JP2010539110A5 - - Google Patents

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Publication number
JP2010539110A5
JP2010539110A5 JP2010524375A JP2010524375A JP2010539110A5 JP 2010539110 A5 JP2010539110 A5 JP 2010539110A5 JP 2010524375 A JP2010524375 A JP 2010524375A JP 2010524375 A JP2010524375 A JP 2010524375A JP 2010539110 A5 JP2010539110 A5 JP 2010539110A5
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JP
Japan
Prior art keywords
alkyl
fluoro
chloro
group
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010524375A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010539110A (ja
JP5461402B2 (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/EP2008/007137 external-priority patent/WO2009033581A1/en
Publication of JP2010539110A publication Critical patent/JP2010539110A/ja
Publication of JP2010539110A5 publication Critical patent/JP2010539110A5/ja
Application granted granted Critical
Publication of JP5461402B2 publication Critical patent/JP5461402B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010524375A 2007-09-14 2008-09-02 置換三環式化合物およびその使用方法 Expired - Fee Related JP5461402B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07018082 2007-09-14
EP07018082.3 2007-09-14
PCT/EP2008/007137 WO2009033581A1 (en) 2007-09-14 2008-09-02 Substituted tricyclic compounds and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2010539110A JP2010539110A (ja) 2010-12-16
JP2010539110A5 true JP2010539110A5 (oth) 2011-10-20
JP5461402B2 JP5461402B2 (ja) 2014-04-02

Family

ID=40130858

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010524375A Expired - Fee Related JP5461402B2 (ja) 2007-09-14 2008-09-02 置換三環式化合物およびその使用方法

Country Status (6)

Country Link
US (1) US8524722B2 (oth)
EP (1) EP2212332B1 (oth)
JP (1) JP5461402B2 (oth)
CA (1) CA2699349C (oth)
ES (1) ES2396602T3 (oth)
WO (1) WO2009033581A1 (oth)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101703941B1 (ko) 2008-11-10 2017-02-07 내셔날 헬스 리서치 인스티튜트 티로신 키나아제 억제제로서의 접합 이환 및 삼환 피리미딘 화합물
US8779192B2 (en) 2009-05-14 2014-07-15 Kolon Life Science, Inc. Process of preparing an alkylamine derivative
EA025367B1 (ru) * 2009-08-17 2016-12-30 Тракон Фармасьютикалз, Инк. Комбинированная терапия рака с помощью антител против эндоглина и агентов против vegf
US8221753B2 (en) 2009-09-30 2012-07-17 Tracon Pharmaceuticals, Inc. Endoglin antibodies
GB0915515D0 (en) * 2009-09-04 2009-10-07 Ucl Business Plc Treatment of vasculoproliferative conditions
AU2011281015B2 (en) 2010-07-23 2015-09-24 President And Fellows Of Harvard College Tricyclic proteasome activity enhancing compounds
WO2012148889A1 (en) * 2011-04-28 2012-11-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inhibitors of human apurinic/apyrimidinic endonuclease 1
CN102875535B (zh) * 2011-07-12 2016-06-08 上海药明康德新药开发有限公司 1,5-[(取代)-甲桥]-四氢-1H-吡咯[1,2-c]-咪唑-3(2H)-酮衍生物及制备方法
CA2861464C (en) 2012-01-25 2018-03-06 Proteostasis Therapeutics, Inc. Proteasome activity modulating tricyclic compounds
WO2013112699A2 (en) * 2012-01-25 2013-08-01 Proteostasis Therapeutics, Inc. Proteasome activity enhancing compounds
WO2013144191A1 (de) 2012-03-29 2013-10-03 Bayer Intellectual Property Gmbh Substituierte 2 -amino - 3 - cyanopyridine als inhibitoren des natrium calcium austausches und ihre verwendung bei kardiovaskulären erkrankungen
US20150133426A1 (en) 2012-05-21 2015-05-14 Bayer Pharma Aktiengesellschaft Substituted pyrrolopyrimidines
UA115789C2 (uk) 2012-09-05 2017-12-26 Трейкон Фармасутікалз, Інк. Композиція антитіла до cd105 та її застосування
EP2961409A1 (en) * 2013-02-26 2016-01-06 Senex Biotechnology, Inc. Inhibitors of cdk8/19 for use in treating estrogen receptor positive breast cancer
JP6087192B2 (ja) * 2013-04-03 2017-03-01 京セラ株式会社 発電システムおよび発電システムの制御方法ならびに燃料電池
CN104016983B (zh) * 2013-10-08 2018-11-02 上海创诺制药有限公司 吡咯并三嗪类衍生物及其制法和用途
AU2015346444A1 (en) 2014-11-12 2017-05-04 Tracon Pharmaceuticals, Inc. Anti-endoglin antibodies and uses thereof
US9926375B2 (en) 2014-11-12 2018-03-27 Tracon Pharmaceuticals, Inc. Anti-endoglin antibodies and uses thereof
ES2718175T3 (es) 2014-12-02 2019-06-28 Lilly Co Eli Compuestos de 1-oxo-1,2-dihidroisoquinolin-7-il-(tiofen-2-il-5-sustituido)-sulfonamida, formulaciones que contienen esos compuestos, y su uso como inhibidores de AICARFT en el tratamiento de cánceres
CN104529800B (zh) * 2014-12-08 2017-01-25 重庆威鹏药业有限公司 反式‑4‑二甲基氨基巴豆酸及盐的制备方法
WO2016133888A1 (en) * 2015-02-16 2016-08-25 Biota Pharmaceuticals, Inc. Compounds for treating respiratory syncytial virus infections
US10561749B2 (en) 2015-07-03 2020-02-18 Kyoto University Nuclear medicine diagnostic imaging agent
JP6709552B2 (ja) * 2015-07-03 2020-06-17 国立大学法人京都大学 核医学画像診断薬
CN108285421A (zh) * 2018-01-26 2018-07-17 黑龙江鑫创生物科技开发有限公司 一种微通道反应器合成拉帕替尼中间体的方法
US12398151B2 (en) 2019-03-19 2025-08-26 Suvalent Therapeutics, Inc. Sumo inhibitor compounds and uses thereof
US20220227765A1 (en) * 2019-08-28 2022-07-21 Ferro Therapeutics, Inc. Pyrido-indole analogues as gpx4 inhibitors
EP4380941A1 (en) * 2021-08-05 2024-06-12 Bristol-Myers Squibb Company Tricyclic fused pyrimidine compounds for use as her2 inhibitors
JP2023099776A (ja) * 2021-08-31 2023-07-13 エーザイ・アール・アンド・ディー・マネジメント株式会社 単環ピリジン誘導体の合成中間体の製造方法
CN115724790A (zh) * 2022-11-21 2023-03-03 安庆朗坤药业有限公司 一种n-(3-氯-4-(2-吡啶甲氧基)苯胺的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9127188D0 (en) 1991-12-21 1992-02-19 Smithkline Beecham Plc Novel compounds
EP1167367A4 (en) 1999-03-30 2002-04-24 Nippon Soda Co THIENOPYRIMIDINE COMPOUNDS AND SALTS THEREOF, AND PROCESS FOR THE PREPARATION THEREOF
AR028261A1 (es) * 2000-03-28 2003-04-30 Wyeth Corp Inhibidores triciclicos de la proteina quinasa
US6849638B2 (en) 2001-04-30 2005-02-01 Bayer Pharmaceuticals Corporation 4-amino-5,6-substituted thiopheno [2,3-d] pyrimidines, pharmaceutical compositions containing the same, and their use in the treatment or prevention of pde7b-mediated diseases and conditions
WO2003035653A1 (en) 2001-10-26 2003-05-01 Nippon Soda Co.,Ltd. Pyridothienopyrimidine compound and salt thereof
US7238701B2 (en) 2003-07-24 2007-07-03 Bayer Pharmaceuticals Corporation Substituted tetrahydrobenzothienopyrimidinamine compounds useful for treating hyper-proliferative disorders
US7427625B2 (en) 2006-02-08 2008-09-23 Janssen Pharmaceutica, N.V. Substituted thiatriazaacenaphthylene-6-carbonitrile kinase inhibitors
EP1987037A2 (en) 2006-02-23 2008-11-05 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
AR059901A1 (es) * 2006-03-20 2008-05-07 Bayer Pharmaceuticals Corp Compuestos de tetrahidropiridotienopirimidina utiles para tratar o prevenir trastornos proliferativos celulares.

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