JP2011037891A5 - - Google Patents
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- JP2011037891A5 JP2011037891A5 JP2010233467A JP2010233467A JP2011037891A5 JP 2011037891 A5 JP2011037891 A5 JP 2011037891A5 JP 2010233467 A JP2010233467 A JP 2010233467A JP 2010233467 A JP2010233467 A JP 2010233467A JP 2011037891 A5 JP2011037891 A5 JP 2011037891A5
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- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims 2
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- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 1
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- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41435702P | 2002-09-30 | 2002-09-30 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004539362A Division JP2006504701A (ja) | 2002-09-30 | 2003-09-29 | 眼疾患の局所的治療方法、並びに、その治療用組成物及び治療用手段 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011037891A JP2011037891A (ja) | 2011-02-24 |
| JP2011037891A5 true JP2011037891A5 (enExample) | 2012-07-12 |
Family
ID=32043384
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004539362A Pending JP2006504701A (ja) | 2002-09-30 | 2003-09-29 | 眼疾患の局所的治療方法、並びに、その治療用組成物及び治療用手段 |
| JP2010233467A Pending JP2011037891A (ja) | 2002-09-30 | 2010-10-18 | 薬剤組成物の製造のための水性眼科用組成物の使用、及び水性眼科用組成物 |
| JP2010233468A Pending JP2011037892A (ja) | 2002-09-30 | 2010-10-18 | 治療手段 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004539362A Pending JP2006504701A (ja) | 2002-09-30 | 2003-09-29 | 眼疾患の局所的治療方法、並びに、その治療用組成物及び治療用手段 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010233468A Pending JP2011037892A (ja) | 2002-09-30 | 2010-10-18 | 治療手段 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US7795203B2 (enExample) |
| EP (1) | EP1551399A4 (enExample) |
| JP (3) | JP2006504701A (enExample) |
| WO (1) | WO2004028536A1 (enExample) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8147816B2 (en) | 2000-08-16 | 2012-04-03 | Encore Health, Llc | Presbyopia treatment by lens alteration |
| US20050112113A1 (en) * | 2000-08-16 | 2005-05-26 | Till Jonathan S. | Presbyopia treatment by lens alteration |
| US7935332B2 (en) | 2000-08-16 | 2011-05-03 | Encore Health, Llc | Presbyopia treatment by lens alteration |
| US7914815B2 (en) | 2000-08-16 | 2011-03-29 | Encore Health, Llc | Method for delivery of pharmaceuticals for treating or preventing presbyopia |
| US8647612B2 (en) | 2008-03-05 | 2014-02-11 | Encore Health, Llc | Dithiol compounds, derivatives, and treatment of presbyopia |
| US8697109B2 (en) | 2000-08-16 | 2014-04-15 | Encore Health, Llc | Caged mercaptan and seleno-mercaptan compounds and methods of using them |
| US7795203B2 (en) * | 2002-09-30 | 2010-09-14 | Babizhayev Mark A | Method for topical treatment of eye disease and composition and device for said treatment |
| WO2004058289A1 (en) * | 2002-12-20 | 2004-07-15 | Chakshu Research, Inc. | Ophthalmic formulation for the prevention and treatment of ocular conditions |
| EP1586332A4 (en) * | 2003-01-20 | 2009-11-11 | Innovative Vision Products Inc | COMBINED USE OF CARNOSINAS INHIBITOR WITH L-CARNOSINES AND COMPOSITION |
| EP1761272B1 (en) | 2004-06-08 | 2013-04-24 | Flamma S.P.A. | Compositions containing d-carnosine |
| JP2006131580A (ja) * | 2004-11-09 | 2006-05-25 | Rohto Pharmaceut Co Ltd | 粘膜適用組成物 |
| US8569367B2 (en) | 2004-11-16 | 2013-10-29 | Allergan, Inc. | Ophthalmic compositions and methods for treating eyes |
| KR101389300B1 (ko) | 2005-02-14 | 2014-04-25 | 존슨 앤드 존슨 비젼 케어, 인코포레이티드 | 안과용 렌즈의 제조방법, 안과용 장치 및 콘택트 렌즈 |
| TW200722109A (en) * | 2005-03-31 | 2007-06-16 | Bausch & Lomb | Polysaccharide and polyol composition for treating dry eye and related methods of manufacture and methods of use |
| TWI393567B (zh) * | 2005-03-31 | 2013-04-21 | 博士倫公司 | 治療乾眼之組合物及相關之製造方法及使用方法 |
| US9052529B2 (en) | 2006-02-10 | 2015-06-09 | Johnson & Johnson Vision Care, Inc. | Comfortable ophthalmic device and methods of its production |
| US7776364B2 (en) | 2006-03-24 | 2010-08-17 | Advanced Scientific, Llc | Non-surgical method for treating cataracts in mammals including man |
| US20120122815A1 (en) * | 2006-03-28 | 2012-05-17 | Erning Xia | Composition for Treating Dry Eye and Related Methods of Manufacture and Methods of Use |
| JP5302546B2 (ja) * | 2008-02-12 | 2013-10-02 | 雪印メグミルク株式会社 | 白内障予防剤 |
| US9044439B2 (en) | 2008-03-05 | 2015-06-02 | Encore Health, Llc | Low dose lipoic and pharmaceutical compositions and methods |
| WO2009111635A2 (en) | 2008-03-05 | 2009-09-11 | Encore Health, Llc | Dithiol compounds, derivatives, and uses therefor |
| NL2002214C2 (en) * | 2008-11-17 | 2010-05-18 | Louis Johan Wagenaar | Contact lens care solution. |
| US9308070B2 (en) | 2008-12-15 | 2016-04-12 | Allergan, Inc. | Pliable silk medical device |
| US20110111031A1 (en) * | 2009-04-20 | 2011-05-12 | Guang-Liang Jiang | Drug Delivery Platforms Comprising Silk Fibroin Hydrogels and Uses Thereof |
| US8299079B2 (en) | 2009-05-22 | 2012-10-30 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
| ES2579173T3 (es) | 2009-06-15 | 2016-08-05 | Encore Health, Llc | Ésteres de colina para tratar presbicia y cataratas |
| EP3069612A3 (en) | 2009-06-15 | 2016-10-19 | Encore Health, LLC | Dithiol compounds, derivatives, and uses therefor |
| DK2493296T3 (en) | 2009-10-30 | 2019-04-15 | Retrotope Inc | REMOVAL OF OXIDATIVE STRESS STATES WITH PUFA DERIVATIVES |
| TN2010000251A1 (fr) * | 2010-06-03 | 2011-11-11 | Rekik Raouf | N-acetyl-dl-leucine medicament neuro et retino protecteur |
| KR102020579B1 (ko) | 2011-04-26 | 2019-09-10 | 레트로토프 인코포레이티드 | 에너지 프로세싱 손상 장애 및 미토콘드리아 결함 |
| US10154983B2 (en) | 2011-04-26 | 2018-12-18 | Retrotope, Inc. | Neurodegenerative disorders and muscle diseases implicating PUFAs |
| US10058522B2 (en) | 2011-04-26 | 2018-08-28 | Retrotope, Inc. | Oxidative retinal diseases |
| WO2012148929A2 (en) | 2011-04-26 | 2012-11-01 | Retrotope, Inc. | Disorders implicating pufa oxidation |
| US8957048B2 (en) | 2011-10-06 | 2015-02-17 | Allergan, Inc. | Compositions for the treatment of dry eye |
| PL2787968T3 (pl) | 2011-12-07 | 2020-08-24 | Allergan, Inc. | Wydajne dostarczanie lipidów do ludzkiego filmu łzowego z użyciem wrażliwego na sól układu emulsyjnego |
| US9907826B2 (en) | 2011-12-07 | 2018-03-06 | Allergan, Inc. | Efficient lipid delivery to human tear film using a salt-sensitive emulsion system |
| CA2934448A1 (en) | 2012-12-20 | 2014-06-26 | Rajiv Bhushan | Antimicrobial compositions |
| KR102276326B1 (ko) | 2013-03-13 | 2021-07-13 | 앙테이스 에스.아. | 피부 회춘을 위한 펩타이드 및 이것을 사용하는 방법 |
| PT3613423T (pt) | 2013-07-10 | 2022-12-07 | Matrix Biology Inst | Composições de hialuronano de elevada elasticidade e suas utilizações |
| AU2014332488B2 (en) | 2013-10-09 | 2017-03-09 | Johnson Living Trust Dated October 26, 2001, Leonidas A. Johnson, Trustee | Methods and compositions for treating and preventing signs or symptoms of eye disease |
| EP3113613A4 (en) * | 2014-03-03 | 2019-03-13 | Encore Vision, Inc. | LIPOIC ACID CHOLINESTER COMPOSITIONS AND METHOD OF USE THEREOF |
| ES2632808T3 (es) | 2014-09-04 | 2017-09-15 | Nicox Science Ireland | Compuestos de carnosina donadores de óxido nítrico |
| US9463201B2 (en) | 2014-10-19 | 2016-10-11 | M.G. Therapeutics Ltd | Compositions and methods for the treatment of meibomian gland dysfunction |
| US12472157B2 (en) | 2014-11-07 | 2025-11-18 | Nacuity Pharmaceuticals, Inc. | Treatment of retinitis pigmentosa with n-acetylcysteine amide |
| US12667548B2 (en) | 2014-11-07 | 2026-06-30 | Nacuity Pharmaceuticals, Inc. | Treatment of retinitis pigmentosa and retinitis pigmentosa associated with Usher Syndrome with N-acetylcysteine amide |
| KR102487299B1 (ko) | 2014-11-25 | 2023-01-10 | 알러간, 인코포레이티드 | 안정화된 오메가-3 안과용 조성물 |
| KR101690539B1 (ko) | 2015-07-30 | 2016-12-29 | 주식회사 아이바이오코리아 | 건성안 예방 또는 치료용 약학조성물 |
| PT3352766T (pt) | 2015-09-24 | 2022-03-22 | Matrix Biology Inst | Composições de hialuronano de elevada elasticidade e processos para o seu uso |
| WO2017055924A2 (en) | 2015-09-28 | 2017-04-06 | M.G. Therapeutics Ltd. | Thiol and disulfide-containing agents for increasing meibomian gland lipid secretion |
| WO2017091279A1 (en) | 2015-11-23 | 2017-06-01 | Retrotope, Inc. | Site-specific isotopic labeling of 1, 4-diene systems |
| US20190038598A1 (en) * | 2016-02-22 | 2019-02-07 | Santen Pharmaceutical Co., Ltd. | Pharmaceutical composition including dorzolamide and brimonidine |
| WO2017147470A1 (en) * | 2016-02-26 | 2017-08-31 | The Regents Of The University Of California | Bicontinuous microemulsions and methods of use thereof |
| WO2017178892A2 (en) | 2016-04-14 | 2017-10-19 | M.G. Therapeutics Ltd. | Selenium disulfide compositions for use in treating meibomian gland dysfunction |
| MX390707B (es) | 2017-01-31 | 2025-03-21 | Kimberly Clark Co | Composición antibacteriana que incluye un éster del ácido benzoico y métodos de inhibición del crecimiento bacteriano mediante el uso de la misma. |
| CN112516080B (zh) * | 2018-01-23 | 2023-09-19 | 盛元医药广州有限公司 | 一种眼用药物组合物及其制备方法和应用 |
| US11077150B2 (en) * | 2018-10-09 | 2021-08-03 | Massoumeh Kharazmi | Methods and compositions for treatment of eye conditions |
| CN113226349A (zh) | 2018-10-19 | 2021-08-06 | 激流生物科学有限公司 | 抗微生物肽及其使用方法 |
| AU2020206139A1 (en) | 2019-01-11 | 2021-07-29 | Nacuity Pharmaceuticals, Inc. | Treatment of age-related macular degeneration, glaucoma, and diabetic retinopathy with N-acetylicysteine amide (NACA) or 2R,2R')-3-3'-disulfanediyl bis (2-acetamidopropanamide) (diNACA) |
| WO2020146660A1 (en) | 2019-01-11 | 2020-07-16 | Nacuity Pharmaceuticals, Inc. | N-acetylcysteine amide (naca) and (2r,2r')-3-3'-disulfanediyl bis (2-acetamidopropanamide) (dinaca) for prevention and treatment of radiation pneumonitis and treatment of pulmonary function in cystic fibrosis |
| JP7631200B2 (ja) | 2019-01-11 | 2025-02-18 | ナキュイティ ファーマシューティカルズ， インク． | 放射線皮膚炎の予防及び治療、並びに皮膚ライトニング、皮膚ホワイトニング、並びに皮膚改善のためのｎ－アセチルシステインアミド（ｎａｃａ）及び（２ｒ，２ｒ’）－３，３’－ジスルファンジイルビス（２－アセトアミドプロパンアミド）（ｄｉｎａｃａ） |
| US20220272987A1 (en) * | 2019-04-12 | 2022-09-01 | Jeffrey H. ROBBINS | Composition including effervescent agents, biostimulant, nutrient, and pesticide |
| EP4087655A4 (en) | 2020-01-10 | 2024-02-21 | Azura Ophthalmics Ltd | INSTRUCTIONS FOR COMPOSITION AND SENSITIVITY |
| EP4107163A4 (en) | 2020-02-21 | 2024-06-19 | Retrotope, Inc. | PROCESSES FOR ISOTOPIC MODIFICATION OF POLYUNSATURATED FATTY ACIDS AND THEIR DERIVATIVES |
| US12109194B2 (en) | 2021-02-05 | 2024-10-08 | Biojiva Llc | Synergistic combination therapy for treating ALS |
| US11491130B2 (en) | 2021-02-05 | 2022-11-08 | Retrotope, Inc. | Methods of treating amyotrophic lateral sclerosis |
| WO2022251710A2 (en) | 2021-05-28 | 2022-12-01 | Sight Sciences, Inc. | Intraocular devices, systems, and methods |
| CN119997951A (zh) * | 2022-09-19 | 2025-05-13 | 西姆莱斯股份公司 | 一种预防、缓解和/或治疗ptgs2诱发的皮肤紊乱及相关功能障碍的方法 |
| KR102513994B1 (ko) * | 2022-10-26 | 2023-03-24 | 김태윤 | 반려동물의 눈물 착색예방용 조성물 |
| AU2023411740A1 (en) | 2022-12-23 | 2025-07-31 | Cell Exosome Therapeutics Inc. | Utilization of mesenchymal stem cells or culture supernatant thereof |
| CN122535417A (zh) | 2023-11-13 | 2026-08-07 | 国立大学法人东京大学 | 坏死性凋亡控制剂 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL188266C (nl) * | 1975-07-29 | 1992-05-18 | Merck & Co Inc | Werkwijze ter bereiding van een oogheelkundig inplantaat. |
| CA1141663A (en) * | 1979-09-06 | 1983-02-22 | Yukihisa Ishii | Ophthalmic solution for intraocular pressure adjustment |
| US4248882A (en) * | 1980-02-12 | 1981-02-03 | Pfizer Inc. | Treating diabetes-associated complications with hydantoin amines |
| JPS57108072A (en) * | 1980-12-18 | 1982-07-05 | Ajinomoto Co Inc | Preparation of n-acylcarnosine |
| JPS57203440A (en) * | 1981-06-11 | 1982-12-13 | Nihon Contact Lens Seizou Kk | Treating tool |
| US4722933A (en) * | 1985-12-20 | 1988-02-02 | Nelson Research & Development Co. | Substituted 2-aminotetralins |
| US4713244A (en) * | 1985-08-16 | 1987-12-15 | Bausch & Lomb Incorporated | Sustained-release formulation containing an amino acid polymer with a lower alkyl (C1 -C4) polar solvent |
| US4738851A (en) * | 1985-09-27 | 1988-04-19 | University Of Iowa Research Foundation, Inc. | Controlled release ophthalmic gel formulation |
| US4771036A (en) * | 1986-02-10 | 1988-09-13 | Trustees Of Columbia University In The City Of New York | Method and ophthalmic composition for the prevention and reversal of cataracts |
| JPS6471822A (en) * | 1987-09-12 | 1989-03-16 | Rohto Pharma | Ophthalmic sustained release preparation |
| US5496820A (en) | 1988-10-20 | 1996-03-05 | Peraelampi; Markku | Ophthalmic use of S-timolol hemihydrate |
| US5192785A (en) * | 1989-09-03 | 1993-03-09 | A. H. Robins Company, Incorporated | Sulfamates as antiglaucoma agents |
| US5192743A (en) * | 1992-01-16 | 1993-03-09 | Genentech, Inc. | Reconstitutable lyophilized protein formulation |
| IT1260467B (it) * | 1992-01-29 | 1996-04-09 | Bruschettini Srl | Medicamento contenente arg-gly-asp per il trattamento del glaucoma |
| JPH06211665A (ja) * | 1993-01-19 | 1994-08-02 | Rohto Pharmaceut Co Ltd | ジラゼプを必須成分とする眼圧降下剤 |
| FR2701948B1 (fr) * | 1993-02-22 | 1996-07-26 | Exsymol Sa | Produit de couplage de l'histamine ou l'histamine méthyl-substituée et d'un acide aminé, procédé de préparation et applications thérapeutiques, cosmétologiques et agroalimentaires. |
| RU2100020C1 (ru) | 1993-06-23 | 1997-12-27 | Лейрас Ой | Средство для местного лечения глазной гипертензии и глаукомы и способ его получения |
| CA2125060C (en) * | 1993-07-02 | 1999-03-30 | Henry P. Dabrowski | Ophthalmic solution for artificial tears |
| AU5084693A (en) * | 1993-08-20 | 1995-03-21 | Alcon Laboratories, Inc. | Topical ophthalmic pharmaceutical vehicles |
| IT1270905B (it) | 1993-10-15 | 1997-05-13 | Bruschettini Srl | Composizioni farmaceutiche contenenti n-acetilcarnosina per il trattamento della cataratta |
| AU3609795A (en) * | 1994-10-10 | 1996-05-02 | Novartis Ag | Ophthalmic and aural compositions containing diclofenac potassium |
| IT1275434B (it) * | 1995-05-19 | 1997-08-07 | Farmila Farma Milano | Composizioni farmaceutiche e/o dietetiche ad attivita' antiossidante |
| JPH0920648A (ja) * | 1995-06-30 | 1997-01-21 | Zenichi Ogita | 外用剤 |
| JPH1017488A (ja) * | 1996-06-25 | 1998-01-20 | Asahi Glass Co Ltd | 緑内障治療薬 |
| WO1998032435A1 (en) * | 1997-01-29 | 1998-07-30 | Braswell, A., Glenn | Liquid eye drop composition |
| RU2114587C1 (ru) | 1997-03-27 | 1998-07-10 | Малое государственное предприятие "Научно-экспериментальное производство" | Раствор для защиты роговицы от повреждений "визитон-1" |
| JPH1171282A (ja) * | 1997-09-01 | 1999-03-16 | Senju Pharmaceut Co Ltd | 点眼用水性製剤 |
| ATE258791T1 (de) * | 1999-11-09 | 2004-02-15 | Alcon Inc | Lipoxin-a4 und deren analoge zur behandlung von trockenen augen |
| AU2001236909A1 (en) * | 2000-02-11 | 2001-08-20 | Duke University | Method of treating disorders of the eye |
| RU2171107C1 (ru) | 2000-04-25 | 2001-07-27 | Общество с ограниченной ответственностью "Научно-экспериментальное производство Микрохирургия глаза" | Глазные капли |
| US6503892B2 (en) * | 2000-04-26 | 2003-01-07 | New England Medical Center Hospitals Inc. | Method of using matrix metalloproteinase inhibitors in filtering blebs following glaucoma filtering surgery and in the treatment of ischemic damage to the retina and optic nerve |
| RU2165749C1 (ru) * | 2000-07-06 | 2001-04-27 | Общество с ограниченной ответственностью "Научно-экспериментальное производство Микрохирургия глаза" | Способ восстановления эндотелия роговицы |
| IT1318640B1 (it) * | 2000-07-25 | 2003-08-27 | Univ Catania | Derivati di carnosina, procedimento per la loro preparazione ecomposizioni farmaceutiche che li contengono. |
| RU2333742C2 (ru) * | 2001-01-09 | 2008-09-20 | Луи Йохан ВАГЕНАР | Применение декспантенола в композиции для ухода за контактными линзами |
| JP2003171276A (ja) * | 2001-11-30 | 2003-06-17 | Menicon Co Ltd | 眼精疲労改善眼科用組成物 |
| US7795203B2 (en) * | 2002-09-30 | 2010-09-14 | Babizhayev Mark A | Method for topical treatment of eye disease and composition and device for said treatment |
-
2003
- 2003-09-29 US US10/480,724 patent/US7795203B2/en active Active - Reinstated
- 2003-09-29 JP JP2004539362A patent/JP2006504701A/ja active Pending
- 2003-09-29 EP EP03748394A patent/EP1551399A4/en not_active Withdrawn
- 2003-09-29 WO PCT/IB2003/004259 patent/WO2004028536A1/en not_active Ceased
-
2010
- 2010-07-19 US US12/838,733 patent/US9044425B2/en not_active Expired - Lifetime
- 2010-07-19 US US12/839,285 patent/US20110245177A1/en not_active Abandoned
- 2010-10-18 JP JP2010233467A patent/JP2011037891A/ja active Pending
- 2010-10-18 JP JP2010233468A patent/JP2011037892A/ja active Pending
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