JP2010529200A - 新規の複素環ｈ３アンタゴニスト - Google Patents
新規の複素環ｈ３アンタゴニスト Download PDFInfo
- Publication number
- JP2010529200A JP2010529200A JP2010512241A JP2010512241A JP2010529200A JP 2010529200 A JP2010529200 A JP 2010529200A JP 2010512241 A JP2010512241 A JP 2010512241A JP 2010512241 A JP2010512241 A JP 2010512241A JP 2010529200 A JP2010529200 A JP 2010529200A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- mmol
- ylmethyl
- compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- NJJRJGVTDADMTP-UHFFFAOYSA-N Brc1ccc(C2CCNCC2)nc1 Chemical compound Brc1ccc(C2CCNCC2)nc1 NJJRJGVTDADMTP-UHFFFAOYSA-N 0.000 description 1
- ALHHKUAVUOTOSE-UHFFFAOYSA-N Brc1cnc(CC2CCNCC2)cc1 Chemical compound Brc1cnc(CC2CCNCC2)cc1 ALHHKUAVUOTOSE-UHFFFAOYSA-N 0.000 description 1
- VORCPNVRAYWBNP-UHFFFAOYSA-N C(CNCC1)C1c(cc1)ncc1-c(cc1)ccc1N1CCOCC1 Chemical compound C(CNCC1)C1c(cc1)ncc1-c(cc1)ccc1N1CCOCC1 VORCPNVRAYWBNP-UHFFFAOYSA-N 0.000 description 1
- KMIVAGCIHIXFIP-UHFFFAOYSA-N CC(C)N(CC1)CCC1c(cc1)ncc1-c(cc1)cc(F)c1C(N1CCCC1)=O Chemical compound CC(C)N(CC1)CCC1c(cc1)ncc1-c(cc1)cc(F)c1C(N1CCCC1)=O KMIVAGCIHIXFIP-UHFFFAOYSA-N 0.000 description 1
- OFQCWRLVOGDQKN-UHFFFAOYSA-N CC(C)N(CC1)CCC1c(cc1)ncc1-c(cc1)ccc1S(N1CCCCC1)(=O)=O Chemical compound CC(C)N(CC1)CCC1c(cc1)ncc1-c(cc1)ccc1S(N1CCCCC1)(=O)=O OFQCWRLVOGDQKN-UHFFFAOYSA-N 0.000 description 1
- YBHCACLGNQGJLP-UHFFFAOYSA-N CC(C)N1CCN(Cc2ccc(-c(cc3)ccc3C(N3CCN(C)CC3)=O)nn2)CC1 Chemical compound CC(C)N1CCN(Cc2ccc(-c(cc3)ccc3C(N3CCN(C)CC3)=O)nn2)CC1 YBHCACLGNQGJLP-UHFFFAOYSA-N 0.000 description 1
- QWJXDWYHZTVSRH-UHFFFAOYSA-N CC(C)N1CCN(Cc2ccc(-c(cc3)ccc3S(N3CCOCC3)(=O)=O)nc2)CC1 Chemical compound CC(C)N1CCN(Cc2ccc(-c(cc3)ccc3S(N3CCOCC3)(=O)=O)nc2)CC1 QWJXDWYHZTVSRH-UHFFFAOYSA-N 0.000 description 1
- GLUVUXHOVXUICA-UHFFFAOYSA-N CCN(CC)C(c(cc1)ccc1-c1cnc(C(CC2)CCN2C(C)C)cc1)=O Chemical compound CCN(CC)C(c(cc1)ccc1-c1cnc(C(CC2)CCN2C(C)C)cc1)=O GLUVUXHOVXUICA-UHFFFAOYSA-N 0.000 description 1
- BMZZANKJFUYGFL-UHFFFAOYSA-N CCS(c(cc1)ccc1-c1ccc(CN(CC2)CCN2C2CCC2)nc1)(=O)=O Chemical compound CCS(c(cc1)ccc1-c1ccc(CN(CC2)CCN2C2CCC2)nc1)(=O)=O BMZZANKJFUYGFL-UHFFFAOYSA-N 0.000 description 1
- JVNMAJRSXAXSLX-UHFFFAOYSA-N CN(CC1)CCN1C(c(cc1)ccc1-c1cnc(C(CC2)CCN2C2=CCC2)cc1)=O Chemical compound CN(CC1)CCN1C(c(cc1)ccc1-c1cnc(C(CC2)CCN2C2=CCC2)cc1)=O JVNMAJRSXAXSLX-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Otolaryngology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07109949A EP2014656A3 (en) | 2007-06-11 | 2007-06-11 | New heteocyclic h3 antagonists |
| US93451407P | 2007-06-13 | 2007-06-13 | |
| PCT/US2008/064106 WO2008154126A1 (en) | 2007-06-11 | 2008-05-19 | New heteocyclic h3 antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010529200A true JP2010529200A (ja) | 2010-08-26 |
| JP2010529200A5 JP2010529200A5 (enExample) | 2011-06-02 |
Family
ID=39337237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010512241A Withdrawn JP2010529200A (ja) | 2007-06-11 | 2008-05-19 | 新規の複素環ｈ３アンタゴニスト |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8344001B2 (enExample) |
| EP (2) | EP2014656A3 (enExample) |
| JP (1) | JP2010529200A (enExample) |
| CN (1) | CN101795567A (enExample) |
| AR (1) | AR066946A1 (enExample) |
| CA (1) | CA2690486A1 (enExample) |
| CL (1) | CL2008001705A1 (enExample) |
| TW (1) | TW200918054A (enExample) |
| WO (1) | WO2008154126A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015524842A (ja) * | 2012-08-13 | 2015-08-27 | ノバルティス アーゲー | １，４−二置換ピリダジン類似体およびｓｍｎ欠損に関連する状態を処置するための方法 |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030236259A1 (en) * | 2002-02-05 | 2003-12-25 | Rolf Hohlweg | Novel aryl- and heteroarylpiperazines |
| ES2375929T3 (es) * | 2005-07-04 | 2012-03-07 | High Point Pharmaceuticals, Llc | Antagonistas del receptor histamina h3. |
| CA2653062A1 (en) * | 2006-05-23 | 2007-11-29 | Transtech Pharma, Inc. | 6- (4-cyclopropylpiperazin-1-yl) -2 ' -methyl- [3, 4 ' ] -bipyridine and its use as a medicament |
| HRP20120227T1 (hr) * | 2006-05-29 | 2012-04-30 | High Point Pharmaceuticals | 3-(1,3-benzodioksol-5-il)-6-(4-ciklopropilpiperazin-1-il)piridazin, njegove soli i solvati te njegova uporaba kao antagonista histaminskog h3 receptora |
| US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
| CA2693169C (en) | 2007-07-19 | 2016-01-12 | Metabolex, Inc. | N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders |
| PL2280704T3 (pl) * | 2008-03-31 | 2015-10-30 | Cymabay Therapeutics Inc | Związki oksymetylenoarylowe i ich zastosowania |
| BRPI0914891A2 (pt) * | 2008-06-20 | 2015-11-24 | Metabolex Inc | agonistas de aril gpr119 e usos dos mesmos |
| WO2010013849A1 (ja) * | 2008-08-01 | 2010-02-04 | 日本ケミファ株式会社 | Ｇｐｒ１１９作動薬 |
| WO2011025006A1 (ja) * | 2009-08-31 | 2011-03-03 | 日本ケミファ株式会社 | Ｇｐｒ１１９作動薬 |
| EP2483281B1 (en) | 2009-10-01 | 2014-06-04 | Cymabay Therapeutics, Inc. | Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts |
| CA2802541A1 (en) | 2010-06-23 | 2011-12-29 | Metabolex, Inc. | Compositions of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| MX2020011652A (es) | 2013-07-31 | 2022-09-27 | Novartis Ag | Derivados de piridazina 1,4-disustituida, y su uso para el tratamiento de afecciones relacionadas con la deficiencia de smn. |
| EP3053577A1 (en) * | 2015-02-09 | 2016-08-10 | F. Hoffmann-La Roche AG | Compounds for the treatment of cancer |
| CN107428729B (zh) * | 2015-02-09 | 2021-07-16 | 豪夫迈·罗氏有限公司 | 用于治疗癌症的化合物 |
| CN113750101A (zh) * | 2015-12-10 | 2021-12-07 | Ptc医疗公司 | 用于治疗亨廷顿病的方法 |
| WO2018026890A1 (en) | 2016-08-03 | 2018-02-08 | Cymabay Therapeutics | Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions |
| JOP20190219A1 (ar) * | 2017-05-09 | 2019-09-22 | Cardix Therapeutics LLC | تركيبات صيدلانية وطرق لعلاج أمراض القلب والأوعية الدموية |
| US11407753B2 (en) | 2017-06-05 | 2022-08-09 | Ptc Therapeutics, Inc. | Compounds for treating Huntington's disease |
| EP3645121B8 (en) | 2017-06-28 | 2025-06-18 | PTC Therapeutics, Inc. | Methods for treating huntington's disease |
| CA3067591A1 (en) | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | Methods for treating huntington's disease |
| KR20210005559A (ko) | 2018-03-27 | 2021-01-14 | 피티씨 테라퓨틱스, 인크. | 헌팅턴병 치료 화합물 |
| TWI657825B (zh) * | 2018-04-04 | 2019-05-01 | 美進醫藥公司 | 治療心血管疾病的組合藥物及其製備和使用方法 |
| CN108440401A (zh) * | 2018-04-13 | 2018-08-24 | 华东理工大学 | 5-[(4-乙基哌嗪-1-基)甲基]吡啶-2-胺的制备方法 |
| LT3814357T (lt) | 2018-06-27 | 2024-06-25 | Ptc Therapeutics, Inc. | Heterocikliniai ir heteroarilų junginiai, skirti hantingtono ligos gydymui |
| US11685746B2 (en) | 2018-06-27 | 2023-06-27 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating Huntington's disease |
| WO2020005877A1 (en) | 2018-06-27 | 2020-01-02 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| WO2023076586A1 (en) | 2021-10-29 | 2023-05-04 | Sensorium Therapeutics, Inc. | Delivery of therapeutic alkaloid compounds |
Family Cites Families (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB753166A (en) | 1953-05-22 | 1956-07-18 | Miles Lab | Improvements in or relating to substituted piperazines |
| US2993899A (en) | 1958-03-31 | 1961-07-25 | Miles Lab | Acetylenically unsaturated piperazine derivatives |
| US3309370A (en) | 1964-07-16 | 1967-03-14 | Miles Lab | Bicycloalkyl piperazine derivatives and process |
| GB1293565A (en) | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
| US3886161A (en) | 1970-12-14 | 1975-05-27 | Sandoz Ag | 2-Piperazino-3-cyano-5-phenyl-pyridines |
| GB1345880A (en) | 1971-06-18 | 1974-02-06 | Cepbepe | Pyridazine derivatives |
| DE2516040C2 (de) | 1974-06-10 | 1984-12-20 | Dr. Karl Thomae Gmbh, 7950 Biberach | Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| FR2306694A1 (fr) | 1975-04-07 | 1976-11-05 | Parcor | Derives de la piperazine |
| GB1545094A (en) | 1976-12-14 | 1979-05-02 | Gist Brocades Nv | Piperazine derivatives |
| US4144346A (en) | 1977-01-31 | 1979-03-13 | Janssen Pharmaceutica N.V. | Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles |
| HU175471B (hu) | 1977-06-13 | 1980-08-28 | Gyogyszerkutato Intezet | Sposob poluchenija novykh proizvodnykh 3-skobka-1-pirazolil-skobka zakryta-piridazina |
| US4163849A (en) | 1978-03-17 | 1979-08-07 | Merck & Co., Inc. | Piperazinylpyrazines |
| DE2824764A1 (de) | 1978-06-06 | 1979-12-20 | Hoechst Ag | Neue pyridylpiperazinderivate und verfahren zu ihrer herstellung |
| EP0034752B1 (en) | 1980-02-22 | 1983-06-08 | Tanabe Seiyaku Co., Ltd. | Phenoxyalkane derivative and processes for preparing same |
| US4518712A (en) | 1980-06-30 | 1985-05-21 | Taiho Pharmaceutical Company Limited | Piperazine derivative and analgesic composition containing the same |
| FR2491470A1 (fr) | 1980-10-08 | 1982-04-09 | Innothera Lab Sa | Nouvelles cyclopropylmethyl piperazines, leur procede de preparation et leur application en therapeutique |
| US4339579A (en) | 1980-12-29 | 1982-07-13 | American Home Products Corporation | 2,6-Bis-(pyrrolopyrazinyl)pyrazines |
| US4616014A (en) | 1981-10-22 | 1986-10-07 | Fujisawa Pharmaceutical Co., Ltd. | Triazine derivatives, and pharmaceutical compositions comprising the same |
| US5001125A (en) | 1984-03-26 | 1991-03-19 | Janssen Pharmaceutica N.V. | Anti-virally active pyridazinamines |
| FR2573075B1 (fr) | 1984-09-14 | 1987-03-20 | Innothera Lab Sa | Nouvelles (pyridyl-2)-1 piperazines, leur procede de preparation et leur application en therapeutique |
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-
2007
- 2007-06-11 EP EP07109949A patent/EP2014656A3/en not_active Withdrawn
-
2008
- 2008-05-19 WO PCT/US2008/064106 patent/WO2008154126A1/en not_active Ceased
- 2008-05-19 US US12/663,103 patent/US8344001B2/en not_active Expired - Fee Related
- 2008-05-19 JP JP2010512241A patent/JP2010529200A/ja not_active Withdrawn
- 2008-05-19 CA CA2690486A patent/CA2690486A1/en not_active Abandoned
- 2008-05-19 EP EP08755859A patent/EP2166850A4/en not_active Withdrawn
- 2008-05-19 CN CN200880100442A patent/CN101795567A/zh active Pending
- 2008-05-30 TW TW097120318A patent/TW200918054A/zh unknown
- 2008-06-10 CL CL2008001705A patent/CL2008001705A1/es unknown
- 2008-06-10 AR ARP080102468A patent/AR066946A1/es unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015524842A (ja) * | 2012-08-13 | 2015-08-27 | ノバルティス アーゲー | １，４−二置換ピリダジン類似体およびｓｍｎ欠損に関連する状態を処置するための方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| AR066946A1 (es) | 2009-09-23 |
| EP2014656A2 (en) | 2009-01-14 |
| WO2008154126A1 (en) | 2008-12-18 |
| CN101795567A (zh) | 2010-08-04 |
| EP2166850A4 (en) | 2010-06-02 |
| CL2008001705A1 (es) | 2009-03-06 |
| EP2166850A1 (en) | 2010-03-31 |
| US20100267721A1 (en) | 2010-10-21 |
| TW200918054A (en) | 2009-05-01 |
| US8344001B2 (en) | 2013-01-01 |
| CA2690486A1 (en) | 2008-12-18 |
| EP2014656A3 (en) | 2011-08-24 |
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