JP2009505964A - 人工血小板 - Google Patents

人工血小板 Download PDF

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Publication number
JP2009505964A
JP2009505964A JP2008524591A JP2008524591A JP2009505964A JP 2009505964 A JP2009505964 A JP 2009505964A JP 2008524591 A JP2008524591 A JP 2008524591A JP 2008524591 A JP2008524591 A JP 2008524591A JP 2009505964 A JP2009505964 A JP 2009505964A
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JP
Japan
Prior art keywords
peptide
fibrinogen binding
fibrinogen
factor
precursor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008524591A
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English (en)
Japanese (ja)
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JP2009505964A5 (enExample
Inventor
アリソン ヘレナ グッダル，
サラ マーガレット テイラー，
グレッグ フランシス ウォーカー，
Original Assignee
ヘモスタティクス リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by ヘモスタティクス リミテッド filed Critical ヘモスタティクス リミテッド
Publication of JP2009505964A publication Critical patent/JP2009505964A/ja
Publication of JP2009505964A5 publication Critical patent/JP2009505964A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2008524591A 2005-08-04 2006-08-04 人工血小板 Pending JP2009505964A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0516091.6A GB0516091D0 (en) 2005-08-04 2005-08-04 Therapeutic agent
PCT/GB2006/002934 WO2007015107A2 (en) 2005-08-04 2006-08-04 Artificial platelets

Publications (2)

Publication Number Publication Date
JP2009505964A true JP2009505964A (ja) 2009-02-12
JP2009505964A5 JP2009505964A5 (enExample) 2009-09-17

Family

ID=34984119

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008524591A Pending JP2009505964A (ja) 2005-08-04 2006-08-04 人工血小板

Country Status (9)

Country Link
US (2) US20090203619A1 (enExample)
EP (2) EP2335737A3 (enExample)
JP (1) JP2009505964A (enExample)
CN (1) CN101267843A (enExample)
AU (1) AU2006274685A1 (enExample)
CA (1) CA2625917A1 (enExample)
GB (2) GB0516091D0 (enExample)
IL (1) IL189105A0 (enExample)
WO (1) WO2007015107A2 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010510818A (ja) * 2006-11-27 2010-04-08 ヘモスタティクス リミテッド バイオゲル
JP2015506764A (ja) * 2012-02-01 2015-03-05 ハエモスタティクス リミティド 止血創傷被覆材
JP2016523919A (ja) * 2013-06-28 2016-08-12 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． Ｘｔｅｎを有するトロンビン切断可能リンカー及びその使用
US11192936B2 (en) 2014-01-10 2021-12-07 Bioverativ Therapeutics Inc. Factor VIII chimeric proteins and uses thereof
US12030925B2 (en) 2018-05-18 2024-07-09 Bioverativ Therapeutics Inc. Methods of treating hemophilia A
US12161696B2 (en) 2016-12-02 2024-12-10 Bioverativ Therapeutics Inc. Methods of treating hemophilic arthropathy using chimeric clotting factors

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008113796A1 (en) * 2007-03-21 2008-09-25 Dsm Ip Assets B.V. Cholesterol lowering protein hydrolysates
KR20100057061A (ko) * 2007-09-11 2010-05-28 몬도바이오테크 래보래토리즈 아게 치료제로서의 펩티드 ｍａｉｐｐｋｋｎｑｄｋ （소 카파 카세인 １０６－１１６）및／또는 ｙｇｆｑｎａ （세로르핀）의 용도
US20100204107A1 (en) * 2007-09-11 2010-08-12 Dorian Bevec Use of urodilatin as a therapeutic agent
GB201101740D0 (en) * 2011-02-01 2011-03-16 Haemostatix Ltd Therapeutic agents with improved fibrinogen binding
WO2013021353A1 (en) * 2011-08-11 2013-02-14 Bar-Ilan University Surface modified proteinaceous spherical particles and uses thereof
WO2014197816A1 (en) * 2013-06-06 2014-12-11 Massachusetts Institute Of Technology Stimulus responsive nanocomplexes and methods of use thereof
EP3069141A4 (en) 2013-11-15 2017-05-10 President and Fellows of Harvard College Methods and assays for factor viii activity
GB201400292D0 (en) * 2014-01-08 2014-02-26 Haemostatix Ltd Peptide dendrimers and agents
GB201508024D0 (en) * 2015-05-11 2015-06-24 Haemostatix Ltd Haemostatic compositions
CN107686506B (zh) * 2016-08-05 2021-03-30 首都医科大学 华法林-4-o-乙酰-gprp,其合成,活性和应用
CN108976285B (zh) * 2017-05-31 2021-11-30 首都医科大学 Gly-Pro-Arg-Pro-AA修饰的华法林,其合成,活性和应用
CN108976284B (zh) * 2017-05-31 2021-11-30 首都医科大学 含Gly-Pro-Arg-Pro的五肽修饰的华法林,其合成,活性和应用
ES2832881T3 (es) * 2018-04-24 2021-06-11 Fibriant B V Variantes de fibrinógeno gamma prima para su uso en el tratamiento de una infección
CN115010784B (zh) * 2022-05-16 2023-03-31 江南大学 一种ace抑制肽及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030143158A1 (en) * 2000-12-23 2003-07-31 Wescott Charles R. Fibrin binding moieties useful as imaging agents
WO2005035002A1 (en) * 2003-10-07 2005-04-21 Haemostatix Limited Fibrinogen targetting microparticles for promoting haemostasie

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9107628D0 (en) 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
DE69334033D1 (de) * 1992-05-21 2006-07-27 Diatide Inc Technetium-99M markierte Peptide zur Bilderzeugung von Thrombus
US6184205B1 (en) * 1994-07-22 2001-02-06 University Of North Carolina At Chapel Hill GRB2 SH3 binding peptides and methods of isolating and using same
ATE217344T1 (de) * 1994-09-21 2002-05-15 Cytogen Corp Antigen bindende peptide (abtides) aus peptidbibliotheken
AU718956B2 (en) * 1996-10-21 2000-05-04 Quadrant Healthcare (Uk) Limited Platelet substitutes and conjugation methods suitable for their preparation
US6264988B1 (en) * 1997-06-05 2001-07-24 Hemosphere, Inc. Fibrinogen-coated microspheres
DK9700423U3 (da) * 1997-11-10 1999-03-12 Simatek A S Multifunktion cip-dyse
US20030021777A1 (en) * 1998-02-20 2003-01-30 Roy Harris Product comprising bound fibrinogen and thrombin for use in wound therapy or surgical repair
GB9827813D0 (en) * 1998-12-17 1999-02-10 Andaris Ltd Pharmaceutical conjugates
GB0413346D0 (en) * 2004-06-15 2004-07-21 Theryte Ltd Treating cancer
GB201201751D0 (en) * 2012-02-01 2012-03-14 Haemostatix Ltd Haemostatic wound dressing

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030143158A1 (en) * 2000-12-23 2003-07-31 Wescott Charles R. Fibrin binding moieties useful as imaging agents
WO2005035002A1 (en) * 2003-10-07 2005-04-21 Haemostatix Limited Fibrinogen targetting microparticles for promoting haemostasie

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010510818A (ja) * 2006-11-27 2010-04-08 ヘモスタティクス リミテッド バイオゲル
JP2013188550A (ja) * 2006-11-27 2013-09-26 Haemostatix Ltd バイオゲル
JP2015506764A (ja) * 2012-02-01 2015-03-05 ハエモスタティクス リミティド 止血創傷被覆材
JP7005800B2 (ja) 2013-06-28 2022-02-10 バイオベラティブ セラピューティクス インコーポレイテッド Ｘｔｅｎを有するトロンビン切断可能リンカー及びその使用
JP2023107932A (ja) * 2013-06-28 2023-08-03 バイオベラティブ セラピューティクス インコーポレイテッド Ｘｔｅｎを有するトロンビン切断可能リンカー及びその使用
JP2021072853A (ja) * 2013-06-28 2021-05-13 バイオベラティブ セラピューティクス インコーポレイテッド Ｘｔｅｎを有するトロンビン切断可能リンカー及びその使用
JP7861172B2 (ja) 2013-06-28 2026-05-18 バイオベラティブ セラピューティクス インコーポレイテッド Ｘｔｅｎを有するトロンビン切断可能リンカー及びその使用
JP2022000053A (ja) * 2013-06-28 2022-01-04 バイオベラティブ セラピューティクス インコーポレイテッド Ｘｔｅｎを有するトロンビン切断可能リンカー及びその使用
JP2016523919A (ja) * 2013-06-28 2016-08-12 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． Ｘｔｅｎを有するトロンビン切断可能リンカー及びその使用
JP7297837B2 (ja) 2013-06-28 2023-06-26 バイオベラティブ セラピューティクス インコーポレイテッド Ｘｔｅｎを有するトロンビン切断可能リンカー及びその使用
JP2019010124A (ja) * 2013-06-28 2019-01-24 バイオベラティブ セラピューティクス インコーポレイテッド Ｘｔｅｎを有するトロンビン切断可能リンカー及びその使用
JP2025061316A (ja) * 2013-06-28 2025-04-10 バイオベラティブ セラピューティクス インコーポレイテッド Ｘｔｅｎを有するトロンビン切断可能リンカー及びその使用
JP7623426B2 (ja) 2013-06-28 2025-01-28 バイオベラティブ セラピューティクス インコーポレイテッド Ｘｔｅｎを有するトロンビン切断可能リンカー及びその使用
US12617839B2 (en) 2014-01-10 2026-05-05 Bioverativ Therapeutics Inc. Factor VIII chimeric proteins and uses thereof
US11192936B2 (en) 2014-01-10 2021-12-07 Bioverativ Therapeutics Inc. Factor VIII chimeric proteins and uses thereof
US12161696B2 (en) 2016-12-02 2024-12-10 Bioverativ Therapeutics Inc. Methods of treating hemophilic arthropathy using chimeric clotting factors
US12030925B2 (en) 2018-05-18 2024-07-09 Bioverativ Therapeutics Inc. Methods of treating hemophilia A

Also Published As

Publication number Publication date
US20090203619A1 (en) 2009-08-13
AU2006274685A1 (en) 2007-02-08
GB2429153A (en) 2007-02-21
WO2007015107A2 (en) 2007-02-08
US20130029913A1 (en) 2013-01-31
EP2335737A2 (en) 2011-06-22
IL189105A0 (en) 2008-08-07
GB0516091D0 (en) 2005-09-14
EP1919508B1 (en) 2015-02-25
GB2429153C (en) 2019-01-23
WO2007015107A3 (en) 2007-07-26
GB2429153B (en) 2010-03-10
GB0615545D0 (en) 2006-09-13
EP2335737A3 (en) 2013-09-25
CA2625917A1 (en) 2007-02-08
EP1919508A2 (en) 2008-05-14
CN101267843A (zh) 2008-09-17

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