|
US4911920A
(en)
*
|
1986-07-30 |
1990-03-27 |
Alcon Laboratories, Inc. |
Sustained release, comfort formulation for glaucoma therapy
|
|
FR2588189B1
(fr)
*
|
1985-10-03 |
1988-12-02 |
Merck Sharp & Dohme |
Composition pharmaceutique de type a transition de phase liquide-gel
|
|
US4801575A
(en)
*
|
1986-07-30 |
1989-01-31 |
The Regents Of The University Of California |
Chimeric peptides for neuropeptide delivery through the blood-brain barrier
|
|
US4902505A
(en)
|
1986-07-30 |
1990-02-20 |
Alkermes |
Chimeric peptides for neuropeptide delivery through the blood-brain barrier
|
|
US5624898A
(en)
*
|
1989-12-05 |
1997-04-29 |
Ramsey Foundation |
Method for administering neurologic agents to the brain
|
|
US6407061B1
(en)
*
|
1989-12-05 |
2002-06-18 |
Chiron Corporation |
Method for administering insulin-like growth factor to the brain
|
|
JP2594486B2
(ja)
*
|
1991-01-15 |
1997-03-26 |
アルコン ラボラトリーズ インコーポレイテッド |
局所的眼薬組成物
|
|
US5212162A
(en)
*
|
1991-03-27 |
1993-05-18 |
Alcon Laboratories, Inc. |
Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
|
|
US6287792B1
(en)
*
|
1991-06-17 |
2001-09-11 |
The Regents Of The University Of California |
Drug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technology
|
|
TW282460B
(esLanguage)
|
1993-12-28 |
1996-08-01 |
Yamanouchi Pharma Co Ltd |
|
|
US6309853B1
(en)
|
1994-08-17 |
2001-10-30 |
The Rockfeller University |
Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
|
|
US5728718A
(en)
*
|
1994-12-20 |
1998-03-17 |
The United States Of America As Represented By The Department Of Health And Human Services |
2,5-diamino-3,4-disubstituted-1,6-diphenylhexane isosteres comprising benzamide, sulfonamide and anthranilamide subunits and methods of using same
|
|
ATE482233T1
(de)
*
|
1999-06-28 |
2010-10-15 |
Oklahoma Med Res Found |
Inhibitoren des memapsin 2 und ihre verwendung
|
|
AU2274201A
(en)
*
|
1999-12-16 |
2001-06-25 |
Emisphere Technologies, Inc. |
Compounds and compositions for delivering active agents
|
|
JP2003530360A
(ja)
*
|
2000-04-12 |
2003-10-14 |
インプリクス リミテッド |
薬剤送達のためのペプチド複合体
|
|
US6372250B1
(en)
*
|
2000-04-25 |
2002-04-16 |
The Regents Of The University Of California |
Non-invasive gene targeting to the brain
|
|
CA2410972A1
(en)
|
2000-06-30 |
2002-01-10 |
Elan Pharmaceuticals, Inc. |
Compounds to treat alzheimer's disease
|
|
PE20020276A1
(es)
|
2000-06-30 |
2002-04-06 |
Elan Pharm Inc |
COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
|
|
US6846813B2
(en)
|
2000-06-30 |
2005-01-25 |
Pharmacia & Upjohn Company |
Compounds to treat alzheimer's disease
|
|
US20040121947A1
(en)
*
|
2000-12-28 |
2004-06-24 |
Oklahoma Medical Research Foundation |
Compounds which inhibit beta-secretase activity and methods of use thereof
|
|
AU2002239727C1
(en)
|
2000-12-28 |
2005-12-22 |
Oklahoma Medical Research Foundation |
Inhibitors of memapsin 2 and use thereof
|
|
AU2002248432A1
(en)
|
2001-02-14 |
2002-08-28 |
Sankyo Company, Limited |
Oxazole derivatives, their preparation and their use as cytokine inhibitors
|
|
US20060234944A1
(en)
*
|
2001-10-23 |
2006-10-19 |
Oklahoma Medical Reseach Foundation |
Beta-secretase inhibitors and methods of use
|
|
AU2002359301B2
(en)
*
|
2001-10-23 |
2008-07-03 |
Comentis, Inc. |
Beta-secretase inhibitors and methods of use
|
|
EP1453789A2
(en)
|
2001-11-08 |
2004-09-08 |
Elan Pharmaceuticals, Inc. |
N,n'-substituted-1,3-diamino-2-hydroxypropane derivatives
|
|
AU2002360508A1
(en)
*
|
2001-12-06 |
2003-06-23 |
Elan Pharmaceuticals, Inc. |
Substituted hydroxyethylamines
|
|
EP1503980A2
(en)
|
2002-02-27 |
2005-02-09 |
Elan Pharmaceuticals, Inc. |
Substituted hydroxyethylamines
|
|
WO2003100031A2
(en)
*
|
2002-05-20 |
2003-12-04 |
Board Of Regents, The University Of Texas System |
Methods and compositions for delivering enzymes and nucleic acid molecules to brain, bone, and other tissues
|
|
KR20050049485A
(ko)
|
2002-09-06 |
2005-05-25 |
엘란 파마슈티칼스, 인크. |
1,3-디아미노-2-히드록시프로판 전구약물 유도체
|
|
CA2505098A1
(en)
*
|
2002-11-12 |
2004-05-27 |
Merck & Co., Inc. |
Phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer's disease
|
|
US20040102369A1
(en)
*
|
2002-11-27 |
2004-05-27 |
The Regents Of The University Of California |
Transport of basic fibroblast growth factor across the blood brain barrier
|
|
US7388079B2
(en)
*
|
2002-11-27 |
2008-06-17 |
The Regents Of The University Of California |
Delivery of pharmaceutical agents via the human insulin receptor
|
|
GB0228410D0
(en)
*
|
2002-12-05 |
2003-01-08 |
Glaxo Group Ltd |
Novel Compounds
|
|
GB0305918D0
(en)
|
2003-03-14 |
2003-04-23 |
Glaxo Group Ltd |
Novel compounds
|
|
CN1863797A
(zh)
|
2003-08-08 |
2006-11-15 |
先灵公司 |
具有苯甲酰胺取代基的环胺bace－1抑制剂
|
|
KR100793095B1
(ko)
|
2003-10-01 |
2008-01-10 |
주식회사 프로메디텍 |
Ｂａｃｅ 저해효능을 가진 신규한 술폰 아미드 유도체
|
|
CN100537523C
(zh)
|
2003-12-19 |
2009-09-09 |
默克公司 |
用于治疗阿尔茨海默病的苯基酰胺和吡啶基酰胺类β-分泌酶抑制剂
|
|
JP2007533740A
(ja)
|
2004-04-22 |
2007-11-22 |
イーライ リリー アンド カンパニー |
Ｂａｃｅ阻害剤としてのアミド
|
|
US7585885B2
(en)
*
|
2004-04-22 |
2009-09-08 |
Eli Lilly And Company |
Pyrrolidine derivatives useful as BACE inhibitors
|
|
US7714021B2
(en)
|
2004-06-15 |
2010-05-11 |
Merck & Co., Inc. |
Pyrrolidin-3-yl compounds useful as beta-secretase inhibitors for the treatment of Alzheimer's disease
|
|
US8436006B2
(en)
*
|
2004-08-06 |
2013-05-07 |
Jansssen Pharmaceutica N.V. |
2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
|
|
AU2005286844A1
(en)
*
|
2004-09-17 |
2006-03-30 |
Comentis, Inc |
Bicyclic compounds which inhibit beta-secretase activity and methods of use thereof
|
|
US7659289B2
(en)
*
|
2004-09-17 |
2010-02-09 |
Comentis, Inc. |
Hydroxyethylene-based β-secretase inhibitors and use thereof
|
|
CN100475786C
(zh)
*
|
2005-02-18 |
2009-04-08 |
中国科学院上海药物研究所 |
一类4-羟基戊酰胺类化合物及其制备方法和用途
|
|
WO2006099352A1
(en)
|
2005-03-10 |
2006-09-21 |
Bristol-Myers Squibb Company |
Novel isophthalates as beta-secretase inhibitors
|
|
BRPI0607019A2
(pt)
*
|
2005-04-08 |
2009-07-28 |
Univ Illinois |
compostos que inibem a atividade de beta -secretase e métodos de uso dos mesmos
|
|
MY158766A
(en)
|
2005-04-11 |
2016-11-15 |
Xenon Pharmaceuticals Inc |
Spiro-oxindole compounds and their uses as therapeutic agents
|
|
AR054044A1
(es)
|
2005-05-23 |
2007-05-30 |
Astrazeneca Ab |
Derivados de cromano y tetrahidronaftaleno como moduladores del receptor 5 - ht6; intermediarios en su preparacion; composiciones farmaceuticas que los contienen y su empelo en la fabricacion de medicamentos para el tratamiento de enfermedades del snc y de la obesidad.
|
|
AR054363A1
(es)
|
2005-05-23 |
2007-06-20 |
Astrazeneca Ab |
Compuestos que exhiben actividad moduladora en el receptor 5-hidroxi-triptamina 6
|
|
GB0513886D0
(en)
|
2005-07-06 |
2005-08-10 |
Glaxo Group Ltd |
Novel compounds
|
|
US7476764B2
(en)
*
|
2005-08-04 |
2009-01-13 |
Bristol-Myers Squibb Company |
Phenylcarboxyamides as beta-secretase inhibitors
|
|
US7790745B2
(en)
|
2005-10-21 |
2010-09-07 |
Bristol-Myers Squibb Company |
Tetrahydroisoquinoline LXR Modulators
|
|
TW200804290A
(en)
|
2005-11-15 |
2008-01-16 |
Astrazeneca Ab |
Compounds and uses thereof
|
|
AU2007297627A1
(en)
|
2006-09-21 |
2008-03-27 |
Merck Sharp & Dohme Corp. |
Piperidine and pyrrolidine beta-secretase inhibitors for the treatment of Alzheimer's disease
|
|
US20100286145A1
(en)
|
2007-07-26 |
2010-11-11 |
Comentis, Inc. |
Isophthalamide derivatives inhibiting beta-secretase activity
|
|
CA2699787A1
(en)
|
2007-09-24 |
2009-04-02 |
Comentis, Inc. |
(3-hydroxy-4-amino-butan-2-yl)-3-(2-thiazol-2-yl-pyrrolidine-1-carbonyl) benzamide derivatives and related compounds as beta-secretase inhibitors for treating
|
|
WO2010002994A1
(en)
|
2008-07-01 |
2010-01-07 |
Purdue Research Foundation |
Nonpeptide hiv-1 protease inhibitors
|
|
US8703947B2
(en)
|
2008-10-10 |
2014-04-22 |
Purdue Research Foundation |
Compounds for treatment of Alzheimer's disease
|
|
US20130102593A1
(en)
|
2008-10-10 |
2013-04-25 |
Geoffrey M. Bilcer |
Pyrrolidine compounds which inhibit beta-secretase activity and methods of use thereof
|
|
JP2012509352A
(ja)
|
2008-11-20 |
2012-04-19 |
パーデュー・リサーチ・ファウンデーション |
Ｂａｃｅ１のキナゾリン阻害剤および使用方法
|
|
WO2010065861A2
(en)
|
2008-12-05 |
2010-06-10 |
Purdue Research Foundation |
Inhibitors of bace 1 and methods for treating alzheimer's disease
|
|
EP2411000A4
(en)
|
2009-03-25 |
2012-09-19 |
Comentis Inc |
PYRROLIDIN COMPOUNDS FOR INHIBITING THE BETA-SECRETASE EFFECT AND METHOD FOR THE APPLICATION THEREOF
|
|
WO2011044057A1
(en)
|
2009-10-05 |
2011-04-14 |
Comentis, Inc. |
Sulfonamido pyrrolidine compounds which inhibit beta-secretase activity and methods of use thereof
|