JP2010532663A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010532663A5 JP2010532663A5 JP2010515276A JP2010515276A JP2010532663A5 JP 2010532663 A5 JP2010532663 A5 JP 2010532663A5 JP 2010515276 A JP2010515276 A JP 2010515276A JP 2010515276 A JP2010515276 A JP 2010515276A JP 2010532663 A5 JP2010532663 A5 JP 2010532663A5
- Authority
- JP
- Japan
- Prior art keywords
- gene
- family member
- androgen
- ets family
- ets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 claims description 83
- 238000000034 method Methods 0.000 claims description 76
- 102000040848 ETS family Human genes 0.000 claims description 46
- 108091071901 ETS family Proteins 0.000 claims description 46
- 230000001105 regulatory effect Effects 0.000 claims description 44
- 239000003098 androgen Substances 0.000 claims description 41
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 37
- 108700039887 Essential Genes Proteins 0.000 claims description 25
- 230000003321 amplification Effects 0.000 claims description 25
- 206010060862 Prostate cancer Diseases 0.000 claims description 23
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 23
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims description 23
- 108020004414 DNA Proteins 0.000 claims description 21
- 230000008711 chromosomal rearrangement Effects 0.000 claims description 21
- 108020004999 messenger RNA Proteins 0.000 claims description 21
- 230000004927 fusion Effects 0.000 claims description 18
- 230000002103 transcriptional effect Effects 0.000 claims description 18
- 108700005075 Regulator Genes Proteins 0.000 claims description 15
- 108091007568 SLC45A3 Proteins 0.000 claims description 15
- 102100037253 Solute carrier family 45 member 3 Human genes 0.000 claims description 15
- 238000007901 in situ hybridization Methods 0.000 claims description 14
- 210000002700 urine Anatomy 0.000 claims description 12
- 102100039577 ETS translocation variant 5 Human genes 0.000 claims description 9
- 101000813745 Homo sapiens ETS translocation variant 5 Proteins 0.000 claims description 9
- 102100039563 ETS translocation variant 1 Human genes 0.000 claims description 8
- 101000813729 Homo sapiens ETS translocation variant 1 Proteins 0.000 claims description 8
- 210000002307 prostate Anatomy 0.000 claims description 7
- 210000005267 prostate cell Anatomy 0.000 claims description 7
- 230000028327 secretion Effects 0.000 claims description 7
- 108700039691 Genetic Promoter Regions Proteins 0.000 claims description 5
- 210000004369 blood Anatomy 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 239000008188 pellet Substances 0.000 claims description 4
- 210000002381 plasma Anatomy 0.000 claims description 4
- 210000000582 semen Anatomy 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- 239000006228 supernatant Substances 0.000 claims description 4
- 210000001519 tissue Anatomy 0.000 claims description 4
- 101000638154 Homo sapiens Transmembrane protease serine 2 Proteins 0.000 claims description 2
- 102100031989 Transmembrane protease serine 2 Human genes 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 20
- 239000000523 sample Substances 0.000 claims 19
- 241000192019 Human endogenous retrovirus K Species 0.000 claims 12
- 230000008707 rearrangement Effects 0.000 claims 12
- 108091034117 Oligonucleotide Proteins 0.000 claims 7
- 239000012472 biological sample Substances 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- 108020001507 fusion proteins Proteins 0.000 claims 4
- 102000037865 fusion proteins Human genes 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 3
- 102100035616 Heterogeneous nuclear ribonucleoproteins A2/B1 Human genes 0.000 claims 2
- 101000854026 Homo sapiens Heterogeneous nuclear ribonucleoproteins A2/B1 Proteins 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 101000976889 Haemophilus phage HP1 (strain HP1c1) Uncharacterized 19.2 kDa protein in cox-rep intergenic region Proteins 0.000 claims 1
- 101000786896 Haemophilus phage HP1 (strain HP1c1) Uncharacterized 19.2 kDa protein in rep-hol intergenic region Proteins 0.000 claims 1
- 101000805098 Orgyia pseudotsugata multicapsid polyhedrosis virus Uncharacterized 73.1 kDa protein Proteins 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 108700026220 vif Genes Proteins 0.000 claims 1
- 238000007834 ligase chain reaction Methods 0.000 description 12
- 238000007899 nucleic acid hybridization Methods 0.000 description 12
- 238000003752 polymerase chain reaction Methods 0.000 description 12
- 238000003757 reverse transcription PCR Methods 0.000 description 12
- 150000007523 nucleic acids Chemical group 0.000 description 11
- 108091028043 Nucleic acid sequence Proteins 0.000 description 6
- 238000006073 displacement reaction Methods 0.000 description 6
- 230000001404 mediated effect Effects 0.000 description 6
- 238000002493 microarray Methods 0.000 description 6
- 238000013518 transcription Methods 0.000 description 6
- 230000035897 transcription Effects 0.000 description 6
- 108020004707 nucleic acids Proteins 0.000 description 5
- 102000039446 nucleic acids Human genes 0.000 description 5
- 238000012163 sequencing technique Methods 0.000 description 5
- 238000000636 Northern blotting Methods 0.000 description 3
- 238000002105 Southern blotting Methods 0.000 description 3
- 101001077418 Homo sapiens Potassium voltage-gated channel subfamily H member 6 Proteins 0.000 description 2
- 102100025135 Potassium voltage-gated channel subfamily H member 6 Human genes 0.000 description 2
- 101001047090 Homo sapiens Potassium voltage-gated channel subfamily H member 2 Proteins 0.000 description 1
- 102100022807 Potassium voltage-gated channel subfamily H member 2 Human genes 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000003203 nucleic acid sequencing method Methods 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/825,552 US10041123B2 (en) | 2005-09-12 | 2007-07-06 | Recurrent gene fusions in prostate cancer |
| US11/825,552 | 2007-07-06 | ||
| PCT/US2008/069204 WO2009009432A2 (en) | 2007-07-06 | 2008-07-03 | Recurrent gene fusions in prostate cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014016532A Division JP6035634B2 (ja) | 2007-07-06 | 2014-01-31 | 前立腺癌における再発性遺伝子融合 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010532663A JP2010532663A (ja) | 2010-10-14 |
| JP2010532663A5 true JP2010532663A5 (enExample) | 2011-08-11 |
| JP5529732B2 JP5529732B2 (ja) | 2014-06-25 |
Family
ID=40210565
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010515276A Expired - Fee Related JP5529732B2 (ja) | 2007-07-06 | 2008-07-03 | 前立腺癌における再発性遺伝子融合 |
| JP2014016532A Expired - Fee Related JP6035634B2 (ja) | 2007-07-06 | 2014-01-31 | 前立腺癌における再発性遺伝子融合 |
| JP2015205414A Withdrawn JP2016019542A (ja) | 2007-07-06 | 2015-10-19 | 前立腺癌における再発性遺伝子融合 |
| JP2017023924A Expired - Fee Related JP6404378B2 (ja) | 2007-07-06 | 2017-02-13 | 前立腺癌における再発性遺伝子融合 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014016532A Expired - Fee Related JP6035634B2 (ja) | 2007-07-06 | 2014-01-31 | 前立腺癌における再発性遺伝子融合 |
| JP2015205414A Withdrawn JP2016019542A (ja) | 2007-07-06 | 2015-10-19 | 前立腺癌における再発性遺伝子融合 |
| JP2017023924A Expired - Fee Related JP6404378B2 (ja) | 2007-07-06 | 2017-02-13 | 前立腺癌における再発性遺伝子融合 |
Country Status (6)
| Country | Link |
|---|---|
| EP (3) | EP2167689B1 (enExample) |
| JP (4) | JP5529732B2 (enExample) |
| AU (1) | AU2008275304B2 (enExample) |
| CA (2) | CA2814246A1 (enExample) |
| WO (1) | WO2009009432A2 (enExample) |
| ZA (1) | ZA201000128B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5512125B2 (ja) | 2005-09-12 | 2014-06-04 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 前立腺癌における再発性遺伝子融合 |
| US9957569B2 (en) | 2005-09-12 | 2018-05-01 | The Regents Of The University Of Michigan | Recurrent gene fusions in prostate cancer |
| WO2008039774A1 (en) | 2006-09-25 | 2008-04-03 | Mayo Foundation For Medical Education And Research | Extracellular and membrane-associated prostate cancer markers |
| US8338109B2 (en) | 2006-11-02 | 2012-12-25 | Mayo Foundation For Medical Education And Research | Predicting cancer outcome |
| CA2814246A1 (en) * | 2007-07-06 | 2009-01-15 | The Regents Of The University Of Michigan | Solute carrier family 45 member 3 (slc45a3) and erg family gene fusions in prostate cancer |
| ES2376509T3 (es) | 2007-07-06 | 2012-03-14 | The Regents Of The University Of Michigan | Reordenamientos de genes mipol 1-etv1. |
| WO2009020521A2 (en) | 2007-08-03 | 2009-02-12 | The Brigham And Women's Hospital, Inc. | Identification and treatment of estrogen responsive prostate tumors |
| CA2725978A1 (en) | 2008-05-28 | 2009-12-03 | Genomedx Biosciences, Inc. | Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer |
| US10407731B2 (en) | 2008-05-30 | 2019-09-10 | Mayo Foundation For Medical Education And Research | Biomarker panels for predicting prostate cancer outcomes |
| WO2011034906A2 (en) | 2009-09-17 | 2011-03-24 | The Regents Of The University Of Michigan | Recurrent gene fusions in prostate cancer |
| US20130267443A1 (en) | 2010-11-19 | 2013-10-10 | The Regents Of The University Of Michigan | ncRNA AND USES THEREOF |
| US8945556B2 (en) | 2010-11-19 | 2015-02-03 | The Regents Of The University Of Michigan | RAF gene fusions |
| US10513737B2 (en) | 2011-12-13 | 2019-12-24 | Decipher Biosciences, Inc. | Cancer diagnostics using non-coding transcripts |
| ES3015226T3 (en) | 2012-08-16 | 2025-04-30 | Veracyte Sd Inc | Prostate cancer prognosis using biomarkers |
| JP6044935B2 (ja) | 2013-03-11 | 2016-12-14 | 学校法人日本大学 | 新規ｐｉポリアミド |
| CN105308186A (zh) * | 2013-03-15 | 2016-02-03 | 詹森药业有限公司 | 预测性生物标记的测定法 |
| EP2975078A1 (en) | 2014-08-14 | 2016-01-20 | Omya International AG | Surface-treated fillers for breathable films |
| JP6920683B2 (ja) | 2015-10-08 | 2021-08-18 | 凸版印刷株式会社 | ピロールイミダゾール含有ポリアミドを用いた標的二本鎖核酸分子の濃縮方法およびキット |
| US11414708B2 (en) | 2016-08-24 | 2022-08-16 | Decipher Biosciences, Inc. | Use of genomic signatures to predict responsiveness of patients with prostate cancer to post-operative radiation therapy |
| AU2018210695B2 (en) | 2017-01-20 | 2024-07-18 | The University Of British Columbia | Molecular subtyping, prognosis, and treatment of bladder cancer |
| WO2018165600A1 (en) | 2017-03-09 | 2018-09-13 | Genomedx Biosciences, Inc. | Subtyping prostate cancer to predict response to hormone therapy |
| US11078542B2 (en) | 2017-05-12 | 2021-08-03 | Decipher Biosciences, Inc. | Genetic signatures to predict prostate cancer metastasis and identify tumor aggressiveness |
| AU2018310987A1 (en) | 2017-08-04 | 2020-02-27 | Decipher Biosciences, Inc. | Use of immune cell-specific gene expression for prognosis of prostate cancer and prediction of responsiveness to radiation therapy |
| CN114634913A (zh) * | 2022-02-27 | 2022-06-17 | 复旦大学 | 肿瘤硬脑膜转移模型的构建方法 |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3687808A (en) | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
| US4109496A (en) | 1977-12-20 | 1978-08-29 | Norris Industries | Trapped key mechanism |
| US4323546A (en) | 1978-05-22 | 1982-04-06 | Nuc Med Inc. | Method and composition for cancer detection in humans |
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| EP0232967B1 (en) | 1986-01-10 | 1993-04-28 | Amoco Corporation | Competitive homogeneous assay |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US5080891A (en) | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| US5283174A (en) | 1987-09-21 | 1994-02-01 | Gen-Probe, Incorporated | Homogenous protection assay |
| US5130238A (en) | 1988-06-24 | 1992-07-14 | Cangene Corporation | Enhanced nucleic acid amplification process |
| US4968103A (en) | 1988-07-22 | 1990-11-06 | Photofinish Cosmetics Inc. | Method of making a brush |
| US5225326A (en) | 1988-08-31 | 1993-07-06 | Research Development Foundation | One step in situ hybridization assay |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| GB8901778D0 (en) | 1989-01-27 | 1989-03-15 | Univ Court Of The University O | Manipulatory technique |
| US5480784A (en) | 1989-07-11 | 1996-01-02 | Gen-Probe Incorporated | Nucleic acid sequence amplification methods |
| CA2020958C (en) | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
| US5614396A (en) | 1990-06-14 | 1997-03-25 | Baylor College Of Medicine | Methods for the genetic modification of endogenous genes in animal cells by homologous recombination |
| US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
| US5489677A (en) | 1990-07-27 | 1996-02-06 | Isis Pharmaceuticals, Inc. | Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms |
| US5455166A (en) | 1991-01-31 | 1995-10-03 | Becton, Dickinson And Company | Strand displacement amplification |
| US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
| US5719262A (en) | 1993-11-22 | 1998-02-17 | Buchardt, Deceased; Ole | Peptide nucleic acids having amino acid side chains |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5270184A (en) | 1991-11-19 | 1993-12-14 | Becton, Dickinson And Company | Nucleic acid target generation |
| US5545524A (en) | 1991-12-04 | 1996-08-13 | The Regents Of The University Of Michigan | Compositions and methods for chromosome region-specific probes |
| CA2087413A1 (en) | 1992-01-17 | 1993-07-18 | Joseph R. Lakowicz | Fluorescent energy transfer immunoassay |
| CA2148252C (en) | 1992-10-30 | 2007-06-12 | Roger Brent | Interaction trap system for isolating novel proteins |
| GB9223084D0 (en) | 1992-11-04 | 1992-12-16 | Imp Cancer Res Tech | Compounds to target cells |
| AU6045094A (en) | 1993-02-19 | 1994-09-14 | Nippon Shinyaku Co. Ltd. | Drug composition containing nucleic acid copolymer |
| US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| US5648211A (en) | 1994-04-18 | 1997-07-15 | Becton, Dickinson And Company | Strand displacement amplification using thermophilic enzymes |
| CA2192442C (en) | 1994-06-10 | 2007-09-25 | Imre Kovesdi | Complementary adenoviral vector systems and cell lines |
| DK0787200T3 (da) | 1994-10-28 | 2005-08-15 | Univ Pennsylvania | Forbedret adenovirus og fremgangsmåder til anvendelse heraf |
| JP3189000B2 (ja) | 1994-12-01 | 2001-07-16 | 東ソー株式会社 | 特定核酸配列の検出方法 |
| US5872154A (en) | 1995-02-24 | 1999-02-16 | The Trustees Of The University Of Pennsylvania | Method of reducing an immune response to a recombinant adenovirus |
| US5707618A (en) | 1995-03-24 | 1998-01-13 | Genzyme Corporation | Adenovirus vectors for gene therapy |
| AU6261696A (en) | 1995-06-05 | 1996-12-24 | Trustees Of The University Of Pennsylvania, The | A replication-defective adenovirus human type 5 recombinant as a vaccine carrier |
| US5710029A (en) | 1995-06-07 | 1998-01-20 | Gen-Probe Incorporated | Methods for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product |
| KR100470180B1 (ko) | 1995-06-15 | 2005-02-04 | 크루셀 홀란드 비.브이. | 유전자 요법에 사용할 수 있는 인간의 재조합아데노바이러스 패키징 시스템 |
| US5854206A (en) | 1995-08-25 | 1998-12-29 | Corixa Corporation | Compounds and methods for treatment and diagnosis of prostate cancer |
| US5994316A (en) | 1996-02-21 | 1999-11-30 | The Immune Response Corporation | Method of preparing polynucleotide-carrier complexes for delivery to cells |
| US6121489A (en) | 1996-03-05 | 2000-09-19 | Trega Biosciences, Inc. | Selectively N-alkylated peptidomimetic combinatorial libraries and compounds therein |
| WO1997033909A2 (en) | 1996-03-15 | 1997-09-18 | Corixa Corporation | Compounds and methods for immunotherapy and immunodiagnosis of prostate cancer |
| AU713667B2 (en) | 1996-04-12 | 1999-12-09 | Phri Properties, Inc. | Detection probes, kits and assays |
| US5994132A (en) | 1996-10-23 | 1999-11-30 | University Of Michigan | Adenovirus vectors |
| HUP0002095A3 (en) | 1997-02-25 | 2002-02-28 | Corixa Corp Seattle | Compounds for immunotherapy of prostate cancer and methods for their use |
| US20030185830A1 (en) | 1997-02-25 | 2003-10-02 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6198107B1 (en) | 1997-03-07 | 2001-03-06 | Clare Chemical Research, Inc. | Fluorometric detection using visible light |
| US6080912A (en) | 1997-03-20 | 2000-06-27 | Wisconsin Alumni Research Foundation | Methods for creating transgenic animals |
| AU7019498A (en) | 1997-04-10 | 1998-10-30 | Diagnocure Inc. | Pca3, pca3 genes, and methods of use |
| US5830730A (en) | 1997-05-08 | 1998-11-03 | The Regents Of The University Of California | Enhanced adenovirus-assisted transfection composition and method |
| WO1999002685A1 (en) | 1997-07-11 | 1999-01-21 | Introgene B.V. | Interleukin-3 gene therapy for cancer |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| US5981225A (en) | 1998-04-16 | 1999-11-09 | Baylor College Of Medicine | Gene transfer vector, recombinant adenovirus particles containing the same, method for producing the same and method of use of the same |
| JP4646404B2 (ja) | 1998-07-02 | 2011-03-09 | ジェン−プローブ・インコーポレーテッド | 分子トーチ（ｔｏｒｃｈ） |
| CA2340682A1 (en) | 1998-08-14 | 2000-02-24 | Aventis Pharmaceuticals Products Inc. | Adenovirus formulations for gene therapy |
| KR20020013464A (ko) | 1998-08-27 | 2002-02-20 | 추후제출 | 이종 유전자의 전달을 위한 표적화된 아데노바이러스 벡터 |
| US6573043B1 (en) | 1998-10-07 | 2003-06-03 | Genentech, Inc. | Tissue analysis and kits therefor |
| US6828429B1 (en) | 1999-03-26 | 2004-12-07 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Prostate-specific gene, PCGEM1, and the methods of using PCGEM1 to detect, treat, and prevent prostate cancer |
| US6303305B1 (en) | 1999-03-30 | 2001-10-16 | Roche Diagnostics, Gmbh | Method for quantification of an analyte |
| EP1055734B1 (en) | 1999-05-24 | 2004-10-13 | Tosoh Corporation | Method for assaying ribonucleic acid |
| WO2001098537A2 (en) | 2000-06-17 | 2001-12-27 | Third Wave Technologies, Inc. | Nucleic acid accessible hybridization sites |
| US7229774B2 (en) | 2001-08-02 | 2007-06-12 | Regents Of The University Of Michigan | Expression profile of prostate cancer |
| JP4336198B2 (ja) | 2001-09-06 | 2009-09-30 | アトナーゲン アクチエンゲゼルシャフト | 細胞の選択、および／または定性および／または定量検出のための方法および診断キット |
| JP2005517450A (ja) | 2002-02-20 | 2005-06-16 | サーナ・セラピューティクス・インコーポレイテッド | 短干渉核酸（ｓｉＮＡ）を用いるＲＮＡ干渉媒介性標的発見および標的評価 |
| CA2524572C (en) | 2003-05-01 | 2018-07-10 | Gen-Probe Incorporated | Oligonucleotides comprising a molecular switch having enhanced sensitivity to the presence of a mismatch |
| WO2005038054A1 (en) | 2003-10-20 | 2005-04-28 | Zicai Liang | METHOD OF MEASURING THE EFFICACY OF siRNA MOLECULES |
| GB0327726D0 (en) | 2003-11-28 | 2003-12-31 | Isis Innovation | Method |
| EP2071031B1 (en) | 2004-08-27 | 2013-10-09 | Gen-Probe Incorporated | Single-primer nucleic acid amplification methods |
| JP5512125B2 (ja) * | 2005-09-12 | 2014-06-04 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 前立腺癌における再発性遺伝子融合 |
| CA2814246A1 (en) * | 2007-07-06 | 2009-01-15 | The Regents Of The University Of Michigan | Solute carrier family 45 member 3 (slc45a3) and erg family gene fusions in prostate cancer |
-
2008
- 2008-07-03 CA CA2814246A patent/CA2814246A1/en not_active Abandoned
- 2008-07-03 AU AU2008275304A patent/AU2008275304B2/en not_active Ceased
- 2008-07-03 WO PCT/US2008/069204 patent/WO2009009432A2/en not_active Ceased
- 2008-07-03 JP JP2010515276A patent/JP5529732B2/ja not_active Expired - Fee Related
- 2008-07-03 EP EP08772418A patent/EP2167689B1/en active Active
- 2008-07-03 EP EP12179588.4A patent/EP2604701B1/en active Active
- 2008-07-03 CA CA2692441A patent/CA2692441C/en not_active Expired - Fee Related
- 2008-07-03 EP EP15185944.4A patent/EP3018216B1/en not_active Not-in-force
-
2010
- 2010-01-07 ZA ZA2010/00128A patent/ZA201000128B/en unknown
-
2014
- 2014-01-31 JP JP2014016532A patent/JP6035634B2/ja not_active Expired - Fee Related
-
2015
- 2015-10-19 JP JP2015205414A patent/JP2016019542A/ja not_active Withdrawn
-
2017
- 2017-02-13 JP JP2017023924A patent/JP6404378B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019196400A5 (enExample) | ||
| JP2017108751A5 (enExample) | ||
| JP2009507492A5 (enExample) | ||
| EP2390371A1 (en) | Diagnosis kit and chip for bladder cancer using bladder cancer specific methylation marker gene | |
| WO2001075171A2 (en) | Methods, compositions and kits for the detection and monitoring of breast cancer | |
| CN104232763A (zh) | 使用肺癌特异性甲基化标记基因检测肺癌的方法 | |
| EP1341930A2 (en) | Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human adult liver | |
| WO2013141266A1 (ja) | 新規ｒｅｔ融合体の検出法 | |
| WO2003062389A2 (en) | UNIVERSAL RT-COUPLED PCR METHOD FOR THE SPECIFIC AMPLIFICATION OF mRNA | |
| CN102439174B (zh) | 基于检测slc45a3-elk4融合转录子的用于诊断前列腺癌的组合物和方法 | |
| Reichmuth et al. | The diagnostic potential of the chromosome translocation t (2; 13) in rhabdomyosarcoma: a PCR study of fresh‐frozen and paraffin‐embedded tumour samples | |
| KR101206029B1 (ko) | 대장암 진단용 다중 ｓｎｐ, 그를 포함하는 마이크로어레이및 키트 및 그를 이용한 대장암 진단 방법 | |
| CN101974642A (zh) | 错配修复基因mlh1突变检测试剂盒及其用途 | |
| US20130116144A1 (en) | Methylation marker for diagnosis of cervical cancer | |
| US8105816B2 (en) | Nucleic acid molecules encoding BANK1 splice variants | |
| CN111485024B (zh) | 用于个体特征确认的引物组合、及其应用 | |
| CN109913552B (zh) | 一种食管鳞癌诊疗靶点及应用 | |
| JP2007532110A (ja) | Ｆｃレセプターの多型の同定のための核酸ベースのアッセイ | |
| EP1856279A1 (en) | Method of diagnosing breast cancer and compositions therefor | |
| Browne et al. | The gene encoding chicken chromosomal protein HMG-14a is transcribed into multiple mRNAs | |
| Reed et al. | High-resolution genetic map of bovine chromosome 29 through focused marker development | |
| Lew et al. | The polymerase chain reaction and other amplification techniques in immunological research and diagnosis | |
| JP2007274986A (ja) | ２型糖尿病に対する感受性の判定方法 | |
| WO2010137671A1 (ja) | ガンのリンパ節転移またはそのリスクを判定する方法及びそのための迅速判定キット | |
| JP2013226074A (ja) | 新規ｄｄｒ２融合体 |