JP2010531878A5 - - Google Patents
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- JP2010531878A5 JP2010531878A5 JP2010514839A JP2010514839A JP2010531878A5 JP 2010531878 A5 JP2010531878 A5 JP 2010531878A5 JP 2010514839 A JP2010514839 A JP 2010514839A JP 2010514839 A JP2010514839 A JP 2010514839A JP 2010531878 A5 JP2010531878 A5 JP 2010531878A5
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- Prior art keywords
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- pharmaceutical composition
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- cancer cells
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- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 101001003140 Homo sapiens Interleukin-15 receptor subunit alpha Proteins 0.000 claims 16
- 206010028980 Neoplasm Diseases 0.000 claims 15
- 201000011510 cancer Diseases 0.000 claims 15
- 101001055157 Homo sapiens Interleukin-15 Proteins 0.000 claims 12
- 102000056003 human IL15 Human genes 0.000 claims 12
- 102000003812 Interleukin-15 Human genes 0.000 claims 10
- 108090000172 Interleukin-15 Proteins 0.000 claims 10
- 238000000034 method Methods 0.000 claims 2
- 229950006780 n-acetylglucosamine Drugs 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 230000036737 immune function Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000001678 irradiating effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 239000012679 serum free medium Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93747107P | 2007-06-27 | 2007-06-27 | |
| PCT/US2008/008084 WO2009002562A2 (en) | 2007-06-27 | 2008-06-27 | Complexes of il-15 and il-15ralpha and uses thereof |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014001373A Division JP2014114294A (ja) | 2007-06-27 | 2014-01-08 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2015115431A Division JP2015212270A (ja) | 2007-06-27 | 2015-06-08 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010531878A JP2010531878A (ja) | 2010-09-30 |
| JP2010531878A5 true JP2010531878A5 (enExample) | 2011-08-11 |
Family
ID=40186225
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010514839A Pending JP2010531878A (ja) | 2007-06-27 | 2008-06-27 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2014001373A Pending JP2014114294A (ja) | 2007-06-27 | 2014-01-08 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2015115431A Pending JP2015212270A (ja) | 2007-06-27 | 2015-06-08 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2016226503A Withdrawn JP2017079745A (ja) | 2007-06-27 | 2016-11-22 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2018245439A Withdrawn JP2019088288A (ja) | 2007-06-27 | 2018-12-27 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2021086283A Pending JP2021152017A (ja) | 2007-06-27 | 2021-05-21 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2022172896A Pending JP2023015158A (ja) | 2007-06-27 | 2022-10-28 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014001373A Pending JP2014114294A (ja) | 2007-06-27 | 2014-01-08 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2015115431A Pending JP2015212270A (ja) | 2007-06-27 | 2015-06-08 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2016226503A Withdrawn JP2017079745A (ja) | 2007-06-27 | 2016-11-22 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2018245439A Withdrawn JP2019088288A (ja) | 2007-06-27 | 2018-12-27 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2021086283A Pending JP2021152017A (ja) | 2007-06-27 | 2021-05-21 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2022172896A Pending JP2023015158A (ja) | 2007-06-27 | 2022-10-28 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US9931377B2 (enExample) |
| EP (3) | EP2724727A1 (enExample) |
| JP (7) | JP2010531878A (enExample) |
| AU (1) | AU2008269032B2 (enExample) |
| CA (1) | CA2691785C (enExample) |
| DK (1) | DK2173378T3 (enExample) |
| ES (2) | ES2716476T3 (enExample) |
| HK (1) | HK1198421A1 (enExample) |
| IL (1) | IL202997A (enExample) |
| NZ (4) | NZ599338A (enExample) |
| WO (1) | WO2009002562A2 (enExample) |
Families Citing this family (117)
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| CA2636111C (en) | 2006-01-13 | 2018-04-03 | The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health | Codon optimized il-15 and il-15r-alpha genes for expression in mammalian cells |
| EP2160401B1 (en) | 2007-05-11 | 2014-09-24 | Altor BioScience Corporation | Fusion molecules and il-15 variants |
| CA2691785C (en) | 2007-06-27 | 2017-01-10 | Marine Polymer Technologies Inc. | Complexes of il-15 and il-15ralpha and uses thereof |
| US8871191B2 (en) | 2009-08-14 | 2014-10-28 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of IL-15 preparations to treat lymphopenia |
| WO2011032179A1 (en) * | 2009-09-14 | 2011-03-17 | The Trustees Of The University Of Pennsylvania | Vaccines and immunotherapeutics comprising il-15 receptor alpha and/or nucleic acid molecules encoding the same, and methods for using the same |
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