JP2011219411A - 褥瘡治療外用液剤および褥瘡治療装置 - Google Patents
褥瘡治療外用液剤および褥瘡治療装置 Download PDFInfo
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- JP2011219411A JP2011219411A JP2010089871A JP2010089871A JP2011219411A JP 2011219411 A JP2011219411 A JP 2011219411A JP 2010089871 A JP2010089871 A JP 2010089871A JP 2010089871 A JP2010089871 A JP 2010089871A JP 2011219411 A JP2011219411 A JP 2011219411A
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- water
- pressure ulcer
- bath water
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- hydrogen gas
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Abstract
【解決手段】水基剤中に水素ガスを含有し、さらに添加成分として、少なくともビタミンC又はプロビタミンCを含有するとともに、ポリビニルピロリドン、ポリビニルアルコール、ポリアクリル酸ナトリウム、ゼラチン、コラーゲン含有タンパク加水分解物、ビタミンAより選ばれる1種又は2種以上を含有する。
【選択図】なし
Description
本発明者らは、褥瘡は高齢化社会を迎え多数の寝たきり患者や重症患者にとって深刻な問題であるが、有効な治療法が見いだされていないという現状に鑑みて鋭意検討を重ねた結果、水基剤に水素ガスを含有させた液剤が褥瘡治療に効果的な外用効果を奏することをついに見出し、本発明の完成に至ったのである。
図3に示す褥瘡治療装置100は、温湯を供給する温湯供給部101と、水素ガスを発生させる水素ガス発生部102と、浴用水を調製する浴用水調製部103と、温湯供給部1にて供給される温湯又は浴用水調製部103にて調製された浴用水に所定の添加剤を供給する添加剤供給部104と、浴用水調製部103より供給ライン107を介して浴用水を排出する浴用水排出部105と、浴用水排出部5より排出された浴用水を収容して褥瘡部位を浸漬させる浴槽部106と、浴槽部106の浴用水の溶存水素濃度を測定する水素濃度測定部110と、水素濃度測定部110で測定された溶存水素濃度に基づいて、浴用水調製部103で製造される浴用水の溶存水素濃度を調節する制御部111と、を具備してなるものである。
本実施例の褥瘡治療外用液剤では、公知の電気分解法又は上述した褥瘡治療装置1にて供給される加水素水(浴用水)を用いて、いずれも温度35.8〜36.4℃、溶存水素濃度1.02〜1.35ppm、溶存酸素濃度1.30〜3.28ppm、酸化還元電位−349〜−583mV、pH5.34〜8.06となるように調製した。一方、比較例試料は、水基剤として通常の水道水又は蒸留水を用いて、温度35.8〜36.4℃となるように調製した。なお、比較例試料においては、溶存水素濃0.01ppm未満、溶存酸素濃度6.07〜9.16ppm、酸化還元電位+77〜+284mV、pH6.19〜7.44のものを用いた。
まず、ddYマウスの背中の中央部(1.5×2.5cm)を創傷させないようにバリカンで毛剃りし、次に、角を丸く平滑に砥削した丸角長方形のメタクリル板(1.0×2.0cm)に二重綿ガーゼを被覆し、そこにマウスの背中の毛剃り面を32mmHgで加圧した。加圧継続2〜4日間で、メタクリル板と背骨に挟まれたマウス背中の皮膚が寝たきり患者等の床ずれに類似した物理的圧迫を受けることで、マウス背中に最も豊富に分布するI型コラーゲン及び表皮と真皮を張り合わせている基底膜のIV型コラーゲンが損傷して、NPUAP(米国褥瘡諮問委員会:National Pressure Ulcer Advisory Panel)分類の褥瘡ステージIに匹敵する皮膚症状が現れた。そして、毛剃り部ほぼ全体が上述した症状を示した3〜6日間のいずれかの時点で、マウス個体ごとに加圧を停止し、その直後から、1試験区ごとに8頭で治療処理を3週間行った。
まず、皮膚組織培養向けブロノフチャンバーの中でI型コラーゲンゲルの中にヒト皮膚線維芽細胞OUMS−36を播種し、その上に再構成基底膜成分であるマトリゲルを重層し、さらに、ヒト皮膚角化細胞HaCaT細胞を播種して生育させ、最後にエアリフティングによって角質層を形成させる3Dヒト皮膚組織モデル形成法によって人工皮膚を調製した(なお、3次元皮膚組織モデルの調製法の詳細は、Kato S et al.,J.of Photochem.&Photobiol.B:Biology.,(2010),vol.98,P.99−105や、Kato S et al.,Journal of Biomedical Nanotechnology.,(2010),vol.6,P.1−7等参照)。
上述した<褥瘡治療外用液剤及び比較例試料の調製>で説明した方法で同様に調製された褥瘡治療外用液剤を浴用水(温度35.8〜36.4℃、溶存水素濃度1.02〜1.35ppm、溶存酸素濃度1.30〜3.28ppm、酸化還元電位−349〜−583mV、pH5.34〜8.06)として用い、褥瘡患者に対して入浴又はシャワーのいずれかの方法により褥瘡部位に浴用水を接触させることで、浴用水の褥瘡に対する治癒効果を検証した。具体的には、褥瘡ステージや褥瘡部位の異なる症状の褥瘡患者に対して、浴用水を収容した浴槽に毎日1回10分間浸かって褥瘡部位を浴用水に浸漬させて治療する方法(入浴処理方法)、又はシャワーにて浴用水を毎日1回10分間浴びて褥瘡部位に浴用水を接触させる方法(シャワー処理方法)のいずれかの物理的治療法を適用して標準的治療を施し、これを4週間継続して行った。なお、比較試験では、通常の水を用いて同様の物理的治療法を行った。また、治療効果は、各々の褥瘡部位に対するNPUAP分類に従ったDTI疑似、ステージI〜IVの各段階で評価するとともに、そのステージ改善度を総合判定により評価した。
2 水素ガス発生部
3 浴用水調製部
4 添加剤供給部
5 浴用水排出部
6 浴槽部
7 供給ライン
10 褥瘡治療装置
Claims (11)
- 水基剤中に水素ガスを含有する褥瘡治療外用液剤。
- 少なくともビタミンC又はプロビタミンCを含有するとともに、
ポリビニルピロリドン、ポリビニルアルコール、ポリアクリル酸ナトリウム、ゼラチン、コラーゲン含有タンパク加水分解物、ビタミンAより選ばれる1種又は2種以上を含有する請求項1に記載の褥瘡治療外用液剤。 - 亜鉛、銅、カルシウム、鉄及びこれらを含む化合物より選ばれる1種又は2種以上を含有する請求項1又は請求項2に記載の褥瘡治療外用液剤。
- 水基剤中に炭酸ガスを含有する請求項1乃至請求項3のいずれか一項に記載の褥瘡治療外用液剤。
- 白金コロイドを含有する請求項1乃至請求項4のいずれか一項に記載の褥瘡治療外用液剤。
- 35〜43℃に調製され、溶存水素濃度が0.5ppm〜2.0ppmで、かつ酸化還元電位が−300mV〜−680mVである請求項1乃至請求項5のいずれか一項に記載の褥瘡治療外用液剤。
- ダブルチューブ構造の管体に、拡散室と、所定の孔径を有する多孔質要素とが設けられた調製装置に、
所定温度の水基剤を高圧で供給するとともに、目的とする溶存水素濃度及び酸化還元電位となるように水基剤の供給量に応じて水素ガスを供給し、
前記拡散室にて水基剤と水素ガスとを混合した混合流体を前記多孔質要素に通過させて得られる、
微細気泡状の水素ガスを含有する請求項1乃至請求項6のいずれか一項に記載の褥瘡治療外用液剤。 - 剤形が塗布剤である請求項1乃至請求項7のいずれか一項に記載の褥瘡治療外用液剤。
- 水素ガスを含有する褥瘡治療用の浴用水を供給する褥瘡治療装置であって、
35〜43℃に調製された温湯を供給する温湯供給部と、
水素ガスを発生させる水素ガス発生部と、
前記温湯供給部により供給された温湯と前記水素ガス発生部にて発生された水素ガスとが供給され、溶存水素濃度が0.8〜2.0ppmで、かつ酸化還元電位が−300〜−680mVとなる浴用水を調製する浴用水調製部と、
前記温湯供給部にて供給される温湯又は前記浴用水調製部にて調製された浴用水に所定の添加剤を供給する添加剤供給部と、
前記浴用水調製部より供給ラインを介して浴用水を排出する浴用水排出部と、
前記浴用水排出部より排出された浴用水を収容して褥瘡部位を浸漬させる浴槽部と、
を具備してなる褥瘡治療装置。 - 前記浴槽部内の浴用水の溶存水素濃度を測定する水素濃度測定部と、
前記水素濃度測定部で測定された溶存水素濃度に基づいて、前記浴用水調製部で製造される浴用水の溶存水素濃度を調節する制御部と、
を具備してなる請求項9に記載の褥瘡治療装置。 - 前記添加剤供給部にて供給される添加剤は、
少なくともビタミンC又はプロビタミンCと、
ポリビニルピロリドン、ポリビニルアルコール、ポリアクリル酸ナトリウム、ゼラチン、タンパク加水分解物、ビタミンAより選ばれる1種又は2種以上と、
を含む請求項9又は請求項10に記載の褥瘡治療装置。
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