JP2010539123A - 変性疾患の処置のための神経内分泌因子 - Google Patents

変性疾患の処置のための神経内分泌因子 Download PDF

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Publication number
JP2010539123A
JP2010539123A JP2010524408A JP2010524408A JP2010539123A JP 2010539123 A JP2010539123 A JP 2010539123A JP 2010524408 A JP2010524408 A JP 2010524408A JP 2010524408 A JP2010524408 A JP 2010524408A JP 2010539123 A JP2010539123 A JP 2010539123A
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pharmaceutical composition
repellent factor
cartilage
repellent
slit3
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Pending
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JP2010524408A
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English (en)
Japanese (ja)
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JP2010539123A5 (enExample
Inventor
ボサーホフ アーニャ
シューベルト トーマス
フステルト エリーザベト
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Bionet Pharma GmbH
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Scil Technology GmbH
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Priority claimed from EP07018131A external-priority patent/EP2036921A1/en
Application filed by Scil Technology GmbH filed Critical Scil Technology GmbH
Publication of JP2010539123A publication Critical patent/JP2010539123A/ja
Publication of JP2010539123A5 publication Critical patent/JP2010539123A5/ja
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2010524408A 2007-09-14 2008-09-12 変性疾患の処置のための神経内分泌因子 Pending JP2010539123A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07018131A EP2036921A1 (en) 2007-09-14 2007-09-14 Use of Slit, nephrin, ephrin or semaphorin for treatment of cartilage diseases
EP08006810 2008-04-03
PCT/EP2008/007579 WO2009033715A2 (en) 2007-09-14 2008-09-12 Neuroendocrine factors for treatment of degenerative diseases

Publications (2)

Publication Number Publication Date
JP2010539123A true JP2010539123A (ja) 2010-12-16
JP2010539123A5 JP2010539123A5 (enExample) 2011-10-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010524408A Pending JP2010539123A (ja) 2007-09-14 2008-09-12 変性疾患の処置のための神経内分泌因子

Country Status (13)

Country Link
US (1) US20110002972A1 (enExample)
EP (1) EP2212344B1 (enExample)
JP (1) JP2010539123A (enExample)
KR (1) KR20100075493A (enExample)
CN (1) CN101821283A (enExample)
AU (1) AU2008297889A1 (enExample)
BR (1) BRPI0816784A8 (enExample)
CA (1) CA2699411A1 (enExample)
MX (1) MX2010002716A (enExample)
NZ (1) NZ583851A (enExample)
RU (1) RU2496790C2 (enExample)
WO (1) WO2009033715A2 (enExample)
ZA (1) ZA201001644B (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014520760A (ja) * 2011-07-04 2014-08-25 メゾブラスト,インコーポレーテッド リウマチ性疾患を予防または治療する方法
WO2015072527A1 (ja) * 2013-11-13 2015-05-21 国立大学法人大阪大学 ネトリン1含有破骨細胞形成抑制剤
JP2015527973A (ja) * 2012-06-15 2015-09-24 ザ アサン ファウンデーション Slit−Roboシステムを用いた骨折又は骨粗鬆症の予防或いは治療用組成物
JPWO2023008337A1 (enExample) * 2021-07-26 2023-02-02

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IT1400024B1 (it) * 2010-05-21 2013-05-17 Uni Politecnica Delle Marche Uso farmaceutico di semaforine.
MX2013007421A (es) * 2010-12-23 2014-02-03 Sanofi Sa Proteina de fusion robo1-fc para uso en el tratamiento del hepatocarcinoma.
ES2442242B1 (es) * 2012-08-09 2014-11-25 Biotechnology Institute, I Mas D, S.L. Composición con factores de crecimiento destinada al tratamiento intranasal de una enfermedad neurodegenerativa u otra patología del sistema nervioso central, y su método de fabricación.
CN104119447A (zh) * 2013-04-26 2014-10-29 李华顺 含有富含亮氨酸重复序列的融合蛋白及其制法和应用
CN104119448A (zh) * 2013-04-26 2014-10-29 李华顺 含有富含亮氨酸重复序列的融合蛋白及其制法和应用
CN104119446A (zh) * 2013-04-26 2014-10-29 李华顺 含有富含亮氨酸重复序列的融合蛋白及其制法和应用
CN104119445A (zh) * 2013-04-26 2014-10-29 李华顺 含有富含亮氨酸重复序列的融合蛋白及其制法和应用
FI3116521T3 (fi) 2014-03-14 2024-10-30 Univ New York State Res Found Luun kasvun ja luun rappeutumisen neurogeeninen regulaatio
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
WO2019161136A1 (en) * 2018-02-14 2019-08-22 Cornell University Slit and bone growth modulation
PH12021552079A1 (en) * 2019-02-27 2022-07-18 Daewoong Pharmaceutical Co Ltd Albumin-bound composition including lrrd2 of slit3 protein for prevention or treatment of bone-related diseases
EP4028532A1 (en) * 2019-09-13 2022-07-20 Rutgers, the State University of New Jersey Aav-compatible laminin-linker polymerization proteins
CN110772632B (zh) * 2019-11-19 2023-08-11 四川大学华西医院 神经导向因子semaphorin 3a在制备治疗骨关节炎药物中的用途
CN110684805B (zh) * 2019-11-19 2023-08-01 四川大学华西医院 神经导向因子Sema基因重组慢病毒载体在制备治疗骨关节炎药物中的应用
CN110841057B (zh) * 2019-11-19 2023-08-01 四川大学华西医院 一种神经导向因子Sema在制备治疗骨关节炎巴布膏剂中的应用
CN110721308B (zh) * 2019-11-19 2023-08-01 四川大学华西医院 一种用于治疗骨关节炎的药物复方制剂及其制备方法
CN110694051B (zh) * 2019-11-19 2023-08-01 四川大学华西医院 一种神经导向因子Sema在制备治疗骨关节炎注射剂中的应用
CN110711244B (zh) * 2019-11-19 2023-08-01 四川大学华西医院 一种神经导向因子Sema在制备治疗骨关节炎搽剂中的应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1116490A (ja) * 1997-06-26 1999-01-22 Kyocera Corp プラズマディスプレイパネル用隔壁の製造方法及びプラズマディスプレイパネル用基板
WO2002006315A2 (en) * 2000-07-18 2002-01-24 Compugen Ltd. Novel nucleic acid and amino acid sequences
WO2002081745A2 (en) * 2001-04-05 2002-10-17 Proskelia Pharmaceuticals Genes involved in osteogenesis, and methods of use
JP2002538823A (ja) * 1999-03-17 2002-11-19 ワシントン・ユニバーシティ 脊椎動物のslitDNA配列、タンパク質およびその使用
WO2005074556A2 (en) * 2004-01-30 2005-08-18 The General Hospital Corporation Netrin compositions and methods of use thereof

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FR2700117B1 (fr) * 1993-01-07 1995-02-03 Rhone Poulenc Rorer Sa Application d'anticonvulsivants dans le traitement de la maladie de Parkinson et des syndromes parkinsoniens.
US20030032057A1 (en) * 1997-08-26 2003-02-13 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO1999023219A1 (en) * 1997-10-31 1999-05-14 Osiris Therapeutics, Inc. Human slit polypeptide and polynucleotides encoding same
JPH11164690A (ja) * 1997-12-05 1999-06-22 Asahi Chem Ind Co Ltd 脊椎動物スリット蛋白質
US20030096955A1 (en) * 1998-09-01 2003-05-22 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2002010217A2 (en) * 2000-08-02 2002-02-07 The Johns Hopkins University Endothelial cell expression patterns
WO2002012346A2 (en) * 2000-08-10 2002-02-14 Pharmacia Corporation A new slit-like protein obtained from a cdna library from hs-5 stromal cell line
US20050014680A1 (en) * 2003-04-15 2005-01-20 Crabtree Gerald R. Methods and compositions for enhancing neuron growth and survival
WO2008073441A2 (en) * 2006-12-11 2008-06-19 University Of Utah Research Foundation Compositions and methods for treating pathologic angiogenesis and vascular permeability

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1116490A (ja) * 1997-06-26 1999-01-22 Kyocera Corp プラズマディスプレイパネル用隔壁の製造方法及びプラズマディスプレイパネル用基板
JP2002538823A (ja) * 1999-03-17 2002-11-19 ワシントン・ユニバーシティ 脊椎動物のslitDNA配列、タンパク質およびその使用
WO2002006315A2 (en) * 2000-07-18 2002-01-24 Compugen Ltd. Novel nucleic acid and amino acid sequences
WO2002081745A2 (en) * 2001-04-05 2002-10-17 Proskelia Pharmaceuticals Genes involved in osteogenesis, and methods of use
WO2005074556A2 (en) * 2004-01-30 2005-08-18 The General Hospital Corporation Netrin compositions and methods of use thereof

Non-Patent Citations (1)

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Title
JPN6013041184; Oncology Reports, 2005, Vol.14, p.1351-1355 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014520760A (ja) * 2011-07-04 2014-08-25 メゾブラスト,インコーポレーテッド リウマチ性疾患を予防または治療する方法
JP2015527973A (ja) * 2012-06-15 2015-09-24 ザ アサン ファウンデーション Slit−Roboシステムを用いた骨折又は骨粗鬆症の予防或いは治療用組成物
JP2017039729A (ja) * 2012-06-15 2017-02-23 ザ アサン ファウンデーション Slit−Roboシステムを用いた骨折又は骨粗鬆症の予防或いは治療用組成物
US9802994B2 (en) 2012-06-15 2017-10-31 The Asan Foundation Composition for preventing or treating fracture or osteoporosis using slit-robo system
WO2015072527A1 (ja) * 2013-11-13 2015-05-21 国立大学法人大阪大学 ネトリン1含有破骨細胞形成抑制剤
JPWO2023008337A1 (enExample) * 2021-07-26 2023-02-02
WO2023008337A1 (ja) * 2021-07-26 2023-02-02 ピューロテックバイオ株式会社 宿主因子lipgをターゲットとした抗b型肝炎ウイルス剤

Also Published As

Publication number Publication date
US20110002972A1 (en) 2011-01-06
WO2009033715A3 (en) 2010-03-18
WO2009033715A2 (en) 2009-03-19
KR20100075493A (ko) 2010-07-02
EP2212344A2 (en) 2010-08-04
CA2699411A1 (en) 2009-03-19
RU2496790C2 (ru) 2013-10-27
AU2008297889A1 (en) 2009-03-19
NZ583851A (en) 2012-06-29
CN101821283A (zh) 2010-09-01
EP2212344B1 (en) 2014-03-26
BRPI0816784A2 (pt) 2015-03-24
ZA201001644B (en) 2011-03-30
BRPI0816784A8 (pt) 2016-01-19
MX2010002716A (es) 2010-07-05
RU2010114713A (ru) 2011-10-20

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