JP2010526091A5 - - Google Patents

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Publication number
JP2010526091A5
JP2010526091A5 JP2010506622A JP2010506622A JP2010526091A5 JP 2010526091 A5 JP2010526091 A5 JP 2010526091A5 JP 2010506622 A JP2010506622 A JP 2010506622A JP 2010506622 A JP2010506622 A JP 2010506622A JP 2010526091 A5 JP2010526091 A5 JP 2010526091A5
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JP
Japan
Prior art keywords
click
independently
saturated
functionalized
group
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Pending
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JP2010506622A
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English (en)
Japanese (ja)
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JP2010526091A (ja
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Priority claimed from PCT/US2008/062113 external-priority patent/WO2008134761A2/en
Publication of JP2010526091A publication Critical patent/JP2010526091A/ja
Publication of JP2010526091A5 publication Critical patent/JP2010526091A5/ja
Pending legal-status Critical Current

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JP2010506622A 2007-04-30 2008-04-30 癌の処置のための生物学的な標的基の改変 Pending JP2010526091A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91507007P 2007-04-30 2007-04-30
PCT/US2008/062113 WO2008134761A2 (en) 2007-04-30 2008-04-30 Modification of biological targeting groups for the treatment of cancer

Publications (2)

Publication Number Publication Date
JP2010526091A JP2010526091A (ja) 2010-07-29
JP2010526091A5 true JP2010526091A5 (US07638558-20091229-C00477.png) 2012-03-15

Family

ID=39820986

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010506622A Pending JP2010526091A (ja) 2007-04-30 2008-04-30 癌の処置のための生物学的な標的基の改変

Country Status (4)

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US (1) US20090110662A1 (US07638558-20091229-C00477.png)
EP (1) EP2155177A2 (US07638558-20091229-C00477.png)
JP (1) JP2010526091A (US07638558-20091229-C00477.png)
WO (1) WO2008134761A2 (US07638558-20091229-C00477.png)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2010477A4 (en) 2006-04-27 2012-05-30 Intezyne Technologies Inc POLY (ETHYLENE GLYCOL) CONTAINING CHEMICALLY DISPARATE ENDOGROUP
EP2502628B1 (en) * 2006-06-23 2016-12-14 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in cancer
US8258190B2 (en) 2007-04-30 2012-09-04 Intezyne Technologies, Inc. Encapsulated contrast agents
GB0803076D0 (en) 2008-02-20 2008-03-26 Univ Ghent Mucosal Membrane Receptor and uses thereof
EP2279011B1 (en) 2008-04-30 2017-10-25 Siemens Medical Solutions USA, Inc. Substrate based pet imaging agents
MX336869B (es) 2008-11-03 2016-02-04 Alethia Biotherapeutics Inc Anticuerpos que bloquean espicificamente la actividad biologica de un antigeno de tumor.
EP2424359A4 (en) 2009-04-30 2014-01-15 Intezyne Technologies Inc POLYMIC MICELLES WITH ANTHRACYCLINES FOR THE TREATMENT OF CANCER
US8524784B2 (en) 2009-04-30 2013-09-03 Intezyne Technologies, Incorporated Polymer micelles containing anthracylines for the treatment of cancer
CA2760771A1 (en) * 2009-05-04 2010-11-11 Intezyne Technologies, Incorporated Polymer micelles containing sn-38 for the treatment of cancer
GB2470770A (en) 2009-06-04 2010-12-08 Medical Res Council Incorporation of unnatural amino acids having an orthogonal functional group into polypeptides using orthogonal tRNA/tRNA synthetase pairs
US11673914B2 (en) 2009-11-10 2023-06-13 Allegro Pharmaceuticals, LLC Peptide therapies for reduction of macular thickening
MX346362B (es) 2009-11-10 2017-03-15 Allegro Pharmaceuticals Inc * Composiciones y metodos para inhibir la adhesion celular o dirigir agentes de diagnostico o terapeuticos a sitios de enlace rgd.
CA2785410A1 (en) * 2009-12-23 2011-06-30 Carlos F. Barbas, Iii Tyrosine bioconjugation through aqueous ene-like reactions
KR101993259B1 (ko) 2011-03-31 2019-06-27 에이디씨 테라퓨틱스 에스에이 신장 결합 항원 1에 대한 항체 및 이의 항원 결합 단편
WO2012142659A1 (en) * 2011-04-19 2012-10-26 Baker Idi Heart And Diabetes Institute Holdings Limited Site-selective modification of proteins
ES2820855T3 (es) 2011-05-09 2021-04-22 Allegro Pharmaceuticals Llc Antagonistas del receptor de integrina y sus métodos de uso
CN102335190B (zh) * 2011-07-18 2013-01-23 华东师范大学 还原降解释药可控的巯嘌呤纳米胶束前药及其应用
DK2802351T3 (da) 2012-01-09 2019-05-13 Adc Therapeutics Sa Midler til behandling af triple-negativ brystkræft
JP5927338B2 (ja) 2012-04-11 2016-06-01 インテザイン テクノロジーズ, インコーポレイテッド 安定なミセルのためのブロックコポリマー
US20150148525A1 (en) 2012-05-18 2015-05-28 Medical Research Council Methods of incorporating an amino acid comprising a bcn group into a polypeptide using an orthogonal codon encoding it and an orthorgonal pylrs synthase
JP6498600B2 (ja) 2012-06-08 2019-04-10 ストロ バイオファーマ インコーポレーテッド 部位特異的な非天然アミノ酸残基を含む抗体、その調製方法、及びその使用方法
US9732161B2 (en) 2012-06-26 2017-08-15 Sutro Biopharma, Inc. Modified Fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
WO2014007632A1 (en) * 2012-07-06 2014-01-09 Stichting Het Nederlands Kanker Instituut Cysteine protease capturing agents
CN104981254B (zh) 2012-08-31 2018-05-22 苏特罗生物制药公司 含有叠氮基的经修饰的氨基酸
SG11201504974PA (en) 2012-12-24 2015-07-30 Agency Science Tech & Res Self-assembling ultrashort peptides modified with bioactive agents by click chemistry
WO2014165842A2 (en) * 2013-04-05 2014-10-09 Igdrasol Nanoparticle formulations in biomarker detection
EP3019522B1 (en) 2013-07-10 2017-12-13 Sutro Biopharma, Inc. Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
US20170080093A1 (en) * 2013-10-22 2017-03-23 Tyme, Inc. Tyrosine Derivatives And Compositions Comprising Them
CN106102835B (zh) 2014-01-13 2020-11-03 博格有限责任公司 烯醇酶1(eno1)组合物及其用途
GB2528227A (en) 2014-03-14 2016-01-20 Medical Res Council Cyclopropene amino acids and methods
US9303069B2 (en) * 2014-05-05 2016-04-05 University Of Mississippi Medical Center Peptides for treating cancer
CN104177476B (zh) * 2014-08-29 2016-10-05 国家纳米科学中心 一种靶向人癌细胞的多肽及其应用
MX2018009085A (es) 2016-01-27 2019-05-09 Sutro Biopharma Inc Conjugados de anticuerpos anti-cd74, composiciones que comprenden conjugados de anticuerpos anti-cd74 y metodos de uso de congujados de anticuerpos anti-cd74.
CN105859834B (zh) * 2016-04-12 2019-07-19 北京大学 一种用于靶向治疗的多肽和核酸偶联化合物
CA3043464A1 (en) * 2016-11-09 2018-05-17 Ohio State Innovation Foundation Di-sulfide containing cell penetrating peptides and methods of making and using thereof
US10913773B2 (en) 2016-11-22 2021-02-09 Ohio State Innovation Foundation Bicyclic peptidyl inhibitor of tumor necrosis factor-alpha
WO2018098282A2 (en) 2016-11-22 2018-05-31 Ohio State Innovation Foundation Cyclic cell penetrating peptides comprising beta-hairpin motifs and methods of making and using thereof
JP7289029B2 (ja) * 2017-07-10 2023-06-09 エスアールアイ インターナショナル 分子誘導システムペプチド及びその使用
CA3075650A1 (en) * 2017-10-17 2019-04-25 University Of Wollongong Anti-cancer agent
EP3790890A4 (en) 2018-05-09 2022-03-02 Ohio State Innovation Foundation CYCLIC PEPTIDES OF CELL PENETRATION WITH ONE OR MORE HYDROPHOBIC RESIDUES
GB201810325D0 (en) * 2018-06-22 2018-08-08 Bicycletx Ltd Peptide ligands for binding to PSMA
CN113876784B (zh) * 2021-09-27 2023-07-21 潍坊博创国际生物医药研究院 硼代亮氨酸类化合物的新用途
CN115869312B (zh) * 2022-12-27 2024-02-27 哈尔滨吉象隆生物技术有限公司 一种pdc抗肿瘤药物及其制备方法与应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650750A (en) * 1982-02-01 1987-03-17 Giese Roger W Method of chemical analysis employing molecular release tag compounds
US5516931A (en) * 1982-02-01 1996-05-14 Northeastern University Release tag compounds producing ketone signal groups
US4709016A (en) * 1982-02-01 1987-11-24 Northeastern University Molecular analytical release tags and their use in chemical analysis
US5650270A (en) * 1982-02-01 1997-07-22 Northeastern University Molecular analytical release tags and their use in chemical analysis
US20030008819A1 (en) * 1995-09-08 2003-01-09 Schnitzer Jan E. Targeting endothelium for tissue-specific delivery of agents
US5622699A (en) * 1995-09-11 1997-04-22 La Jolla Cancer Research Foundation Method of identifying molecules that home to a selected organ in vivo
US6068829A (en) * 1995-09-11 2000-05-30 The Burnham Institute Method of identifying molecules that home to a selected organ in vivo
US6576239B1 (en) * 1996-09-10 2003-06-10 The Burnham Institute Angiogenic homing molecules and conjugates derived therefrom
US6180084B1 (en) * 1998-08-25 2001-01-30 The Burnham Institute NGR receptor and methods of identifying tumor homing molecules that home to angiogenic vasculature using same
US6232287B1 (en) * 1998-03-13 2001-05-15 The Burnham Institute Molecules that home to various selected organs or tissues
US6174687B1 (en) * 1999-02-26 2001-01-16 The Burnham Institute Methods of identifying lung homing molecules using membrane dipeptidase
US6303573B1 (en) * 1999-06-07 2001-10-16 The Burnham Institute Heart homing peptides and methods of using same
US20020041898A1 (en) * 2000-01-05 2002-04-11 Unger Evan C. Novel targeted delivery systems for bioactive agents
US20010046498A1 (en) * 2000-01-21 2001-11-29 Ruoslahti Erkki I. Chimeric prostate-homing peptides with pro-apoptotic activity
US20030077826A1 (en) * 2001-02-02 2003-04-24 Lena Edelman Chimeric molecules containing a module able to target specific cells and a module regulating the apoptogenic function of the permeability transition pore complex (PTPC)
WO2004055160A2 (en) * 2002-12-13 2004-07-01 The Trustees Of Columbia University In The City Of New York Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry
WO2005081898A2 (en) * 2004-02-20 2005-09-09 The Trustees Of The University Of Pennsylvania Binding peptidomimetics and uses of the same
WO2005120585A1 (en) * 2004-06-04 2005-12-22 Case Western Reserve University Dual function polymer micelles
US7612153B2 (en) * 2004-10-25 2009-11-03 Intezyne Technologies, Inc. Heterobifunctional poly(ethylene glycol) and uses thereof
ITMI20050328A1 (it) * 2005-03-03 2006-09-04 Univ Degli Studi Milano Composti peptidomimetrici e preparazione di derivati biologicamente attivi
WO2007016542A2 (en) * 2005-08-01 2007-02-08 President And Fellows Of Harvard College Her-2 blocking bifunctional targeted peptides
CA2630415A1 (en) * 2005-10-20 2007-04-26 The Scripps Research Institute Fc labeling for immunostaining and immunotargeting
AU2007294685B2 (en) * 2006-09-15 2012-06-07 Siemens Medical Solutions Usa, Inc. Click chemistry-derived cyclopeptide derivatives as imaging agents for integrins

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