JP2011133364A - 血球凝集像判定方法及び血球凝集像判定装置 - Google Patents
血球凝集像判定方法及び血球凝集像判定装置 Download PDFInfo
- Publication number
- JP2011133364A JP2011133364A JP2009293376A JP2009293376A JP2011133364A JP 2011133364 A JP2011133364 A JP 2011133364A JP 2009293376 A JP2009293376 A JP 2009293376A JP 2009293376 A JP2009293376 A JP 2009293376A JP 2011133364 A JP2011133364 A JP 2011133364A
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- Prior art keywords
- image
- hemagglutination
- reaction
- well
- microplate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 230000035931 haemagglutination Effects 0.000 title claims abstract description 77
- 238000000034 method Methods 0.000 title claims abstract description 49
- 238000006243 chemical reaction Methods 0.000 claims abstract description 82
- 210000004369 blood Anatomy 0.000 claims abstract description 55
- 239000008280 blood Substances 0.000 claims abstract description 55
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 16
- 210000003743 erythrocyte Anatomy 0.000 claims description 29
- 210000000601 blood cell Anatomy 0.000 claims description 23
- 238000003384 imaging method Methods 0.000 claims description 12
- 230000003028 elevating effect Effects 0.000 claims description 3
- 230000007246 mechanism Effects 0.000 abstract description 2
- 210000002966 serum Anatomy 0.000 description 21
- 230000004520 agglutination Effects 0.000 description 16
- 238000012360 testing method Methods 0.000 description 16
- 238000010586 diagram Methods 0.000 description 14
- 239000006285 cell suspension Substances 0.000 description 9
- 230000002776 aggregation Effects 0.000 description 8
- 238000004220 aggregation Methods 0.000 description 8
- 230000002093 peripheral effect Effects 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 5
- 238000005119 centrifugation Methods 0.000 description 4
- 238000005286 illumination Methods 0.000 description 4
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000008188 pellet Substances 0.000 description 3
- 239000002504 physiological saline solution Substances 0.000 description 3
- 239000012736 aqueous medium Substances 0.000 description 2
- 210000000078 claw Anatomy 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 210000004180 plasmocyte Anatomy 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/82—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/251—Colorimeters; Construction thereof
- G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/82—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity
- G01N2021/825—Agglutination
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/07—Centrifugal type cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/04—Batch operation; multisample devices
- G01N2201/0461—Simultaneous, e.g. video imaging
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Ecology (AREA)
- Biophysics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009293376A JP2011133364A (ja) | 2009-12-24 | 2009-12-24 | 血球凝集像判定方法及び血球凝集像判定装置 |
| EP10838966A EP2518502A1 (en) | 2009-12-24 | 2010-12-22 | Method for determining hemagglutination image and device for determining hemagglutination image |
| PCT/JP2010/007451 WO2011077728A1 (ja) | 2009-12-24 | 2010-12-22 | 血球凝集像判定方法及び血球凝集像判定装置 |
| CN2010800586338A CN102687017A (zh) | 2009-12-24 | 2010-12-22 | 用于判定血细胞凝集图像的方法以及用于判定血细胞凝集图像的装置 |
| US13/530,041 US20120288887A1 (en) | 2009-12-24 | 2012-06-21 | Blood cell agglutination image determining method and blood cell agglutination image determining apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009293376A JP2011133364A (ja) | 2009-12-24 | 2009-12-24 | 血球凝集像判定方法及び血球凝集像判定装置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011133364A true JP2011133364A (ja) | 2011-07-07 |
| JP2011133364A5 JP2011133364A5 (enExample) | 2013-02-14 |
Family
ID=44195281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009293376A Withdrawn JP2011133364A (ja) | 2009-12-24 | 2009-12-24 | 血球凝集像判定方法及び血球凝集像判定装置 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20120288887A1 (enExample) |
| EP (1) | EP2518502A1 (enExample) |
| JP (1) | JP2011133364A (enExample) |
| CN (1) | CN102687017A (enExample) |
| WO (1) | WO2011077728A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160065943A (ko) * | 2013-10-09 | 2016-06-09 | 얀타이 아우스바이오 라보라토리즈 컴퍼니 리미티드 | 응집반응 결과 판정방법 및 응집반응물 판정용 마이크로플레이트 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103487377B (zh) * | 2013-10-11 | 2016-03-09 | 江苏英诺华医疗技术有限公司 | 一种全血凝血功能检测仪及检测方法 |
| EP2929939A1 (en) * | 2014-04-07 | 2015-10-14 | Yantai AusBio Laboratories Co., Ltd. | Microplate |
| WO2016014429A1 (en) | 2014-07-21 | 2016-01-28 | Beckman Coulter, Inc. | Methods and systems for tube inspection and liquid level detection |
| CN107167616B (zh) * | 2017-03-13 | 2019-06-07 | 中国科学院苏州生物医学工程技术研究所 | 血型检测方法及装置 |
| CN113614532A (zh) * | 2019-01-16 | 2021-11-05 | 烟台澳斯邦生物工程有限公司 | 沉积用于显微镜检查的生物样品的自动液体处理系统和方法 |
| CN109932517B (zh) * | 2019-04-04 | 2022-03-11 | 烟台海深威医学技术有限公司 | 一种血液凝集判断方法及装置 |
| CN110286239A (zh) * | 2019-08-12 | 2019-09-27 | 杭州美川合佳生物科技有限公司 | 一种血型全自动分析装置 |
| CN110780080B (zh) * | 2019-11-08 | 2024-07-12 | 安邦(厦门)生物科技有限公司 | 一种血型分析仪及血型分析方法 |
| JP7470587B2 (ja) * | 2020-07-14 | 2024-04-18 | 株式会社日立製作所 | 検体性状判別装置及び検体性状判別方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5811835A (ja) * | 1981-07-16 | 1983-01-22 | Olympus Optical Co Ltd | 粒子凝集判定装置および判定容器 |
| EP0396115A3 (en) * | 1989-05-03 | 1991-07-24 | Abbott Laboratories | Method of forming agglutinates in blood samples |
| JPH03110468A (ja) * | 1989-09-26 | 1991-05-10 | Anariiteikaru Instr:Kk | 遠心式免疫凝集自動判定装置 |
| JP2683944B2 (ja) * | 1989-12-21 | 1997-12-03 | 富士レビオ株式会社 | 間接凝集免疫測定方法及び装置 |
| US6258607B1 (en) * | 1989-10-31 | 2001-07-10 | Fujirebio Inc. | Indirect agglutination immunoassay and apparatus therefor |
| JPH05172816A (ja) * | 1991-05-13 | 1993-07-13 | Denka Seiken Co Ltd | 抗原の測定方法 |
| US5541417A (en) * | 1995-05-18 | 1996-07-30 | Abbott Laboratories | Quantative agglutination reaction analysis method |
| JP2883064B2 (ja) * | 1997-12-19 | 1999-04-19 | オリンパス光学工業株式会社 | 分布パターンの形成方法および装置 |
| JPH11271308A (ja) * | 1998-03-20 | 1999-10-08 | Olympus Optical Co Ltd | 分析装置 |
| JP2001133397A (ja) * | 1999-11-05 | 2001-05-18 | Fujirebio Inc | 検体の検査装置 |
| JP2002286719A (ja) * | 2001-03-23 | 2002-10-03 | Olympus Optical Co Ltd | 複数のパラメータを用いて凝集反応を解析評価する方法およびその方法に用いる容器 |
| JP4469990B2 (ja) * | 2007-04-19 | 2010-06-02 | ベックマン・コールター・インコーポレーテッド | 粒子凝集判定用容器 |
| EP2209008B1 (en) * | 2007-10-04 | 2016-12-21 | Panasonic Healthcare Holdings Co., Ltd. | Analysis device, and analysis apparatus and method using the same |
-
2009
- 2009-12-24 JP JP2009293376A patent/JP2011133364A/ja not_active Withdrawn
-
2010
- 2010-12-22 EP EP10838966A patent/EP2518502A1/en not_active Withdrawn
- 2010-12-22 WO PCT/JP2010/007451 patent/WO2011077728A1/ja not_active Ceased
- 2010-12-22 CN CN2010800586338A patent/CN102687017A/zh active Pending
-
2012
- 2012-06-21 US US13/530,041 patent/US20120288887A1/en not_active Abandoned
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160065943A (ko) * | 2013-10-09 | 2016-06-09 | 얀타이 아우스바이오 라보라토리즈 컴퍼니 리미티드 | 응집반응 결과 판정방법 및 응집반응물 판정용 마이크로플레이트 |
| JP2016533486A (ja) * | 2013-10-09 | 2016-10-27 | ヤンタイ・アウスビオ・ラボラトリーズ・カンパニー・リミテッド | 凝集反応の結果を決定するための方法、および凝集反応の生成物を決定するためのマイクロプレート |
| KR20180055936A (ko) * | 2013-10-09 | 2018-05-25 | 얀타이 아우스바이오 라보라토리즈 컴퍼니 리미티드 | 응집반응물 판정용 마이크로플레이트 |
| KR101922718B1 (ko) * | 2013-10-09 | 2018-11-27 | 얀타이 아우스바이오 라보라토리즈 컴퍼니 리미티드 | 응집반응 결과 판정방법 및 응집반응물 판정용 마이크로플레이트 |
| KR101940586B1 (ko) * | 2013-10-09 | 2019-01-21 | 얀타이 아우스바이오 라보라토리즈 컴퍼니 리미티드 | 응집반응물 판정용 마이크로플레이트 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2518502A1 (en) | 2012-10-31 |
| WO2011077728A1 (ja) | 2011-06-30 |
| US20120288887A1 (en) | 2012-11-15 |
| CN102687017A (zh) | 2012-09-19 |
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Legal Events
| Date | Code | Title | Description |
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| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20121219 |
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| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20121219 |
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| A761 | Written withdrawal of application |
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