CA2692604A1 - Compositions and methods for identifying substrate specificity of inhibitors of gamma secretase - Google Patents
Compositions and methods for identifying substrate specificity of inhibitors of gamma secretase Download PDFInfo
- Publication number
- CA2692604A1 CA2692604A1 CA 2692604 CA2692604A CA2692604A1 CA 2692604 A1 CA2692604 A1 CA 2692604A1 CA 2692604 CA2692604 CA 2692604 CA 2692604 A CA2692604 A CA 2692604A CA 2692604 A1 CA2692604 A1 CA 2692604A1
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- Prior art keywords
- gamma secretase
- substrate
- gamma
- app
- jmd
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- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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- G—PHYSICS
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
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- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94973807P | 2007-07-13 | 2007-07-13 | |
| US60/949,738 | 2007-07-13 | ||
| US12/172,978 US20090023158A1 (en) | 2007-07-13 | 2008-07-14 | Compositions and Methods for Identifying Substrate Specificity of Inhibitors of Gamma Secretase |
| US12/172,978 | 2008-07-14 | ||
| PCT/US2008/070012 WO2009012237A1 (en) | 2007-07-13 | 2008-07-14 | Compositions and methods for identifying substrate specificity of inhibitors of gamma secretase |
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| Publication Number | Publication Date |
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| CA2692604A1 true CA2692604A1 (en) | 2009-01-22 |
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| CA 2692604 Abandoned CA2692604A1 (en) | 2007-07-13 | 2008-07-14 | Compositions and methods for identifying substrate specificity of inhibitors of gamma secretase |
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| US (2) | US20090023158A1 (enExample) |
| EP (1) | EP2183598A1 (enExample) |
| JP (1) | JP2010533478A (enExample) |
| CA (1) | CA2692604A1 (enExample) |
| WO (1) | WO2009012237A1 (enExample) |
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| EP2166110B1 (en) * | 2007-06-08 | 2012-02-22 | Eisai R&D Management Co., Ltd. | Screening method utilizing novel substrate epha4 for gamma-secretase |
| EP2177623A4 (en) * | 2007-07-19 | 2010-12-29 | Eisai R&D Man Co Ltd | SCREENING METHOD USING C-MET, A NEW SUBSTRATE FOR GAMMA SECRETASE |
| WO2009017234A1 (ja) * | 2007-08-01 | 2009-02-05 | Eisai R & D Management Co., Ltd. | γ-セクレターゼの新規基質c-Retを利用したスクリーニング方法 |
| US20090163594A1 (en) * | 2007-10-31 | 2009-06-25 | Elan Pharmaceuticals, Inc. | Triple Assay System for Identifying Substrate Selectivity of Gamma Secretase Inhibitors |
| US8530181B2 (en) * | 2007-11-15 | 2013-09-10 | Eisai R&D Management Co., Ltd. | Method of screening for compounds which affect the cleavage of EphA7 byγ-secretase |
| US7892769B2 (en) * | 2007-11-30 | 2011-02-22 | Eisai R&D Management Co., Ltd. | Processing of EphA4 polypeptide by γ-secretase activity |
| WO2012081502A1 (ja) | 2010-12-17 | 2012-06-21 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ゼラチナーゼによるEphA4の切断反応を指標としたスクリーニング方法 |
| US9784751B2 (en) | 2011-04-25 | 2017-10-10 | Eisai R&D Management Co., Ltd. | Method for detecting neurological disease associated with cognitive impairment by measuring EphA4 extracellular domain |
| KR102038357B1 (ko) | 2012-06-22 | 2019-10-31 | 젠티엄 에스알엘 | 디파이브로타이드의 생물학적 활성 측정을 위한 유우글로불린에 기초한 방법 |
| EP3026122A1 (en) * | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Cellular-based method for determining the potency of defibrotide |
| WO2019169243A1 (en) * | 2018-03-02 | 2019-09-06 | Ionis Pharmaceuticals, Inc. | Compounds and methods for the modulation of amyloid-beta precursor protein |
| EP3995582B1 (en) | 2019-07-01 | 2026-04-22 | Eisai R&D Management Co., Ltd. | Anti-epha4 antibody |
| US11913964B2 (en) | 2020-02-27 | 2024-02-27 | Adeptrix Corp. | Multiplexed bead-based analytical assays |
| WO2021206910A1 (en) * | 2020-04-09 | 2021-10-14 | The Regents Of The University Of California | Notch receptors with zinc finger-containing transcriptional effector |
| MX2023001222A (es) | 2020-07-28 | 2023-04-26 | Ionis Pharmaceuticals Inc | Compuestos y metodos para reducir la expresion de app. |
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| US5441870A (en) | 1992-04-15 | 1995-08-15 | Athena Neurosciences, Inc. | Methods for monitoring cellular processing of β-amyloid precursor protein |
| US5604102A (en) * | 1992-04-15 | 1997-02-18 | Athena Neurosciences, Inc. | Methods of screening for β-amyloid peptide production inhibitors |
| US5766846A (en) * | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
| US5605811A (en) * | 1992-10-26 | 1997-02-25 | Athena Neurosciences, Inc. | Methods and compositions for monitoring cellular processing of beta-amyloid precursor protein |
| AU702293B2 (en) * | 1993-10-27 | 1999-02-18 | Athena Neurosciences, Inc. | Transgenic animals harboring APP allele having Swedish mutation |
| DE10131899A1 (de) * | 2001-07-04 | 2003-02-27 | Boehringer Ingelheim Pharma | In vitro-Screening-Assay für gamma-Secretase |
| WO2007058987A1 (en) * | 2005-11-10 | 2007-05-24 | Bristol-Myers Squibb Company | Methods of identifying compounds that inhibit notch cleavage |
| US20090163594A1 (en) * | 2007-10-31 | 2009-06-25 | Elan Pharmaceuticals, Inc. | Triple Assay System for Identifying Substrate Selectivity of Gamma Secretase Inhibitors |
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Also Published As
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| US20090023158A1 (en) | 2009-01-22 |
| WO2009012237A1 (en) | 2009-01-22 |
| EP2183598A1 (en) | 2010-05-12 |
| US20110306071A1 (en) | 2011-12-15 |
| JP2010533478A (ja) | 2010-10-28 |
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