JP2011103891A5 - - Google Patents

Info

Publication number

JP2011103891A5

JP2011103891A5 JP2011010411A JP2011010411A JP2011103891A5 JP 2011103891 A5 JP2011103891 A5 JP 2011103891A5 JP 2011010411 A JP2011010411 A JP 2011010411A JP 2011010411 A JP2011010411 A JP 2011010411A JP 2011103891 A5 JP2011103891 A5 JP 2011103891A5

Authority

JP

Japan

Prior art keywords

antibody

amino acid

seq

acid residues

tumor cells

Prior art date

2011-01-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 210000004881 tumor cell Anatomy 0.000 claims 24
• 125000000539 amino acid group Chemical group 0.000 claims 16
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 10
• 229920001184 polypeptide Polymers 0.000 claims 10
• 108090000765 processed proteins & peptides Proteins 0.000 claims 10
• 102000004196 processed proteins & peptides Human genes 0.000 claims 10
• 125000003275 alpha amino acid group Chemical group 0.000 claims 9
• 101150092419 STRA6 gene Proteins 0.000 claims 7
• 210000004027 cell Anatomy 0.000 claims 7
• 229940127089 cytotoxic agent Drugs 0.000 claims 7
• 150000004492 retinoid derivatives Chemical class 0.000 claims 7
• 208000008839 Kidney Neoplasms Diseases 0.000 claims 5
• 239000003814 drug Substances 0.000 claims 5
• 239000002254 cytotoxic agent Substances 0.000 claims 4
• 230000002401 inhibitory effect Effects 0.000 claims 4
• 239000000203 mixture Substances 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• 206010006187 Breast cancer Diseases 0.000 claims 3
• 208000026310 Breast neoplasm Diseases 0.000 claims 3
• 101100156752 Caenorhabditis elegans cwn-1 gene Proteins 0.000 claims 3
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 3
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
• 102000052547 Wnt-1 Human genes 0.000 claims 3
• 108700020987 Wnt-1 Proteins 0.000 claims 3
• 239000002246 antineoplastic agent Substances 0.000 claims 3
• 231100000599 cytotoxic agent Toxicity 0.000 claims 3
• 208000023965 endometrium neoplasm Diseases 0.000 claims 3
• 230000009395 genetic defect Effects 0.000 claims 3
• 208000020816 lung neoplasm Diseases 0.000 claims 3
• 208000037841 lung tumor Diseases 0.000 claims 3
• 201000001441 melanoma Diseases 0.000 claims 3
• 230000037361 pathway Effects 0.000 claims 3
• 208000028591 pheochromocytoma Diseases 0.000 claims 3
• 102000015735 Beta-catenin Human genes 0.000 claims 2
• 108060000903 Beta-catenin Proteins 0.000 claims 2
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
• 239000012190 activator Substances 0.000 claims 2
• SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 2
• 231100000433 cytotoxic Toxicity 0.000 claims 2
• 230000001472 cytotoxic effect Effects 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 230000012010 growth Effects 0.000 claims 2
• 229940002612 prodrug Drugs 0.000 claims 2
• 239000000651 prodrug Substances 0.000 claims 2
• 238000001959 radiotherapy Methods 0.000 claims 2
• 229930002330 retinoic acid Natural products 0.000 claims 2
• 229960001727 tretinoin Drugs 0.000 claims 2
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
• 230000002159 abnormal effect Effects 0.000 claims 1
• 230000004913 activation Effects 0.000 claims 1
• 230000030833 cell death Effects 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 230000007547 defect Effects 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 230000035772 mutation Effects 0.000 claims 1
• 230000002018 overexpression Effects 0.000 claims 1
• 230000011664 signaling Effects 0.000 claims 1
• 229940126585 therapeutic drug Drugs 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• 230000004565 tumor cell growth Effects 0.000 claims 1
• 230000004614 tumor growth Effects 0.000 claims 1