JP2010535264A5 - - Google Patents
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- JP2010535264A5 JP2010535264A5 JP2010518773A JP2010518773A JP2010535264A5 JP 2010535264 A5 JP2010535264 A5 JP 2010535264A5 JP 2010518773 A JP2010518773 A JP 2010518773A JP 2010518773 A JP2010518773 A JP 2010518773A JP 2010535264 A5 JP2010535264 A5 JP 2010535264A5
- Authority
- JP
- Japan
- Prior art keywords
- peox
- monomer
- process according
- pei
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 14
- 239000012861 aquazol Substances 0.000 claims 12
- 229920006187 aquazol Polymers 0.000 claims 12
- 239000000178 monomer Substances 0.000 claims 10
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 9
- 229920002873 Polyethylenimine Polymers 0.000 claims 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 6
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 6
- 239000002904 solvent Substances 0.000 claims 5
- 238000005160 1H NMR spectroscopy Methods 0.000 claims 3
- 238000001035 drying Methods 0.000 claims 3
- 238000001914 filtration Methods 0.000 claims 3
- 239000003999 initiator Substances 0.000 claims 3
- 239000013067 intermediate product Substances 0.000 claims 3
- 238000006116 polymerization reaction Methods 0.000 claims 3
- 235000019260 propionic acid Nutrition 0.000 claims 3
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 230000003301 hydrolyzing effect Effects 0.000 claims 2
- 238000000746 purification Methods 0.000 claims 2
- 238000005406 washing Methods 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- NYEZZYQZRQDLEH-UHFFFAOYSA-N 2-ethyl-4,5-dihydro-1,3-oxazole Chemical compound CCC1=NCCO1 NYEZZYQZRQDLEH-UHFFFAOYSA-N 0.000 claims 1
- 238000010533 azeotropic distillation Methods 0.000 claims 1
- 229920002301 cellulose acetate Polymers 0.000 claims 1
- 238000012790 confirmation Methods 0.000 claims 1
- 238000001704 evaporation Methods 0.000 claims 1
- 230000008020 evaporation Effects 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 238000005227 gel permeation chromatography Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 239000003505 polymerization initiator Substances 0.000 claims 1
- 230000000379 polymerizing effect Effects 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 238000001890 transfection Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95299307P | 2007-07-31 | 2007-07-31 | |
| PCT/IB2008/002339 WO2009016507A2 (en) | 2007-07-31 | 2008-07-31 | Method for manufacturing linear polyethylenimine (pei) for transfection purpose and linear pei obtained with such method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010535264A JP2010535264A (ja) | 2010-11-18 |
| JP2010535264A5 true JP2010535264A5 (enExample) | 2011-07-14 |
Family
ID=40304983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010518773A Pending JP2010535264A (ja) | 2007-07-31 | 2008-07-31 | トランスフェクション目的の直鎖ポリエチレンイミン（ｐｅｉ）を製造するための方法及びその方法で得られた直鎖ｐｅｉ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20100197888A1 (enExample) |
| EP (1) | EP2183297A2 (enExample) |
| JP (1) | JP2010535264A (enExample) |
| KR (1) | KR20100050523A (enExample) |
| CN (1) | CN101821317A (enExample) |
| CA (1) | CA2694610A1 (enExample) |
| WO (1) | WO2009016507A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5937966B2 (ja) * | 2009-08-11 | 2016-06-22 | エージェンシー フォー サイエンス， テクノロジー アンド リサーチ | 生体活性物質の細胞送達のための粒子状ヒアルロン酸製剤 |
| CA2851617A1 (en) | 2011-10-14 | 2013-04-18 | University Of Georgia Research Foundation, Inc. | Synthesis and application reactive antimicrobial copolymers for textile fibers |
| CN102399267B (zh) * | 2011-11-22 | 2013-06-12 | 上海海洋大学 | 一种双功能肽修饰的基因载体及其制备方法 |
| WO2014053245A1 (en) | 2012-10-05 | 2014-04-10 | Lipocalyx Gmbh | Hydroxylated polyamine derivatives as transfection reagents |
| HUE058785T2 (hu) | 2012-10-08 | 2022-09-28 | Biontech Delivery Tech Gmbh | Karboxilált poliamin-származékok, mint transzfekciós reagensek |
| US8902303B2 (en) | 2013-03-15 | 2014-12-02 | Orcam Technologies Ltd. | Apparatus connectable to glasses |
| AU2015287661B2 (en) * | 2014-07-11 | 2019-07-11 | Genzyme Corporation | Main chain polyamines |
| US10118991B2 (en) * | 2014-07-18 | 2018-11-06 | Universiteit Gent | Method for the preparation of uniform, high molar mass cyclic imino ether polymers |
| CN106832270A (zh) * | 2017-01-18 | 2017-06-13 | 南京工业大学 | 一种聚（2‑r‑噁唑啉）嵌段聚（乙撑亚胺）的制备方法 |
| CN109794175A (zh) * | 2018-12-26 | 2019-05-24 | 浙江大学 | 具有pH响应性的氧化石墨烯复合膜及其制备方法和用途 |
| US11559477B2 (en) | 2019-03-01 | 2023-01-24 | Shanghai Cheermore Biological Technology Co., Ltd. | Preparation method and use of artificial exosome complex |
| CN110638690B (zh) * | 2019-03-01 | 2021-06-04 | 上海澄穆生物科技有限公司 | 一种人工外泌体复合物的制备方法及应用 |
| IT202000012055A1 (it) | 2020-05-22 | 2021-11-22 | Milano Politecnico | Dispositivo, metodo e composizione per la trasfezione di cellule con acidi nucleici |
| US11879031B2 (en) * | 2020-10-22 | 2024-01-23 | Solenis Technologies, L.P. | Low critical solution temperature purification of oxazoline polymer solutions |
| IT202100000149A1 (it) * | 2021-01-05 | 2022-07-05 | Themis S R L | Sistema e metodo per il tracciamento e per garantire la qualità di materie prime |
| EP4234609B1 (en) * | 2022-02-25 | 2024-07-17 | PolyPlus Transfection | Methods for purification, detection and quantification of residual pei-based transfection reagents |
| CN116854908A (zh) * | 2023-07-10 | 2023-10-10 | 中国科学院长春应用化学研究所 | 一种阳离子聚合物、其制备方法及应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3640909A (en) * | 1969-02-17 | 1972-02-08 | Dow Chemical Co | Substituted acylated polyimine resins |
| JPS5223000B2 (enExample) * | 1971-08-21 | 1977-06-21 | ||
| US4857599A (en) * | 1988-02-08 | 1989-08-15 | The Dow Chemical Company | Modified dense star polymers |
| JPH02255725A (ja) * | 1989-03-29 | 1990-10-16 | Kao Corp | ポリ（ｎ―アシルエチレンイミン）系重合体の製造方法 |
| US5017644A (en) * | 1989-05-22 | 1991-05-21 | Xerox Corporation | Ink jet ink compositions |
| US6025104A (en) * | 1992-07-29 | 2000-02-15 | Xerox Corporation | Toner and developer compositions with polyoxazoline resin particles |
| WO1997006833A1 (en) * | 1995-08-11 | 1997-02-27 | Dendritech, Inc. | Hyper comb-branched polymer conjugates |
| DE19743135A1 (de) * | 1997-09-30 | 1999-04-01 | Hoechst Marion Roussel De Gmbh | Biologisch verträgliche niedermolekular Polyethylenimine |
| CN1433478A (zh) * | 1999-12-30 | 2003-07-30 | 诺瓦提斯公司 | 用于基因治疗的新的胶体合成载体 |
| JP2004510829A (ja) * | 2000-10-09 | 2004-04-08 | バイエル アクチェンゲゼルシャフト | 核酸を細胞内に転移させるための複合体 |
| US20050038197A1 (en) * | 2003-08-13 | 2005-02-17 | Tomalia Donald A. | Ultra_high molecular weight hybrid dendrigraft architectures |
| WO2005075527A1 (en) * | 2004-01-30 | 2005-08-18 | The General Hospital Corporation | Hyperbranched polymers |
| CA2637931A1 (en) * | 2006-01-23 | 2007-07-26 | Abbott Laboratories | Chemically modified polycation polymer for sirna delivery |
-
2008
- 2008-07-31 US US12/671,312 patent/US20100197888A1/en not_active Abandoned
- 2008-07-31 WO PCT/IB2008/002339 patent/WO2009016507A2/en not_active Ceased
- 2008-07-31 EP EP08807030A patent/EP2183297A2/en not_active Withdrawn
- 2008-07-31 CA CA2694610A patent/CA2694610A1/en not_active Abandoned
- 2008-07-31 KR KR1020107004337A patent/KR20100050523A/ko not_active Withdrawn
- 2008-07-31 CN CN200880104653A patent/CN101821317A/zh active Pending
- 2008-07-31 JP JP2010518773A patent/JP2010535264A/ja active Pending
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