CN101952719A - 检测测定法及其用途 - Google Patents

检测测定法及其用途 Download PDF

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Publication number
CN101952719A
CN101952719A CN2008801092681A CN200880109268A CN101952719A CN 101952719 A CN101952719 A CN 101952719A CN 2008801092681 A CN2008801092681 A CN 2008801092681A CN 200880109268 A CN200880109268 A CN 200880109268A CN 101952719 A CN101952719 A CN 101952719A
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CN
China
Prior art keywords
oligonucleotide
binding
sequence
seq
reporter
Prior art date
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Pending
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CN2008801092681A
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English (en)
Chinese (zh)
Inventor
劳伦斯·A·哈夫
黄玉梅
理查德·A·马蒂纳里
本杰明·亚当·赛格尔
大卫·J·利维斯顿
维-川·孙
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Ensemble Discovery Corp
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Ensemble Discovery Corp
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Publication of CN101952719A publication Critical patent/CN101952719A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
    • G01N2333/91215—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases with a definite EC number (2.7.1.-)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN2008801092681A 2007-07-27 2008-07-21 检测测定法及其用途 Pending CN101952719A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96233307P 2007-07-27 2007-07-27
US60/962,333 2007-07-27
PCT/US2008/070643 WO2009018003A2 (en) 2007-07-27 2008-07-21 Detection assays and use thereof

Publications (1)

Publication Number Publication Date
CN101952719A true CN101952719A (zh) 2011-01-19

Family

ID=39930667

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008801092681A Pending CN101952719A (zh) 2007-07-27 2008-07-21 检测测定法及其用途

Country Status (7)

Country Link
US (1) US20100159446A1 (enExample)
EP (1) EP2191268A2 (enExample)
JP (1) JP2010534836A (enExample)
CN (1) CN101952719A (enExample)
AU (1) AU2008282557A1 (enExample)
CA (1) CA2730565A1 (enExample)
WO (1) WO2009018003A2 (enExample)

Cited By (3)

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Publication number Priority date Publication date Assignee Title
CN110082524A (zh) * 2019-04-29 2019-08-02 上海大学 检测脂多糖用荧光传感器、其制备方法和应用
CN110286215A (zh) * 2013-03-11 2019-09-27 梅索磅秤技术有限公司 用于进行多路测定法的改进方法
CN113439205A (zh) * 2018-12-28 2021-09-24 贝克顿·迪金森公司 用于对样本的荧光团进行光谱解析的方法及其系统

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IL163822A0 (en) 2002-03-15 2005-12-18 Nuevolution As An improved method for synthesising templated molecules
AU2003247266A1 (en) 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
DK2348125T3 (en) 2002-10-30 2017-10-02 Nuevolution As Process for the synthesis of a bifunctional complex
DE60330406D1 (de) 2002-12-19 2010-01-14 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
EP1597395A2 (en) 2003-02-21 2005-11-23 Nuevolution A/S Method for producing second-generation library
DK1670939T3 (da) 2003-09-18 2010-03-01 Nuevolution As Fremgangsmåde til opnåelse af strukturel information om et kodet molekyle og fremgangsmåde til udvælgelse af forbindelser
JP2008541698A (ja) * 2005-05-03 2008-11-27 アンサンブル ディスカバリー コーポレイション 核酸検出のためのターンオーバープローブおよびその使用
SI3018206T1 (sl) 2005-12-01 2022-02-28 Nuevolution A/S Postopki encimskega kodiranja za učinkovito sintezo velikih knjižnic
ATE544870T1 (de) * 2006-09-18 2012-02-15 Ensemble Therapeutics Corp Profilierung einer rezeptorfamilie
AU2007314516A1 (en) * 2006-09-28 2008-05-08 Ensemble Discovery Corporation Compositions and methods for biodetection by nucleic acid-templated chemistry
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
RS54482B1 (sr) 2010-04-05 2016-06-30 Prognosys Biosciences, Inc. Biološka testiranja sa prostornim kodiranjem
EP2558577B1 (en) 2010-04-16 2018-12-12 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
US20130035259A1 (en) 2010-11-22 2013-02-07 The University Of Chicago Methods and/or Systems Producing and Providing Sets of Oligonucleotide Conjugates for Assays and Detections
US20140194383A1 (en) * 2011-04-07 2014-07-10 Cornell University Monomers capable of dimerizing in an aqueous solution, and methods of using same
US20140296181A1 (en) * 2011-04-07 2014-10-02 Coferon, Inc. Methods of modulating oncogenic fusion proteins
JP2014511865A (ja) * 2011-04-07 2014-05-19 コーネル ユニバーシティー 水溶液中で多量化できるシリル単量体、およびその使用法
US20140161729A1 (en) * 2011-04-07 2014-06-12 Cornell University Cofluorons and methods of making and using them
US20120258871A1 (en) 2011-04-08 2012-10-11 Prognosys Biosciences, Inc. Peptide constructs and assay systems
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
JP2013074824A (ja) * 2011-09-30 2013-04-25 Toyobo Co Ltd Ｍｄｒ１遺伝子の多型を検出するためのプローブ
AU2013240090B2 (en) 2012-03-27 2017-01-05 Ventana Medical Systems, Inc. Signaling conjugates and methods of use
WO2013177046A1 (en) 2012-05-21 2013-11-28 Solulink, Inc. Methods and/or use of oligonucleotide conjugates for suppressing background due to cross-hybridization
USRE50065E1 (en) 2012-10-17 2024-07-30 10X Genomics Sweden Ab Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
CA2901513C (en) * 2013-03-12 2020-12-29 Ventana Medical Systems, Inc. Proximity assay for in situ detection of targets
EP3736573A1 (en) 2013-03-15 2020-11-11 Prognosys Biosciences, Inc. Methods for detecting peptide/mhc/tcr binding
CN105849275B (zh) 2013-06-25 2020-03-17 普罗格诺西斯生物科学公司 检测样品中生物靶标的空间分布的方法和系统
US10288608B2 (en) * 2013-11-08 2019-05-14 Prognosys Biosciences, Inc. Polynucleotide conjugates and methods for analyte detection
IL282614B2 (en) 2015-02-06 2024-02-01 Cell Idx Inc Antigen-conjugated immune reagents
HK1250245A1 (zh) 2015-04-10 2018-12-07 Spatial Transcriptomics Ab 生物样本的空间区别、多重核酸分析
WO2016183359A1 (en) 2015-05-12 2016-11-17 Blinkbio, Inc. Silicon based drug conjugates and methods of using same
CN107923915B (zh) 2015-08-28 2021-05-04 文塔纳医疗系统公司 使用经掩蔽的半抗原在福尔马林固定石蜡包埋的组织中的蛋白质邻近测定
CN109475567A (zh) 2016-06-09 2019-03-15 布兰克生物股份有限公司 基于硅烷醇的治疗有效载荷
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110286215A (zh) * 2013-03-11 2019-09-27 梅索磅秤技术有限公司 用于进行多路测定法的改进方法
CN113439205A (zh) * 2018-12-28 2021-09-24 贝克顿·迪金森公司 用于对样本的荧光团进行光谱解析的方法及其系统
CN110082524A (zh) * 2019-04-29 2019-08-02 上海大学 检测脂多糖用荧光传感器、其制备方法和应用
CN110082524B (zh) * 2019-04-29 2022-06-14 上海大学 检测脂多糖用荧光传感器、其制备方法和应用

Also Published As

Publication number Publication date
AU2008282557A1 (en) 2009-02-05
JP2010534836A (ja) 2010-11-11
WO2009018003A3 (en) 2009-07-16
US20100159446A1 (en) 2010-06-24
CA2730565A1 (en) 2009-02-05
WO2009018003A2 (en) 2009-02-05
EP2191268A2 (en) 2010-06-02

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