CN102935069A - 控释组合物的制备方法 - Google Patents

控释组合物的制备方法 Download PDF

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Publication number
CN102935069A
CN102935069A CN2012104691508A CN201210469150A CN102935069A CN 102935069 A CN102935069 A CN 102935069A CN 2012104691508 A CN2012104691508 A CN 2012104691508A CN 201210469150 A CN201210469150 A CN 201210469150A CN 102935069 A CN102935069 A CN 102935069A
Authority
CN
China
Prior art keywords
organic
controlled release
bioactive agent
organic phase
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2012104691508A
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English (en)
Chinese (zh)
Inventor
P·库克·盖瑞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brooke Wood Pharmaceuticals Ltd
Evonik Corp
Original Assignee
PR Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PR Pharmaceuticals Inc filed Critical PR Pharmaceuticals Inc
Publication of CN102935069A publication Critical patent/CN102935069A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2012104691508A 2003-07-15 2004-07-15 控释组合物的制备方法 Pending CN102935069A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48766303P 2003-07-15 2003-07-15
US60/487,663 2003-07-15

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN200480026606.7A Division CN1852687B (zh) 2003-07-15 2004-07-15 控释组合物的制备方法

Publications (1)

Publication Number Publication Date
CN102935069A true CN102935069A (zh) 2013-02-20

Family

ID=34102710

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2012104691508A Pending CN102935069A (zh) 2003-07-15 2004-07-15 控释组合物的制备方法
CN200480026606.7A Expired - Fee Related CN1852687B (zh) 2003-07-15 2004-07-15 控释组合物的制备方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN200480026606.7A Expired - Fee Related CN1852687B (zh) 2003-07-15 2004-07-15 控释组合物的制备方法

Country Status (9)

Country Link
US (1) US8871269B2 (enExample)
EP (2) EP2462896A1 (enExample)
JP (2) JP5165239B2 (enExample)
CN (2) CN102935069A (enExample)
AU (1) AU2004259208B2 (enExample)
BR (1) BRPI0412059A (enExample)
CA (1) CA2532302C (enExample)
ES (1) ES2625343T3 (enExample)
WO (1) WO2005009356A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102552948A (zh) * 2010-12-10 2012-07-11 财团法人工业技术研究院 可控制释放的组合物及其制造方法
US8900636B2 (en) 2003-07-23 2014-12-02 Evonik Corporation Controlled release compositions
US8916196B2 (en) 2003-04-10 2014-12-23 Evonik Corporation Method for the production of emulsion-based microparticles
CN106999443A (zh) * 2014-12-02 2017-08-01 安特里阿比奥有限公司 具有增加的疏水性的蛋白质及蛋白质偶联物
CN111643483A (zh) * 2020-07-06 2020-09-11 济南大学 一种用于制备加兰他敏缓释微球的新方法

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WO2005009356A2 (en) 2003-07-15 2005-02-03 Pr Pharmaceuticals, Inc. Method for the preparation of controlled release formulations
CA2819769C (en) * 2003-07-18 2016-06-28 Oakwood Laboratories, L.L.C. Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions
US20060003008A1 (en) * 2003-12-30 2006-01-05 Gibson John W Polymeric devices for controlled release of active agents
EP1679065A1 (en) * 2005-01-07 2006-07-12 OctoPlus Sciences B.V. Controlled release compositions for interferon based on PEGT/PBT block copolymers
US9023395B2 (en) * 2007-04-13 2015-05-05 University Of North Texas Health Science Center At Fort Worth Formulation of active agent loaded activated PLGA nanoparticles for targeted cancer nano-therapeutics
US20100290982A1 (en) * 2007-04-13 2010-11-18 University Of North Texas Health Science Center At Fort Worth Solid in oil/water emulsion-diffusion-evaporation formulation for preparing curcumin-loaded plga nanoparticles
EP2139458A4 (en) * 2007-04-19 2013-01-23 Dong A Pharm Co Ltd COMPOSITION OF BIODEGRADABLE MICROSPHERES WITH CONTROLLED RELEASE OF A GLUCOSE REGULATING PEPTIDE AND RELATED FORMULA
GB0709322D0 (en) * 2007-05-15 2007-06-20 Nordic Bioscience As Exposure agent for detection of vitamin d
WO2008145183A1 (en) * 2007-05-30 2008-12-04 Nestec S.A. Oil-in-water emulsion and its use for the delayed release of active elements
ES2667945T3 (es) 2007-10-08 2018-05-16 Aurinia Pharmaceuticals Inc. Composiciones oftálmicas que comprenden inhibidores de calcineurina o Inhibidores de mTOR
ES2324009B1 (es) * 2007-11-23 2010-05-21 Gp Pharm S.A. Composicion farmaceutica de liberacion sostenida de somatostatina o un analogo suyo.
US8071914B2 (en) * 2007-12-26 2011-12-06 Noboru Oshima Heating apparatus
JP5222550B2 (ja) * 2007-12-27 2013-06-26 財團法人工業技術研究院 徐放性組成物およびその製造方法
US9161943B2 (en) 2007-12-31 2015-10-20 Industrial Technology Research Institute Sustained release composition and manufacturing method thereof
WO2009100222A1 (en) * 2008-02-08 2009-08-13 Qps Llc Non-polymeric compositions for controlled drug delivery
JP5713897B2 (ja) * 2008-07-16 2015-05-07 エボニック コーポレイションＥｖｏｎｉｋ Ｃｏｒｐｏｒａｔｉｏｎ 生理活性ペプチドを含有する微粒子を調製するためのプロセス
WO2010144194A1 (en) 2009-06-09 2010-12-16 Lux Biosciences, Inc. Topical drug delivery systems for ophthalmic use
BR112012002709A2 (pt) * 2009-08-05 2019-04-30 Pieris Ag formulações de liberação controlada de muteínas de lipocalina
US20110151028A1 (en) * 2009-12-19 2011-06-23 Filiberto Zadini Topical vaginal preparation
ES2362604B1 (es) * 2009-12-22 2012-06-28 Bcn Peptides, S.A. Formulación tópica oftálmica de péptidos.
MA34146B1 (fr) * 2010-03-11 2013-04-03 Wyeth Llc Formulations oralles et sels lipophiles de methylnaltrexone
JP5222917B2 (ja) * 2010-09-21 2013-06-26 財團法人工業技術研究院 徐放性組成物およびその製造方法
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
US20190117573A1 (en) * 2017-10-19 2019-04-25 Hyalo Technologies, LLC Composition and method of preparation of risperidone extended release preparation
US20230062487A1 (en) * 2020-01-24 2023-03-02 W. L. Gore & Associates, Inc. Sustained-release matrices for adventitial or periadventitial neural ablation and uses thereof
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US20250268836A1 (en) * 2021-04-23 2025-08-28 Flow Pharma, Inc. Microsphere formulations comprising multiple non-identical peptides and methods for making the same
WO2023102018A1 (en) * 2021-12-02 2023-06-08 University Of Connecticut Long-acting injectable in situ forming biodegradable implants comprising non-steroidal anti-inflammatory drugs
CN116421578A (zh) * 2023-03-31 2023-07-14 辉粒药业(苏州)有限公司 生长抑素类似物缓释微球及其制备方法
AU2024253395A1 (en) * 2023-04-03 2025-10-02 Ferring B.V. Methods of manufacturing peptide salts

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8916196B2 (en) 2003-04-10 2014-12-23 Evonik Corporation Method for the production of emulsion-based microparticles
US10272044B2 (en) 2003-04-10 2019-04-30 Evonik Corporation Method for the production of emulsion-based microparticles
US8900636B2 (en) 2003-07-23 2014-12-02 Evonik Corporation Controlled release compositions
CN102552948A (zh) * 2010-12-10 2012-07-11 财团法人工业技术研究院 可控制释放的组合物及其制造方法
CN102552948B (zh) * 2010-12-10 2015-08-26 财团法人工业技术研究院 可控制释放的组合物及其制造方法
CN106999443A (zh) * 2014-12-02 2017-08-01 安特里阿比奥有限公司 具有增加的疏水性的蛋白质及蛋白质偶联物
US10702611B2 (en) 2014-12-02 2020-07-07 Rezolute, Inc. Use of hydrophobic organic acids to increase hydrophobicity of proteins and protein conjugates
CN111643483A (zh) * 2020-07-06 2020-09-11 济南大学 一种用于制备加兰他敏缓释微球的新方法

Also Published As

Publication number Publication date
EP1651136A4 (en) 2009-07-08
EP2462896A1 (en) 2012-06-13
EP1651136A2 (en) 2006-05-03
WO2005009356A3 (en) 2005-06-09
ES2625343T3 (es) 2017-07-19
US8871269B2 (en) 2014-10-28
JP5165239B2 (ja) 2013-03-21
JP2007524645A (ja) 2007-08-30
CA2532302C (en) 2016-12-20
EP1651136B1 (en) 2017-03-08
AU2004259208B2 (en) 2011-04-28
JP2011144207A (ja) 2011-07-28
BRPI0412059A (pt) 2006-09-05
CA2532302A1 (en) 2005-02-03
US20060228414A1 (en) 2006-10-12
CN1852687B (zh) 2014-01-22
AU2004259208A1 (en) 2005-02-03
CN1852687A (zh) 2006-10-25
WO2005009356A2 (en) 2005-02-03

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