JP2011085586A5 - - Google Patents
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- Publication number
- JP2011085586A5 JP2011085586A5 JP2010229934A JP2010229934A JP2011085586A5 JP 2011085586 A5 JP2011085586 A5 JP 2011085586A5 JP 2010229934 A JP2010229934 A JP 2010229934A JP 2010229934 A JP2010229934 A JP 2010229934A JP 2011085586 A5 JP2011085586 A5 JP 2011085586A5
- Authority
- JP
- Japan
- Prior art keywords
- pct
- acute stroke
- patient
- ischemic attack
- bacterial infection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 14
- 208000006011 Stroke Diseases 0.000 claims 7
- CWCXERYKLSEGEZ-KDKHKZEGSA-N procalcitonin Chemical compound C([C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)NCC(O)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](N)CSSC1)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 CWCXERYKLSEGEZ-KDKHKZEGSA-N 0.000 claims 7
- 108010048233 Procalcitonin Proteins 0.000 claims 6
- 208000035143 Bacterial infection Diseases 0.000 claims 5
- 208000022362 bacterial infectious disease Diseases 0.000 claims 5
- 230000000302 ischemic effect Effects 0.000 claims 4
- 208000032109 Transient ischaemic attack Diseases 0.000 claims 3
- 239000003242 anti bacterial agent Substances 0.000 claims 3
- 230000002490 cerebral effect Effects 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 201000010875 transient cerebral ischemia Diseases 0.000 claims 3
- 230000001052 transient effect Effects 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- 108010074051 C-Reactive Protein Proteins 0.000 claims 2
- 102100032752 C-reactive protein Human genes 0.000 claims 2
- 230000003115 biocidal effect Effects 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 210000000265 leukocyte Anatomy 0.000 claims 2
- 208000016988 Hemorrhagic Stroke Diseases 0.000 claims 1
- 208000032382 Ischaemic stroke Diseases 0.000 claims 1
- 208000002151 Pleural effusion Diseases 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- BMQYVXCPAOLZOK-UHFFFAOYSA-N Trihydroxypropylpterisin Natural products OCC(O)C(O)C1=CN=C2NC(N)=NC(=O)C2=N1 BMQYVXCPAOLZOK-UHFFFAOYSA-N 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 230000036760 body temperature Effects 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 claims 1
- 238000010230 functional analysis Methods 0.000 claims 1
- 208000020658 intracerebral hemorrhage Diseases 0.000 claims 1
- BMQYVXCPAOLZOK-XINAWCOVSA-N neopterin Chemical compound OC[C@@H](O)[C@@H](O)C1=CN=C2NC(N)=NC(=O)C2=N1 BMQYVXCPAOLZOK-XINAWCOVSA-N 0.000 claims 1
- 210000000440 neutrophil Anatomy 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 238000004062 sedimentation Methods 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09012947.9 | 2009-10-13 | ||
| EP09012947 | 2009-10-13 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014237837A Division JP2015057611A (ja) | 2009-10-13 | 2014-11-25 | 急性脳卒中または一過性脳虚血発作を有する患者における細菌感染の診断のためのプロカルシトニン及び抗生物質治療のガイダンス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011085586A JP2011085586A (ja) | 2011-04-28 |
| JP2011085586A5 true JP2011085586A5 (enExample) | 2013-05-09 |
| JP5722587B2 JP5722587B2 (ja) | 2015-05-20 |
Family
ID=41362428
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010229934A Active JP5722587B2 (ja) | 2009-10-13 | 2010-10-12 | 急性脳卒中または一過性脳虚血発作を有する患者における細菌感染の診断のためのプロカルシトニン及び抗生物質治療のガイダンス |
| JP2014237837A Withdrawn JP2015057611A (ja) | 2009-10-13 | 2014-11-25 | 急性脳卒中または一過性脳虚血発作を有する患者における細菌感染の診断のためのプロカルシトニン及び抗生物質治療のガイダンス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014237837A Withdrawn JP2015057611A (ja) | 2009-10-13 | 2014-11-25 | 急性脳卒中または一過性脳虚血発作を有する患者における細菌感染の診断のためのプロカルシトニン及び抗生物質治療のガイダンス |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8383332B2 (enExample) |
| EP (1) | EP2320237B1 (enExample) |
| JP (2) | JP5722587B2 (enExample) |
| CN (1) | CN102081101B (enExample) |
| ES (1) | ES2601104T3 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103123359B (zh) * | 2007-08-03 | 2015-07-29 | B.R.A.H.M.S有限公司 | 降钙素原(pct)在患原发性非传染疾病的患者的风险分级和预后中的应用 |
| US8383332B2 (en) | 2009-10-13 | 2013-02-26 | B.R.A.H.M.S. Gmbh | Procalcitonin for the diagnosis of bacterial infections and guidance of antibiotic treatment in patients with acute stroke or transient ischemic attack |
| ITRM20100121A1 (it) * | 2010-03-18 | 2011-09-19 | Univ Pisa | Marcatori molecolari per infezioni delle vie urinarie. |
| CN102305858B (zh) * | 2011-07-26 | 2013-08-21 | 深圳市国赛生物技术有限公司 | 一种检测降钙素原的试剂盒 |
| ES2886979T3 (es) | 2012-02-09 | 2021-12-21 | Memed Diagnostics Ltd | Distintivos y determinantes para diagnosticar infecciones y métodos para usarlos |
| EP3180621B1 (en) | 2014-08-14 | 2020-04-01 | Memed Diagnostics Ltd. | Computational analysis of biological data using manifold and a hyperplane |
| CN111624345A (zh) | 2014-12-11 | 2020-09-04 | 米密德诊断学有限公司 | 用于诊断多种感染的标记组合及其使用方法 |
| WO2017008894A1 (en) * | 2015-07-13 | 2017-01-19 | University Of Geneva | Biomarker panels for brain injury complications |
| CA3015046A1 (en) | 2016-03-03 | 2017-09-08 | Memed Diagnostics Ltd. | Rna determinants for distinguishing between bacterial and viral infections |
| AU2017246588A1 (en) * | 2016-04-08 | 2018-09-27 | Centre National De La Recherche Scientifique - Cnrs - | Methods and kits for diagnosing postoperative pulmonary infections in patients who underwent surgery |
| CN107490683A (zh) * | 2016-06-09 | 2017-12-19 | 常州博闻迪医药科技有限公司 | 一种唾液降钙素原胶体金检测方法 |
| CN107490679A (zh) * | 2016-06-09 | 2017-12-19 | 常州博闻迪医药科技有限公司 | 一种唾液降钙素原酶联免疫检测方法 |
| CN109804245B (zh) * | 2016-07-10 | 2022-10-25 | 米密德诊断学有限公司 | 感染的早期诊断 |
| EP4141448A1 (en) | 2016-07-10 | 2023-03-01 | MeMed Diagnostics Ltd. | Protein signatures for distinguishing between bacterial and viral infections |
| WO2018060998A1 (en) | 2016-09-29 | 2018-04-05 | Memed Diagnostics Ltd. | Methods of prognosis and treatment |
| WO2018114044A1 (en) * | 2016-12-22 | 2018-06-28 | University Of Geneva | Biomarker panels for brain injury complications |
| EP3438668A1 (en) | 2017-08-04 | 2019-02-06 | B.R.A.H.M.S GmbH | Diagnosis and risk stratification of fungal infections |
| EP3682247B1 (en) | 2017-09-13 | 2022-02-09 | B.R.A.H.M.S GmbH | Proadrenomedullin as a marker for abnormal platelet levels |
| CN111630381B (zh) * | 2017-12-20 | 2025-08-01 | B.R.A.H.M.S有限公司 | 基于pro-adm的抗生素疗法指导 |
| EP3502706A1 (en) * | 2017-12-20 | 2019-06-26 | B.R.A.H.M.S GmbH | Workflow for risk assessment and patient management using procalcitonin and midregional-proadrenomedullin |
| WO2019122088A1 (en) | 2017-12-20 | 2019-06-27 | B.R.A.H.M.S Gmbh | Antibiotic therapy guidance based on procalcitonin in patients with comorbidities |
| BR112022008068A2 (pt) | 2019-10-28 | 2022-07-12 | Hoffmann La Roche | Métodos para auxiliar na avaliação de risco de um paciente com suspeita de sepse e método implementado por computador para a avaliação de um paciente com suspeita de sepse |
| KR102362951B1 (ko) * | 2020-08-13 | 2022-02-14 | 연세대학교 원주산학협력단 | 프로칼시토닌 대 ｃ반응성 단백질의 비율을 이용한 허혈성 뇌졸중의 단기 사망률 예측 방법 |
| WO2022229422A2 (en) | 2021-04-30 | 2022-11-03 | Roche Diagnostics Gmbh | Igfbp7 marker panels for early detection of sepsis |
| CN117203528A (zh) | 2021-04-30 | 2023-12-08 | 豪夫迈·罗氏有限公司 | 用于脓毒症的早期检测的gdf15标志物组 |
| WO2022229440A2 (en) | 2021-04-30 | 2022-11-03 | F. Hoffmann-La Roche Ag | Sflt1 marker panels for early detection of sepsis |
| US20240221958A1 (en) | 2021-04-30 | 2024-07-04 | Roche Diagnostics Operations, Inc. | Pct marker panels for early detection of sepsis |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3147470A1 (de) | 1981-12-01 | 1983-07-14 | Bizerba-Werke Wilhelm Kraut GmbH & Co KG, 7460 Balingen | Kraftmessvorrichtung |
| DE19600875C1 (de) * | 1996-01-12 | 1997-06-26 | Brahms Diagnostica Gmbh | Diagnostisches Verfahren zur Bestimmung der Ätiologie entzündlicher Prozesse |
| US5993811A (en) * | 1997-02-03 | 1999-11-30 | Biology Associates, Llc | Method and compositions for preventing and treating the systemic inflammatory response syndrome including sepsis |
| US7713705B2 (en) * | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
| US20050170443A1 (en) * | 2003-10-03 | 2005-08-04 | Scantibodies Laboratory, Inc. | Methods and use of binding components for improving assay specificity |
| CN101029897A (zh) * | 2007-02-09 | 2007-09-05 | 深圳市新产业生物医学工程有限公司 | 一种降钙素原测试试剂盒及其测试方法 |
| DE102007009751A1 (de) * | 2007-02-28 | 2008-09-04 | B.R.A.H.M.S Aktiengesellschaft | Verfahren zur selektiven Bestimmung von Procalcitonin 1-116 für diagnostische Zwecke sowie Antikörper und Kits zur Durchführung eines solchen Verfahrens |
| EP2167965B1 (de) * | 2007-06-22 | 2013-04-10 | B.R.A.H.M.S GmbH | Verfahren zur detektion von analyten |
| CN103123359B (zh) * | 2007-08-03 | 2015-07-29 | B.R.A.H.M.S有限公司 | 降钙素原(pct)在患原发性非传染疾病的患者的风险分级和预后中的应用 |
| EP2101178A1 (en) * | 2008-03-12 | 2009-09-16 | BRAHMS Aktiengesellschaft | Use of Procalcitonin (PCT) in prognosis following acute coronary syndromes |
| EP2020603A1 (en) * | 2007-08-03 | 2009-02-04 | BRAHMS Aktiengesellschaft | Method for risk stratification in stable coronary artery disease |
| GB0722729D0 (en) * | 2007-11-20 | 2007-12-27 | Bristol Myers Squibb Co | Diagnostic markers of wound infection |
| US8383332B2 (en) | 2009-10-13 | 2013-02-26 | B.R.A.H.M.S. Gmbh | Procalcitonin for the diagnosis of bacterial infections and guidance of antibiotic treatment in patients with acute stroke or transient ischemic attack |
-
2010
- 2010-10-12 US US12/902,533 patent/US8383332B2/en active Active
- 2010-10-12 EP EP10187310.7A patent/EP2320237B1/en not_active Revoked
- 2010-10-12 JP JP2010229934A patent/JP5722587B2/ja active Active
- 2010-10-12 ES ES10187310.7T patent/ES2601104T3/es active Active
- 2010-10-13 CN CN201010510497.3A patent/CN102081101B/zh active Active
-
2014
- 2014-11-25 JP JP2014237837A patent/JP2015057611A/ja not_active Withdrawn
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