JP2010531166A

JP2010531166A - 眼科用溶液

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Publication number: JP2010531166A
Authority: JP; Japan
Prior art keywords: monomer; substituted; unsubstituted; solution; group
Prior art date: 2007-06-22
Legal status : Pending

Application number

JP2010513330A

Other languages

English (en)

Japanese (ja)

Other versions

JP2010531166A5 (https=

Inventor

ライ，ユ−チン

ラン，ウェイホン

Original Assignee

ボーシュアンドロームインコーポレイティド

Priority date

2007-06-22

Filing date

2008-06-11

Publication date

2010-09-24

2008-06-11 Application filed by ボーシュアンドロームインコーポレイティド filed Critical ボーシュアンドロームインコーポレイティド

2010-09-24 Publication of JP2010531166A publication Critical patent/JP2010531166A/ja

2011-07-28 Publication of JP2010531166A5 publication Critical patent/JP2010531166A5/ja

Status Pending legal-status Critical Current

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239000002997 ophthalmic solution Substances 0.000 title abstract description 13
229940054534 ophthalmic solution Drugs 0.000 title abstract description 9
239000000178 monomer Substances 0.000 claims abstract description 163
239000000243 solution Substances 0.000 claims abstract description 121
239000000203 mixture Substances 0.000 claims abstract description 108
238000004806 packaging method and process Methods 0.000 claims abstract description 77
238000006116 polymerization reaction Methods 0.000 claims abstract description 29
230000001954 sterilising effect Effects 0.000 claims abstract description 26
230000003204 osmotic effect Effects 0.000 claims abstract description 11
-1 hydroxyalkyl acrylate Chemical compound 0.000 claims description 68
125000002947 alkylene group Chemical group 0.000 claims description 47
238000000034 method Methods 0.000 claims description 47
229920001577 copolymer Polymers 0.000 claims description 39
239000001257 hydrogen Substances 0.000 claims description 28
229910052739 hydrogen Inorganic materials 0.000 claims description 28
125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 26
239000007864 aqueous solution Substances 0.000 claims description 19
125000002091 cationic group Chemical group 0.000 claims description 16
244000005700 microbiome Species 0.000 claims description 16
150000001875 compounds Chemical class 0.000 claims description 14
239000000417 fungicide Substances 0.000 claims description 11
OXJGJKIURHREKH-UHFFFAOYSA-O CC(=C)C(=O)OCCP(=O)=C(O)C[N+](C)(C)C Chemical compound CC(=C)C(=O)OCCP(=O)=C(O)C[N+](C)(C)C OXJGJKIURHREKH-UHFFFAOYSA-O 0.000 claims description 8
125000001453 quaternary ammonium group Chemical group 0.000 claims description 8
230000000844 anti-bacterial effect Effects 0.000 claims description 7
238000012545 processing Methods 0.000 claims description 7
UZNHKBFIBYXPDV-UHFFFAOYSA-N trimethyl-[3-(2-methylprop-2-enoylamino)propyl]azanium;chloride Chemical compound [Cl-].CC(=C)C(=O)NCCC[N+](C)(C)C UZNHKBFIBYXPDV-UHFFFAOYSA-N 0.000 claims description 7
NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 6
DENRZWYUOJLTMF-UHFFFAOYSA-N diethyl sulfate Chemical compound CCOS(=O)(=O)OCC DENRZWYUOJLTMF-UHFFFAOYSA-N 0.000 claims description 6
229940008406 diethyl sulfate Drugs 0.000 claims description 6
125000003709 fluoroalkyl group Chemical group 0.000 claims description 6
229920002554 vinyl polymer Polymers 0.000 claims description 6
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 5
JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 claims description 5
239000000872 buffer Substances 0.000 claims description 5
238000007789 sealing Methods 0.000 claims description 5
FZGFBJMPSHGTRQ-UHFFFAOYSA-M trimethyl(2-prop-2-enoyloxyethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCOC(=O)C=C FZGFBJMPSHGTRQ-UHFFFAOYSA-M 0.000 claims description 5
RRHXZLALVWBDKH-UHFFFAOYSA-M trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium;chloride Chemical compound [Cl-].CC(=C)C(=O)OCC[N+](C)(C)C RRHXZLALVWBDKH-UHFFFAOYSA-M 0.000 claims description 5
DQHTXJNVTIBYSA-UHFFFAOYSA-N dimethyl-[3-(2-methylprop-2-enoylamino)propyl]-(3-sulfopropyl)azanium;hydroxide Chemical compound [OH-].CC(=C)C(=O)NCCC[N+](C)(C)CCCS(O)(=O)=O DQHTXJNVTIBYSA-UHFFFAOYSA-N 0.000 claims description 4
VYFGDMAXYITNFT-UHFFFAOYSA-N ethyl phosphate;trimethylazanium Chemical compound C[NH+](C)C.C[NH+](C)C.CCOP([O-])([O-])=O VYFGDMAXYITNFT-UHFFFAOYSA-N 0.000 claims description 4
125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims description 4
229910019142 PO4 Inorganic materials 0.000 claims description 2
125000000129 anionic group Chemical group 0.000 claims description 2
125000004435 hydrogen atom Chemical class [H]* 0.000 claims 9
HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 2
239000006172 buffering agent Substances 0.000 claims 1
239000010452 phosphate Substances 0.000 claims 1
239000003206 sterilizing agent Substances 0.000 claims 1
238000004140 cleaning Methods 0.000 abstract description 10
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 47
239000000047 product Substances 0.000 description 36
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238000004659 sterilization and disinfection Methods 0.000 description 15
239000004094 surface-active agent Substances 0.000 description 13
GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 12
239000003085 diluting agent Substances 0.000 description 12
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229910021641 deionized water Inorganic materials 0.000 description 11
150000002431 hydrogen Chemical class 0.000 description 11
229910052757 nitrogen Inorganic materials 0.000 description 11
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 9
150000003839 salts Chemical class 0.000 description 9
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 8
239000002253 acid Substances 0.000 description 8
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125000003118 aryl group Chemical group 0.000 description 7
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239000004615 ingredient Substances 0.000 description 7
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NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 6
239000007983 Tris buffer Substances 0.000 description 6
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235000014113 dietary fatty acids Nutrition 0.000 description 6
239000000194 fatty acid Substances 0.000 description 6
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150000004665 fatty acids Chemical class 0.000 description 6
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CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 6
238000002360 preparation method Methods 0.000 description 6
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239000011780 sodium chloride Substances 0.000 description 6
239000004215 Carbon black (E152) Substances 0.000 description 5
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SUHOQUVVVLNYQR-MRVPVSSYSA-N choline alfoscerate Chemical compound C[N+](C)(C)CCOP([O-])(=O)OC[C@H](O)CO SUHOQUVVVLNYQR-MRVPVSSYSA-N 0.000 description 5
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230000018044 dehydration Effects 0.000 description 5
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125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 4
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LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 description 4
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125000004433 nitrogen atom Chemical group N* 0.000 description 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
238000001228 spectrum Methods 0.000 description 4
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