JP2010535804A - Ｐｉ３キナーゼ阻害薬としてのキノキサリン誘導体 - Google Patents

Ｐｉ３キナーゼ阻害薬としてのキノキサリン誘導体 Download PDF

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JP2010535804A
JP2010535804A JP2010520295A JP2010520295A JP2010535804A JP 2010535804 A JP2010535804 A JP 2010535804A JP 2010520295 A JP2010520295 A JP 2010520295A JP 2010520295 A JP2010520295 A JP 2010520295A JP 2010535804 A JP2010535804 A JP 2010535804A
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substituted
cancer
amino
alkyl
heterocycloalkyl
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スティーブン・デイビッド・ナイト
シンシア・エイ・パリッシュ
ランス・エイチ・リジャース
マーサ・エイ・サーポング
アミタ・エム・チョーダリ
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GlaxoSmithKline LLC
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JP2010520295A 2007-08-09 2008-08-07 Ｐｉ３キナーゼ阻害薬としてのキノキサリン誘導体 Withdrawn JP2010535804A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95484507P 2007-08-09 2007-08-09
PCT/US2008/072401 WO2009021083A1 (en) 2007-08-09 2008-08-07 Quinoxaline derivatives as pi3 kinase inhibitors

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EP (1) EP2173354A4 (de)
JP (1) JP2010535804A (de)
WO (1) WO2009021083A1 (de)

Cited By (5)

* Cited by examiner, † Cited by third party
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JP2013543883A (ja) * 2010-11-29 2013-12-09 アステックス、セラピューティックス、リミテッド 癌疾患の治療のためのｆｇｆｒキナーゼ阻害剤としての置換ベンゾピラジン誘導体
JP2015524843A (ja) * 2012-08-13 2015-08-27 エンヴォイ セラピューティクス インコーポレイテッド Ｇｐｒ６モジュレーターとしてのキノキサリン誘導体
JP2016536302A (ja) * 2013-10-23 2016-11-24 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 有害生物防除剤としての置換されているキノキサリン誘導体
JP2018535199A (ja) * 2015-10-09 2018-11-29 ヤンセン ファーマシューティカ エヌ．ベー． ＰＩ３Ｋβ阻害剤としてのキノキサリンおよびピリドピラジン誘導体
JP2020512352A (ja) * 2017-03-29 2020-04-23 ヤンセン ファーマシューティカ エヌ．ベー． ＰＩ３Ｋβ阻害剤としてのキノキサリン及びピリドピラジン誘導体

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JP5728683B2 (ja) * 2009-09-04 2015-06-03 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ チロシンスレオニンキナーゼ阻害剤としての置換アミノキノキサリン
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US9512126B2 (en) 2012-03-14 2016-12-06 Bayer Intellectual Property Gmbh Substituted imidazopyridazines
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WO2014007951A2 (en) 2012-06-13 2014-01-09 Incyte Corporation Substituted tricyclic compounds as fgfr inhibitors
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
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KR102469849B1 (ko) 2013-04-19 2022-11-23 인사이트 홀딩스 코포레이션 Fgfr 저해제로서 이환식 헤테로사이클
GB201307577D0 (en) 2013-04-26 2013-06-12 Astex Therapeutics Ltd New compounds
PE20160156A1 (es) 2013-06-11 2016-04-20 Bayer Pharma AG Derivados de prodroga de triazolpiridinas sustituidas
US10179783B2 (en) 2014-02-14 2019-01-15 Taketa Pharmaceutical Company Limited Tetrahydropyridopyrazines as modulators of GPR6
JO3512B1 (ar) 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
JP6752715B2 (ja) 2014-03-26 2020-09-09 アステックス、セラピューティックス、リミテッドＡｓｔｅｘ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ 組合せ
CN106456648B (zh) 2014-03-26 2021-11-02 阿斯特克斯治疗有限公司 Fgfr抑制剂和igf1r抑制剂的组合
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RU2747644C2 (ru) 2015-09-23 2021-05-11 Янссен Фармацевтика Нв Бигетероарил-замещенные 1,4-бензодиазепины и пути их применения для лечения рака
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US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
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