JP2019523772A5 - - Google Patents

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JP2019523772A5
JP2019523772A5 JP2018565715A JP2018565715A JP2019523772A5 JP 2019523772 A5 JP2019523772 A5 JP 2019523772A5 JP 2018565715 A JP2018565715 A JP 2018565715A JP 2018565715 A JP2018565715 A JP 2018565715A JP 2019523772 A5 JP2019523772 A5 JP 2019523772A5
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group
compound
formula
amino
protecting
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JP2018565715A
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Japanese (ja)
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JP6998896B2 (ja
JP2019523772A (ja
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Priority claimed from CN201610432126.5A external-priority patent/CN107513069A/zh
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JP2018565715A 2016-06-16 2017-06-15 キラルピロロピリミジン化合物の製造方法 Active JP6998896B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610432126.5A CN107513069A (zh) 2016-06-16 2016-06-16 手性吡咯并嘧啶化合物的制备方法
CN201610432126.5 2016-06-16
PCT/CN2017/088421 WO2017215627A1 (zh) 2016-06-16 2017-06-15 手性吡咯并嘧啶化合物的制备方法

Publications (3)

Publication Number Publication Date
JP2019523772A JP2019523772A (ja) 2019-08-29
JP2019523772A5 true JP2019523772A5 (https=) 2020-05-21
JP6998896B2 JP6998896B2 (ja) 2022-02-04

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JP2018565715A Active JP6998896B2 (ja) 2016-06-16 2017-06-15 キラルピロロピリミジン化合物の製造方法

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US (1) US10766901B2 (https=)
EP (1) EP3473625B1 (https=)
JP (1) JP6998896B2 (https=)
CN (3) CN107513069A (https=)
ES (1) ES2877678T3 (https=)
WO (1) WO2017215627A1 (https=)

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WO2020135401A1 (zh) 2018-12-24 2020-07-02 正大天晴药业集团股份有限公司 吡咯并嘧啶化合物的治疗用途及其固体药物组合物
CN120267676A (zh) 2020-03-09 2025-07-08 正大天晴药业集团股份有限公司 吡咯并嘧啶化合物的治疗噬血细胞综合征的用途
CA3192099A1 (en) 2020-08-18 2022-02-24 Incyte Corporation Process and intermediates for preparing a jak inhibitor
CR20230130A (es) 2020-08-18 2023-07-13 Incyte Corp Proceso e intermedios para preparar un inhibidor de jak1
CN114085224A (zh) * 2020-08-25 2022-02-25 北京普祺医药科技有限公司 一种吡咯并嘧啶化合物的制备方法
US20240285635A1 (en) 2021-06-21 2024-08-29 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Use of pyrrolopyrimidine compound and pharmaceutical composition thereof for treating chronic graft versus host disease
CN118317946A (zh) 2021-07-12 2024-07-09 因赛特公司 用于制备巴瑞替尼的方法和中间体
US20250213570A1 (en) 2022-03-21 2025-07-03 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Use of pyrrolopyrimidine compound in treatment of medium-risk or high-risk myelofibrosis
WO2024027790A1 (zh) 2022-08-04 2024-02-08 正大天晴药业集团股份有限公司 吡咯并嘧啶化合物治疗急性移植物抗宿主病的用途
US20250215003A1 (en) * 2022-08-22 2025-07-03 Granules India Limited An improved process for the preparation of ruxolitinib
CN120882718A (zh) * 2023-03-17 2025-10-31 北京普祺医药科技股份有限公司 吡咯并嘧啶化合物或其可药用盐的制备方法
CN121285550A (zh) * 2023-05-09 2026-01-06 正大天晴药业集团股份有限公司 一种吡咯并[2,3-c]吡啶酮化合物的联用药物组合物及其用途

Family Cites Families (14)

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JPS5616499A (en) * 1979-07-19 1981-02-17 Yamasa Shoyu Co Ltd 6-c-purine nucleoside derivative and its preparation
JPS5841897A (ja) * 1981-09-04 1983-03-11 Yamasa Shoyu Co Ltd ６−（４−ピラゾリル）プリンリボヌクレオシド誘導体およびその製造法
PA8474101A1 (es) * 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
WO2004100868A2 (en) 2003-04-23 2004-11-25 Abbott Laboratories Method of treating transplant rejection
EP2455382B1 (en) 2005-12-13 2016-10-26 Incyte Holdings Corporation Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
CA3121743A1 (en) * 2009-01-15 2010-07-22 Incyte Holdings Corporation Processes for preparing jak inhibitors and related intermediate compounds
AR078012A1 (es) 2009-09-01 2011-10-05 Incyte Corp Derivados heterociclicos de las pirazol-4-il- pirrolo (2,3-d) pirimidinas como inhibidores de la quinasa janus
CN103848810A (zh) * 2012-11-30 2014-06-11 北京赛林泰医药技术有限公司 鲁顿酪氨酸激酶抑制剂
CN103739607A (zh) * 2014-01-22 2014-04-23 无锡方圆环球显示技术股份有限公司 一种基于三并咔唑多臂结构红光材料及其制备方法与应用
US9796733B2 (en) * 2014-06-04 2017-10-24 Merck Sharp & Dohme Corp. Imidazo-pyrazine derivatives useful as soluble guanylate cyclase activators
CN105218548A (zh) * 2014-06-09 2016-01-06 上海海和药物研究开发有限公司 一种新型杂环化合物及其制备方法和作为激酶抑制剂的用途
CN105315286B (zh) * 2014-07-30 2018-08-17 连云港润众制药有限公司 西格列汀的制备
CN105777754B (zh) * 2014-12-16 2019-07-26 北京赛林泰医药技术有限公司 吡咯并嘧啶化合物
CN107759600A (zh) * 2016-06-16 2018-03-06 正大天晴药业集团股份有限公司 作为jak抑制剂的吡咯并嘧啶化合物的结晶

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