JP2010538618A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010538618A5 JP2010538618A5 JP2010524259A JP2010524259A JP2010538618A5 JP 2010538618 A5 JP2010538618 A5 JP 2010538618A5 JP 2010524259 A JP2010524259 A JP 2010524259A JP 2010524259 A JP2010524259 A JP 2010524259A JP 2010538618 A5 JP2010538618 A5 JP 2010538618A5
- Authority
- JP
- Japan
- Prior art keywords
- donor
- antibody
- library
- specific antibody
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000013598 vector Substances 0.000 claims description 58
- 108020004707 nucleic acids Proteins 0.000 claims description 44
- 102000039446 nucleic acids Human genes 0.000 claims description 44
- 150000007523 nucleic acids Chemical class 0.000 claims description 44
- 238000000034 method Methods 0.000 claims description 34
- 201000010099 disease Diseases 0.000 claims description 31
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 31
- 239000000427 antigen Substances 0.000 claims description 28
- 108091007433 antigens Proteins 0.000 claims description 28
- 102000036639 antigens Human genes 0.000 claims description 28
- 239000012634 fragment Substances 0.000 claims description 26
- 239000002773 nucleotide Substances 0.000 claims description 26
- 125000003729 nucleotide group Chemical group 0.000 claims description 26
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 22
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 22
- 108020004999 messenger RNA Proteins 0.000 claims description 10
- 241001515965 unidentified phage Species 0.000 claims description 9
- 241000712431 Influenza A virus Species 0.000 claims description 8
- 108091092724 Noncoding DNA Proteins 0.000 claims description 8
- 210000004027 cell Anatomy 0.000 claims description 8
- 230000003472 neutralizing effect Effects 0.000 claims description 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 8
- 108020004705 Codon Proteins 0.000 claims description 6
- 108060003951 Immunoglobulin Proteins 0.000 claims description 6
- 102000018358 immunoglobulin Human genes 0.000 claims description 6
- 230000016784 immunoglobulin production Effects 0.000 claims description 6
- 210000004698 lymphocyte Anatomy 0.000 claims description 6
- 101150098499 III gene Proteins 0.000 claims description 5
- 108091026890 Coding region Proteins 0.000 claims description 4
- 241001500351 Influenzavirus A Species 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 230000000405 serological effect Effects 0.000 claims description 4
- 230000037432 silent mutation Effects 0.000 claims description 4
- 101710098119 Chaperonin GroEL 2 Proteins 0.000 claims description 2
- 241000588724 Escherichia coli Species 0.000 claims description 2
- 241001473385 H5N1 subtype Species 0.000 claims description 2
- 108091023045 Untranslated Region Proteins 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000001185 bone marrow Anatomy 0.000 claims description 2
- 239000013604 expression vector Substances 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 210000001165 lymph node Anatomy 0.000 claims description 2
- 238000002824 mRNA display Methods 0.000 claims description 2
- 230000000813 microbial effect Effects 0.000 claims description 2
- 238000002818 protein evolution Methods 0.000 claims description 2
- 238000010839 reverse transcription Methods 0.000 claims description 2
- 238000002702 ribosome display Methods 0.000 claims description 2
- 238000012163 sequencing technique Methods 0.000 claims description 2
- 210000000952 spleen Anatomy 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 6
- 238000002372 labelling Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/853,795 US8148085B2 (en) | 2006-05-15 | 2007-09-11 | Donor specific antibody libraries |
| PCT/US2008/075998 WO2009036157A1 (en) | 2007-09-11 | 2008-09-11 | Donor specific antibody libraries |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010538618A JP2010538618A (ja) | 2010-12-16 |
| JP2010538618A5 true JP2010538618A5 (enExample) | 2012-11-15 |
Family
ID=40220152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010524259A Withdrawn JP2010538618A (ja) | 2007-09-11 | 2008-09-11 | ドナー特異的抗体ライブラリー |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US8148085B2 (enExample) |
| EP (1) | EP2190477A1 (enExample) |
| JP (1) | JP2010538618A (enExample) |
| CN (1) | CN101854950A (enExample) |
| AU (1) | AU2008298939A1 (enExample) |
| WO (1) | WO2009036157A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7584439B2 (en) * | 2006-12-07 | 2009-09-01 | Agere Systems Inc. | Cell modeling for integrated circuit design with characterization of upstream driver strength |
| CA2787099A1 (en) | 2009-03-30 | 2010-10-14 | Anice C. Lowen | Influenza virus hemagglutinin polypeptides containing stem domains, vaccines and uses thereof |
| KR101790354B1 (ko) | 2009-05-11 | 2017-10-25 | 얀센 백신스 앤드 프리벤션 비.브이. | 인플루엔자 바이러스 ｈ3ｎ2를 중화시킬 수 있는 인간 결합 분자 및 그것의 용도 |
| US20120128671A1 (en) * | 2009-05-13 | 2012-05-24 | Lawrence Horowitz | Neutralizing molecules to influenza viruses |
| JP5941841B2 (ja) | 2009-05-26 | 2016-06-29 | アイカーン スクール オブ メディシン アット マウント サイナイ | 周期的投与によって作製されたインフルエンザウイルスに対するモノクローナル抗体及びその使用 |
| US20110077966A1 (en) * | 2009-09-28 | 2011-03-31 | Augusta E.N.T., P.C. | Allergy electronic medical record system and method |
| US9701723B2 (en) | 2010-02-18 | 2017-07-11 | Icahn School Of Medicine At Mount Sinai | Vaccines for use in the prophylaxis and treatment of influenza virus disease |
| WO2011123495A1 (en) | 2010-03-30 | 2011-10-06 | Mount Sinai School Of Medicine | Influenza virus vaccines and uses thereof |
| US20120107355A1 (en) * | 2010-10-27 | 2012-05-03 | Harrisvaccines, Inc. | Method of rapidly producing improved vaccines for animals |
| US20230287392A1 (en) * | 2011-04-28 | 2023-09-14 | The Board Of Trustees Of The Leland Stanford Junior University | Identification of Polynucleotides Associated with a Sample |
| SG10201900183VA (en) * | 2011-04-28 | 2019-05-30 | Univ Leland Stanford Junior | Identification of polynucleotides associated with a sample |
| EP2758075B1 (en) | 2011-09-20 | 2023-05-03 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
| EA026527B1 (ru) | 2011-09-30 | 2017-04-28 | Селлтрион Инк. | Связующая молекула, обладающая нейтрализующей активностью в отношении вируса гриппа а, полученная из в-клеток человека |
| US9977861B2 (en) * | 2012-07-18 | 2018-05-22 | Illumina Cambridge Limited | Methods and systems for determining haplotypes and phasing of haplotypes |
| UA118441C2 (uk) | 2012-10-08 | 2019-01-25 | Протена Біосаєнсиз Лімітед | Антитіло, що розпізнає альфа-синуклеїн |
| EP2934581B1 (en) | 2012-12-18 | 2022-09-14 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
| US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| UY35620A (es) | 2013-06-21 | 2015-01-30 | Novartis Ag | Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso |
| AR096601A1 (es) | 2013-06-21 | 2016-01-20 | Novartis Ag | Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso |
| US9850302B2 (en) | 2013-07-12 | 2017-12-26 | Prothena Biosciences Limited | Antibodies that recognize IAPP |
| WO2015004633A1 (en) | 2013-07-12 | 2015-01-15 | Neotope Biosciences Limited | Antibodies that recognize islet-amyloid polypeptide (iapp) |
| US20150225770A1 (en) * | 2014-02-12 | 2015-08-13 | U.S. Army Research Laboratory Attn: Rdrl-Loc-I | Phenotype-neutral barcodes for digital analysis |
| KR101740030B1 (ko) | 2014-03-07 | 2017-05-29 | 사회복지법인 삼성생명공익재단 | ScFv 항체 라이브러리, 이의 제조방법 및 이를 이용한 ScFv 항체 스크리닝 방법 |
| EP4050026A1 (en) * | 2014-04-01 | 2022-08-31 | Adimab, LLC | Method of obtaining or identifying one or more common light chains for use in preparing a multispecific antibody |
| US10562973B2 (en) | 2014-04-08 | 2020-02-18 | Prothena Bioscience Limited | Blood-brain barrier shuttles containing antibodies recognizing alpha-synuclein |
| US20180008702A1 (en) * | 2014-12-05 | 2018-01-11 | Celltrion Inc. | Adjuvant composition containing at least one influenza virus neutralizing and binding molecule and vaccine composition containing same |
| JP2018504412A (ja) | 2015-01-23 | 2018-02-15 | アイカーン スクール オブ メディシン アット マウント サイナイ | インフルエンザウイルスワクチン接種レジメン |
| EP3262216A4 (en) * | 2015-02-24 | 2018-12-05 | Academia Sinica | A phage-displayed single-chain variable fragment library |
| EP3344803B1 (en) * | 2015-09-01 | 2021-08-04 | The Regents of The University of California | Modular polypeptide libraries and methods of making and using same |
| EP3471767A4 (en) | 2016-06-15 | 2020-01-15 | Icahn School of Medicine at Mount Sinai | Influenza virus hemagglutinin proteins and uses thereof |
| JP7185929B2 (ja) * | 2016-10-31 | 2022-12-08 | ウニベルシテート チューリッヒ | タンパク質のスクリーニングおよび検出方法 |
| WO2018187706A2 (en) | 2017-04-07 | 2018-10-11 | Icahn School Of Medicine At Mount Sinai | Anti-influenza b virus neuraminidase antibodies and uses thereof |
| WO2019246363A1 (en) | 2018-06-21 | 2019-12-26 | Icahn School Of Medicine At Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| WO2020219719A1 (en) | 2019-04-24 | 2020-10-29 | Icahn School Of Medicine At Mount Sinai | Anti-influenza b virus neuraminidase antibodies and uses thereof |
| WO2021016529A1 (en) * | 2019-07-25 | 2021-01-28 | The Johns Hopkins University | Methods and compositions for hepatitis c virus (hcv) |
| CN115003328A (zh) | 2019-10-22 | 2022-09-02 | 西奈山伊坎医学院 | 重组神经氨酸酶及其用途 |
| WO2025019631A1 (en) | 2023-07-19 | 2025-01-23 | Icahn School Of Medicine At Mount Sinai | Immunogenic compositions containing inactivated influenza a virus and cpg oligonucleotide adjuvant and uses thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA836080B (en) | 1982-08-23 | 1984-04-25 | Scripps Clinic Res | Broad spectrum influenza antisera |
| US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US6337070B1 (en) * | 1993-04-29 | 2002-01-08 | Takara Shuzo Co., Ltd. | Polypeptides for use in generating anti-human influenza virus antibodies |
| EP0699750A1 (en) * | 1994-06-07 | 1996-03-06 | Gesellschaft für biotechnologische Forschung mbH (GBF) | A collection of phagemids, a collection of Escherichia coli cells carrying the phagemids, a collection of phagemid particles produced from said collection and phagemid particles obtained according to the process |
| US6169175B1 (en) * | 1997-08-06 | 2001-01-02 | Centers For Disease Control And Prevention | Preparation and use of recombinant influenza A virus M2 construct vaccines |
| US6607878B2 (en) * | 1997-10-06 | 2003-08-19 | Stratagene | Collections of uniquely tagged molecules |
| SK13242001A3 (sk) | 1999-03-23 | 2002-09-10 | Biovation Limited | Izolácia a analýza proteínov |
| FR2817869B1 (fr) | 2000-12-07 | 2005-01-14 | Technopharm | Anticorps monoclonal humain dirige contre le virus influenza ou un fragment de celui-ci |
| JP4860098B2 (ja) | 2000-12-18 | 2012-01-25 | ダイアックス、コープ | 遺伝的パッケージの焦点を合わせたライブラリー |
| WO2003052101A1 (en) | 2001-12-14 | 2003-06-26 | Rosetta Inpharmatics, Inc. | Sample tracking using molecular barcodes |
| US20030219442A1 (en) | 2002-03-13 | 2003-11-27 | Toshifumi Mikayama | Human monoclonal antibodies to influenza M2 protein and methods of making and using same |
| US7824856B2 (en) | 2003-09-10 | 2010-11-02 | Althea Technologies, Inc. | Expression profiling using microarrays |
| EP1647600A3 (en) | 2004-09-17 | 2006-06-28 | Affymetrix, Inc. (A US Entity) | Methods for identifying biological samples by addition of nucleic acid bar-code tags |
| AU2006290736B2 (en) | 2005-09-15 | 2011-09-15 | Crucell Holland B.V. | Method for preparing immunoglobulin libraries |
| GB0522460D0 (en) | 2005-11-03 | 2005-12-14 | Prendergast Patrick T | Composition and method for the treatment of avian influenza |
| CN101379397A (zh) | 2006-01-26 | 2009-03-04 | Hx诊断公司 | H5亚型禽流感病毒血凝素蛋白的单克隆抗体或其结合活性片段及其用途 |
| JP2009537147A (ja) | 2006-05-15 | 2009-10-29 | シー レーン バイオテクノロジーズ， エルエルシー | インフルエンザウイルスに対する中和抗体 |
| CA2663388C (en) | 2006-09-07 | 2017-01-17 | Crucell Holland B.V. | Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof |
| AU2008230795B2 (en) | 2007-03-27 | 2014-05-29 | Bioassets, Llc | Constructs and libraries comprising antibody surrogate light chain sequences |
-
2007
- 2007-09-11 US US11/853,795 patent/US8148085B2/en active Active
-
2008
- 2008-09-11 CN CN200880115462A patent/CN101854950A/zh active Pending
- 2008-09-11 AU AU2008298939A patent/AU2008298939A1/en not_active Abandoned
- 2008-09-11 EP EP08830817A patent/EP2190477A1/en not_active Withdrawn
- 2008-09-11 WO PCT/US2008/075998 patent/WO2009036157A1/en not_active Ceased
- 2008-09-11 JP JP2010524259A patent/JP2010538618A/ja not_active Withdrawn
- 2008-09-11 US US12/676,737 patent/US20100291066A1/en not_active Abandoned
-
2012
- 2012-03-16 US US13/422,313 patent/US20120264647A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7828725B2 (ja) | がんのネオエピトープ | |
| Somasundaram et al. | An approach towards development of monoclonal IgY antibodies against SARS CoV-2 spike protein (S) using phage display method: A review | |
| ES2236605T3 (es) | Tecnologia de anticuerpos dirigida. | |
| Tohidkia et al. | Molecular considerations for development of phage antibody libraries | |
| JP2006020633A (ja) | 糸球体腎炎および他の炎症性疾患の治療のための組成物および方法 | |
| Vishwanath et al. | A computationally designed antigen eliciting broad humoral responses against SARS-CoV-2 and related sarbecoviruses | |
| JP2014509853A5 (enExample) | ||
| JP2009544284A5 (enExample) | ||
| JP2024167352A (ja) | ｍＲＮＡディスプレイ抗体ライブラリー及び方法 | |
| Shahsavarian et al. | Exploitation of rolling circle amplification for the construction of large phage-display antibody libraries | |
| Ren et al. | RAMIHM generates fully human monoclonal antibodies by rapid mRNA immunization of humanized mice and BCR-seq | |
| Zheng et al. | Vaccine molecule design based on phage display and computational modeling against rhabdovirus | |
| CN115485392A (zh) | 用于鉴别配体阻断性抗体及用于确定抗体效价的方法 | |
| Ogishi et al. | Delineation of autoantibody repertoire through differential proteogenomics in hepatitis C virus-induced cryoglobulinemia | |
| JP6665274B2 (ja) | 標的分子に結合するポリペプチドの決定方法及び決定システム | |
| CN113667011B (zh) | 制备抗原结合单元的方法 | |
| EP2917363A1 (en) | Means and methods for identifying ribosome associated rna molecules | |
| CN113710801A (zh) | 一种使用cDNA展示的新型免疫PCR方法 | |
| He et al. | Production of human single-chain antibodies by ribosome display | |
| CN106957905A (zh) | 一种用于评估肿瘤免疫治疗效果的分子检测方法及引物组合物及试剂盒 | |
| Xu et al. | Screening of random peptide library of hemagglutinin from pandemic 2009 A (H1N1) influenza virus reveals unexpected antigenically important regions | |
| JP6083728B2 (ja) | タンパク質機能改変法 | |
| Kumari et al. | Phage display and human disease detection | |
| US20230407291A1 (en) | Targeting host-bacteria interactions for the treatment of microbiota-mediated diseases | |
| JP5109040B2 (ja) | ヒト一本鎖抗体遺伝子断片の効率的な新規調製法 |