JP2010530746A5 - - Google Patents
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- Publication number
- JP2010530746A5 JP2010530746A5 JP2010512384A JP2010512384A JP2010530746A5 JP 2010530746 A5 JP2010530746 A5 JP 2010530746A5 JP 2010512384 A JP2010512384 A JP 2010512384A JP 2010512384 A JP2010512384 A JP 2010512384A JP 2010530746 A5 JP2010530746 A5 JP 2010530746A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- rrm1
- level
- cancer
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010022394 Threonine synthase Proteins 0.000 claims 20
- 102000005497 Thymidylate Synthase Human genes 0.000 claims 20
- 238000000034 method Methods 0.000 claims 18
- 230000014509 gene expression Effects 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 230000001086 cytosolic effect Effects 0.000 claims 6
- 239000003153 chemical reaction reagent Substances 0.000 claims 5
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 4
- 238000002512 chemotherapy Methods 0.000 claims 4
- 201000005202 lung cancer Diseases 0.000 claims 4
- 208000020816 lung neoplasm Diseases 0.000 claims 4
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 3
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 102000000505 Ribonucleotide Reductases Human genes 0.000 claims 2
- 108010041388 Ribonucleotide Reductases Proteins 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000002299 complementary DNA Substances 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 2
- 229960005277 gemcitabine Drugs 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 230000036210 malignancy Effects 0.000 claims 2
- QOFFJEBXNKRSPX-ZDUSSCGKSA-N pemetrexed Chemical compound C1=N[C]2NC(N)=NC(=O)C2=C1CCC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QOFFJEBXNKRSPX-ZDUSSCGKSA-N 0.000 claims 2
- 229960005079 pemetrexed Drugs 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- 238000004393 prognosis Methods 0.000 claims 2
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 1
- 102100034343 Integrase Human genes 0.000 claims 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims 1
- 101150118217 RRM1 gene Proteins 0.000 claims 1
- 101150112897 TS gene Proteins 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000007853 buffer solution Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000002055 immunohistochemical effect Effects 0.000 claims 1
- 238000010249 in-situ analysis Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 238000010837 poor prognosis Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000001262 western blot Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94415707P | 2007-06-15 | 2007-06-15 | |
| US60/944,157 | 2007-06-15 | ||
| US3955508P | 2008-03-26 | 2008-03-26 | |
| US61/039,555 | 2008-03-26 | ||
| PCT/US2008/066918 WO2008157353A1 (en) | 2007-06-15 | 2008-06-13 | Methods of diagnosing and treating cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010530746A JP2010530746A (ja) | 2010-09-16 |
| JP2010530746A5 true JP2010530746A5 (enExample) | 2012-05-24 |
| JP5479332B2 JP5479332B2 (ja) | 2014-04-23 |
Family
ID=40156627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010512384A Expired - Fee Related JP5479332B2 (ja) | 2007-06-15 | 2008-06-13 | 癌の診断方法および治療方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20090017012A1 (enExample) |
| EP (1) | EP2171086B1 (enExample) |
| JP (1) | JP5479332B2 (enExample) |
| KR (1) | KR20100044780A (enExample) |
| CN (1) | CN101815793A (enExample) |
| AU (1) | AU2008266048A1 (enExample) |
| BR (1) | BRPI0813364A2 (enExample) |
| CA (1) | CA2690865A1 (enExample) |
| ES (1) | ES2401475T3 (enExample) |
| MX (1) | MX2009013646A (enExample) |
| RU (1) | RU2010101093A (enExample) |
| WO (1) | WO2008157353A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008541701A (ja) * | 2005-05-04 | 2008-11-27 | ユニヴァーシティ オブ サウス フロリダ | がんの対象における処置応答の予測 |
| US8700335B2 (en) | 2006-05-18 | 2014-04-15 | Caris Mpi, Inc. | System and method for determining individualized medical intervention for a disease state |
| US8768629B2 (en) * | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
| EP2350320A4 (en) * | 2008-11-12 | 2012-11-14 | Caris Life Sciences Luxembourg Holdings | METHOD AND SYSTEMS FOR USE OF EXOSOMES FOR THE DETERMINATION OF PHENOTYPES |
| JP5024736B2 (ja) | 2009-10-15 | 2012-09-12 | 住友電気工業株式会社 | 発電システム |
| AU2011223789A1 (en) | 2010-03-01 | 2012-09-20 | Caris Life Sciences Switzerland Holdings Gmbh | Biomarkers for theranostics |
| KR20130028727A (ko) | 2010-03-29 | 2013-03-19 | 아브락시스 바이오사이언스, 엘엘씨 | 치료제의 약물 전달 및 유효성 향상 방법 |
| US9393318B2 (en) * | 2010-03-29 | 2016-07-19 | Abraxis Bioscience, Llc | Methods of treating cancer |
| KR20130043104A (ko) | 2010-04-06 | 2013-04-29 | 카리스 라이프 사이언스 룩셈부르크 홀딩스 | 질병용 순환 생물학적 지표들 |
| KR101602532B1 (ko) * | 2013-08-29 | 2016-03-11 | 경북대학교 산학협력단 | 위암의 재발 가능성 예측을 위한 정보제공 방법 |
| JP6681475B2 (ja) * | 2015-10-26 | 2020-04-15 | サイフェローム | がん患者のゲノム塩基配列変異情報と生存情報を利用したカスタマイズ型の薬物選択方法及びシステム |
| EP4178448A4 (en) * | 2020-07-10 | 2025-06-18 | Progenics Pharmaceuticals, Inc. | Methods of making prostate cancer treatment decisions |
| CN113957145B (zh) * | 2021-10-19 | 2023-09-26 | 中国医学科学院肿瘤医院 | m6A相关lncRNA在预测小细胞肺癌预后和化疗反应的应用 |
| CN114564622B (zh) * | 2022-03-03 | 2025-07-25 | 苏州良医汇网络科技有限公司 | 一种tnm分期表录入系统的方法、装置以及设备 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5705336A (en) * | 1995-03-07 | 1998-01-06 | The United States Of America As Represented By The Department Of Health And Human Services | Assay for sensitivity of tumors to DNA-platinating chemotherapy |
| US20020090642A1 (en) * | 1995-12-11 | 2002-07-11 | Patrick G. Johnston | Methods for determining the prognosis of breast cancer using antibodies specific for thymidylate synthase |
| WO1998033518A1 (en) * | 1997-02-04 | 1998-08-06 | Sloan-Kettering Institute For Cancer Research | Mutants of thymidylate synthase and uses thereof |
| US6087489A (en) * | 1998-06-02 | 2000-07-11 | Isis Pharmaceuticals Inc. | Antisense oligonucleotide modulation of human thymidylate synthase expression |
| EP1191096B1 (en) * | 1999-06-28 | 2011-10-12 | Yusuke Nakamura | Ovel protein and dna thereof |
| US6248535B1 (en) * | 1999-12-20 | 2001-06-19 | University Of Southern California | Method for isolation of RNA from formalin-fixed paraffin-embedded tissue specimens |
| US6602670B2 (en) * | 2000-12-01 | 2003-08-05 | Response Genetics, Inc. | Method of determining a chemotherapeutic regimen based on ERCC1 expression |
| US6582919B2 (en) * | 2001-06-11 | 2003-06-24 | Response Genetics, Inc. | Method of determining epidermal growth factor receptor and HER2-neu gene expression and correlation of levels thereof with survival rates |
| US7049059B2 (en) * | 2000-12-01 | 2006-05-23 | Response Genetics, Inc. | Method of determining a chemotherapeutic regimen based on ERCC1 and TS expression |
| US6518416B1 (en) * | 2000-12-01 | 2003-02-11 | Response Genetics, Inc. | Method of determining a chemotherapeutic regimen based on ERCC1 expression |
| US6956111B2 (en) * | 2001-03-02 | 2005-10-18 | Response Genetics, Inc. | Method of determining dihydropyrimidine dehydrogenase gene expression |
| US6686155B2 (en) * | 2001-06-14 | 2004-02-03 | Response Genetics, Inc. | Method of determining a chemotherapeutic regimen based on glutathione-S-transferase pi expression |
| WO2004031408A1 (en) * | 2002-09-30 | 2004-04-15 | F.Hoffmann-La Roche Ag | Oligonucleotides for genotyping thymidylate synthase gene |
| AU2004285103A1 (en) * | 2003-09-29 | 2005-05-12 | Pathwork Diagnostics, Inc. | Systems and methods for detecting biological features |
| JP2008541701A (ja) * | 2005-05-04 | 2008-11-27 | ユニヴァーシティ オブ サウス フロリダ | がんの対象における処置応答の予測 |
-
2008
- 2008-06-13 RU RU2010101093/10A patent/RU2010101093A/ru not_active Application Discontinuation
- 2008-06-13 BR BRPI0813364-6A2A patent/BRPI0813364A2/pt not_active IP Right Cessation
- 2008-06-13 AU AU2008266048A patent/AU2008266048A1/en not_active Abandoned
- 2008-06-13 WO PCT/US2008/066918 patent/WO2008157353A1/en not_active Ceased
- 2008-06-13 ES ES08771019T patent/ES2401475T3/es active Active
- 2008-06-13 EP EP08771019A patent/EP2171086B1/en not_active Not-in-force
- 2008-06-13 CN CN200880102571A patent/CN101815793A/zh active Pending
- 2008-06-13 CA CA2690865A patent/CA2690865A1/en not_active Abandoned
- 2008-06-13 MX MX2009013646A patent/MX2009013646A/es not_active Application Discontinuation
- 2008-06-13 US US12/139,134 patent/US20090017012A1/en not_active Abandoned
- 2008-06-13 JP JP2010512384A patent/JP5479332B2/ja not_active Expired - Fee Related
- 2008-06-13 KR KR1020107000955A patent/KR20100044780A/ko not_active Withdrawn
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