JP2002543825A5 - - Google Patents
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- JP2002543825A5 JP2002543825A5 JP2000618312A JP2000618312A JP2002543825A5 JP 2002543825 A5 JP2002543825 A5 JP 2002543825A5 JP 2000618312 A JP2000618312 A JP 2000618312A JP 2000618312 A JP2000618312 A JP 2000618312A JP 2002543825 A5 JP2002543825 A5 JP 2002543825A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- pdz
- clasp
- peptide
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000004169 proteins and genes Human genes 0.000 description 30
- 108090000623 proteins and genes Proteins 0.000 description 30
- 108090000765 processed proteins & peptides Proteins 0.000 description 25
- 238000000034 method Methods 0.000 description 24
- -1 Clasp-2 Proteins 0.000 description 14
- 150000001875 compounds Chemical class 0.000 description 11
- 102000000470 PDZ domains Human genes 0.000 description 10
- 108050008994 PDZ domains Proteins 0.000 description 10
- 125000003275 alpha amino acid group Chemical group 0.000 description 10
- 229920001184 polypeptide Polymers 0.000 description 10
- 102000004196 processed proteins & peptides Human genes 0.000 description 10
- 102100038077 CD226 antigen Human genes 0.000 description 8
- 101000884298 Homo sapiens CD226 antigen Proteins 0.000 description 8
- 102100026423 Adhesion G protein-coupled receptor E5 Human genes 0.000 description 6
- 102100032912 CD44 antigen Human genes 0.000 description 6
- 102100035793 CD83 antigen Human genes 0.000 description 6
- 102100031597 Dedicator of cytokinesis protein 2 Human genes 0.000 description 6
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 6
- 101000718243 Homo sapiens Adhesion G protein-coupled receptor E5 Proteins 0.000 description 6
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 description 6
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 description 6
- 101000866237 Homo sapiens Dedicator of cytokinesis protein 2 Proteins 0.000 description 6
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 6
- 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 description 6
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 description 6
- 102100031988 Tumor necrosis factor ligand superfamily member 6 Human genes 0.000 description 6
- 108050002568 Tumor necrosis factor ligand superfamily member 6 Proteins 0.000 description 6
- 102100040403 Tumor necrosis factor receptor superfamily member 6 Human genes 0.000 description 6
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 description 6
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 description 6
- 239000003112 inhibitor Substances 0.000 description 6
- 108010078791 Carrier Proteins Proteins 0.000 description 5
- 210000004899 c-terminal region Anatomy 0.000 description 4
- 108700019745 Disks Large Homolog 4 Proteins 0.000 description 3
- 102100024099 Disks large homolog 1 Human genes 0.000 description 3
- 102100022264 Disks large homolog 4 Human genes 0.000 description 3
- 101001053984 Homo sapiens Disks large homolog 1 Proteins 0.000 description 3
- 101000951365 Homo sapiens Disks large-associated protein 5 Proteins 0.000 description 3
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 description 3
- 239000005557 antagonist Substances 0.000 description 3
- 230000008827 biological function Effects 0.000 description 3
- 101150069842 dlg4 gene Proteins 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 102100027123 55 kDa erythrocyte membrane protein Human genes 0.000 description 2
- 102100036514 Amyloid-beta A4 precursor protein-binding family A member 1 Human genes 0.000 description 2
- 108700006830 Drosophila Antp Proteins 0.000 description 2
- 101000928690 Homo sapiens Amyloid-beta A4 precursor protein-binding family A member 1 Proteins 0.000 description 2
- 108010070875 Human Immunodeficiency Virus tat Gene Products Proteins 0.000 description 2
- 108050007394 Kinesin-like protein KIF20B Proteins 0.000 description 2
- 102100035772 Regulator of G-protein signaling 12 Human genes 0.000 description 2
- 101710148337 Regulator of G-protein signaling 12 Proteins 0.000 description 2
- 241000700584 Simplexvirus Species 0.000 description 2
- 101710192266 Tegument protein VP22 Proteins 0.000 description 2
- 239000000556 agonist Substances 0.000 description 2
- 230000003172 anti-dna Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000009918 complex formation Effects 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 108020001507 fusion proteins Proteins 0.000 description 2
- 102000037865 fusion proteins Human genes 0.000 description 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 2
- 239000000816 peptidomimetic Substances 0.000 description 2
- 101100152504 Arabidopsis thaliana TAX2 gene Proteins 0.000 description 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 description 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 description 1
- 101000907578 Homo sapiens Forkhead box protein M1 Proteins 0.000 description 1
- 101001005128 Homo sapiens LIM domain kinase 1 Proteins 0.000 description 1
- 101000620894 Homo sapiens Lysophosphatidic acid phosphatase type 6 Proteins 0.000 description 1
- 101000590691 Homo sapiens MAGUK p55 subfamily member 2 Proteins 0.000 description 1
- 101001018294 Homo sapiens Microtubule-associated serine/threonine-protein kinase 3 Proteins 0.000 description 1
- 101001018298 Homo sapiens Microtubule-associated serine/threonine-protein kinase 4 Proteins 0.000 description 1
- 101001113469 Homo sapiens Partitioning defective 6 homolog alpha Proteins 0.000 description 1
- 101000922137 Homo sapiens Peripheral plasma membrane protein CASK Proteins 0.000 description 1
- 101001135804 Homo sapiens Protein tyrosine phosphatase receptor type C-associated protein Proteins 0.000 description 1
- 101000867413 Homo sapiens Segment polarity protein dishevelled homolog DVL-1 Proteins 0.000 description 1
- 102100029874 Kappa-casein Human genes 0.000 description 1
- 102100026023 LIM domain kinase 1 Human genes 0.000 description 1
- 102100032498 MAGUK p55 subfamily member 2 Human genes 0.000 description 1
- 102100033251 Microtubule-associated serine/threonine-protein kinase 3 Human genes 0.000 description 1
- 102100033252 Microtubule-associated serine/threonine-protein kinase 4 Human genes 0.000 description 1
- 102100023711 Partitioning defective 6 homolog alpha Human genes 0.000 description 1
- 102100036937 Protein tyrosine phosphatase receptor type C-associated protein Human genes 0.000 description 1
- 102100032758 Segment polarity protein dishevelled homolog DVL-1 Human genes 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Applications Claiming Priority (27)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13411799P | 1999-05-14 | 1999-05-14 | |
| US13411899P | 1999-05-14 | 1999-05-14 | |
| US13411499P | 1999-05-14 | 1999-05-14 | |
| US60/134,118 | 1999-05-14 | ||
| US60/134,114 | 1999-05-14 | ||
| US60/134,117 | 1999-05-14 | ||
| US16086099P | 1999-10-21 | 1999-10-21 | |
| US60/160,860 | 1999-10-21 | ||
| US16249899P | 1999-10-29 | 1999-10-29 | |
| US60/162,498 | 1999-10-29 | ||
| US17045399P | 1999-12-13 | 1999-12-13 | |
| US60/170,453 | 1999-12-13 | ||
| US17619500P | 2000-01-14 | 2000-01-14 | |
| US60/176,195 | 2000-01-14 | ||
| US18229600P | 2000-02-14 | 2000-02-14 | |
| US60/182,296 | 2000-02-14 | ||
| US19652800P | 2000-04-11 | 2000-04-11 | |
| US19626700P | 2000-04-11 | 2000-04-11 | |
| US54727600A | 2000-04-11 | 2000-04-11 | |
| US19652700P | 2000-04-11 | 2000-04-11 | |
| US19646000P | 2000-04-11 | 2000-04-11 | |
| US09/547,276 | 2000-04-11 | ||
| US60/196,528 | 2000-04-11 | ||
| US60/196,460 | 2000-04-11 | ||
| US60/196,527 | 2000-04-11 | ||
| US60/196267 | 2000-04-11 | ||
| PCT/US2000/013161 WO2000069896A2 (en) | 1999-05-14 | 2000-05-12 | Molecular interactions in haematopoietic cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011029100A Division JP2011102326A (ja) | 1999-05-14 | 2011-02-14 | 造血細胞内分子相互作用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002543825A JP2002543825A (ja) | 2002-12-24 |
| JP2002543825A5 true JP2002543825A5 (enExample) | 2007-07-05 |
Family
ID=27584529
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000618312A Withdrawn JP2002543825A (ja) | 1999-05-14 | 2000-05-12 | 造血細胞内分子相互作用 |
| JP2011029100A Pending JP2011102326A (ja) | 1999-05-14 | 2011-02-14 | 造血細胞内分子相互作用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011029100A Pending JP2011102326A (ja) | 1999-05-14 | 2011-02-14 | 造血細胞内分子相互作用 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1178817A2 (enExample) |
| JP (2) | JP2002543825A (enExample) |
| ES (1) | ES2436624T3 (enExample) |
| WO (2) | WO2000069896A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1100890A2 (en) | 1998-07-27 | 2001-05-23 | Genentech, Inc. | Improved transformation efficiency in phage display through modification of a coat protein |
| US6942981B1 (en) | 1999-05-14 | 2005-09-13 | Arbor Vita Corporation | Method of determining interactions with PDZ-domain polypeptides |
| US20030049695A1 (en) * | 2001-02-16 | 2003-03-13 | Lu Peter S. | PDZ domain interactions and lipid rafts |
| US7510824B2 (en) | 1999-06-02 | 2009-03-31 | Nono Inc. | Method of screening peptides useful in treating traumatic injury to the brain or spinal cord |
| US7595297B2 (en) | 1999-06-02 | 2009-09-29 | Michael Tymianski | Method of reducing injury to mammalian cells |
| WO2002031512A2 (en) * | 2000-10-13 | 2002-04-18 | Arbor Vita Corporation | Molecular interactions in hematopoietic cells |
| CA2445309A1 (en) * | 2001-04-24 | 2002-11-07 | Otsuka Pharmaceutical Co., Ltd. | Crohn's disease antibody-binding peptide and method of examining crohn's disease |
| AU2011211347B2 (en) * | 2001-05-07 | 2015-02-19 | Agriculture Victoria Services Pty Ltd | Modification of plant and seed development and plant responses to stresses and stimuli (3) |
| DE10124342A1 (de) * | 2001-05-18 | 2002-11-28 | Biotecon Diagnostics Gmbh | Verfahren zum Nachweis von Mikroorganismen der Spezies Yersinia pestis/Yersinia pseudotuberculosis und/oder zur Differzierung zwischen Yersinia pestis und Yersinia pseudotuberculosis |
| EP1493028A4 (en) * | 2001-07-06 | 2006-06-14 | Genentech Inc | PHAGEN DISPLAY PRESENTED LIGANDS OF THE PDZ DOMAIN |
| AU2003291558B2 (en) * | 2001-08-03 | 2009-08-13 | Arbor Vita Corporation | Molecular interactions in neurons |
| AU2002321903A1 (en) * | 2001-08-03 | 2003-02-24 | Arbor Vita Corporation | Molecular interactions in cells |
| JP2003199459A (ja) | 2002-01-07 | 2003-07-15 | Japan Science & Technology Corp | リンパ球遊走制御機能欠失モデル非ヒト動物 |
| EP2289535B8 (en) | 2004-12-21 | 2018-08-08 | MUSC Foundation for Research Development | Compositions and methods for promoting wound healing and tissue regeneration |
| AU2012202117B2 (en) * | 2004-12-21 | 2014-06-26 | Musc Foundation For Research Development | Compositions and methods for promoting wound healing and tissue regeneration |
| US9408381B2 (en) | 2004-12-21 | 2016-08-09 | Musc Foundation For Research Development | Alpha Connexin c-Terminal (ACT) peptides for use in transplant |
| JP2008537478A (ja) * | 2005-02-24 | 2008-09-18 | ザ・スクリプス・リサーチ・インステイチユート | 単離骨髄球様骨髄細胞集団及びそれを用いた治療方法 |
| JP2009503439A (ja) * | 2005-07-01 | 2009-01-29 | アルボー ビータ コーポレーション | ウイルス感染および細菌感染の診断および処置のための方法および組成物 |
| WO2007071448A2 (en) * | 2005-12-23 | 2007-06-28 | Partnership & Corp. Technology Transfer | Synthetic peptides for use as inhibitors of neurotransmitter secretion and as inducers of muscle relaxation |
| CA2648629C (en) * | 2006-04-07 | 2017-08-29 | University Of Tsukuba | Graft-versus-host disease predicting marker and use thereof |
| RU2657535C2 (ru) | 2012-03-01 | 2018-06-14 | Ферстстринг Рисерч, Инк. | Гели для местного применения, содержащие с-концевые пептиды альфа-коннексина (act) |
| JP6683686B2 (ja) | 2014-08-22 | 2020-04-22 | オークランド ユニサービシーズ リミティド | チャネル調節剤 |
| KR20200003160A (ko) * | 2017-05-03 | 2020-01-08 | 바이오마린 파머수티컬 인크. | 조혈모세포의 형질도입을 위한 개선된 렌티바이러스 |
| AU2019403393A1 (en) * | 2018-12-20 | 2021-08-05 | The University Of Chicago | Methods and compositions related to therapeutic peptides for cancer therapy |
| CA3196342A1 (en) | 2020-10-22 | 2022-04-28 | Gautam Ghatnekar | Peptide formulations and ophthalmic uses thereof |
| CN114457005B (zh) * | 2022-01-12 | 2024-03-26 | 佛山市妇幼保健院 | 一种小儿尿道平滑肌细胞的分离纯化方法 |
| WO2024199407A1 (en) * | 2023-03-31 | 2024-10-03 | Qihan Hong Kong Limited | Cancer immunotherapies using engineered cells |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6911526B2 (en) * | 1996-07-22 | 2005-06-28 | The Trustees Of Columbia University In The City Of New York | Compounds that inhibit the interaction between signal-transducing proteins and the GLGF (PDZ/DHR) domain and uses thereof |
-
2000
- 2000-05-12 EP EP00932386A patent/EP1178817A2/en not_active Withdrawn
- 2000-05-12 WO PCT/US2000/013161 patent/WO2000069896A2/en not_active Ceased
- 2000-05-12 WO PCT/US2000/013166 patent/WO2000069897A2/en not_active Ceased
- 2000-05-12 ES ES10186068.2T patent/ES2436624T3/es not_active Expired - Lifetime
- 2000-05-12 JP JP2000618312A patent/JP2002543825A/ja not_active Withdrawn
-
2011
- 2011-02-14 JP JP2011029100A patent/JP2011102326A/ja active Pending
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