JP2010539076A5 - - Google Patents
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- Publication number
- JP2010539076A5 JP2010539076A5 JP2010523590A JP2010523590A JP2010539076A5 JP 2010539076 A5 JP2010539076 A5 JP 2010539076A5 JP 2010523590 A JP2010523590 A JP 2010523590A JP 2010523590 A JP2010523590 A JP 2010523590A JP 2010539076 A5 JP2010539076 A5 JP 2010539076A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- derivative
- reacting
- sorafenib
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(Nc(cc1C(F)(F)F)ccc1Cl)=O Chemical compound *C(Nc(cc1C(F)(F)F)ccc1Cl)=O 0.000 description 1
- ASPDJZINBYYZRU-UHFFFAOYSA-N Nc(cc1)cc(C(F)(F)F)c1Cl Chemical compound Nc(cc1)cc(C(F)(F)F)c1Cl ASPDJZINBYYZRU-UHFFFAOYSA-N 0.000 description 1
- PLIKAWJENQZMHA-UHFFFAOYSA-N Nc(cc1)ccc1O Chemical compound Nc(cc1)ccc1O PLIKAWJENQZMHA-UHFFFAOYSA-N 0.000 description 1
- QUZCXFJNKCWQIU-UHFFFAOYSA-N Oc(cc1)ccc1NC(NC1C=C(C(F)(F)F)C(Cl)=CC1)=O Chemical compound Oc(cc1)ccc1NC(NC1C=C(C(F)(F)F)C(Cl)=CC1)=O QUZCXFJNKCWQIU-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1734MU2007 | 2007-09-10 | ||
| IN1734/MUM/2007 | 2007-09-10 | ||
| IN1733/MUM/2007 | 2007-09-10 | ||
| IN1733MU2007 | 2007-09-10 | ||
| PCT/GB2008/003048 WO2009034308A2 (en) | 2007-09-10 | 2008-09-10 | Process for the preparation of a raf kinase inhibitor and intermediates for use in the process |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010539076A JP2010539076A (ja) | 2010-12-16 |
| JP2010539076A5 true JP2010539076A5 (https=) | 2011-10-27 |
| JP5438680B2 JP5438680B2 (ja) | 2014-03-12 |
Family
ID=40351766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010523590A Expired - Fee Related JP5438680B2 (ja) | 2007-09-10 | 2008-09-10 | Ｒａｆキナーゼ阻害剤の製造方法及び該方法に使用する中間体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8445687B2 (https=) |
| EP (1) | EP2195286A2 (https=) |
| JP (1) | JP5438680B2 (https=) |
| KR (1) | KR101553211B1 (https=) |
| AU (1) | AU2008299703C1 (https=) |
| CA (1) | CA2698795C (https=) |
| NZ (1) | NZ583790A (https=) |
| WO (1) | WO2009034308A2 (https=) |
| ZA (1) | ZA201001935B (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| ATE538794T1 (de) | 1999-01-13 | 2012-01-15 | Bayer Healthcare Llc | Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer |
| MXPA04007832A (es) | 2002-02-11 | 2005-09-08 | Bayer Pharmaceuticals Corp | Aril-ureas con actividad inhibitoria de angiogenesis. |
| WO2004113274A2 (en) | 2003-05-20 | 2004-12-29 | Bayer Pharmaceuticals Corporation | Diaryl ureas with kinase inhibiting activity |
| EP2195286A2 (en) | 2007-09-10 | 2010-06-16 | Cipla Limited | Process for the preparation of a raf kinase inhibitor and intermediates for use in the process |
| MX2011002365A (es) | 2008-09-02 | 2011-04-04 | Novartis Ag | Derivados de picolinamida como inhibidres de cinasa. |
| US8604208B2 (en) | 2009-09-24 | 2013-12-10 | Ranbaxy Laboratories Limited | Polymorphs of sorafenib acid addition salts |
| WO2011036647A1 (en) | 2009-09-24 | 2011-03-31 | Ranbaxy Laboratories Limited | Process for the preparation of sorafenib tosylate |
| WO2011058522A1 (en) | 2009-11-12 | 2011-05-19 | Ranbaxy Laboratories Limited | Sorafenib ethylsulfonate salt, process for preparation and use |
| AU2011210326B2 (en) | 2010-01-29 | 2014-10-09 | Sun Pharmaceutical Industries Limited | Sorafenib dimethyl sulphoxide solvate |
| CN102190616B (zh) * | 2010-03-18 | 2015-07-29 | 苏州泽璟生物制药有限公司 | 一种氘代的ω-二苯基脲的合成及生产的方法和工艺 |
| SG191309A1 (en) * | 2011-01-18 | 2013-07-31 | Glaxo Group Ltd | Process for the preparation of retigabine |
| CN102485714B (zh) * | 2011-10-09 | 2013-07-24 | 连云港盛和生物科技有限公司 | 一种羰基化合成索拉菲尼的方法 |
| US9173883B2 (en) | 2012-05-21 | 2015-11-03 | Novartis Ag | Ring-substituted N-pyridinyl amides as kinase inhibitors |
| CN103508961B (zh) * | 2012-06-26 | 2015-07-22 | 中美冠科生物技术（太仓）有限公司 | 抗肿瘤药物 |
| CN103408488A (zh) * | 2013-08-13 | 2013-11-27 | 张家港威胜生物医药有限公司 | 一种索拉非尼的优化合成方法 |
| PT3039424T (pt) | 2013-08-28 | 2020-09-03 | Crown Bioscience Inc Taicang | Assinaturas de expressão genética que permitem prever a resposta de um sujeito a um inibidor multiquinase e métodos de utilização do mesmo |
| CN104761492A (zh) * | 2014-01-03 | 2015-07-08 | 正大天晴药业集团股份有限公司 | 对甲苯磺酸索拉非尼的晶型及其制备方法 |
| CN105481764A (zh) * | 2014-09-16 | 2016-04-13 | 重庆圣华曦药业股份有限公司 | 一种索拉非尼对甲苯磺酸盐的制备方法 |
| CN105399668B (zh) * | 2015-12-29 | 2018-11-16 | 开封制药(集团)有限公司 | 一种“一锅法”制备索拉菲尼的方法 |
| CN105801475B (zh) * | 2016-04-25 | 2018-01-12 | 华润双鹤利民药业（济南）有限公司 | 一种甲苯磺酸索拉非尼的制备方法 |
| CN109796400B (zh) * | 2017-11-16 | 2022-07-29 | 四川科伦药物研究院有限公司 | 一种甲苯磺酸索拉菲尼晶型及其制备方法 |
| CN108623521B (zh) * | 2018-03-22 | 2020-09-04 | 盐城师范学院 | 一种乐伐替尼的制备方法 |
| CN108341770A (zh) * | 2018-03-31 | 2018-07-31 | 山东罗欣药业集团恒欣药业有限公司 | 一种索拉非尼化合物的制备方法 |
| CN108276328A (zh) * | 2018-03-31 | 2018-07-13 | 山东罗欣药业集团恒欣药业有限公司 | 一种索拉非尼的制备方法 |
| CN108586329A (zh) * | 2018-03-31 | 2018-09-28 | 山东罗欣药业集团恒欣药业有限公司 | 一种索拉非尼的合成方法 |
| CN108558747A (zh) * | 2018-03-31 | 2018-09-21 | 山东罗欣药业集团恒欣药业有限公司 | 一种瑞戈非尼的制备方法 |
| CN108276327A (zh) * | 2018-03-31 | 2018-07-13 | 山东罗欣药业集团恒欣药业有限公司 | 一种索拉非尼的制备方法 |
| CN108440403A (zh) * | 2018-03-31 | 2018-08-24 | 山东罗欣药业集团恒欣药业有限公司 | 一种瑞戈非尼的制备方法 |
| CN108586330A (zh) * | 2018-04-18 | 2018-09-28 | 日照市普达医药科技有限公司 | 一种治疗肿瘤药物的制备方法及其应用 |
| KR20220038696A (ko) | 2019-07-19 | 2022-03-29 | 아나제네시스 바이오테크놀로지스 에스.에이.에스. | 폴리방향족 우레아 유도체 및 근육 질환 치료에서의 이들의 용도 |
| EP4029501A1 (en) | 2021-01-19 | 2022-07-20 | Anagenesis Biotechnologies | Combination of polyaromatic urea derivatives and glucocorticoid or hdac inhibitor for the treatment of diseases or conditions associated with muscle cells and/or satellite cells |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL123536C (https=) | 1963-07-09 | |||
| FR1484461A (fr) | 1965-06-25 | 1967-06-09 | Grace W R & Co | Compositions herbicides |
| CH497117A (de) | 1968-01-12 | 1970-06-30 | Ciba Geigy | Verwendung eines Carbanilsäurederivates zum antimikrobiellen Ausrüsten bzw. zum Schützen von Textilfasern gegen Befall und Schädigung durch Mikroorganismen |
| CH490005A (de) * | 1968-02-06 | 1970-05-15 | Ciba Geigy | Schädlingsbekämpfungsmittel |
| BE788983A (fr) * | 1971-09-22 | 1973-01-15 | Rolland Sa A | 3-trifluoromethylanilides |
| US5541224A (en) * | 1994-03-14 | 1996-07-30 | Eli Lilly And Company | Carbanilide anticoccidials |
| CN100522934C (zh) * | 1999-01-13 | 2009-08-05 | 拜尔有限公司 | 用ω-羧基芳基取代的二苯脲作为raf激酶抑制剂 |
| WO2000042012A1 (en) | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS |
| ATE538794T1 (de) * | 1999-01-13 | 2012-01-15 | Bayer Healthcare Llc | Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer |
| US6242385B1 (en) * | 2000-02-28 | 2001-06-05 | Uniroyal Chemical Company, Inc. | Enhancement of seed/fruit/nut yields from flowering plants |
| JP4618127B2 (ja) | 2003-08-28 | 2011-01-26 | 大正製薬株式会社 | １，３−ジヒドロ−２ｈ−インドール−２−オン誘導体 |
| UY28931A1 (es) | 2004-06-03 | 2005-12-30 | Bayer Pharmaceuticals Corp | Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis |
| AU2005289099B2 (en) * | 2004-09-29 | 2012-07-19 | Bayer Healthcare Llc | Process for the preparation of 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-N-methylpyridine-2-carboxamide |
| TW200730503A (en) | 2005-10-21 | 2007-08-16 | Daiichi Seiyaku Co | Tricyclic compound |
| KR101461680B1 (ko) * | 2005-12-02 | 2014-11-19 | 바이엘 헬스케어 엘엘씨 | 과다-증식성 장애 및 맥관형성과 관련된 질환의 치료에유용한 치환된 4-아미노-피롤로트리아진 유도체 |
| EP2195286A2 (en) | 2007-09-10 | 2010-06-16 | Cipla Limited | Process for the preparation of a raf kinase inhibitor and intermediates for use in the process |
-
2008
- 2008-09-10 EP EP08806217A patent/EP2195286A2/en not_active Ceased
- 2008-09-10 WO PCT/GB2008/003048 patent/WO2009034308A2/en not_active Ceased
- 2008-09-10 NZ NZ583790A patent/NZ583790A/en not_active IP Right Cessation
- 2008-09-10 KR KR1020107007688A patent/KR101553211B1/ko not_active Expired - Fee Related
- 2008-09-10 AU AU2008299703A patent/AU2008299703C1/en not_active Ceased
- 2008-09-10 JP JP2010523590A patent/JP5438680B2/ja not_active Expired - Fee Related
- 2008-09-10 US US12/677,195 patent/US8445687B2/en not_active Expired - Fee Related
- 2008-09-10 CA CA2698795A patent/CA2698795C/en not_active Expired - Fee Related
-
2010
- 2010-03-18 ZA ZA2010/01935A patent/ZA201001935B/en unknown
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