JP2010532663A5 - - Google Patents
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- JP2010532663A5 JP2010532663A5 JP2010515276A JP2010515276A JP2010532663A5 JP 2010532663 A5 JP2010532663 A5 JP 2010532663A5 JP 2010515276 A JP2010515276 A JP 2010515276A JP 2010515276 A JP2010515276 A JP 2010515276A JP 2010532663 A5 JP2010532663 A5 JP 2010532663A5
- Authority
- JP
- Japan
- Prior art keywords
- gene
- family member
- androgen
- ets family
- ets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000623 proteins and genes Proteins 0.000 claims description 83
- 238000000034 method Methods 0.000 claims description 76
- 102000040848 ETS family Human genes 0.000 claims description 46
- 108091071901 ETS family Proteins 0.000 claims description 46
- 230000001105 regulatory effect Effects 0.000 claims description 44
- 239000003098 androgen Substances 0.000 claims description 41
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 37
- 108700039887 Essential Genes Proteins 0.000 claims description 25
- 230000003321 amplification Effects 0.000 claims description 25
- 206010060862 Prostate cancer Diseases 0.000 claims description 23
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 23
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims description 23
- 108020004414 DNA Proteins 0.000 claims description 21
- 230000008711 chromosomal rearrangement Effects 0.000 claims description 21
- 108020004999 messenger RNA Proteins 0.000 claims description 21
- 230000004927 fusion Effects 0.000 claims description 18
- 230000002103 transcriptional effect Effects 0.000 claims description 18
- 108700005075 Regulator Genes Proteins 0.000 claims description 15
- 108091007568 SLC45A3 Proteins 0.000 claims description 15
- 102100037253 Solute carrier family 45 member 3 Human genes 0.000 claims description 15
- 238000007901 in situ hybridization Methods 0.000 claims description 14
- 210000002700 urine Anatomy 0.000 claims description 12
- 102100039577 ETS translocation variant 5 Human genes 0.000 claims description 9
- 101000813745 Homo sapiens ETS translocation variant 5 Proteins 0.000 claims description 9
- 102100039563 ETS translocation variant 1 Human genes 0.000 claims description 8
- 101000813729 Homo sapiens ETS translocation variant 1 Proteins 0.000 claims description 8
- 210000002307 prostate Anatomy 0.000 claims description 7
- 210000005267 prostate cell Anatomy 0.000 claims description 7
- 230000028327 secretion Effects 0.000 claims description 7
- 108700039691 Genetic Promoter Regions Proteins 0.000 claims description 5
- 210000004369 blood Anatomy 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 239000008188 pellet Substances 0.000 claims description 4
- 210000002381 plasma Anatomy 0.000 claims description 4
- 210000000582 semen Anatomy 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- 239000006228 supernatant Substances 0.000 claims description 4
- 210000001519 tissue Anatomy 0.000 claims description 4
- 101000638154 Homo sapiens Transmembrane protease serine 2 Proteins 0.000 claims description 2
- 102100031989 Transmembrane protease serine 2 Human genes 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 20
- 239000000523 sample Substances 0.000 claims 19
- 241000192019 Human endogenous retrovirus K Species 0.000 claims 12
- 230000008707 rearrangement Effects 0.000 claims 12
- 108091034117 Oligonucleotide Proteins 0.000 claims 7
- 239000012472 biological sample Substances 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- 108020001507 fusion proteins Proteins 0.000 claims 4
- 102000037865 fusion proteins Human genes 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 3
- 102100035616 Heterogeneous nuclear ribonucleoproteins A2/B1 Human genes 0.000 claims 2
- 101000854026 Homo sapiens Heterogeneous nuclear ribonucleoproteins A2/B1 Proteins 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 101000976889 Haemophilus phage HP1 (strain HP1c1) Uncharacterized 19.2 kDa protein in cox-rep intergenic region Proteins 0.000 claims 1
- 101000786896 Haemophilus phage HP1 (strain HP1c1) Uncharacterized 19.2 kDa protein in rep-hol intergenic region Proteins 0.000 claims 1
- 101000805098 Orgyia pseudotsugata multicapsid polyhedrosis virus Uncharacterized 73.1 kDa protein Proteins 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 108700026220 vif Genes Proteins 0.000 claims 1
- 238000007834 ligase chain reaction Methods 0.000 description 12
- 238000007899 nucleic acid hybridization Methods 0.000 description 12
- 238000003752 polymerase chain reaction Methods 0.000 description 12
- 238000003757 reverse transcription PCR Methods 0.000 description 12
- 150000007523 nucleic acids Chemical group 0.000 description 11
- 108091028043 Nucleic acid sequence Proteins 0.000 description 6
- 238000006073 displacement reaction Methods 0.000 description 6
- 230000001404 mediated effect Effects 0.000 description 6
- 238000002493 microarray Methods 0.000 description 6
- 238000013518 transcription Methods 0.000 description 6
- 230000035897 transcription Effects 0.000 description 6
- 108020004707 nucleic acids Proteins 0.000 description 5
- 102000039446 nucleic acids Human genes 0.000 description 5
- 238000012163 sequencing technique Methods 0.000 description 5
- 238000000636 Northern blotting Methods 0.000 description 3
- 238000002105 Southern blotting Methods 0.000 description 3
- 101001077418 Homo sapiens Potassium voltage-gated channel subfamily H member 6 Proteins 0.000 description 2
- 102100025135 Potassium voltage-gated channel subfamily H member 6 Human genes 0.000 description 2
- 101001047090 Homo sapiens Potassium voltage-gated channel subfamily H member 2 Proteins 0.000 description 1
- 102100022807 Potassium voltage-gated channel subfamily H member 2 Human genes 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000003203 nucleic acid sequencing method Methods 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/825,552 US10041123B2 (en) | 2005-09-12 | 2007-07-06 | Recurrent gene fusions in prostate cancer |
| US11/825,552 | 2007-07-06 | ||
| PCT/US2008/069204 WO2009009432A2 (en) | 2007-07-06 | 2008-07-03 | Recurrent gene fusions in prostate cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014016532A Division JP6035634B2 (ja) | 2007-07-06 | 2014-01-31 | 前立腺癌における再発性遺伝子融合 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010532663A JP2010532663A (ja) | 2010-10-14 |
| JP2010532663A5 true JP2010532663A5 (enExample) | 2011-08-11 |
| JP5529732B2 JP5529732B2 (ja) | 2014-06-25 |
Family
ID=40210565
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010515276A Expired - Fee Related JP5529732B2 (ja) | 2007-07-06 | 2008-07-03 | 前立腺癌における再発性遺伝子融合 |
| JP2014016532A Expired - Fee Related JP6035634B2 (ja) | 2007-07-06 | 2014-01-31 | 前立腺癌における再発性遺伝子融合 |
| JP2015205414A Withdrawn JP2016019542A (ja) | 2007-07-06 | 2015-10-19 | 前立腺癌における再発性遺伝子融合 |
| JP2017023924A Expired - Fee Related JP6404378B2 (ja) | 2007-07-06 | 2017-02-13 | 前立腺癌における再発性遺伝子融合 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014016532A Expired - Fee Related JP6035634B2 (ja) | 2007-07-06 | 2014-01-31 | 前立腺癌における再発性遺伝子融合 |
| JP2015205414A Withdrawn JP2016019542A (ja) | 2007-07-06 | 2015-10-19 | 前立腺癌における再発性遺伝子融合 |
| JP2017023924A Expired - Fee Related JP6404378B2 (ja) | 2007-07-06 | 2017-02-13 | 前立腺癌における再発性遺伝子融合 |
Country Status (6)
| Country | Link |
|---|---|
| EP (3) | EP3018216B1 (enExample) |
| JP (4) | JP5529732B2 (enExample) |
| AU (1) | AU2008275304B2 (enExample) |
| CA (2) | CA2692441C (enExample) |
| WO (1) | WO2009009432A2 (enExample) |
| ZA (1) | ZA201000128B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2622295C (en) | 2005-09-12 | 2019-01-15 | The Regents Of The University Of Michigan | Recurrent gene fusions in prostate cancer |
| US9957569B2 (en) | 2005-09-12 | 2018-05-01 | The Regents Of The University Of Michigan | Recurrent gene fusions in prostate cancer |
| US8273539B2 (en) | 2006-09-25 | 2012-09-25 | Mayo Foundation For Medical Education And Research | Extracellular and membrane-associated prostate cancer markers |
| US8338109B2 (en) | 2006-11-02 | 2012-12-25 | Mayo Foundation For Medical Education And Research | Predicting cancer outcome |
| CA2692441C (en) * | 2007-07-06 | 2020-01-21 | The Regents Of The University Of Michigan | Solute carrier family 45 member 3 (slc45a3) and ets family gene fusions in prostate cancer |
| US9303291B2 (en) | 2007-07-06 | 2016-04-05 | The Regents Of The University Of Michigan | MIPOL1-ETV1 gene rearrangements |
| US8106037B2 (en) | 2007-08-03 | 2012-01-31 | The Brigham And Women's Hospital, Inc. | Identification and treatment of estrogen responsive prostate tumors |
| CA2725978A1 (en) | 2008-05-28 | 2009-12-03 | Genomedx Biosciences, Inc. | Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer |
| US10407731B2 (en) | 2008-05-30 | 2019-09-10 | Mayo Foundation For Medical Education And Research | Biomarker panels for predicting prostate cancer outcomes |
| US9938582B2 (en) | 2009-09-17 | 2018-04-10 | The Regents Of The University Of Michigan | Recurrent gene fusions in prostate cancer |
| US20130267443A1 (en) | 2010-11-19 | 2013-10-10 | The Regents Of The University Of Michigan | ncRNA AND USES THEREOF |
| US8945556B2 (en) | 2010-11-19 | 2015-02-03 | The Regents Of The University Of Michigan | RAF gene fusions |
| EP2791359B1 (en) | 2011-12-13 | 2020-01-15 | Decipher Biosciences, Inc. | Cancer diagnostics using non-coding transcripts |
| ES3015226T3 (en) | 2012-08-16 | 2025-04-30 | Veracyte Sd Inc | Prostate cancer prognosis using biomarkers |
| JP6044935B2 (ja) | 2013-03-11 | 2016-12-14 | 学校法人日本大学 | 新規ｐｉポリアミド |
| US10041125B2 (en) | 2013-03-15 | 2018-08-07 | Janssen Pharmaceutica Nv | Assay for predictive biomarkers |
| EP2975078A1 (en) | 2014-08-14 | 2016-01-20 | Omya International AG | Surface-treated fillers for breathable films |
| JP6920683B2 (ja) | 2015-10-08 | 2021-08-18 | 凸版印刷株式会社 | ピロールイミダゾール含有ポリアミドを用いた標的二本鎖核酸分子の濃縮方法およびキット |
| EP3504348B1 (en) | 2016-08-24 | 2022-12-14 | Decipher Biosciences, Inc. | Use of genomic signatures to predict responsiveness of patients with prostate cancer to post-operative radiation therapy |
| WO2018132916A1 (en) | 2017-01-20 | 2018-07-26 | Genomedx Biosciences, Inc. | Molecular subtyping, prognosis, and treatment of bladder cancer |
| AU2018230784A1 (en) | 2017-03-09 | 2019-10-10 | Decipher Biosciences, Inc. | Subtyping prostate cancer to predict response to hormone therapy |
| WO2018205035A1 (en) | 2017-05-12 | 2018-11-15 | Genomedx Biosciences, Inc | Genetic signatures to predict prostate cancer metastasis and identify tumor agressiveness |
| WO2019028285A2 (en) | 2017-08-04 | 2019-02-07 | Genomedx, Inc. | USE OF SPECIFIC GENE EXPRESSION OF IMMUNE CELLS FOR THE PROGNOSIS OF PROSTATE CANCER AND THE PREDICTION OF SENSITIVITY TO RADIOTHERAPY |
| CN114634913A (zh) * | 2022-02-27 | 2022-06-17 | 复旦大学 | 肿瘤硬脑膜转移模型的构建方法 |
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| CA2622295C (en) * | 2005-09-12 | 2019-01-15 | The Regents Of The University Of Michigan | Recurrent gene fusions in prostate cancer |
| CA2692441C (en) * | 2007-07-06 | 2020-01-21 | The Regents Of The University Of Michigan | Solute carrier family 45 member 3 (slc45a3) and ets family gene fusions in prostate cancer |
-
2008
- 2008-07-03 CA CA2692441A patent/CA2692441C/en not_active Expired - Fee Related
- 2008-07-03 EP EP15185944.4A patent/EP3018216B1/en not_active Not-in-force
- 2008-07-03 JP JP2010515276A patent/JP5529732B2/ja not_active Expired - Fee Related
- 2008-07-03 WO PCT/US2008/069204 patent/WO2009009432A2/en not_active Ceased
- 2008-07-03 EP EP12179588.4A patent/EP2604701B1/en active Active
- 2008-07-03 AU AU2008275304A patent/AU2008275304B2/en not_active Ceased
- 2008-07-03 EP EP08772418A patent/EP2167689B1/en active Active
- 2008-07-03 CA CA2814246A patent/CA2814246A1/en not_active Abandoned
-
2010
- 2010-01-07 ZA ZA2010/00128A patent/ZA201000128B/en unknown
-
2014
- 2014-01-31 JP JP2014016532A patent/JP6035634B2/ja not_active Expired - Fee Related
-
2015
- 2015-10-19 JP JP2015205414A patent/JP2016019542A/ja not_active Withdrawn
-
2017
- 2017-02-13 JP JP2017023924A patent/JP6404378B2/ja not_active Expired - Fee Related
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