JP2010529200A5 - - Google Patents
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- Publication number
- JP2010529200A5 JP2010529200A5 JP2010512241A JP2010512241A JP2010529200A5 JP 2010529200 A5 JP2010529200 A5 JP 2010529200A5 JP 2010512241 A JP2010512241 A JP 2010512241A JP 2010512241 A JP2010512241 A JP 2010512241A JP 2010529200 A5 JP2010529200 A5 JP 2010529200A5
- Authority
- JP
- Japan
- Prior art keywords
- isopropylpiperazin
- ylmethyl
- phenyl
- bipyridinyl
- hexahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 3
- PNOOMSVMGWAEBT-UHFFFAOYSA-N n,n-dimethyl-4-[6-[(4-propan-2-ylpiperazin-1-yl)methyl]pyridin-3-yl]benzamide Chemical compound C1CN(C(C)C)CCN1CC1=CC=C(C=2C=CC(=CC=2)C(=O)N(C)C)C=N1 PNOOMSVMGWAEBT-UHFFFAOYSA-N 0.000 claims 2
- DAVZGTOMALWXCJ-UHFFFAOYSA-N (4-methylpiperazin-1-yl)-[4-[5-[(4-propan-2-ylpiperazin-1-yl)methyl]pyridin-2-yl]phenyl]methanone Chemical compound C1CN(C(C)C)CCN1CC1=CC=C(C=2C=CC(=CC=2)C(=O)N2CCN(C)CC2)N=C1 DAVZGTOMALWXCJ-UHFFFAOYSA-N 0.000 claims 1
- NHTOQWBSOYPAMS-UHFFFAOYSA-N (4-methylpiperazin-1-yl)-[4-[6-(1-propan-2-ylpiperidin-4-yl)pyridin-3-yl]phenyl]methanone Chemical compound C1CN(C(C)C)CCC1C1=CC=C(C=2C=CC(=CC=2)C(=O)N2CCN(C)CC2)C=N1 NHTOQWBSOYPAMS-UHFFFAOYSA-N 0.000 claims 1
- YBHCACLGNQGJLP-UHFFFAOYSA-N (4-methylpiperazin-1-yl)-[4-[6-[(4-propan-2-ylpiperazin-1-yl)methyl]pyridazin-3-yl]phenyl]methanone Chemical compound C1CN(C(C)C)CCN1CC1=CC=C(C=2C=CC(=CC=2)C(=O)N2CCN(C)CC2)N=N1 YBHCACLGNQGJLP-UHFFFAOYSA-N 0.000 claims 1
- XQSHJCISSDLGEV-UHFFFAOYSA-N (4-methylpiperazin-1-yl)-[4-[6-[(4-propan-2-ylpiperazin-1-yl)methyl]pyridin-3-yl]phenyl]methanone Chemical compound C1CN(C(C)C)CCN1CC1=CC=C(C=2C=CC(=CC=2)C(=O)N2CCN(C)CC2)C=N1 XQSHJCISSDLGEV-UHFFFAOYSA-N 0.000 claims 1
- KMIVAGCIHIXFIP-UHFFFAOYSA-N [2-fluoro-4-[6-(1-propan-2-ylpiperidin-4-yl)pyridin-3-yl]phenyl]-pyrrolidin-1-ylmethanone Chemical compound C1CN(C(C)C)CCC1C1=CC=C(C=2C=C(F)C(C(=O)N3CCCC3)=CC=2)C=N1 KMIVAGCIHIXFIP-UHFFFAOYSA-N 0.000 claims 1
- XVLBUNVMXRTBHP-UHFFFAOYSA-N [4-[6-(1-propan-2-ylpiperidin-4-yl)pyridin-3-yl]phenyl]-pyrrolidin-1-ylmethanone Chemical compound C1CN(C(C)C)CCC1C1=CC=C(C=2C=CC(=CC=2)C(=O)N2CCCC2)C=N1 XVLBUNVMXRTBHP-UHFFFAOYSA-N 0.000 claims 1
- QNBXHIFHBCHDGL-UHFFFAOYSA-N morpholin-4-yl-[4-[6-[(4-propan-2-ylpiperazin-1-yl)methyl]pyridazin-3-yl]phenyl]methanone Chemical compound C1CN(C(C)C)CCN1CC1=CC=C(C=2C=CC(=CC=2)C(=O)N2CCOCC2)N=N1 QNBXHIFHBCHDGL-UHFFFAOYSA-N 0.000 claims 1
- YDSYVOPWZSMHER-UHFFFAOYSA-N n,n-dimethyl-4-[5-[(4-propan-2-ylpiperazin-1-yl)methyl]pyridin-2-yl]benzamide Chemical compound C1CN(C(C)C)CCN1CC1=CC=C(C=2C=CC(=CC=2)C(=O)N(C)C)N=C1 YDSYVOPWZSMHER-UHFFFAOYSA-N 0.000 claims 1
- AVRKXXJCLSNMEN-UHFFFAOYSA-N n,n-dimethyl-4-[6-[(4-propan-2-ylpiperazin-1-yl)methyl]pyridazin-3-yl]benzamide Chemical compound C1CN(C(C)C)CCN1CC1=CC=C(C=2C=CC(=CC=2)C(=O)N(C)C)N=N1 AVRKXXJCLSNMEN-UHFFFAOYSA-N 0.000 claims 1
- MMEYJWQPBRFMNG-UHFFFAOYSA-N n-[4-[5-[(4-propan-2-ylpiperazin-1-yl)methyl]pyridin-2-yl]phenyl]acetamide Chemical compound C1CN(C(C)C)CCN1CC1=CC=C(C=2C=CC(NC(C)=O)=CC=2)N=C1 MMEYJWQPBRFMNG-UHFFFAOYSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- PWJLBMVKVLMYOA-UHFFFAOYSA-N piperidin-1-yl-[4-[6-[(4-propan-2-ylpiperazin-1-yl)methyl]pyridazin-3-yl]phenyl]methanone Chemical compound C1CN(C(C)C)CCN1CC1=CC=C(C=2C=CC(=CC=2)C(=O)N2CCCCC2)N=N1 PWJLBMVKVLMYOA-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07109949A EP2014656A3 (en) | 2007-06-11 | 2007-06-11 | New heteocyclic h3 antagonists |
| US93451407P | 2007-06-13 | 2007-06-13 | |
| PCT/US2008/064106 WO2008154126A1 (en) | 2007-06-11 | 2008-05-19 | New heteocyclic h3 antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010529200A JP2010529200A (ja) | 2010-08-26 |
| JP2010529200A5 true JP2010529200A5 (enExample) | 2011-06-02 |
Family
ID=39337237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010512241A Withdrawn JP2010529200A (ja) | 2007-06-11 | 2008-05-19 | 新規の複素環ｈ３アンタゴニスト |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8344001B2 (enExample) |
| EP (2) | EP2014656A3 (enExample) |
| JP (1) | JP2010529200A (enExample) |
| CN (1) | CN101795567A (enExample) |
| AR (1) | AR066946A1 (enExample) |
| CA (1) | CA2690486A1 (enExample) |
| CL (1) | CL2008001705A1 (enExample) |
| TW (1) | TW200918054A (enExample) |
| WO (1) | WO2008154126A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030236259A1 (en) * | 2002-02-05 | 2003-12-25 | Rolf Hohlweg | Novel aryl- and heteroarylpiperazines |
| ES2375929T3 (es) * | 2005-07-04 | 2012-03-07 | High Point Pharmaceuticals, Llc | Antagonistas del receptor histamina h3. |
| CA2653062A1 (en) * | 2006-05-23 | 2007-11-29 | Transtech Pharma, Inc. | 6- (4-cyclopropylpiperazin-1-yl) -2 ' -methyl- [3, 4 ' ] -bipyridine and its use as a medicament |
| HRP20120227T1 (hr) * | 2006-05-29 | 2012-04-30 | High Point Pharmaceuticals | 3-(1,3-benzodioksol-5-il)-6-(4-ciklopropilpiperazin-1-il)piridazin, njegove soli i solvati te njegova uporaba kao antagonista histaminskog h3 receptora |
| US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
| CA2693169C (en) | 2007-07-19 | 2016-01-12 | Metabolex, Inc. | N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders |
| PL2280704T3 (pl) * | 2008-03-31 | 2015-10-30 | Cymabay Therapeutics Inc | Związki oksymetylenoarylowe i ich zastosowania |
| BRPI0914891A2 (pt) * | 2008-06-20 | 2015-11-24 | Metabolex Inc | agonistas de aril gpr119 e usos dos mesmos |
| WO2010013849A1 (ja) * | 2008-08-01 | 2010-02-04 | 日本ケミファ株式会社 | Ｇｐｒ１１９作動薬 |
| WO2011025006A1 (ja) * | 2009-08-31 | 2011-03-03 | 日本ケミファ株式会社 | Ｇｐｒ１１９作動薬 |
| EP2483281B1 (en) | 2009-10-01 | 2014-06-04 | Cymabay Therapeutics, Inc. | Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts |
| CA2802541A1 (en) | 2010-06-23 | 2011-12-29 | Metabolex, Inc. | Compositions of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| US8729263B2 (en) * | 2012-08-13 | 2014-05-20 | Novartis Ag | 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions |
| MX2020011652A (es) | 2013-07-31 | 2022-09-27 | Novartis Ag | Derivados de piridazina 1,4-disustituida, y su uso para el tratamiento de afecciones relacionadas con la deficiencia de smn. |
| EP3053577A1 (en) * | 2015-02-09 | 2016-08-10 | F. Hoffmann-La Roche AG | Compounds for the treatment of cancer |
| CN107428729B (zh) * | 2015-02-09 | 2021-07-16 | 豪夫迈·罗氏有限公司 | 用于治疗癌症的化合物 |
| CN113750101A (zh) * | 2015-12-10 | 2021-12-07 | Ptc医疗公司 | 用于治疗亨廷顿病的方法 |
| WO2018026890A1 (en) | 2016-08-03 | 2018-02-08 | Cymabay Therapeutics | Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions |
| JOP20190219A1 (ar) * | 2017-05-09 | 2019-09-22 | Cardix Therapeutics LLC | تركيبات صيدلانية وطرق لعلاج أمراض القلب والأوعية الدموية |
| US11407753B2 (en) | 2017-06-05 | 2022-08-09 | Ptc Therapeutics, Inc. | Compounds for treating Huntington's disease |
| EP3645121B8 (en) | 2017-06-28 | 2025-06-18 | PTC Therapeutics, Inc. | Methods for treating huntington's disease |
| CA3067591A1 (en) | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | Methods for treating huntington's disease |
| KR20210005559A (ko) | 2018-03-27 | 2021-01-14 | 피티씨 테라퓨틱스, 인크. | 헌팅턴병 치료 화합물 |
| TWI657825B (zh) * | 2018-04-04 | 2019-05-01 | 美進醫藥公司 | 治療心血管疾病的組合藥物及其製備和使用方法 |
| CN108440401A (zh) * | 2018-04-13 | 2018-08-24 | 华东理工大学 | 5-[(4-乙基哌嗪-1-基)甲基]吡啶-2-胺的制备方法 |
| LT3814357T (lt) | 2018-06-27 | 2024-06-25 | Ptc Therapeutics, Inc. | Heterocikliniai ir heteroarilų junginiai, skirti hantingtono ligos gydymui |
| US11685746B2 (en) | 2018-06-27 | 2023-06-27 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating Huntington's disease |
| WO2020005877A1 (en) | 2018-06-27 | 2020-01-02 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| WO2023076586A1 (en) | 2021-10-29 | 2023-05-04 | Sensorium Therapeutics, Inc. | Delivery of therapeutic alkaloid compounds |
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| FR2885616B1 (fr) * | 2005-05-12 | 2007-06-22 | Servier Lab | Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| ES2375929T3 (es) | 2005-07-04 | 2012-03-07 | High Point Pharmaceuticals, Llc | Antagonistas del receptor histamina h3. |
| US7956050B2 (en) | 2005-07-15 | 2011-06-07 | Albany Molecular Research, Inc. | Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
| JP2009506987A (ja) | 2005-08-02 | 2009-02-19 | ニューロゲン コーポレイション | ジピペラジニルケトンおよび関連する類似体 |
| JP2009531376A (ja) | 2006-03-28 | 2009-09-03 | ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー | ヒスタミンｈ３受容体活性を有するベンゾチアゾール |
| CA2653062A1 (en) | 2006-05-23 | 2007-11-29 | Transtech Pharma, Inc. | 6- (4-cyclopropylpiperazin-1-yl) -2 ' -methyl- [3, 4 ' ] -bipyridine and its use as a medicament |
| HRP20120227T1 (hr) | 2006-05-29 | 2012-04-30 | High Point Pharmaceuticals | 3-(1,3-benzodioksol-5-il)-6-(4-ciklopropilpiperazin-1-il)piridazin, njegove soli i solvati te njegova uporaba kao antagonista histaminskog h3 receptora |
-
2007
- 2007-06-11 EP EP07109949A patent/EP2014656A3/en not_active Withdrawn
-
2008
- 2008-05-19 WO PCT/US2008/064106 patent/WO2008154126A1/en not_active Ceased
- 2008-05-19 US US12/663,103 patent/US8344001B2/en not_active Expired - Fee Related
- 2008-05-19 JP JP2010512241A patent/JP2010529200A/ja not_active Withdrawn
- 2008-05-19 CA CA2690486A patent/CA2690486A1/en not_active Abandoned
- 2008-05-19 EP EP08755859A patent/EP2166850A4/en not_active Withdrawn
- 2008-05-19 CN CN200880100442A patent/CN101795567A/zh active Pending
- 2008-05-30 TW TW097120318A patent/TW200918054A/zh unknown
- 2008-06-10 CL CL2008001705A patent/CL2008001705A1/es unknown
- 2008-06-10 AR ARP080102468A patent/AR066946A1/es unknown
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