JP2010530238A5 - - Google Patents

Info

Publication number

JP2010530238A5

JP2010530238A5 JP2010512807A JP2010512807A JP2010530238A5 JP 2010530238 A5 JP2010530238 A5 JP 2010530238A5 JP 2010512807 A JP2010512807 A JP 2010512807A JP 2010512807 A JP2010512807 A JP 2010512807A JP 2010530238 A5 JP2010530238 A5 JP 2010530238A5

Authority

JP

Japan

Prior art keywords

seq

thrombin

amino acid

acid sequence

exosite

Prior art date

2008-06-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 claims 12
• 101000712605 Theromyzon tessulatum Theromin Proteins 0.000 claims 10
• 108090000190 Thrombin Proteins 0.000 claims 10
• 229940122388 Thrombin inhibitor Drugs 0.000 claims 10
• 125000003275 alpha amino acid group Chemical group 0.000 claims 10
• 229960004072 thrombin Drugs 0.000 claims 10
• 239000003868 thrombin inhibitor Substances 0.000 claims 10
• 101710083324 Variegin Proteins 0.000 claims 8
• 201000010099 disease Diseases 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 238000003776 cleavage reaction Methods 0.000 claims 4
• 102000039446 nucleic acids Human genes 0.000 claims 4
• 108020004707 nucleic acids Proteins 0.000 claims 4
• 150000007523 nucleic acids Chemical class 0.000 claims 4
• 230000007017 scission Effects 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 208000007536 Thrombosis Diseases 0.000 claims 2
• 238000009825 accumulation Methods 0.000 claims 2
• 208000015294 blood coagulation disease Diseases 0.000 claims 2
• 239000012634 fragment Substances 0.000 claims 2
• 230000003211 malignant effect Effects 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 102000009123 Fibrin Human genes 0.000 claims 1
• 108010073385 Fibrin Proteins 0.000 claims 1
• BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 1
• 230000002159 abnormal effect Effects 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 229950003499 fibrin Drugs 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 230000000069 prophylactic effect Effects 0.000 claims 1