JP2011144207A5 - - Google Patents
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- JP2011144207A5 JP2011144207A5 JP2011100206A JP2011100206A JP2011144207A5 JP 2011144207 A5 JP2011144207 A5 JP 2011144207A5 JP 2011100206 A JP2011100206 A JP 2011100206A JP 2011100206 A JP2011100206 A JP 2011100206A JP 2011144207 A5 JP2011144207 A5 JP 2011144207A5
- Authority
- JP
- Japan
- Prior art keywords
- poly
- group
- agents
- organic
- naphthoate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000012074 organic phase Substances 0.000 claims description 24
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 21
- 239000008346 aqueous phase Substances 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 18
- 150000002500 ions Chemical class 0.000 claims description 17
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 14
- DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 claims description 10
- 108010016076 Octreotide Proteins 0.000 claims description 10
- 239000006184 cosolvent Substances 0.000 claims description 10
- 229960002700 octreotide Drugs 0.000 claims description 6
- 238000000034 method Methods 0.000 claims 60
- 230000000975 bioactive effect Effects 0.000 claims 15
- WVYADZUPLLSGPU-UHFFFAOYSA-N salsalate Chemical compound OC(=O)C1=CC=CC=C1OC(=O)C1=CC=CC=C1O WVYADZUPLLSGPU-UHFFFAOYSA-N 0.000 claims 14
- 239000011859 microparticle Substances 0.000 claims 12
- 238000013270 controlled release Methods 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 239000000126 substance Substances 0.000 claims 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 9
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 9
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 9
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 9
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 9
- 238000004945 emulsification Methods 0.000 claims 9
- 239000003995 emulsifying agent Substances 0.000 claims 9
- -1 polyacetyls Polymers 0.000 claims 9
- 239000004632 polycaprolactone Substances 0.000 claims 9
- 229920001610 polycaprolactone Polymers 0.000 claims 9
- 229920001223 polyethylene glycol Polymers 0.000 claims 9
- 229920000642 polymer Polymers 0.000 claims 9
- 229940080296 2-naphthalenesulfonate Drugs 0.000 claims 7
- ALKYHXVLJMQRLQ-UHFFFAOYSA-N 3-Hydroxy-2-naphthoate Chemical compound C1=CC=C2C=C(O)C(C(=O)O)=CC2=C1 ALKYHXVLJMQRLQ-UHFFFAOYSA-N 0.000 claims 7
- 108010000817 Leuprolide Proteins 0.000 claims 7
- GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical group CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 claims 7
- 229960004338 leuprorelin Drugs 0.000 claims 7
- 238000002156 mixing Methods 0.000 claims 7
- KHARCSTZAGNHOT-UHFFFAOYSA-L naphthalene-2,3-dicarboxylate Chemical compound C1=CC=C2C=C(C([O-])=O)C(C(=O)[O-])=CC2=C1 KHARCSTZAGNHOT-UHFFFAOYSA-L 0.000 claims 7
- KVBGVZZKJNLNJU-UHFFFAOYSA-M naphthalene-2-sulfonate Chemical compound C1=CC=CC2=CC(S(=O)(=O)[O-])=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-M 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 229960000953 salsalate Drugs 0.000 claims 7
- UOBYKYZJUGYBDK-UHFFFAOYSA-M 2-naphthoate Chemical compound C1=CC=CC2=CC(C(=O)[O-])=CC=C21 UOBYKYZJUGYBDK-UHFFFAOYSA-M 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 6
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 6
- 229920001710 Polyorthoester Polymers 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 229920001577 copolymer Polymers 0.000 claims 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 6
- 239000002105 nanoparticle Substances 0.000 claims 6
- 229920000747 poly(lactic acid) Polymers 0.000 claims 6
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 6
- WILNLXGNKANPKN-UHFFFAOYSA-N trifluoromethyl 4-methylbenzoate Chemical compound CC1=CC=C(C(=O)OC(F)(F)F)C=C1 WILNLXGNKANPKN-UHFFFAOYSA-N 0.000 claims 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 6
- SJJCQDRGABAVBB-UHFFFAOYSA-N 1-hydroxy-2-naphthoic acid Chemical compound C1=CC=CC2=C(O)C(C(=O)O)=CC=C21 SJJCQDRGABAVBB-UHFFFAOYSA-N 0.000 claims 5
- 150000003384 small molecules Chemical class 0.000 claims 5
- DSZOEVVLZMNAEH-BXUJZNQYSA-N acetic acid;(2s)-1-[(4r,7s,10s,13s,16s,19r)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2s)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-n-[(2s)-1-[(2-amino-2-oxoe Chemical compound CC(O)=O.C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 DSZOEVVLZMNAEH-BXUJZNQYSA-N 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 229960001494 octreotide acetate Drugs 0.000 claims 4
- 229940062856 oxytocin acetate Drugs 0.000 claims 4
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims 3
- 102000009027 Albumins Human genes 0.000 claims 3
- 108010088751 Albumins Proteins 0.000 claims 3
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical group [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 claims 3
- 102000004877 Insulin Human genes 0.000 claims 3
- 108090001061 Insulin Proteins 0.000 claims 3
- 101800000989 Oxytocin Proteins 0.000 claims 3
- 102400000050 Oxytocin Human genes 0.000 claims 3
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 claims 3
- 229920002732 Polyanhydride Polymers 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 229920000954 Polyglycolide Polymers 0.000 claims 3
- AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 claims 3
- 229940050528 albumin Drugs 0.000 claims 3
- 229940035676 analgesics Drugs 0.000 claims 3
- 229940035674 anesthetics Drugs 0.000 claims 3
- 239000000730 antalgic agent Substances 0.000 claims 3
- 239000003242 anti bacterial agent Substances 0.000 claims 3
- 230000003474 anti-emetic effect Effects 0.000 claims 3
- 230000002921 anti-spasmodic effect Effects 0.000 claims 3
- 229940088710 antibiotic agent Drugs 0.000 claims 3
- 239000003146 anticoagulant agent Substances 0.000 claims 3
- 229940127219 anticoagulant drug Drugs 0.000 claims 3
- 239000003472 antidiabetic agent Substances 0.000 claims 3
- 229940125708 antidiabetic agent Drugs 0.000 claims 3
- 229940125683 antiemetic agent Drugs 0.000 claims 3
- 239000002111 antiemetic agent Substances 0.000 claims 3
- 239000003429 antifungal agent Substances 0.000 claims 3
- 229940121375 antifungal agent Drugs 0.000 claims 3
- 229940125715 antihistaminic agent Drugs 0.000 claims 3
- 239000000739 antihistaminic agent Substances 0.000 claims 3
- 239000002220 antihypertensive agent Substances 0.000 claims 3
- 229940030600 antihypertensive agent Drugs 0.000 claims 3
- 229960005475 antiinfective agent Drugs 0.000 claims 3
- 239000003430 antimalarial agent Substances 0.000 claims 3
- 229940033495 antimalarials Drugs 0.000 claims 3
- 239000004599 antimicrobial Substances 0.000 claims 3
- 239000000164 antipsychotic agent Substances 0.000 claims 3
- 229940124575 antispasmodic agent Drugs 0.000 claims 3
- 239000003443 antiviral agent Substances 0.000 claims 3
- 235000019445 benzyl alcohol Nutrition 0.000 claims 3
- 239000012867 bioactive agent Substances 0.000 claims 3
- 229940125692 cardiovascular agent Drugs 0.000 claims 3
- 239000002327 cardiovascular agent Substances 0.000 claims 3
- 230000015556 catabolic process Effects 0.000 claims 3
- 229940127089 cytotoxic agent Drugs 0.000 claims 3
- 239000002254 cytotoxic agent Substances 0.000 claims 3
- 231100000599 cytotoxic agent Toxicity 0.000 claims 3
- 238000006731 degradation reaction Methods 0.000 claims 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethyl sulfoxide Natural products CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 3
- 235000019441 ethanol Nutrition 0.000 claims 3
- 239000003193 general anesthetic agent Substances 0.000 claims 3
- 229940088597 hormone Drugs 0.000 claims 3
- 239000005556 hormone Substances 0.000 claims 3
- 230000003308 immunostimulating effect Effects 0.000 claims 3
- 239000003018 immunosuppressive agent Substances 0.000 claims 3
- 229940125721 immunosuppressive agent Drugs 0.000 claims 3
- 229940125396 insulin Drugs 0.000 claims 3
- 239000000787 lecithin Substances 0.000 claims 3
- 229940067606 lecithin Drugs 0.000 claims 3
- 235000010445 lecithin Nutrition 0.000 claims 3
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 3
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 3
- 229960001723 oxytocin Drugs 0.000 claims 3
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 claims 3
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims 3
- 229920001308 poly(aminoacid) Polymers 0.000 claims 3
- 229920000117 poly(dioxanone) Polymers 0.000 claims 3
- 229940065514 poly(lactide) Drugs 0.000 claims 3
- 229920000515 polycarbonate Polymers 0.000 claims 3
- 239000004417 polycarbonate Substances 0.000 claims 3
- 229920002721 polycyanoacrylate Polymers 0.000 claims 3
- 229920006149 polyester-amide block copolymer Polymers 0.000 claims 3
- 229920000136 polysorbate Polymers 0.000 claims 3
- 229950008882 polysorbate Drugs 0.000 claims 3
- 239000004814 polyurethane Substances 0.000 claims 3
- 229920002635 polyurethane Polymers 0.000 claims 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 3
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 150000003431 steroids Chemical class 0.000 claims 3
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 claims 3
- LNETULKMXZVUST-UHFFFAOYSA-N 1-naphthoic acid Chemical compound C1=CC=C2C(C(=O)O)=CC=CC2=C1 LNETULKMXZVUST-UHFFFAOYSA-N 0.000 claims 2
- UOBYKYZJUGYBDK-UHFFFAOYSA-N 2-naphthoic acid Chemical compound C1=CC=CC2=CC(C(=O)O)=CC=C21 UOBYKYZJUGYBDK-UHFFFAOYSA-N 0.000 claims 1
- 229920002988 biodegradable polymer Polymers 0.000 claims 1
- 239000004621 biodegradable polymer Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000009472 formulation Methods 0.000 description 3
- WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 3
- 238000005538 encapsulation Methods 0.000 description 2
- 238000000710 polymer precipitation Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48766303P | 2003-07-15 | 2003-07-15 | |
| US60/487,663 | 2003-07-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006520347A Division JP5165239B2 (ja) | 2003-07-15 | 2004-07-15 | 制御放出処方物の調製のための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011144207A JP2011144207A (ja) | 2011-07-28 |
| JP2011144207A5 true JP2011144207A5 (enExample) | 2013-06-06 |
Family
ID=34102710
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006520347A Expired - Fee Related JP5165239B2 (ja) | 2003-07-15 | 2004-07-15 | 制御放出処方物の調製のための方法 |
| JP2011100206A Pending JP2011144207A (ja) | 2003-07-15 | 2011-04-27 | 制御放出処方物の調製のための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006520347A Expired - Fee Related JP5165239B2 (ja) | 2003-07-15 | 2004-07-15 | 制御放出処方物の調製のための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8871269B2 (enExample) |
| EP (2) | EP2462896A1 (enExample) |
| JP (2) | JP5165239B2 (enExample) |
| CN (2) | CN1852687B (enExample) |
| AU (1) | AU2004259208B2 (enExample) |
| BR (1) | BRPI0412059A (enExample) |
| CA (1) | CA2532302C (enExample) |
| ES (1) | ES2625343T3 (enExample) |
| WO (1) | WO2005009356A2 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070207211A1 (en) * | 2003-04-10 | 2007-09-06 | Pr Pharmaceuticals, Inc. | Emulsion-based microparticles and methods for the production thereof |
| WO2005003180A2 (en) | 2003-04-10 | 2005-01-13 | Pr Pharmaceuticals | A method for the production of emulsion-based micro particles |
| AU2004259208B2 (en) | 2003-07-15 | 2011-04-28 | Evonik Corporation | Method for the preparation of controlled release formulations |
| EP1660039B1 (en) * | 2003-07-18 | 2016-09-28 | Oakwood Laboratories L.L.C. | Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions |
| AU2004259209A1 (en) | 2003-07-23 | 2005-02-03 | Pr Pharmaceuticals, Inc. | Controlled release compositions |
| CA2552241C (en) * | 2003-12-30 | 2013-10-01 | Durect Corporation | Co-polymeric devices for controlled release of active agents |
| EP1679065A1 (en) * | 2005-01-07 | 2006-07-12 | OctoPlus Sciences B.V. | Controlled release compositions for interferon based on PEGT/PBT block copolymers |
| US20100290982A1 (en) * | 2007-04-13 | 2010-11-18 | University Of North Texas Health Science Center At Fort Worth | Solid in oil/water emulsion-diffusion-evaporation formulation for preparing curcumin-loaded plga nanoparticles |
| AU2008240155B2 (en) * | 2007-04-13 | 2012-09-20 | University Of North Texas Health Science Center At Fort Worth | Formulation of active agent loaded activated PLGA nanoparticles for targeted cancer nano-therapeutics |
| WO2008130158A1 (en) * | 2007-04-19 | 2008-10-30 | Dong-A Pharmaceutical. Co., Ltd | A biodegradable microsphere composition suitable for the controlled release of glucose controlling peptide and formulation thereof |
| GB0709322D0 (en) * | 2007-05-15 | 2007-06-20 | Nordic Bioscience As | Exposure agent for detection of vitamin d |
| WO2008145183A1 (en) * | 2007-05-30 | 2008-12-04 | Nestec S.A. | Oil-in-water emulsion and its use for the delayed release of active elements |
| JP5668476B2 (ja) | 2007-10-08 | 2015-02-12 | オーリニア・ファーマシューティカルズ・インコーポレイテッドＡｕｒｉｎｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | カルシニューリン阻害剤またはｍＴＯＲ阻害剤を含む眼科用組成物 |
| ES2324009B1 (es) * | 2007-11-23 | 2010-05-21 | Gp Pharm S.A. | Composicion farmaceutica de liberacion sostenida de somatostatina o un analogo suyo. |
| US8071914B2 (en) * | 2007-12-26 | 2011-12-06 | Noboru Oshima | Heating apparatus |
| JP5222550B2 (ja) * | 2007-12-27 | 2013-06-26 | 財團法人工業技術研究院 | 徐放性組成物およびその製造方法 |
| US9161943B2 (en) * | 2007-12-31 | 2015-10-20 | Industrial Technology Research Institute | Sustained release composition and manufacturing method thereof |
| WO2009100222A1 (en) * | 2008-02-08 | 2009-08-13 | Qps Llc | Non-polymeric compositions for controlled drug delivery |
| CA2730760A1 (en) * | 2008-07-16 | 2010-01-21 | Surmodics Pharmaceuticals, Inc. | Process for preparing microparticles containing bioactive peptides |
| EP2440185B1 (en) | 2009-06-09 | 2015-04-08 | Aurinia Pharmaceuticals Inc. | Topical drug delivery systems for ophthalmic use |
| BR112012002709A2 (pt) * | 2009-08-05 | 2019-04-30 | Pieris Ag | formulações de liberação controlada de muteínas de lipocalina |
| US20110151028A1 (en) * | 2009-12-19 | 2011-06-23 | Filiberto Zadini | Topical vaginal preparation |
| ES2362604B1 (es) * | 2009-12-22 | 2012-06-28 | Bcn Peptides, S.A. | Formulación tópica oftálmica de péptidos. |
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- 2004-07-15 EP EP11187402A patent/EP2462896A1/en not_active Withdrawn
- 2004-07-15 EP EP04778360.0A patent/EP1651136B1/en not_active Expired - Lifetime
- 2004-07-15 US US10/564,494 patent/US8871269B2/en active Active
- 2004-07-15 JP JP2006520347A patent/JP5165239B2/ja not_active Expired - Fee Related
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- 2004-07-15 CN CN200480026606.7A patent/CN1852687B/zh not_active Expired - Fee Related
- 2004-07-15 CN CN2012104691508A patent/CN102935069A/zh active Pending
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2011
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