CN1852687B - 控释组合物的制备方法 - Google Patents

控释组合物的制备方法 Download PDF

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Publication number
CN1852687B
CN1852687B CN200480026606.7A CN200480026606A CN1852687B CN 1852687 B CN1852687 B CN 1852687B CN 200480026606 A CN200480026606 A CN 200480026606A CN 1852687 B CN1852687 B CN 1852687B
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CN
China
Prior art keywords
organic
acid
polymer
water
octreotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200480026606.7A
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English (en)
Chinese (zh)
Other versions
CN1852687A (zh
Inventor
P·库克·盖瑞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brooke Wood Pharmaceuticals Ltd
Evonik Corp
Original Assignee
Evonik Corp
PR Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of CN1852687A publication Critical patent/CN1852687A/zh
Application granted granted Critical
Publication of CN1852687B publication Critical patent/CN1852687B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200480026606.7A 2003-07-15 2004-07-15 控释组合物的制备方法 Expired - Fee Related CN1852687B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48766303P 2003-07-15 2003-07-15
US60/487,663 2003-07-15
PCT/US2004/022816 WO2005009356A2 (en) 2003-07-15 2004-07-15 Method for the preparation of controlled release formulations

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2012104691508A Division CN102935069A (zh) 2003-07-15 2004-07-15 控释组合物的制备方法

Publications (2)

Publication Number Publication Date
CN1852687A CN1852687A (zh) 2006-10-25
CN1852687B true CN1852687B (zh) 2014-01-22

Family

ID=34102710

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2012104691508A Pending CN102935069A (zh) 2003-07-15 2004-07-15 控释组合物的制备方法
CN200480026606.7A Expired - Fee Related CN1852687B (zh) 2003-07-15 2004-07-15 控释组合物的制备方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN2012104691508A Pending CN102935069A (zh) 2003-07-15 2004-07-15 控释组合物的制备方法

Country Status (9)

Country Link
US (1) US8871269B2 (enExample)
EP (2) EP2462896A1 (enExample)
JP (2) JP5165239B2 (enExample)
CN (2) CN102935069A (enExample)
AU (1) AU2004259208B2 (enExample)
BR (1) BRPI0412059A (enExample)
CA (1) CA2532302C (enExample)
ES (1) ES2625343T3 (enExample)
WO (1) WO2005009356A2 (enExample)

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EP2462896A1 (en) 2003-07-15 2012-06-13 PR Pharmaceuticals Inc. Method for the preparation of controlled release formulations
CA2819769C (en) * 2003-07-18 2016-06-28 Oakwood Laboratories, L.L.C. Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions
BRPI0412211A (pt) * 2003-07-23 2006-08-22 Pr Pharmaceuticals Inc composições de liberação controlada
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AU2008240155B2 (en) * 2007-04-13 2012-09-20 University Of North Texas Health Science Center At Fort Worth Formulation of active agent loaded activated PLGA nanoparticles for targeted cancer nano-therapeutics
US20100290982A1 (en) * 2007-04-13 2010-11-18 University Of North Texas Health Science Center At Fort Worth Solid in oil/water emulsion-diffusion-evaporation formulation for preparing curcumin-loaded plga nanoparticles
NZ580700A (en) 2007-04-19 2012-01-12 Dong A Pharm Co Ltd A biodegradable microsphere composition suitable for the controlled release of glucose controlling peptide and formulation thereof
GB0709322D0 (en) * 2007-05-15 2007-06-20 Nordic Bioscience As Exposure agent for detection of vitamin d
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US8071914B2 (en) * 2007-12-26 2011-12-06 Noboru Oshima Heating apparatus
JP5222550B2 (ja) * 2007-12-27 2013-06-26 財團法人工業技術研究院 徐放性組成物およびその製造方法
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US9017725B2 (en) 2009-06-09 2015-04-28 Aurinia Pharmaceuticals Inc. Topical drug delivery systems for ophthalmic use
CN102612362A (zh) * 2009-08-05 2012-07-25 皮里斯股份公司 脂质运载蛋白突变蛋白的控制释放制剂
US20110151028A1 (en) * 2009-12-19 2011-06-23 Filiberto Zadini Topical vaginal preparation
ES2362604B1 (es) * 2009-12-22 2012-06-28 Bcn Peptides, S.A. Formulación tópica oftálmica de péptidos.
KR101982482B1 (ko) * 2010-03-11 2019-05-27 와이어쓰 엘엘씨 메틸날트렉손의 경구 제형 및 친유성 염
JP5222917B2 (ja) * 2010-09-21 2013-06-26 財團法人工業技術研究院 徐放性組成物およびその製造方法
TWI501781B (zh) * 2010-12-10 2015-10-01 Ind Tech Res Inst 可控制釋放的組合物及其製造方法
US10046058B2 (en) 2014-12-02 2018-08-14 Rezolute, Inc. Use of hydrophobic organic acids to increase hydrophobicity of proteins and protein conjugates
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
US20190117573A1 (en) * 2017-10-19 2019-04-25 Hyalo Technologies, LLC Composition and method of preparation of risperidone extended release preparation
EP4093378A1 (en) * 2020-01-24 2022-11-30 W.L. Gore & Associates, Inc. Sustained-release matrices for adventitial or periadventitial neural ablation and uses thereof
CN111643483B (zh) * 2020-07-06 2022-03-29 济南大学 一种用于制备加兰他敏缓释微球的方法
EP4297753A4 (en) 2021-02-24 2025-01-01 Oakwood Laboratories, Llc Microsphere formulations comprising lurasidone and methods for making and using the same
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CN116421578A (zh) * 2023-03-31 2023-07-14 辉粒药业(苏州)有限公司 生长抑素类似物缓释微球及其制备方法
CN120958013A (zh) * 2023-04-03 2025-11-14 辉凌公司 制造肽盐的方法

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Also Published As

Publication number Publication date
US20060228414A1 (en) 2006-10-12
CA2532302A1 (en) 2005-02-03
AU2004259208A1 (en) 2005-02-03
EP1651136A2 (en) 2006-05-03
WO2005009356A2 (en) 2005-02-03
WO2005009356A3 (en) 2005-06-09
JP2007524645A (ja) 2007-08-30
US8871269B2 (en) 2014-10-28
EP1651136B1 (en) 2017-03-08
JP2011144207A (ja) 2011-07-28
CA2532302C (en) 2016-12-20
CN1852687A (zh) 2006-10-25
EP2462896A1 (en) 2012-06-13
EP1651136A4 (en) 2009-07-08
AU2004259208B2 (en) 2011-04-28
CN102935069A (zh) 2013-02-20
JP5165239B2 (ja) 2013-03-21
BRPI0412059A (pt) 2006-09-05
ES2625343T3 (es) 2017-07-19

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