JP2011224018A5 - - Google Patents
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- JP2011224018A5 JP2011224018A5 JP2011171887A JP2011171887A JP2011224018A5 JP 2011224018 A5 JP2011224018 A5 JP 2011224018A5 JP 2011171887 A JP2011171887 A JP 2011171887A JP 2011171887 A JP2011171887 A JP 2011171887A JP 2011224018 A5 JP2011224018 A5 JP 2011224018A5
- Authority
- JP
- Japan
- Prior art keywords
- receptor
- receptor mutant
- mutant
- leu
- ala
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims 22
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims 22
- 102000005962 receptors Human genes 0.000 claims 13
- 108020003175 receptors Proteins 0.000 claims 13
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 5
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 4
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 claims 4
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 claims 4
- 102000017922 Neurotensin receptor Human genes 0.000 claims 4
- 102000012740 beta Adrenergic Receptors Human genes 0.000 claims 4
- 108010079452 beta Adrenergic Receptors Proteins 0.000 claims 4
- -1 such as an antibody Proteins 0.000 claims 4
- 102000009346 Adenosine receptors Human genes 0.000 claims 3
- 108050000203 Adenosine receptors Proteins 0.000 claims 3
- 239000000556 agonist Substances 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- GJLXVWOMRRWCIB-MERZOTPQSA-N (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanamide Chemical compound C([C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)C1=CC=C(O)C=C1 GJLXVWOMRRWCIB-MERZOTPQSA-N 0.000 claims 2
- 108060003345 Adrenergic Receptor Proteins 0.000 claims 2
- 102000017910 Adrenergic receptor Human genes 0.000 claims 2
- 102000018208 Cannabinoid Receptor Human genes 0.000 claims 2
- 108050007331 Cannabinoid receptor Proteins 0.000 claims 2
- 101000783751 Homo sapiens Adenosine receptor A2a Proteins 0.000 claims 2
- 108060003370 Neurotensin receptor Proteins 0.000 claims 2
- 101500028886 Rattus norvegicus Neurotensin Proteins 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 102000055905 human ADORA2A Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 claims 1
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 claims 1
- 108091008803 APLNR Proteins 0.000 claims 1
- 102000008873 Angiotensin II receptor Human genes 0.000 claims 1
- 108050000824 Angiotensin II receptor Proteins 0.000 claims 1
- 102000008102 Ankyrins Human genes 0.000 claims 1
- 108010049777 Ankyrins Proteins 0.000 claims 1
- 102000016555 Apelin receptors Human genes 0.000 claims 1
- 102000003916 Arrestin Human genes 0.000 claims 1
- 108090000328 Arrestin Proteins 0.000 claims 1
- 108070000005 Bile acid receptors Proteins 0.000 claims 1
- 102000017002 Bile acid receptors Human genes 0.000 claims 1
- 108010073466 Bombesin Receptors Proteins 0.000 claims 1
- 102000010183 Bradykinin receptor Human genes 0.000 claims 1
- 108050001736 Bradykinin receptor Proteins 0.000 claims 1
- 108010001789 Calcitonin Receptors Proteins 0.000 claims 1
- 102100038520 Calcitonin receptor Human genes 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 102000009410 Chemokine receptor Human genes 0.000 claims 1
- 108050000299 Chemokine receptor Proteins 0.000 claims 1
- 102000004859 Cholecystokinin Receptors Human genes 0.000 claims 1
- 108090001085 Cholecystokinin Receptors Proteins 0.000 claims 1
- 102400000739 Corticotropin Human genes 0.000 claims 1
- 101800000414 Corticotropin Proteins 0.000 claims 1
- 102000015554 Dopamine receptor Human genes 0.000 claims 1
- 108050004812 Dopamine receptor Proteins 0.000 claims 1
- 102000010180 Endothelin receptor Human genes 0.000 claims 1
- 108050001739 Endothelin receptor Proteins 0.000 claims 1
- 102000016359 Fibronectins Human genes 0.000 claims 1
- 108010067306 Fibronectins Proteins 0.000 claims 1
- 108070000009 Free fatty acid receptors Proteins 0.000 claims 1
- 102000005915 GABA Receptors Human genes 0.000 claims 1
- 108010005551 GABA Receptors Proteins 0.000 claims 1
- 102000008924 GPCR kinases Human genes 0.000 claims 1
- 108050000878 GPCR kinases Proteins 0.000 claims 1
- 102000011392 Galanin receptor Human genes 0.000 claims 1
- 108050001605 Galanin receptor Proteins 0.000 claims 1
- 108010016122 Ghrelin Receptors Proteins 0.000 claims 1
- 108010063919 Glucagon Receptors Proteins 0.000 claims 1
- 102100040890 Glucagon receptor Human genes 0.000 claims 1
- 102000017357 Glycoprotein hormone receptor Human genes 0.000 claims 1
- 108050005395 Glycoprotein hormone receptor Proteins 0.000 claims 1
- 102100039256 Growth hormone secretagogue receptor type 1 Human genes 0.000 claims 1
- 102000000543 Histamine Receptors Human genes 0.000 claims 1
- 108010002059 Histamine Receptors Proteins 0.000 claims 1
- 101001060451 Homo sapiens Pyroglutamylated RF-amide peptide receptor Proteins 0.000 claims 1
- 102100030643 Hydroxycarboxylic acid receptor 2 Human genes 0.000 claims 1
- 101710125793 Hydroxycarboxylic acid receptor 2 Proteins 0.000 claims 1
- 101150020170 KISS1R gene Proteins 0.000 claims 1
- 108010093008 Kinins Proteins 0.000 claims 1
- 102000002397 Kinins Human genes 0.000 claims 1
- 102000008238 LHRH Receptors Human genes 0.000 claims 1
- 108010021290 LHRH Receptors Proteins 0.000 claims 1
- 102000016994 Lysolipids receptors Human genes 0.000 claims 1
- 108070000013 Lysolipids receptors Proteins 0.000 claims 1
- 102000029828 Melanin-concentrating hormone receptor Human genes 0.000 claims 1
- 108010047068 Melanin-concentrating hormone receptor Proteins 0.000 claims 1
- 102000004378 Melanocortin Receptors Human genes 0.000 claims 1
- 108090000950 Melanocortin Receptors Proteins 0.000 claims 1
- 108050009605 Melatonin receptor Proteins 0.000 claims 1
- 102000001419 Melatonin receptor Human genes 0.000 claims 1
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 claims 1
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 claims 1
- 102100033818 Motilin receptor Human genes 0.000 claims 1
- 108700040483 Motilin receptors Proteins 0.000 claims 1
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 claims 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 claims 1
- 102100021126 N-formyl peptide receptor 2 Human genes 0.000 claims 1
- 101710091942 N-formyl peptide receptor 2 Proteins 0.000 claims 1
- 102000030937 Neuromedin U receptor Human genes 0.000 claims 1
- 108010002741 Neuromedin U receptor Proteins 0.000 claims 1
- 101800001814 Neurotensin Proteins 0.000 claims 1
- 102400001103 Neurotensin Human genes 0.000 claims 1
- 102000003840 Opioid Receptors Human genes 0.000 claims 1
- 108090000137 Opioid Receptors Proteins 0.000 claims 1
- 108050000742 Orexin Receptor Proteins 0.000 claims 1
- 102000008834 Orexin receptor Human genes 0.000 claims 1
- 108010064032 Pituitary Adenylate Cyclase-Activating Polypeptide Receptors Proteins 0.000 claims 1
- 102000014743 Pituitary Adenylate Cyclase-Activating Polypeptide Receptors Human genes 0.000 claims 1
- 108700023400 Platelet-activating factor receptors Proteins 0.000 claims 1
- 108070000023 Prokineticin receptors Proteins 0.000 claims 1
- 102000056271 Prolactin-releasing peptide receptors Human genes 0.000 claims 1
- 108700024163 Prolactin-releasing peptide receptors Proteins 0.000 claims 1
- 102000002020 Protease-activated receptors Human genes 0.000 claims 1
- 108050009310 Protease-activated receptors Proteins 0.000 claims 1
- 102000002298 Purinergic P2Y Receptors Human genes 0.000 claims 1
- 108010000818 Purinergic P2Y Receptors Proteins 0.000 claims 1
- 102100027888 Pyroglutamylated RF-amide peptide receptor Human genes 0.000 claims 1
- 102000008944 RGS Proteins Human genes 0.000 claims 1
- 108010074020 RGS Proteins Proteins 0.000 claims 1
- 102000004215 Relaxin receptors Human genes 0.000 claims 1
- 108090000728 Relaxin receptors Proteins 0.000 claims 1
- 108050001286 Somatostatin Receptor Proteins 0.000 claims 1
- 102000011096 Somatostatin receptor Human genes 0.000 claims 1
- 102000004852 Thyrotropin-releasing hormone receptors Human genes 0.000 claims 1
- 108090001094 Thyrotropin-releasing hormone receptors Proteins 0.000 claims 1
- 108070000027 Trace amine receptors Proteins 0.000 claims 1
- 102000016981 Trace amine receptors Human genes 0.000 claims 1
- 108010075974 Vasoactive Intestinal Peptide Receptors Proteins 0.000 claims 1
- 102000012088 Vasoactive Intestinal Peptide Receptors Human genes 0.000 claims 1
- 102000017937 Vasopressin/oxytocin receptor Human genes 0.000 claims 1
- 108060003373 Vasopressin/oxytocin receptor Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 238000011948 assay development Methods 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 230000003196 chaotropic effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 claims 1
- 229960000258 corticotropin Drugs 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 claims 1
- 230000008025 crystallization Effects 0.000 claims 1
- 238000007876 drug discovery Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- JCVAGGLLUIBFSY-UHFFFAOYSA-H hexasodium 5-[(1,8-dihydroxy-3,6-disulfonatonaphthalen-2-yl)diazenyl]-4-hydroxy-3-[(8-hydroxy-3,6-disulfonatonaphthalen-1-yl)diazenyl]naphthalene-2,7-disulfonate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].Oc1cc(cc2cc(c(N=Nc3cc(cc4cc(c(N=Nc5cc(cc6cc(cc(O)c56)S([O-])(=O)=O)S([O-])(=O)=O)c(O)c34)S([O-])(=O)=O)S([O-])(=O)=O)c(O)c12)S([O-])(=O)=O)S([O-])(=O)=O JCVAGGLLUIBFSY-UHFFFAOYSA-H 0.000 claims 1
- 108090000146 leukotriene receptors Proteins 0.000 claims 1
- 102000003835 leukotriene receptors Human genes 0.000 claims 1
- 150000002617 leukotrienes Chemical class 0.000 claims 1
- 230000003551 muscarinic effect Effects 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- PCJGZPGTCUMMOT-ISULXFBGSA-N neurotensin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 PCJGZPGTCUMMOT-ISULXFBGSA-N 0.000 claims 1
- 108091008880 orphan GPCRs Proteins 0.000 claims 1
- 239000004031 partial agonist Substances 0.000 claims 1
- 102000014187 peptide receptors Human genes 0.000 claims 1
- 108010011903 peptide receptors Proteins 0.000 claims 1
- 102000030769 platelet activating factor receptor Human genes 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 102000017953 prostanoid receptors Human genes 0.000 claims 1
- 108050007059 prostanoid receptors Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000027426 receptor tyrosine kinases Human genes 0.000 claims 1
- 108091008598 receptor tyrosine kinases Proteins 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0705450A GB0705450D0 (en) | 2007-03-22 | 2007-03-22 | Mutant proteins and method for selecting them |
| GB0705450.5 | 2007-03-22 | ||
| GB0724052A GB0724052D0 (en) | 2007-12-08 | 2007-12-08 | Mutant proteins and methods for selecting them |
| GB0724052.6 | 2007-12-08 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010500347A Division JP4842400B2 (ja) | 2007-03-22 | 2008-03-20 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014100213A Division JP2014155502A (ja) | 2007-03-22 | 2014-05-14 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011224018A JP2011224018A (ja) | 2011-11-10 |
| JP2011224018A5 true JP2011224018A5 (https=) | 2012-11-01 |
Family
ID=39386585
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010500347A Active JP4842400B2 (ja) | 2007-03-22 | 2008-03-20 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2011171887A Pending JP2011224018A (ja) | 2007-03-22 | 2011-08-05 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2014100213A Pending JP2014155502A (ja) | 2007-03-22 | 2014-05-14 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2016129938A Active JP6426661B2 (ja) | 2007-03-22 | 2016-06-30 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2018135756A Pending JP2018164456A (ja) | 2007-03-22 | 2018-07-19 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2020193343A Active JP7419217B2 (ja) | 2007-03-22 | 2020-11-20 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010500347A Active JP4842400B2 (ja) | 2007-03-22 | 2008-03-20 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014100213A Pending JP2014155502A (ja) | 2007-03-22 | 2014-05-14 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2016129938A Active JP6426661B2 (ja) | 2007-03-22 | 2016-06-30 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2018135756A Pending JP2018164456A (ja) | 2007-03-22 | 2018-07-19 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2020193343A Active JP7419217B2 (ja) | 2007-03-22 | 2020-11-20 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (7) | US8785135B2 (https=) |
| EP (4) | EP2386635A3 (https=) |
| JP (6) | JP4842400B2 (https=) |
| CN (2) | CN101688203B (https=) |
| AT (1) | ATE544854T1 (https=) |
| AU (1) | AU2008228085B2 (https=) |
| CA (1) | CA2681415C (https=) |
| DK (1) | DK2121919T3 (https=) |
| ES (2) | ES3008359T3 (https=) |
| GB (4) | GB2456236B8 (https=) |
| HR (1) | HRP20120336T1 (https=) |
| PL (1) | PL2121919T3 (https=) |
| PT (1) | PT2121919E (https=) |
| WO (1) | WO2008114020A2 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2456236B8 (en) * | 2007-03-22 | 2009-12-09 | Heptares Therapeutics Ltd | Stable muscarinic receptor mutants |
| GB0724051D0 (en) * | 2007-12-08 | 2008-01-16 | Medical Res Council | Mutant proteins and methods for producing them |
| GB0724860D0 (en) * | 2007-12-20 | 2008-01-30 | Heptares Therapeutics Ltd | Screening |
| GB0802474D0 (en) * | 2008-02-11 | 2008-03-19 | Heptares Therapeutics Ltd | Mutant proteins and methods for selecting them |
| WO2008068534A2 (en) * | 2008-03-05 | 2008-06-12 | Heptares Therapeutics Limited | Crystal structure of a betal -adremergi c receptor and uses thereof |
| GB0910725D0 (en) | 2009-06-22 | 2009-08-05 | Heptares Therapeutics Ltd | Mutant proteins and methods for producing them |
| GB201014715D0 (en) * | 2010-09-06 | 2010-10-20 | Vib Vzw | Nanobodies stabilizing functional conformational states of GPCRS |
| WO2012022928A2 (en) | 2010-08-20 | 2012-02-23 | Heptares Therapeutic Ltd | Biological materials and uses thereof |
| WO2012098413A1 (en) | 2011-01-21 | 2012-07-26 | Heptares Therapeutics Limited | Mutant g-protein coupled receptor proteins and methods for producing them |
| AU2012220558A1 (en) | 2011-02-23 | 2013-08-22 | Massachusetts Institute Of Technology | Water soluble membrane proteins and methods for the preparation and use thereof |
| WO2012120315A2 (en) | 2011-03-10 | 2012-09-13 | Heptares Therapeutics Limited | Mutant proteins and methods for producing them |
| US10174101B2 (en) | 2011-08-10 | 2019-01-08 | Heptares Therapeutics Limited | Stable proteins |
| ES2676827T3 (es) * | 2012-06-01 | 2018-07-25 | Heptares Therapeutics Limited | Ensayos |
| CN105102478A (zh) | 2013-01-30 | 2015-11-25 | 弗拉芒区生物技术研究所 | 用于筛选和药物发现目的的新型嵌合多肽 |
| US9932385B2 (en) | 2013-03-15 | 2018-04-03 | Medical Research Council | Mutant proteins and methods for their production |
| EP2989440A4 (en) | 2013-04-25 | 2017-01-04 | The Trustees Of The University Of Pennsylvania | Opioid detection based on high quality graphene transistor arrays and a synthetic mu receptor |
| US9670264B2 (en) | 2013-04-25 | 2017-06-06 | The Trustees Of The University Of Pennsylvania | Water soluble G-protein coupled receptor |
| CN105593240B (zh) * | 2013-06-11 | 2024-05-31 | 保罗·谢勒学院 | 用于以单氨基酸分辨率确定可突变配体-gpcr结合的方法以及突变配体和gpcr对 |
| US10373702B2 (en) | 2014-03-27 | 2019-08-06 | Massachusetts Institute Of Technology | Water-soluble trans-membrane proteins and methods for the preparation and use thereof |
| CN104151401A (zh) * | 2014-06-05 | 2014-11-19 | 维亚生物科技(上海)有限公司 | 融合表达离子通道蛋白及运输蛋白的方法及其使用的蛋白片断 |
| GB2527286A (en) * | 2014-06-11 | 2015-12-23 | Rsr Ltd | Glycoprotein hormone receptor mutations |
| US10287349B2 (en) | 2014-10-31 | 2019-05-14 | Abilita Bio, Inc. | Modified membrane spanning proteins and methods for the preparation and use thereof |
| CA3032514C (en) | 2015-07-31 | 2021-05-04 | Takehiro SHINODA | Method of producing membrane protein and utilization thereof |
| GB201601690D0 (en) | 2016-01-29 | 2016-03-16 | Heptares Therapeutics Ltd | G proteins |
| EP3205450A1 (de) * | 2016-02-09 | 2017-08-16 | Hermes Schleifkörper GmbH | Verfahren zur herstellung eines keramischen formkörpers |
| AU2017259821B2 (en) | 2016-05-04 | 2024-07-18 | Abilita Bio, Inc. | Methods and platform for preparing multispanning membrane proteins |
| CN113501881B (zh) * | 2017-09-27 | 2023-07-28 | 北京大学 | 融合蛋白 |
| US12123814B1 (en) * | 2019-06-14 | 2024-10-22 | Pierce Biotechnology, Inc. | G- protein coupled receptor extraction formulations |
| IL303865A (en) | 2020-12-23 | 2023-08-01 | Regeneron Pharma | Methods for obtaining antibodies that bind transmembrane proteins and cells that produce them |
| CN114038498B (zh) * | 2022-01-06 | 2022-03-18 | 北京晶泰科技有限公司 | Gpcr的热稳定性突变预测方法、结构筛选方法及其装置 |
| CN120948816B (zh) * | 2025-10-20 | 2026-03-03 | 国科大杭州高等研究院 | 一种g蛋白偶联受体的热稳定性突变位点筛选方法及其用途 |
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