JP2011500024A5 - - Google Patents
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- JP2011500024A5 JP2011500024A5 JP2010528899A JP2010528899A JP2011500024A5 JP 2011500024 A5 JP2011500024 A5 JP 2011500024A5 JP 2010528899 A JP2010528899 A JP 2010528899A JP 2010528899 A JP2010528899 A JP 2010528899A JP 2011500024 A5 JP2011500024 A5 JP 2011500024A5
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- 238000000034 method Methods 0.000 claims description 105
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- 238000009472 formulation Methods 0.000 claims description 58
- 239000002609 medium Substances 0.000 claims description 53
- 108090000623 proteins and genes Proteins 0.000 claims description 22
- 238000012258 culturing Methods 0.000 claims description 19
- 102000004169 proteins and genes Human genes 0.000 claims description 17
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 14
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 12
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims description 12
- 208000002780 macular degeneration Diseases 0.000 claims description 12
- 210000001671 embryonic stem cell Anatomy 0.000 claims description 10
- 108050002823 Bestrophin Proteins 0.000 claims description 9
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- 101001078886 Homo sapiens Retinaldehyde-binding protein 1 Proteins 0.000 claims description 9
- 101150092239 OTX2 gene Proteins 0.000 claims description 9
- 102100035846 Pigment epithelium-derived factor Human genes 0.000 claims description 9
- 102100028001 Retinaldehyde-binding protein 1 Human genes 0.000 claims description 9
- 108090000102 pigment epithelium-derived factor Proteins 0.000 claims description 9
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- 102000004190 Enzymes Human genes 0.000 claims description 8
- 108090000790 Enzymes Proteins 0.000 claims description 8
- 238000004115 adherent culture Methods 0.000 claims description 8
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims description 6
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- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims description 6
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 6
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims description 6
- 208000035719 Maculopathy Diseases 0.000 claims description 6
- 101710098940 Pro-epidermal growth factor Proteins 0.000 claims description 6
- 201000007737 Retinal degeneration Diseases 0.000 claims description 6
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims description 6
- 102000013275 Somatomedins Human genes 0.000 claims description 6
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims description 6
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 6
- 206010064930 age-related macular degeneration Diseases 0.000 claims description 6
- 229960005070 ascorbic acid Drugs 0.000 claims description 6
- 235000010323 ascorbic acid Nutrition 0.000 claims description 6
- 239000011668 ascorbic acid Substances 0.000 claims description 6
- 210000002242 embryoid body Anatomy 0.000 claims description 6
- 229960002897 heparin Drugs 0.000 claims description 6
- 229920000669 heparin Polymers 0.000 claims description 6
- 229960000890 hydrocortisone Drugs 0.000 claims description 6
- 230000004258 retinal degeneration Effects 0.000 claims description 6
- 101100518992 Mus musculus Pax2 gene Proteins 0.000 claims description 5
- 102000007354 PAX6 Transcription Factor Human genes 0.000 claims description 5
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- 102000003425 Tyrosinase Human genes 0.000 claims description 5
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- 210000004694 pigment cell Anatomy 0.000 claims 3
- 108010023082 activin A Proteins 0.000 claims 1
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- 239000006285 cell suspension Substances 0.000 claims 1
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- 210000003583 retinal pigment epithelium Anatomy 0.000 description 92
- 238000002360 preparation method Methods 0.000 description 21
- 239000003102 growth factor Substances 0.000 description 8
- 239000011159 matrix material Substances 0.000 description 8
- 238000011194 good manufacturing practice Methods 0.000 description 7
- 101000670189 Homo sapiens Ribulose-phosphate 3-epimerase Proteins 0.000 description 6
- 229940088598 enzyme Drugs 0.000 description 6
- 108020004999 messenger RNA Proteins 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 102000029816 Collagenase Human genes 0.000 description 3
- 108060005980 Collagenase Proteins 0.000 description 3
- 102000004142 Trypsin Human genes 0.000 description 3
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- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 229960002424 collagenase Drugs 0.000 description 3
- 210000004263 induced pluripotent stem cell Anatomy 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
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- 238000012544 monitoring process Methods 0.000 description 3
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- 230000002265 prevention Effects 0.000 description 3
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- 210000001082 somatic cell Anatomy 0.000 description 3
- 239000012588 trypsin Substances 0.000 description 3
- 101710126211 POU domain, class 5, transcription factor 1 Proteins 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 210000000844 retinal pigment epithelial cell Anatomy 0.000 description 2
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- 239000003814 drug Substances 0.000 description 1
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- 230000002538 fungal effect Effects 0.000 description 1
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- 238000004519 manufacturing process Methods 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
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- 238000010257 thawing Methods 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99866807P | 2007-10-12 | 2007-10-12 | |
| US99876607P | 2007-10-12 | 2007-10-12 | |
| US991108P | 2008-01-02 | 2008-01-02 | |
| US990808P | 2008-01-02 | 2008-01-02 | |
| PCT/US2008/011669 WO2009051671A1 (en) | 2007-10-12 | 2008-10-10 | Improved methods of producing rpe cells and compositions of rpe cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014125977A Division JP6137626B2 (ja) | 2007-10-12 | 2014-06-19 | Ｒｐｅ細胞を生成する改良された方法およびｒｐｅ細胞の組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011500024A JP2011500024A (ja) | 2011-01-06 |
| JP2011500024A5 true JP2011500024A5 (enExample) | 2012-11-15 |
Family
ID=40567677
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010528899A Withdrawn JP2011500024A (ja) | 2007-10-12 | 2008-10-10 | Ｒｐｅ細胞を生成する改良された方法およびｒｐｅ細胞の組成物 |
| JP2014125977A Active JP6137626B2 (ja) | 2007-10-12 | 2014-06-19 | Ｒｐｅ細胞を生成する改良された方法およびｒｐｅ細胞の組成物 |
| JP2017083243A Active JP6692768B2 (ja) | 2007-10-12 | 2017-04-19 | Ｒｐｅ細胞を生成する改良された方法およびｒｐｅ細胞の組成物 |
| JP2020072683A Pending JP2020115882A (ja) | 2007-10-12 | 2020-04-15 | Ｒｐｅ細胞を生成する改良された方法およびｒｐｅ細胞の組成物 |
| JP2022035111A Pending JP2022079484A (ja) | 2007-10-12 | 2022-03-08 | Ｒｐｅ細胞を生成する改良された方法およびｒｐｅ細胞の組成物 |
| JP2024205622A Pending JP2025036424A (ja) | 2007-10-12 | 2024-11-26 | Ｒｐｅ細胞を生成する改良された方法およびｒｐｅ細胞の組成物 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014125977A Active JP6137626B2 (ja) | 2007-10-12 | 2014-06-19 | Ｒｐｅ細胞を生成する改良された方法およびｒｐｅ細胞の組成物 |
| JP2017083243A Active JP6692768B2 (ja) | 2007-10-12 | 2017-04-19 | Ｒｐｅ細胞を生成する改良された方法およびｒｐｅ細胞の組成物 |
| JP2020072683A Pending JP2020115882A (ja) | 2007-10-12 | 2020-04-15 | Ｒｐｅ細胞を生成する改良された方法およびｒｐｅ細胞の組成物 |
| JP2022035111A Pending JP2022079484A (ja) | 2007-10-12 | 2022-03-08 | Ｒｐｅ細胞を生成する改良された方法およびｒｐｅ細胞の組成物 |
| JP2024205622A Pending JP2025036424A (ja) | 2007-10-12 | 2024-11-26 | Ｒｐｅ細胞を生成する改良された方法およびｒｐｅ細胞の組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US20110274662A1 (enExample) |
| EP (2) | EP2209888B1 (enExample) |
| JP (6) | JP2011500024A (enExample) |
| KR (2) | KR101849336B1 (enExample) |
| CN (2) | CN104946591A (enExample) |
| AU (1) | AU2008312007A1 (enExample) |
| CA (3) | CA3006687C (enExample) |
| DK (1) | DK2209888T3 (enExample) |
| ES (1) | ES2764473T3 (enExample) |
| IL (4) | IL292561A (enExample) |
| PL (1) | PL2209888T3 (enExample) |
| PT (1) | PT2209888T (enExample) |
| WO (1) | WO2009051671A1 (enExample) |
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| SG188122A1 (en) | 2004-01-23 | 2013-03-28 | Advanced Cell Tech Inc | Improved modalities for the treatment of degenerative diseases of the retina |
| US7794704B2 (en) | 2004-01-23 | 2010-09-14 | Advanced Cell Technology, Inc. | Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration |
| JP5441099B2 (ja) | 2007-01-18 | 2014-03-12 | 独立行政法人理化学研究所 | 視細胞への分化誘導方法 |
| ES2764473T3 (es) | 2007-10-12 | 2020-06-03 | Astellas Inst For Regenerative Medicine | Métodos mejorados para producir células RPE y composiciones de células RPE |
| WO2009132156A1 (en) * | 2008-04-22 | 2009-10-29 | Regenerative Research Foundation | Retinal pigment epithelial stem cells |
| WO2009148170A1 (ja) | 2008-06-06 | 2009-12-10 | 独立行政法人理化学研究所 | 幹細胞の培養方法 |
| ES2509567T3 (es) * | 2009-08-28 | 2014-10-17 | Cellular Dynamics International, Inc. | Identificación de variación genética en tejidos afectados |
| WO2011055855A1 (en) * | 2009-11-05 | 2011-05-12 | Riken | A method for differentiation induction in cultured stem cells |
| WO2011063005A2 (en) | 2009-11-17 | 2011-05-26 | Advanced Cell Technology, Inc. | Methods of producing human rpe cells and pharmaceutical preparations of human rpe cells |
| CA2783699C (en) | 2009-12-08 | 2019-01-15 | Case Western Reserve University | Primary amine compounds for treating ocular disorders |
| ES2874953T3 (es) * | 2010-07-23 | 2021-11-05 | Astellas Inst For Regenerative Medicine | Métodos para la detección de subpoblaciones raras de células y composiciones muy purificadas de células |
| FI20106354A0 (fi) * | 2010-12-20 | 2010-12-20 | Suomen Punainen Risti Veripalvelu | Menetelmä ihmisen retinan pigmentti-epiteelisolujen valmistamiseksi |
| JP6223963B2 (ja) | 2011-05-18 | 2017-11-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 網膜疾患を処置するための組成物および方法 |
| CA2855941A1 (en) * | 2011-11-14 | 2013-05-23 | Advanced Cell Technology, Inc. | Pharmaceutical preparations of human rpe cells and uses thereof |
| JP5985207B2 (ja) * | 2011-11-25 | 2016-09-06 | 住友化学株式会社 | 網膜色素上皮細胞の製造方法 |
| JP5985208B2 (ja) * | 2011-11-25 | 2016-09-06 | 住友化学株式会社 | 網膜組織の製造方法 |
| JP6012164B2 (ja) * | 2011-11-25 | 2016-10-25 | 住友化学株式会社 | 多能性幹細胞由来の組織の凍結保存方法 |
| JP5985209B2 (ja) * | 2011-11-25 | 2016-09-06 | 住友化学株式会社 | 眼杯様構造体の製造方法 |
| CN113817679A (zh) * | 2011-11-25 | 2021-12-21 | 住友化学株式会社 | 制备视网膜组织和视网膜相关细胞的方法 |
| JP6067232B2 (ja) * | 2011-11-25 | 2017-01-25 | 住友化学株式会社 | 網膜層特異的神経細胞を製造する方法 |
| KR102108245B1 (ko) | 2011-11-30 | 2020-05-08 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 중간엽 간질 세포 및 이에 관련된 용도 |
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| US10519422B2 (en) * | 2012-02-29 | 2019-12-31 | Riken | Method of producing human retinal pigment epithelial cells |
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| KR102728629B1 (ko) * | 2014-12-18 | 2024-11-12 | 쏘흐본느 유니베흐시테 | 망막 변성의 치료를 위한 otx2를 과발현하는 형질전환 rpe 세포 |
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| EA201791518A1 (ru) * | 2014-12-30 | 2017-10-31 | Селл Кьюр Нейросайансес Лтд. | Способы лечения заболеваний сетчатки |
| EP4343331A3 (en) | 2015-03-23 | 2024-06-19 | Astellas Institute for Regenerative Medicine | Improved assays for potency of human retinal pigment epithelium (rpe) cells and photoreceptor progenitors |
| AU2016308818B2 (en) | 2015-08-18 | 2022-04-21 | Astellas Institute For Regenerative Medicine | Clinical formulations |
| AU2016318774B2 (en) | 2015-09-08 | 2022-08-18 | FUJIFILM Cellular Dynamics, Inc. | MACS-based purification of stem cell-derived retinal pigment epithelium |
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| JP6987769B2 (ja) | 2015-10-26 | 2022-01-05 | セル キュア ニューロサイエンシズ リミテッド | 網膜色素上皮細胞の調製法 |
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| KR102198942B1 (ko) * | 2019-07-02 | 2021-01-05 | 의료법인 성광의료재단 | Pedf를 발현하거나 모세포에 비하여 pedf를 과발현하도록 유전적으로 조작된 중간엽 줄기세포 |
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