JP2010180217A5 - - Google Patents
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- Publication number
- JP2010180217A5 JP2010180217A5 JP2010045882A JP2010045882A JP2010180217A5 JP 2010180217 A5 JP2010180217 A5 JP 2010180217A5 JP 2010045882 A JP2010045882 A JP 2010045882A JP 2010045882 A JP2010045882 A JP 2010045882A JP 2010180217 A5 JP2010180217 A5 JP 2010180217A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- hiv
- coil
- helix coiled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 36
- 125000000539 amino acid group Chemical group 0.000 claims description 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 7
- 108091035707 Consensus sequence Proteins 0.000 claims description 2
- 101800001690 Transmembrane protein gp41 Proteins 0.000 claims 35
- 241000725303 Human immunodeficiency virus Species 0.000 claims 34
- 239000003814 drug Substances 0.000 claims 26
- 229940079593 drug Drugs 0.000 claims 25
- 238000000034 method Methods 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 14
- 230000004931 aggregating effect Effects 0.000 claims 7
- 239000000523 sample Substances 0.000 claims 5
- 239000013068 control sample Substances 0.000 claims 4
- 239000013078 crystal Substances 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 238000002823 phage display Methods 0.000 claims 4
- 101710091045 Envelope protein Proteins 0.000 claims 3
- 101710188315 Protein X Proteins 0.000 claims 3
- 102100021696 Syncytin-1 Human genes 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 150000008574 D-amino acids Chemical group 0.000 claims 2
- ROHFNLRQFUQHCH-RXMQYKEDSA-N D-leucine Chemical compound CC(C)C[C@@H](N)C(O)=O ROHFNLRQFUQHCH-RXMQYKEDSA-N 0.000 claims 2
- 229930182819 D-leucine Natural products 0.000 claims 2
- 229930182827 D-tryptophan Natural products 0.000 claims 2
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 claims 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 2
- 239000003433 contraceptive agent Substances 0.000 claims 2
- 230000002254 contraceptive effect Effects 0.000 claims 2
- 230000002209 hydrophobic effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000000214 mouth Anatomy 0.000 claims 2
- 210000000664 rectum Anatomy 0.000 claims 2
- 210000001215 vagina Anatomy 0.000 claims 2
- WHUUTDBJXJRKMK-GSVOUGTGSA-N D-glutamic acid Chemical compound OC(=O)[C@H](N)CCC(O)=O WHUUTDBJXJRKMK-GSVOUGTGSA-N 0.000 claims 1
- 229930182847 D-glutamic acid Natural products 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 150000008575 L-amino acids Chemical class 0.000 claims 1
- 108010067902 Peptide Library Proteins 0.000 claims 1
- 238000002441 X-ray diffraction Methods 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 239000006215 rectal suppository Substances 0.000 claims 1
- 229940100618 rectal suppository Drugs 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000006216 vaginal suppository Substances 0.000 claims 1
- 229940120293 vaginal suppository Drugs 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 230000034217 membrane fusion Effects 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9467698P | 1998-07-30 | 1998-07-30 | |
| US10026598P | 1998-09-14 | 1998-09-14 | |
| US10105898P | 1998-09-18 | 1998-09-18 | |
| US13229599P | 1999-05-03 | 1999-05-03 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000562395A Division JP5101764B2 (ja) | 1998-07-30 | 1999-07-30 | Ｈｉｖ膜融合のインヒビター |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010180217A JP2010180217A (ja) | 2010-08-19 |
| JP2010180217A5 true JP2010180217A5 (enExample) | 2010-11-25 |
Family
ID=27492743
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000562395A Expired - Fee Related JP5101764B2 (ja) | 1998-07-30 | 1999-07-30 | Ｈｉｖ膜融合のインヒビター |
| JP2010045882A Pending JP2010180217A (ja) | 1998-07-30 | 2010-03-02 | Ｈｉｖ膜融合のインヒビター |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000562395A Expired - Fee Related JP5101764B2 (ja) | 1998-07-30 | 1999-07-30 | Ｈｉｖ膜融合のインヒビター |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1100818B1 (enExample) |
| JP (2) | JP5101764B2 (enExample) |
| KR (1) | KR20010099605A (enExample) |
| AU (1) | AU770482B2 (enExample) |
| CA (1) | CA2338022C (enExample) |
| WO (1) | WO2000006599A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6841657B2 (en) | 1997-04-17 | 2005-01-11 | Whitehead Institute For Biomedical Research | Inhibitors of HIV membrane fusion |
| US6150088A (en) | 1997-04-17 | 2000-11-21 | Whitehead Institute For Biomedical Research | Core structure of gp41 from the HIV envelope glycoprotein |
| US6818740B1 (en) | 1997-04-17 | 2004-11-16 | Whitehead Institute For Biomedical Research | Inhibitors of HIV membrane fusion |
| US7960504B2 (en) | 1998-07-30 | 2011-06-14 | Whitehead Institute For Biomedical Research | Inhibitors of HIV membrane fusion |
| US6747126B1 (en) | 1998-07-30 | 2004-06-08 | Whitehead Institute For Biomedical Research | Peptide inhibitors of HIV entry |
| US7053179B2 (en) | 1999-12-16 | 2006-05-30 | Whitehead Institute For Biomedical Research | Five-Helix protein |
| AU2001233340B2 (en) | 2000-02-10 | 2006-05-04 | Panacos Pharmaceuticals, Inc. | Assay for detection of viral fusion inhibitors |
| US6664230B1 (en) * | 2000-08-24 | 2003-12-16 | The Regents Of The University Of California | Orally administered peptides to ameliorate atherosclerosis |
| US7199102B2 (en) | 2000-08-24 | 2007-04-03 | The Regents Of The University Of California | Orally administered peptides synergize statin activity |
| CA2423004C (en) * | 2000-09-22 | 2012-09-11 | Whitehead Institute For Biomedical Research | Peptide inhibitors of hiv entry |
| KR100447943B1 (ko) * | 2000-11-06 | 2004-09-08 | 한국과학기술연구원 | Ｈｉｖ의 감염 억제 펩타이드 |
| CN1100564C (zh) * | 2001-08-29 | 2003-02-05 | 周根发 | 用于治疗hiv感染的药物、其组合物及其用途 |
| CA2461853A1 (en) * | 2001-09-27 | 2003-04-03 | Tibotec Pharmaceuticals Ltd. | Anti-fusion assay |
| WO2003029284A1 (en) * | 2001-09-27 | 2003-04-10 | Nobutaka Fujii | Anti-hiv agent |
| EP1463521A4 (en) * | 2001-12-17 | 2009-06-24 | Us Gov Health & Human Serv | INHIBITOR OF GP41 |
| WO2005118886A2 (en) | 2004-06-01 | 2005-12-15 | Merck & Co., Inc. | Stable peptide mimetic of hiv gp41 fusion intermediate |
| RU2414236C2 (ru) | 2004-12-06 | 2011-03-20 | Зе Риджентс Оф Зи Юнивесити Оф Кэлифонье | Способ улучшения структуры и/или функций артериол |
| EP2005177B1 (en) * | 2006-04-06 | 2013-07-10 | Janssen R&D Ireland | A homogeneous time resolved fluorescence based test method |
| WO2013142298A1 (en) * | 2012-03-20 | 2013-09-26 | Merck Sharp & Dohme Corp. | Stable peptide mimetics of the hiv-1 gp41 pre-hairpin intermediate |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994002505A1 (en) * | 1992-07-20 | 1994-02-03 | Duke University | Compounds which inhibit hiv replication |
-
1999
- 1999-07-30 JP JP2000562395A patent/JP5101764B2/ja not_active Expired - Fee Related
- 1999-07-30 EP EP99937691A patent/EP1100818B1/en not_active Expired - Lifetime
- 1999-07-30 AU AU57886/01A patent/AU770482B2/en not_active Ceased
- 1999-07-30 KR KR1020017001273A patent/KR20010099605A/ko not_active Ceased
- 1999-07-30 CA CA2338022A patent/CA2338022C/en not_active Expired - Fee Related
- 1999-07-30 WO PCT/US1999/017351 patent/WO2000006599A1/en not_active Ceased
-
2010
- 2010-03-02 JP JP2010045882A patent/JP2010180217A/ja active Pending
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