CN102081101B - 用于在急性中风或暂时性缺血性发作的患者中诊断细菌感染和指导抗生素治疗的降钙素原 - Google Patents

用于在急性中风或暂时性缺血性发作的患者中诊断细菌感染和指导抗生素治疗的降钙素原 Download PDF

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CN102081101B
CN102081101B CN201010510497.3A CN201010510497A CN102081101B CN 102081101 B CN102081101 B CN 102081101B CN 201010510497 A CN201010510497 A CN 201010510497A CN 102081101 B CN102081101 B CN 102081101B
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application
procalcitonin
patients
sample
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CN102081101A (zh
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安德烈亚斯·贝格曼
奥利弗·哈特曼
弗劳克·海因
比特·穆勒
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Universita di Pisa
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911Bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575Hormones
    • G01N2333/585Calcitonins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/26Infectious diseases, e.g. generalised sepsis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2871Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Immunology (AREA)
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  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
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  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201010510497.3A 2009-10-13 2010-10-13 用于在急性中风或暂时性缺血性发作的患者中诊断细菌感染和指导抗生素治疗的降钙素原 Active CN102081101B (zh)

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EP09012947.9 2009-10-13
EP09012947 2009-10-13

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CN102081101A CN102081101A (zh) 2011-06-01
CN102081101B true CN102081101B (zh) 2014-08-20

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US (1) US8383332B2 (enExample)
EP (1) EP2320237B1 (enExample)
JP (2) JP5722587B2 (enExample)
CN (1) CN102081101B (enExample)
ES (1) ES2601104T3 (enExample)

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ITRM20100121A1 (it) * 2010-03-18 2011-09-19 Univ Pisa Marcatori molecolari per infezioni delle vie urinarie.
CN102305858B (zh) * 2011-07-26 2013-08-21 深圳市国赛生物技术有限公司 一种检测降钙素原的试剂盒
ES2886979T3 (es) 2012-02-09 2021-12-21 Memed Diagnostics Ltd Distintivos y determinantes para diagnosticar infecciones y métodos para usarlos
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CN111624345A (zh) 2014-12-11 2020-09-04 米密德诊断学有限公司 用于诊断多种感染的标记组合及其使用方法
WO2017008894A1 (en) * 2015-07-13 2017-01-19 University Of Geneva Biomarker panels for brain injury complications
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AU2017246588A1 (en) * 2016-04-08 2018-09-27 Centre National De La Recherche Scientifique - Cnrs - Methods and kits for diagnosing postoperative pulmonary infections in patients who underwent surgery
CN107490683A (zh) * 2016-06-09 2017-12-19 常州博闻迪医药科技有限公司 一种唾液降钙素原胶体金检测方法
CN107490679A (zh) * 2016-06-09 2017-12-19 常州博闻迪医药科技有限公司 一种唾液降钙素原酶联免疫检测方法
CN109804245B (zh) * 2016-07-10 2022-10-25 米密德诊断学有限公司 感染的早期诊断
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WO2018114044A1 (en) * 2016-12-22 2018-06-28 University Of Geneva Biomarker panels for brain injury complications
EP3438668A1 (en) 2017-08-04 2019-02-06 B.R.A.H.M.S GmbH Diagnosis and risk stratification of fungal infections
EP3682247B1 (en) 2017-09-13 2022-02-09 B.R.A.H.M.S GmbH Proadrenomedullin as a marker for abnormal platelet levels
CN111630381B (zh) * 2017-12-20 2025-08-01 B.R.A.H.M.S有限公司 基于pro-adm的抗生素疗法指导
EP3502706A1 (en) * 2017-12-20 2019-06-26 B.R.A.H.M.S GmbH Workflow for risk assessment and patient management using procalcitonin and midregional-proadrenomedullin
WO2019122088A1 (en) 2017-12-20 2019-06-27 B.R.A.H.M.S Gmbh Antibiotic therapy guidance based on procalcitonin in patients with comorbidities
BR112022008068A2 (pt) 2019-10-28 2022-07-12 Hoffmann La Roche Métodos para auxiliar na avaliação de risco de um paciente com suspeita de sepse e método implementado por computador para a avaliação de um paciente com suspeita de sepse
KR102362951B1 (ko) * 2020-08-13 2022-02-14 연세대학교 원주산학협력단 프로칼시토닌 대 c­반응성 단백질의 비율을 이용한 허혈성 뇌졸중의 단기 사망률 예측 방법
WO2022229422A2 (en) 2021-04-30 2022-11-03 Roche Diagnostics Gmbh Igfbp7 marker panels for early detection of sepsis
CN117203528A (zh) 2021-04-30 2023-12-08 豪夫迈·罗氏有限公司 用于脓毒症的早期检测的gdf15标志物组
WO2022229440A2 (en) 2021-04-30 2022-11-03 F. Hoffmann-La Roche Ag Sflt1 marker panels for early detection of sepsis
US20240221958A1 (en) 2021-04-30 2024-07-04 Roche Diagnostics Operations, Inc. Pct marker panels for early detection of sepsis

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EP2320237B1 (en) 2016-08-03
US8383332B2 (en) 2013-02-26
HK1156690A1 (en) 2012-06-15
JP2011085586A (ja) 2011-04-28
US20110086831A1 (en) 2011-04-14
JP5722587B2 (ja) 2015-05-20
JP2015057611A (ja) 2015-03-26
CN102081101A (zh) 2011-06-01
ES2601104T3 (es) 2017-02-14
EP2320237A1 (en) 2011-05-11

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