JP2010533478A5 - - Google Patents
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- Publication number
- JP2010533478A5 JP2010533478A5 JP2010516305A JP2010516305A JP2010533478A5 JP 2010533478 A5 JP2010533478 A5 JP 2010533478A5 JP 2010516305 A JP2010516305 A JP 2010516305A JP 2010516305 A JP2010516305 A JP 2010516305A JP 2010533478 A5 JP2010533478 A5 JP 2010533478A5
- Authority
- JP
- Japan
- Prior art keywords
- gamma secretase
- seq
- ledaefrhds
- lvml
- substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94973807P | 2007-07-13 | 2007-07-13 | |
| PCT/US2008/070012 WO2009012237A1 (en) | 2007-07-13 | 2008-07-14 | Compositions and methods for identifying substrate specificity of inhibitors of gamma secretase |
| US12/172,978 US20090023158A1 (en) | 2007-07-13 | 2008-07-14 | Compositions and Methods for Identifying Substrate Specificity of Inhibitors of Gamma Secretase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010533478A JP2010533478A (ja) | 2010-10-28 |
| JP2010533478A5 true JP2010533478A5 (enExample) | 2011-09-01 |
Family
ID=39739883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010516305A Withdrawn JP2010533478A (ja) | 2007-07-13 | 2008-07-14 | ガンマセクレターゼの阻害剤の基質特異性を同定するための組成物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20090023158A1 (enExample) |
| EP (1) | EP2183598A1 (enExample) |
| JP (1) | JP2010533478A (enExample) |
| CA (1) | CA2692604A1 (enExample) |
| WO (1) | WO2009012237A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008150010A1 (ja) * | 2007-06-08 | 2008-12-11 | Eisai R & D Management Co., Ltd. | γ-セクレターゼの新規基質EphA4を利用したスクリーニング方法 |
| EP2177623A4 (en) * | 2007-07-19 | 2010-12-29 | Eisai R&D Man Co Ltd | SCREENING METHOD USING C-MET, A NEW SUBSTRATE FOR GAMMA SECRETASE |
| EP2192181A4 (en) * | 2007-08-01 | 2010-12-08 | Eisai R&D Man Co Ltd | SCREENING METHOD USING THE NEW C-RET SUBSTRATE FOR GAMMA-SECRETASE |
| US20090163594A1 (en) * | 2007-10-31 | 2009-06-25 | Elan Pharmaceuticals, Inc. | Triple Assay System for Identifying Substrate Selectivity of Gamma Secretase Inhibitors |
| JP5580598B2 (ja) * | 2007-11-15 | 2014-08-27 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | γ−セクレターゼの新規基質ＥｐｈＡ７を利用したスクリーニング方法 |
| EP2223999B1 (en) * | 2007-11-30 | 2017-10-18 | Eisai R&D Management Co., Ltd. | Epha4 polypeptide having novel activity and use thereof |
| EP2653552B1 (en) | 2010-12-17 | 2016-10-19 | Eisai R&D Management Co., Ltd. | SCREENING METHOD USING GELATINASE-MEDIATED EphA4 CLEAVAGE REACTION AS AN INDICATOR |
| US9784751B2 (en) | 2011-04-25 | 2017-10-10 | Eisai R&D Management Co., Ltd. | Method for detecting neurological disease associated with cognitive impairment by measuring EphA4 extracellular domain |
| KR102038357B1 (ko) | 2012-06-22 | 2019-10-31 | 젠티엄 에스알엘 | 디파이브로타이드의 생물학적 활성 측정을 위한 유우글로불린에 기초한 방법 |
| EP3026122A1 (en) * | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Cellular-based method for determining the potency of defibrotide |
| US11732260B2 (en) * | 2018-03-02 | 2023-08-22 | Ionis Pharmaceuticals, Inc. | Compounds and methods for the modulation of amyloid-β precursor protein |
| EP3995582B1 (en) | 2019-07-01 | 2026-04-22 | Eisai R&D Management Co., Ltd. | Anti-epha4 antibody |
| WO2021174075A1 (en) * | 2020-02-27 | 2021-09-02 | Adeptrix Corp. | Multiplexed bead-based analytical assays |
| WO2021206910A1 (en) * | 2020-04-09 | 2021-10-14 | The Regents Of The University Of California | Notch receptors with zinc finger-containing transcriptional effector |
| KR20230043914A (ko) | 2020-07-28 | 2023-03-31 | 아이오니스 파마수티컬즈, 인코포레이티드 | App 발현을 감소시키기 위한 화합물 및 방법 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5604102A (en) | 1992-04-15 | 1997-02-18 | Athena Neurosciences, Inc. | Methods of screening for β-amyloid peptide production inhibitors |
| US5441870A (en) * | 1992-04-15 | 1995-08-15 | Athena Neurosciences, Inc. | Methods for monitoring cellular processing of β-amyloid precursor protein |
| US5766846A (en) * | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
| US5605811A (en) | 1992-10-26 | 1997-02-25 | Athena Neurosciences, Inc. | Methods and compositions for monitoring cellular processing of beta-amyloid precursor protein |
| JPH09507746A (ja) * | 1993-10-27 | 1997-08-12 | アテナ ニューロサイエンシズ，インコーポレイティド | Ｓｗｅｄｉｓｈ変異を有するＡＰＰ対立遺伝子を含有するトランスジェニック動物 |
| DE10131899A1 (de) * | 2001-07-04 | 2003-02-27 | Boehringer Ingelheim Pharma | In vitro-Screening-Assay für gamma-Secretase |
| WO2007058987A1 (en) * | 2005-11-10 | 2007-05-24 | Bristol-Myers Squibb Company | Methods of identifying compounds that inhibit notch cleavage |
| US20090163594A1 (en) * | 2007-10-31 | 2009-06-25 | Elan Pharmaceuticals, Inc. | Triple Assay System for Identifying Substrate Selectivity of Gamma Secretase Inhibitors |
-
2008
- 2008-07-14 US US12/172,978 patent/US20090023158A1/en not_active Abandoned
- 2008-07-14 JP JP2010516305A patent/JP2010533478A/ja not_active Withdrawn
- 2008-07-14 WO PCT/US2008/070012 patent/WO2009012237A1/en not_active Ceased
- 2008-07-14 EP EP08826401A patent/EP2183598A1/en not_active Withdrawn
- 2008-07-14 CA CA 2692604 patent/CA2692604A1/en not_active Abandoned
-
2011
- 2011-03-08 US US13/043,278 patent/US20110306071A1/en not_active Abandoned
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