JP2010540555A5 - - Google Patents
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- Publication number
- JP2010540555A5 JP2010540555A5 JP2010527139A JP2010527139A JP2010540555A5 JP 2010540555 A5 JP2010540555 A5 JP 2010540555A5 JP 2010527139 A JP2010527139 A JP 2010527139A JP 2010527139 A JP2010527139 A JP 2010527139A JP 2010540555 A5 JP2010540555 A5 JP 2010540555A5
- Authority
- JP
- Japan
- Prior art keywords
- der
- pharmaceutical composition
- formula
- alkenyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims description 13
- 125000003342 alkenyl group Chemical group 0.000 claims description 12
- 230000004968 inflammatory condition Effects 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 201000010099 disease Diseases 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- 230000001613 neoplastic effect Effects 0.000 claims description 6
- 201000011510 cancer Diseases 0.000 claims description 5
- 210000004072 lung Anatomy 0.000 claims description 5
- 210000002808 connective tissue Anatomy 0.000 claims description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 3
- 210000005166 vasculature Anatomy 0.000 claims description 3
- 206010025323 Lymphomas Diseases 0.000 claims description 2
- 208000034578 Multiple myelomas Diseases 0.000 claims description 2
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 2
- 210000004556 brain Anatomy 0.000 claims description 2
- 210000000481 breast Anatomy 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000032839 leukemia Diseases 0.000 claims description 2
- 210000001672 ovary Anatomy 0.000 claims description 2
- 239000008024 pharmaceutical diluent Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 229940124531 pharmaceutical excipient Drugs 0.000 claims description 2
- 210000002307 prostate Anatomy 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 210000003932 urinary bladder Anatomy 0.000 claims description 2
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 230000009149 molecular binding Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 13
- 230000007608 epigenetic mechanism Effects 0.000 description 2
- 230000002489 hematologic effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97543707P | 2007-09-26 | 2007-09-26 | |
| PCT/US2008/077669 WO2009042766A1 (en) | 2007-09-26 | 2008-09-25 | Azacytidine analogues and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010540555A JP2010540555A (ja) | 2010-12-24 |
| JP2010540555A5 true JP2010540555A5 (OSRAM) | 2011-08-25 |
Family
ID=40511851
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527140A Pending JP2010540556A (ja) | 2007-09-26 | 2008-09-25 | アザシチジン類似体およびその使用 |
| JP2010527139A Pending JP2010540555A (ja) | 2007-09-26 | 2008-09-25 | アザシチジン類似体およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527140A Pending JP2010540556A (ja) | 2007-09-26 | 2008-09-25 | アザシチジン類似体およびその使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8158605B2 (OSRAM) |
| EP (2) | EP2205073A4 (OSRAM) |
| JP (2) | JP2010540556A (OSRAM) |
| KR (2) | KR20100072230A (OSRAM) |
| CN (2) | CN101815437A (OSRAM) |
| AU (2) | AU2008304380A1 (OSRAM) |
| BR (2) | BRPI0817269A2 (OSRAM) |
| CA (2) | CA2700267A1 (OSRAM) |
| IL (1) | IL204690A0 (OSRAM) |
| MX (2) | MX2010003261A (OSRAM) |
| NZ (2) | NZ583824A (OSRAM) |
| RU (1) | RU2488591C2 (OSRAM) |
| UA (2) | UA99308C2 (OSRAM) |
| WO (2) | WO2009042767A1 (OSRAM) |
| ZA (1) | ZA201001660B (OSRAM) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8497292B2 (en) * | 2005-12-28 | 2013-07-30 | Translational Therapeutics, Inc. | Translational dysfunction based therapeutics |
| EP2205073A4 (en) | 2007-09-26 | 2013-03-06 | Sinai School Medicine | AZACYTIDINE ANALOGS AND USES THEREOF |
| NZ589437A (en) | 2008-05-15 | 2012-11-30 | Celgene Corp | Immediate release tablet comprising 5-azacytidine and a non-enteric coating applied with an ethanol solvent |
| WO2010014883A2 (en) | 2008-08-01 | 2010-02-04 | Dr. Reddy's Laboratories Ltd. | Azacitidine process and polymorphs |
| EP2424845A4 (en) * | 2009-04-27 | 2014-03-05 | Reddys Lab Ltd Dr | PREPARATION OF DECITABIN |
| CA2825152A1 (en) | 2011-01-31 | 2012-08-09 | Celgene Corporation | Pharmaceutical compositions of cytidine analogs and methods of use thereof |
| US20120264710A1 (en) * | 2011-04-15 | 2012-10-18 | Marit Liland Sandvold | Systems and Methods for Detecting hENT1 Expression in Hematological Disorders |
| TWI558401B (zh) | 2011-11-01 | 2016-11-21 | 西建公司 | 利用胞嘧啶核苷類似物之口服配方治療癌症的方法 |
| US9375443B2 (en) | 2012-02-24 | 2016-06-28 | Signal Pharmaceuticals, Llc | Method for treating advanced non-small cell lung cancer (NSCLC) by administering a combination of a TOR kinase inhibitor and azacitidine or erlotinib |
| US9493500B2 (en) | 2012-07-19 | 2016-11-15 | Richard Daifuku | Fluorinated pyrimidine analogs and methods of use thereof |
| US9782427B2 (en) * | 2013-04-17 | 2017-10-10 | Signal Pharmaceuticals, Llc | Methods for treating cancer using TOR kinase inhibitor combination therapy |
| WO2015195786A2 (en) | 2014-06-17 | 2015-12-23 | Celgene Corporation | Methods for treating cancers using oral formulations of cytidine analogs |
| CA2972259A1 (en) * | 2014-12-26 | 2016-06-30 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| WO2017090264A1 (ja) | 2015-11-27 | 2017-06-01 | 大原薬品工業株式会社 | ５－アザシチジン又は其の２'－デオキシ体の５'位ジベンジル燐酸エステル |
| CA3007357C (en) | 2015-12-03 | 2023-12-05 | Epidestiny, Inc. | Compositions containing decitabine, 5azacytidine and tetrahydrouridine and uses thereof |
| DK3600419T5 (en) | 2017-03-20 | 2024-05-27 | Vaccinex Inc | Treatment of cancer with a semaphorin-4d antibody in combination with an epigenetic modulating agent |
| MY198676A (en) | 2017-06-22 | 2023-09-15 | Celgene Corp | Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection |
| KR102810546B1 (ko) * | 2018-04-19 | 2025-05-20 | 써던 리서취 인스티튜트 | 암의 치료를 위한 4'-티오-뉴클레오타이드 및 -뉴클레오사이드 전구약물 |
| WO2022035852A1 (en) * | 2020-08-10 | 2022-02-17 | The Johns Hopkins University | Decitabine analogs for immunological and oncological therapy |
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| BE612384A (fr) * | 1961-01-10 | 1962-05-02 | Spofa Vereinigte Pharma Werke | Procédé de préparation des 1-glycosyle-6-aza-uraciles |
| GB1050899A (OSRAM) | 1963-12-22 | |||
| DE2012888C3 (de) | 1970-03-14 | 1981-04-02 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden |
| DE2122991C2 (de) | 1971-05-04 | 1982-06-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von Cytosin- und 6-Azacytosinnucleosiden |
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| GB2260319B (en) | 1991-10-07 | 1995-12-06 | Norsk Hydro As | Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity |
| GB9307043D0 (en) | 1993-04-05 | 1993-05-26 | Norsk Hydro As | Chemical compounds |
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| US20070225248A1 (en) | 2006-03-21 | 2007-09-27 | Clavis Pharma As | Oral dosage forms of gemcitabine derivatives |
| EP2205073A4 (en) | 2007-09-26 | 2013-03-06 | Sinai School Medicine | AZACYTIDINE ANALOGS AND USES THEREOF |
-
2008
- 2008-09-25 EP EP08832961A patent/EP2205073A4/en not_active Withdrawn
- 2008-09-25 US US12/238,125 patent/US8158605B2/en not_active Expired - Fee Related
- 2008-09-25 KR KR1020107007252A patent/KR20100072230A/ko not_active Withdrawn
- 2008-09-25 JP JP2010527140A patent/JP2010540556A/ja active Pending
- 2008-09-25 BR BRPI0817269-2A2A patent/BRPI0817269A2/pt not_active IP Right Cessation
- 2008-09-25 UA UAA201004927A patent/UA99308C2/ru unknown
- 2008-09-25 NZ NZ583824A patent/NZ583824A/en not_active IP Right Cessation
- 2008-09-25 MX MX2010003261A patent/MX2010003261A/es not_active Application Discontinuation
- 2008-09-25 NZ NZ583923A patent/NZ583923A/en not_active IP Right Cessation
- 2008-09-25 BR BRPI0817234-0A2A patent/BRPI0817234A2/pt not_active IP Right Cessation
- 2008-09-25 CN CN200880108584A patent/CN101815437A/zh active Pending
- 2008-09-25 RU RU2010116274/04A patent/RU2488591C2/ru not_active IP Right Cessation
- 2008-09-25 US US12/238,054 patent/US8399420B2/en not_active Expired - Fee Related
- 2008-09-25 CA CA2700267A patent/CA2700267A1/en not_active Abandoned
- 2008-09-25 CN CN2008801085550A patent/CN101877964A/zh active Pending
- 2008-09-25 WO PCT/US2008/077673 patent/WO2009042767A1/en not_active Ceased
- 2008-09-25 CA CA2700207A patent/CA2700207A1/en not_active Abandoned
- 2008-09-25 AU AU2008304380A patent/AU2008304380A1/en not_active Abandoned
- 2008-09-25 AU AU2008304381A patent/AU2008304381A1/en not_active Abandoned
- 2008-09-25 KR KR1020107008902A patent/KR20100102092A/ko not_active Withdrawn
- 2008-09-25 EP EP08834291A patent/EP2197274A4/en not_active Withdrawn
- 2008-09-25 UA UAA201004928A patent/UA99836C2/ru unknown
- 2008-09-25 MX MX2010003002A patent/MX2010003002A/es active IP Right Grant
- 2008-09-25 WO PCT/US2008/077669 patent/WO2009042766A1/en not_active Ceased
- 2008-09-25 JP JP2010527139A patent/JP2010540555A/ja active Pending
-
2010
- 2010-03-08 ZA ZA2010/01660A patent/ZA201001660B/en unknown
- 2010-03-23 IL IL204690A patent/IL204690A0/en unknown