741A JP2010500416A5 JP 2010500416 A5 JP2010500416 A5 JP 2010500416A5 JP 2009524741 A JP2009524741 A JP 2009524741A JP 2009524741 A JP2009524741 A JP 2009524741A JP 2010500416 A5 JP2010500416 A5 JP 2010500416A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- carbon atoms
- substituted
- alkyl
- prodrug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000004432 carbon atom Chemical group C* 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- -1 5- (3-propyl) thiophen-2-yl Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical class C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010030043 Ocular hypertension Diseases 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 230000004410 intraocular pressure Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 150000007524 organic acids Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82210806P | 2006-08-11 | 2006-08-11 | |
| PCT/US2007/075615 WO2008021975A2 (en) | 2006-08-11 | 2007-08-09 | Therapeutic lactams |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010500416A JP2010500416A (ja) | 2010-01-07 |
| JP2010500416A5 true JP2010500416A5 (OSRAM) | 2010-09-24 |
Family
ID=38683367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009524741A Pending JP2010500416A (ja) | 2006-08-11 | 2007-08-09 | 治療用ラクタム類 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7482475B2 (OSRAM) |
| EP (1) | EP2066660A2 (OSRAM) |
| JP (1) | JP2010500416A (OSRAM) |
| KR (1) | KR101422305B1 (OSRAM) |
| CN (1) | CN101522669B (OSRAM) |
| AU (1) | AU2007286177B2 (OSRAM) |
| BR (1) | BRPI0716742A2 (OSRAM) |
| CA (1) | CA2660608A1 (OSRAM) |
| MX (1) | MX2009001578A (OSRAM) |
| NZ (1) | NZ597866A (OSRAM) |
| WO (1) | WO2008021975A2 (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7592364B2 (en) * | 2006-02-28 | 2009-09-22 | Allergan, Inc. | Substituted gamma lactams as therapeutic agents |
| AU2007226957B2 (en) * | 2006-03-20 | 2013-08-15 | Allergan, Inc. | Substituted gamma lactams as prostaglandin EP2 agonists |
| CA2660608A1 (en) * | 2006-08-11 | 2008-02-21 | Allergan, Inc. | Therapeutic lactams |
| US7589213B2 (en) * | 2007-04-27 | 2009-09-15 | Old David W | Therapeutic substituted lactams |
| US8440819B2 (en) * | 2008-02-22 | 2013-05-14 | Allergan, Inc. | Therapeutic substituted beta-lactams |
| MX2010011636A (es) * | 2008-04-24 | 2010-11-25 | Allergan Inc | Gamma lactamas sustituidas como agentes terapeuticos. |
| EP2888250B1 (en) * | 2012-08-21 | 2017-07-19 | Allergan, Inc. | Process for the synthesis of substituted gamma lactams |
| US20150274658A1 (en) * | 2014-03-27 | 2015-10-01 | Allergan, Inc. | Therapeutic lactams |
| KR20170124602A (ko) | 2015-03-13 | 2017-11-10 | 포르마 세라퓨틱스 인크. | Hdac8 억제제로서의 알파-신나미드 화합물 및 조성물 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1991504A (en) * | 1928-09-12 | 1935-02-19 | American District Telegraph Co | Key-trapping valve lock for transmitter-supervised sprinkler systems |
| US5049577A (en) * | 1990-01-29 | 1991-09-17 | E. R. Squibb & Sons, Inc. | 2-pyrrolidone substituted dihydroxy alkanoic, alkenoic and alkynoic acids, compositions and HMG-CoA reductase inhibition therewith |
| US5902726A (en) | 1994-12-23 | 1999-05-11 | Glaxo Wellcome Inc. | Activators of the nuclear orphan receptor peroxisome proliferator-activated receptor gamma |
| JP4547912B2 (ja) * | 2002-03-05 | 2010-09-22 | 小野薬品工業株式会社 | ８−アザプロスタグランジン誘導体化合物およびその化合物を有効成分として含有する薬剤 |
| CA2495917A1 (en) | 2002-08-28 | 2004-03-11 | Merck Frosst Canada & Co. | Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma |
| WO2006061366A1 (en) * | 2004-12-06 | 2006-06-15 | Laboratoires Serono S.A. | Pyrrolidin-2-one derivatives for use as dp1 receptor agonists |
| BRPI0609021A2 (pt) * | 2005-03-10 | 2010-01-12 | Allergan Inc | gama lactamas substituìdas, composição e uso das mesmas |
| AU2007226957B2 (en) * | 2006-03-20 | 2013-08-15 | Allergan, Inc. | Substituted gamma lactams as prostaglandin EP2 agonists |
| CA2660608A1 (en) * | 2006-08-11 | 2008-02-21 | Allergan, Inc. | Therapeutic lactams |
-
2007
- 2007-08-09 CA CA002660608A patent/CA2660608A1/en not_active Abandoned
- 2007-08-09 BR BRPI0716742 patent/BRPI0716742A2/pt not_active IP Right Cessation
- 2007-08-09 JP JP2009524741A patent/JP2010500416A/ja active Pending
- 2007-08-09 WO PCT/US2007/075615 patent/WO2008021975A2/en not_active Ceased
- 2007-08-09 NZ NZ597866A patent/NZ597866A/xx not_active IP Right Cessation
- 2007-08-09 CN CN2007800369601A patent/CN101522669B/zh not_active Expired - Fee Related
- 2007-08-09 US US11/836,655 patent/US7482475B2/en active Active
- 2007-08-09 MX MX2009001578A patent/MX2009001578A/es active IP Right Grant
- 2007-08-09 EP EP07840832A patent/EP2066660A2/en not_active Withdrawn
- 2007-08-09 AU AU2007286177A patent/AU2007286177B2/en not_active Ceased
- 2007-08-09 KR KR1020097004976A patent/KR101422305B1/ko not_active Expired - Fee Related
-
2008
- 2008-12-15 US US12/334,704 patent/US8686025B2/en not_active Expired - Fee Related
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