CA2532302C - Method for the preparation of controlled release formulations - Google Patents

Method for the preparation of controlled release formulations Download PDF

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Publication number
CA2532302C
CA2532302C CA2532302A CA2532302A CA2532302C CA 2532302 C CA2532302 C CA 2532302C CA 2532302 A CA2532302 A CA 2532302A CA 2532302 A CA2532302 A CA 2532302A CA 2532302 C CA2532302 C CA 2532302C
Authority
CA
Canada
Prior art keywords
poly
organic
agent
organic phase
bioactive agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2532302A
Other languages
English (en)
French (fr)
Other versions
CA2532302A1 (en
Inventor
P. Cook Gary
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Corp
Original Assignee
Evonik Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Corp filed Critical Evonik Corp
Publication of CA2532302A1 publication Critical patent/CA2532302A1/en
Application granted granted Critical
Publication of CA2532302C publication Critical patent/CA2532302C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2532302A 2003-07-15 2004-07-15 Method for the preparation of controlled release formulations Expired - Fee Related CA2532302C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48766303P 2003-07-15 2003-07-15
US60/487,663 2003-07-15
PCT/US2004/022816 WO2005009356A2 (en) 2003-07-15 2004-07-15 Method for the preparation of controlled release formulations

Publications (2)

Publication Number Publication Date
CA2532302A1 CA2532302A1 (en) 2005-02-03
CA2532302C true CA2532302C (en) 2016-12-20

Family

ID=34102710

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2532302A Expired - Fee Related CA2532302C (en) 2003-07-15 2004-07-15 Method for the preparation of controlled release formulations

Country Status (9)

Country Link
US (1) US8871269B2 (enExample)
EP (2) EP1651136B1 (enExample)
JP (2) JP5165239B2 (enExample)
CN (2) CN1852687B (enExample)
AU (1) AU2004259208B2 (enExample)
BR (1) BRPI0412059A (enExample)
CA (1) CA2532302C (enExample)
ES (1) ES2625343T3 (enExample)
WO (1) WO2005009356A2 (enExample)

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CA2683698C (en) * 2007-04-19 2013-09-10 Hyun Hee Kwak A biodegradable microsphere composition suitable for the controlled release of glucose controlling peptide and formulation thereof
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US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
US20190117573A1 (en) * 2017-10-19 2019-04-25 Hyalo Technologies, LLC Composition and method of preparation of risperidone extended release preparation
US20230062487A1 (en) * 2020-01-24 2023-03-02 W. L. Gore & Associates, Inc. Sustained-release matrices for adventitial or periadventitial neural ablation and uses thereof
CN111643483B (zh) * 2020-07-06 2022-03-29 济南大学 一种用于制备加兰他敏缓释微球的方法
AU2022226584A1 (en) 2021-02-24 2023-08-17 Oakwood Laboratories, Llc Microsphere formulations comprising lurasidone and methods for making and using the same
CA3216277A1 (en) * 2021-04-23 2022-10-27 Bradley MINROVIC Microsphere formulations comprising multiple non-identical peptides and methods for making the same
US20250009644A1 (en) * 2021-12-02 2025-01-09 University Of Connecticut Long-acting injectable in situ forming biodegradable implants comprising non-steroidal anti-inflammatory drugs
CN116421578A (zh) * 2023-03-31 2023-07-14 辉粒药业(苏州)有限公司 生长抑素类似物缓释微球及其制备方法
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Also Published As

Publication number Publication date
BRPI0412059A (pt) 2006-09-05
US20060228414A1 (en) 2006-10-12
AU2004259208B2 (en) 2011-04-28
JP5165239B2 (ja) 2013-03-21
CN1852687B (zh) 2014-01-22
EP1651136B1 (en) 2017-03-08
WO2005009356A3 (en) 2005-06-09
AU2004259208A1 (en) 2005-02-03
CN1852687A (zh) 2006-10-25
WO2005009356A2 (en) 2005-02-03
ES2625343T3 (es) 2017-07-19
EP1651136A4 (en) 2009-07-08
US8871269B2 (en) 2014-10-28
EP1651136A2 (en) 2006-05-03
JP2007524645A (ja) 2007-08-30
JP2011144207A (ja) 2011-07-28
EP2462896A1 (en) 2012-06-13
CA2532302A1 (en) 2005-02-03
CN102935069A (zh) 2013-02-20

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Effective date: 20190715