JP2010534836A5 - - Google Patents
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- JP2010534836A5 JP2010534836A5 JP2010518318A JP2010518318A JP2010534836A5 JP 2010534836 A5 JP2010534836 A5 JP 2010534836A5 JP 2010518318 A JP2010518318 A JP 2010518318A JP 2010518318 A JP2010518318 A JP 2010518318A JP 2010534836 A5 JP2010534836 A5 JP 2010534836A5
- Authority
- JP
- Japan
- Prior art keywords
- oligonucleotide
- sequence
- binding
- zip code
- biological target
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 108091034117 Oligonucleotide Proteins 0.000 claims 65
- 238000000034 method Methods 0.000 claims 34
- 239000000523 sample Substances 0.000 claims 29
- 239000002243 precursor Substances 0.000 claims 19
- 239000000047 product Substances 0.000 claims 19
- 239000007795 chemical reaction product Substances 0.000 claims 17
- 238000001514 detection method Methods 0.000 claims 10
- 102000004190 Enzymes Human genes 0.000 claims 8
- 108090000790 Enzymes Proteins 0.000 claims 8
- 230000003321 amplification Effects 0.000 claims 7
- 238000003199 nucleic acid amplification method Methods 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 239000003248 enzyme activator Substances 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 4
- 102000001301 EGF receptor Human genes 0.000 claims 2
- 108060006698 EGF receptor Proteins 0.000 claims 2
- 239000000833 heterodimer Substances 0.000 claims 2
- 238000009396 hybridization Methods 0.000 claims 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims 1
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims 1
- 102000003992 Peroxidases Human genes 0.000 claims 1
- 102000006382 Ribonucleases Human genes 0.000 claims 1
- 108010083644 Ribonucleases Proteins 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000002532 enzyme inhibitor Substances 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 239000000710 homodimer Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 125000001151 peptidyl group Chemical group 0.000 claims 1
- 108040007629 peroxidase activity proteins Proteins 0.000 claims 1
- 239000000575 pesticide Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000009257 reactivity Effects 0.000 claims 1
- 150000003384 small molecules Chemical group 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96233307P | 2007-07-27 | 2007-07-27 | |
| PCT/US2008/070643 WO2009018003A2 (en) | 2007-07-27 | 2008-07-21 | Detection assays and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010534836A JP2010534836A (ja) | 2010-11-11 |
| JP2010534836A5 true JP2010534836A5 (enExample) | 2012-09-27 |
Family
ID=39930667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010518318A Withdrawn JP2010534836A (ja) | 2007-07-27 | 2008-07-21 | 検出アッセイとそれらの使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20100159446A1 (enExample) |
| EP (1) | EP2191268A2 (enExample) |
| JP (1) | JP2010534836A (enExample) |
| CN (1) | CN101952719A (enExample) |
| AU (1) | AU2008282557A1 (enExample) |
| CA (1) | CA2730565A1 (enExample) |
| WO (1) | WO2009018003A2 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1401850A1 (en) | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Nucleoside derivatives for library preparation |
| IL163822A0 (en) | 2002-03-15 | 2005-12-18 | Nuevolution As | An improved method for synthesising templated molecules |
| AU2003247266A1 (en) | 2002-08-01 | 2004-02-23 | Nuevolution A/S | Multi-step synthesis of templated molecules |
| DK2348125T3 (en) | 2002-10-30 | 2017-10-02 | Nuevolution As | Process for the synthesis of a bifunctional complex |
| DE60330406D1 (de) | 2002-12-19 | 2010-01-14 | Nuevolution As | Durch quasizufallsstrukturen und funktionen geführte synthesemethode |
| EP1597395A2 (en) | 2003-02-21 | 2005-11-23 | Nuevolution A/S | Method for producing second-generation library |
| DK1670939T3 (da) | 2003-09-18 | 2010-03-01 | Nuevolution As | Fremgangsmåde til opnåelse af strukturel information om et kodet molekyle og fremgangsmåde til udvælgelse af forbindelser |
| JP2008541698A (ja) * | 2005-05-03 | 2008-11-27 | アンサンブル ディスカバリー コーポレイション | 核酸検出のためのターンオーバープローブおよびその使用 |
| SI3018206T1 (sl) | 2005-12-01 | 2022-02-28 | Nuevolution A/S | Postopki encimskega kodiranja za učinkovito sintezo velikih knjižnic |
| ATE544870T1 (de) * | 2006-09-18 | 2012-02-15 | Ensemble Therapeutics Corp | Profilierung einer rezeptorfamilie |
| AU2007314516A1 (en) * | 2006-09-28 | 2008-05-08 | Ensemble Discovery Corporation | Compositions and methods for biodetection by nucleic acid-templated chemistry |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| RS54482B1 (sr) | 2010-04-05 | 2016-06-30 | Prognosys Biosciences, Inc. | Biološka testiranja sa prostornim kodiranjem |
| EP2558577B1 (en) | 2010-04-16 | 2018-12-12 | Nuevolution A/S | Bi-functional complexes and methods for making and using such complexes |
| US20130035259A1 (en) | 2010-11-22 | 2013-02-07 | The University Of Chicago | Methods and/or Systems Producing and Providing Sets of Oligonucleotide Conjugates for Assays and Detections |
| US20140194383A1 (en) * | 2011-04-07 | 2014-07-10 | Cornell University | Monomers capable of dimerizing in an aqueous solution, and methods of using same |
| US20140296181A1 (en) * | 2011-04-07 | 2014-10-02 | Coferon, Inc. | Methods of modulating oncogenic fusion proteins |
| JP2014511865A (ja) * | 2011-04-07 | 2014-05-19 | コーネル ユニバーシティー | 水溶液中で多量化できるシリル単量体、およびその使用法 |
| US20140161729A1 (en) * | 2011-04-07 | 2014-06-12 | Cornell University | Cofluorons and methods of making and using them |
| US20120258871A1 (en) | 2011-04-08 | 2012-10-11 | Prognosys Biosciences, Inc. | Peptide constructs and assay systems |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| JP2013074824A (ja) * | 2011-09-30 | 2013-04-25 | Toyobo Co Ltd | Ｍｄｒ１遺伝子の多型を検出するためのプローブ |
| AU2013240090B2 (en) | 2012-03-27 | 2017-01-05 | Ventana Medical Systems, Inc. | Signaling conjugates and methods of use |
| WO2013177046A1 (en) | 2012-05-21 | 2013-11-28 | Solulink, Inc. | Methods and/or use of oligonucleotide conjugates for suppressing background due to cross-hybridization |
| USRE50065E1 (en) | 2012-10-17 | 2024-07-30 | 10X Genomics Sweden Ab | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
| EP4219750A3 (en) * | 2013-03-11 | 2023-12-13 | Meso Scale Technologies, LLC. | Improved methods for conducting multiplexed assays |
| CA2901513C (en) * | 2013-03-12 | 2020-12-29 | Ventana Medical Systems, Inc. | Proximity assay for in situ detection of targets |
| EP3736573A1 (en) | 2013-03-15 | 2020-11-11 | Prognosys Biosciences, Inc. | Methods for detecting peptide/mhc/tcr binding |
| CN105849275B (zh) | 2013-06-25 | 2020-03-17 | 普罗格诺西斯生物科学公司 | 检测样品中生物靶标的空间分布的方法和系统 |
| US10288608B2 (en) * | 2013-11-08 | 2019-05-14 | Prognosys Biosciences, Inc. | Polynucleotide conjugates and methods for analyte detection |
| IL282614B2 (en) | 2015-02-06 | 2024-02-01 | Cell Idx Inc | Antigen-conjugated immune reagents |
| HK1250245A1 (zh) | 2015-04-10 | 2018-12-07 | Spatial Transcriptomics Ab | 生物样本的空间区别、多重核酸分析 |
| WO2016183359A1 (en) | 2015-05-12 | 2016-11-17 | Blinkbio, Inc. | Silicon based drug conjugates and methods of using same |
| CN107923915B (zh) | 2015-08-28 | 2021-05-04 | 文塔纳医疗系统公司 | 使用经掩蔽的半抗原在福尔马林固定石蜡包埋的组织中的蛋白质邻近测定 |
| CN109475567A (zh) | 2016-06-09 | 2019-03-15 | 布兰克生物股份有限公司 | 基于硅烷醇的治疗有效载荷 |
| WO2018208755A1 (en) * | 2017-05-09 | 2018-11-15 | The Regents Of The University Of California | Compositions and methods for tagging target proteins in proximity to a nucleotide sequence of interest |
| WO2019152391A1 (en) * | 2018-01-30 | 2019-08-08 | Rush University Medical Center | Sequential staining for multiplex analyses of tissues and cells |
| WO2020139848A1 (en) * | 2018-12-28 | 2020-07-02 | Becton, Dickinson And Company | Methods for spectrally resolving fluorophores of a sample and systems for same |
| US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| CN110082524B (zh) * | 2019-04-29 | 2022-06-14 | 上海大学 | 检测脂多糖用荧光传感器、其制备方法和应用 |
| US12110541B2 (en) | 2020-02-03 | 2024-10-08 | 10X Genomics, Inc. | Methods for preparing high-resolution spatial arrays |
| US11768175B1 (en) | 2020-03-04 | 2023-09-26 | 10X Genomics, Inc. | Electrophoretic methods for spatial analysis |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60213826T3 (de) * | 2001-03-19 | 2013-10-17 | President And Fellows Of Harvard College | Entwicklung neuer molekularer funktionen |
| JP4657919B2 (ja) * | 2002-08-19 | 2011-03-23 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 進化する新しい分子機能 |
| US7662554B2 (en) * | 2002-10-09 | 2010-02-16 | The Trustees Of Boston University | Nucleic acid supported protein complementation |
| US8017323B2 (en) * | 2003-03-26 | 2011-09-13 | President And Fellows Of Harvard College | Free reactant use in nucleic acid-templated synthesis |
| JP2008541698A (ja) * | 2005-05-03 | 2008-11-27 | アンサンブル ディスカバリー コーポレイション | 核酸検出のためのターンオーバープローブおよびその使用 |
| US20070154899A1 (en) * | 2005-05-26 | 2007-07-05 | Coull James M | Biodetection by nucleic acid-templated chemistry |
| US7795009B2 (en) * | 2005-06-15 | 2010-09-14 | Saint Louis University | Three-component biosensors for detecting macromolecules and other analytes |
| JP2009506025A (ja) * | 2005-08-26 | 2009-02-12 | 国立大学法人京都大学 | 抗ウイルス剤及びウイルス複製阻害剤 |
| ATE544870T1 (de) * | 2006-09-18 | 2012-02-15 | Ensemble Therapeutics Corp | Profilierung einer rezeptorfamilie |
| AU2007314516A1 (en) * | 2006-09-28 | 2008-05-08 | Ensemble Discovery Corporation | Compositions and methods for biodetection by nucleic acid-templated chemistry |
-
2008
- 2008-07-21 CN CN2008801092681A patent/CN101952719A/zh active Pending
- 2008-07-21 AU AU2008282557A patent/AU2008282557A1/en not_active Abandoned
- 2008-07-21 US US12/176,798 patent/US20100159446A1/en not_active Abandoned
- 2008-07-21 EP EP08796373A patent/EP2191268A2/en not_active Withdrawn
- 2008-07-21 JP JP2010518318A patent/JP2010534836A/ja not_active Withdrawn
- 2008-07-21 WO PCT/US2008/070643 patent/WO2009018003A2/en not_active Ceased
- 2008-07-21 CA CA2730565A patent/CA2730565A1/en not_active Abandoned
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