CN101821317A - 用于转染目的的线性聚乙烯亚胺(pei)的制造方法和用此方法得到的线性pei - Google Patents

用于转染目的的线性聚乙烯亚胺(pei)的制造方法和用此方法得到的线性pei Download PDF

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Publication number
CN101821317A
CN101821317A CN200880104653A CN200880104653A CN101821317A CN 101821317 A CN101821317 A CN 101821317A CN 200880104653 A CN200880104653 A CN 200880104653A CN 200880104653 A CN200880104653 A CN 200880104653A CN 101821317 A CN101821317 A CN 101821317A
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peox
pei
monomer
oxazoline
linear
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CN200880104653A
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Chinese (zh)
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A·阿迪布
F·斯多克
P·埃尔巴彻
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Polyplus Transfection SA
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Polyplus Transfection SA
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0233—Polyamines derived from (poly)oxazolines, (poly)oxazines or having pendant acyl groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
CN200880104653A 2007-07-31 2008-07-31 用于转染目的的线性聚乙烯亚胺(pei)的制造方法和用此方法得到的线性pei Pending CN101821317A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95299307P 2007-07-31 2007-07-31
US60/952,993 2007-07-31
PCT/IB2008/002339 WO2009016507A2 (en) 2007-07-31 2008-07-31 Method for manufacturing linear polyethylenimine (pei) for transfection purpose and linear pei obtained with such method

Publications (1)

Publication Number Publication Date
CN101821317A true CN101821317A (zh) 2010-09-01

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CN200880104653A Pending CN101821317A (zh) 2007-07-31 2008-07-31 用于转染目的的线性聚乙烯亚胺(pei)的制造方法和用此方法得到的线性pei

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Country Link
US (1) US20100197888A1 (enExample)
EP (1) EP2183297A2 (enExample)
JP (1) JP2010535264A (enExample)
KR (1) KR20100050523A (enExample)
CN (1) CN101821317A (enExample)
CA (1) CA2694610A1 (enExample)
WO (1) WO2009016507A2 (enExample)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102399267A (zh) * 2011-11-22 2012-04-04 上海海洋大学 一种双功能肽修饰的基因载体及其制备方法
CN106832270A (zh) * 2017-01-18 2017-06-13 南京工业大学 一种聚（2‑r‑噁唑啉）嵌段聚（乙撑亚胺）的制备方法
CN109794175A (zh) * 2018-12-26 2019-05-24 浙江大学 具有pH响应性的氧化石墨烯复合膜及其制备方法和用途
CN110638690A (zh) * 2019-03-01 2020-01-03 上海澄穆生物科技有限公司 一种人工外泌体复合物的制备方法及应用
US11559477B2 (en) 2019-03-01 2023-01-24 Shanghai Cheermore Biological Technology Co., Ltd. Preparation method and use of artificial exosome complex
CN116490540A (zh) * 2020-10-22 2023-07-25 索理思科技开曼公司 噁唑啉聚合物溶液的低临界溶液温度纯化
CN116854908A (zh) * 2023-07-10 2023-10-10 中国科学院长春应用化学研究所 一种阳离子聚合物、其制备方法及应用
CN118891306A (zh) * 2022-02-25 2024-11-01 宝利普拉斯生物转染公司 用于纯化、检测和定量残留的基于pei的转染试剂的方法

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US8753687B2 (en) * 2009-08-11 2014-06-17 Agency For Science, Technology And Research Particulate hyaluronic acid/flavonoid suspensions for cellular delivery of bioactive agents
US8968421B2 (en) 2011-10-14 2015-03-03 University Of Georgia Research Foundation, Inc. Synthesis and application reactive antimicrobial copolymers for textile fibers
WO2014053245A1 (en) 2012-10-05 2014-04-10 Lipocalyx Gmbh Hydroxylated polyamine derivatives as transfection reagents
JP6395711B2 (ja) 2012-10-08 2018-09-26 リポカリクス・ゲーエムベーハー 形質導入試薬としてのカルボキシル化ポリアミン誘導体
US9436887B2 (en) 2013-03-15 2016-09-06 OrCam Technologies, Ltd. Apparatus and method for automatic action selection based on image context
MX2017000447A (es) * 2014-07-11 2017-04-27 Genzyme Corp Poliaminas de cadena principal.
EP3204442B1 (en) * 2014-07-18 2018-09-12 Universiteit Gent Method for the preparation of uniform, high molar mass cyclic imino ether polymers
IT202000012055A1 (it) 2020-05-22 2021-11-22 Milano Politecnico Dispositivo, metodo e composizione per la trasfezione di cellule con acidi nucleici
IT202100000149A1 (it) * 2021-01-05 2022-07-05 Themis S R L Sistema e metodo per il tracciamento e per garantire la qualità di materie prime

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US3640909A (en) * 1969-02-17 1972-02-08 Dow Chemical Co Substituted acylated polyimine resins
JPS5223000B2 (enExample) * 1971-08-21 1977-06-21
US4857599A (en) * 1988-02-08 1989-08-15 The Dow Chemical Company Modified dense star polymers
JPH02255725A (ja) * 1989-03-29 1990-10-16 Kao Corp ポリ（ｎ―アシルエチレンイミン）系重合体の製造方法
US5017644A (en) * 1989-05-22 1991-05-21 Xerox Corporation Ink jet ink compositions
US6025104A (en) * 1992-07-29 2000-02-15 Xerox Corporation Toner and developer compositions with polyoxazoline resin particles
EP0844891A4 (en) * 1995-08-11 2004-05-06 Dow Chemical Co HYPER COMBED POLYMER CONJUGATES
DE19743135A1 (de) * 1997-09-30 1999-04-01 Hoechst Marion Roussel De Gmbh Biologisch verträgliche niedermolekular Polyethylenimine
CN1433478A (zh) * 1999-12-30 2003-07-30 诺瓦提斯公司 用于基因治疗的新的胶体合成载体
CN1479632A (zh) * 2000-10-09 2004-03-03 拜尔公司 用于将核酸导入细胞的复合物
US20050038197A1 (en) * 2003-08-13 2005-02-17 Tomalia Donald A. Ultra_high molecular weight hybrid dendrigraft architectures
WO2005075527A1 (en) * 2004-01-30 2005-08-18 The General Hospital Corporation Hyperbranched polymers
EP1981543A1 (en) * 2006-01-23 2008-10-22 Abbott Laboratories Chemically modified polycation polymer for sirna delivery

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102399267A (zh) * 2011-11-22 2012-04-04 上海海洋大学 一种双功能肽修饰的基因载体及其制备方法
CN102399267B (zh) * 2011-11-22 2013-06-12 上海海洋大学 一种双功能肽修饰的基因载体及其制备方法
CN106832270A (zh) * 2017-01-18 2017-06-13 南京工业大学 一种聚（2‑r‑噁唑啉）嵌段聚（乙撑亚胺）的制备方法
CN109794175A (zh) * 2018-12-26 2019-05-24 浙江大学 具有pH响应性的氧化石墨烯复合膜及其制备方法和用途
CN110638690B (zh) * 2019-03-01 2021-06-04 上海澄穆生物科技有限公司 一种人工外泌体复合物的制备方法及应用
WO2020182226A1 (zh) * 2019-03-01 2020-09-17 上海澄穆生物科技有限公司 一种人工外泌体复合物的制备方法及应用
CN110638690A (zh) * 2019-03-01 2020-01-03 上海澄穆生物科技有限公司 一种人工外泌体复合物的制备方法及应用
US11559477B2 (en) 2019-03-01 2023-01-24 Shanghai Cheermore Biological Technology Co., Ltd. Preparation method and use of artificial exosome complex
AU2020235305B2 (en) * 2019-03-01 2025-07-03 Shanghai Cheermore Industrial Development Co., Ltd. Preparation method and use for artificial exocrine complex
CN116490540A (zh) * 2020-10-22 2023-07-25 索理思科技开曼公司 噁唑啉聚合物溶液的低临界溶液温度纯化
CN118891306A (zh) * 2022-02-25 2024-11-01 宝利普拉斯生物转染公司 用于纯化、检测和定量残留的基于pei的转染试剂的方法
CN118891306B (zh) * 2022-02-25 2025-09-12 宝利普拉斯生物转染公司 用于纯化、检测和定量残留的基于pei的转染试剂的方法
CN116854908A (zh) * 2023-07-10 2023-10-10 中国科学院长春应用化学研究所 一种阳离子聚合物、其制备方法及应用

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Publication number Publication date
US20100197888A1 (en) 2010-08-05
WO2009016507A3 (en) 2009-09-03
WO2009016507A2 (en) 2009-02-05
JP2010535264A (ja) 2010-11-18
EP2183297A2 (en) 2010-05-12
CA2694610A1 (en) 2009-02-05
KR20100050523A (ko) 2010-05-13

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