JP2009505964A5 - - Google Patents

Info

Publication number

JP2009505964A5

JP2009505964A5 JP2008524591A JP2008524591A JP2009505964A5 JP 2009505964 A5 JP2009505964 A5 JP 2009505964A5 JP 2008524591 A JP2008524591 A JP 2008524591A JP 2008524591 A JP2008524591 A JP 2008524591A JP 2009505964 A5 JP2009505964 A5 JP 2009505964A5

Authority

JP

Japan

Prior art keywords

fibrinogen binding

factor

fibrinogen

peptide

wound site

Prior art date

2006-08-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 108010049003 Fibrinogen Proteins 0.000 claims 51
• 102000008946 Fibrinogen Human genes 0.000 claims 51
• 229940012952 fibrinogen Drugs 0.000 claims 51
• 239000002243 precursor Substances 0.000 claims 34
• 108090000765 processed proteins & peptides Proteins 0.000 claims 18
• 239000003795 chemical substances by application Substances 0.000 claims 14
• 108090000190 Thrombin Proteins 0.000 claims 13
• 229960004072 thrombin Drugs 0.000 claims 13
• VWJLJHZPMZGDDV-HOCDWTQPSA-N (4s)-4-amino-5-[[(2s)-1-[[(2s,3s)-1-[(2s)-2-[[(1s)-1-carboxyethyl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@@H](N)CCC(O)=O)C1=CN=CN1 VWJLJHZPMZGDDV-HOCDWTQPSA-N 0.000 claims 9
• 150000001413 amino acids Chemical group 0.000 claims 7
• 238000011534 incubation Methods 0.000 claims 7
• 230000008685 targeting Effects 0.000 claims 7
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 6
• 238000000034 method Methods 0.000 claims 5
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
• 238000003776 cleavage reaction Methods 0.000 claims 4
• 230000007017 scission Effects 0.000 claims 4
• 102000018697 Membrane Proteins Human genes 0.000 claims 3
• 108010052285 Membrane Proteins Proteins 0.000 claims 3
• 108010000499 Thromboplastin Proteins 0.000 claims 3
• 102000002262 Thromboplastin Human genes 0.000 claims 3
• 235000001014 amino acid Nutrition 0.000 claims 3
• 230000000903 blocking effect Effects 0.000 claims 3
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 2
• 230000035602 clotting Effects 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 239000012634 fragment Substances 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 125000006850 spacer group Chemical group 0.000 claims 2
• 206010043554 thrombocytopenia Diseases 0.000 claims 2
• WXPZDDCNKXMOMC-AVGNSLFASA-N (2s)-1-[(2s)-2-[[(2s)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carboxylic acid Chemical compound NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@H](C(O)=O)CCC1 WXPZDDCNKXMOMC-AVGNSLFASA-N 0.000 claims 1
• 102100023804 Coagulation factor VII Human genes 0.000 claims 1
• 108010023321 Factor VII Proteins 0.000 claims 1
• 108010054218 Factor VIII Proteins 0.000 claims 1
• 102000001690 Factor VIII Human genes 0.000 claims 1
• 108010054265 Factor VIIa Proteins 0.000 claims 1
• 108010007267 Hirudins Proteins 0.000 claims 1
• 206010020608 Hypercoagulation Diseases 0.000 claims 1
• ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
• 102000032626 PAR-1 Receptor Human genes 0.000 claims 1
• 108010070519 PAR-1 Receptor Proteins 0.000 claims 1
• 238000004220 aggregation Methods 0.000 claims 1
• 230000002776 aggregation Effects 0.000 claims 1
• 235000003704 aspartic acid Nutrition 0.000 claims 1
• 206010003549 asthenia Diseases 0.000 claims 1
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
• 238000006243 chemical reaction Methods 0.000 claims 1
• 238000005520 cutting process Methods 0.000 claims 1
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 229940012413 factor vii Drugs 0.000 claims 1
• 229940012414 factor viia Drugs 0.000 claims 1
• 229960000301 factor viii Drugs 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 238000002372 labelling Methods 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 208000010110 spontaneous platelet aggregation Diseases 0.000 claims 1
• 201000005665 thrombophilia Diseases 0.000 claims 1