JP2010526025A5 - - Google Patents

Info

Publication number

JP2010526025A5

JP2010526025A5 JP2009546409A JP2009546409A JP2010526025A5 JP 2010526025 A5 JP2010526025 A5 JP 2010526025A5 JP 2009546409 A JP2009546409 A JP 2009546409A JP 2009546409 A JP2009546409 A JP 2009546409A JP 2010526025 A5 JP2010526025 A5 JP 2010526025A5

Authority

JP

Japan

Prior art keywords

bis

trifluoromethyl

propyl

hydrazinecarboxamide

substituted

Prior art date

2008-01-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 23
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 23
• 125000000217 alkyl group Chemical group 0.000 claims 14
• -1 N- [1,1-bis (trifluoromethyl) propyl] -2- (4-tert-butylbenzoyl) hydrazine Chemical compound 0.000 claims 12
• 150000001875 compounds Chemical class 0.000 claims 11
• 239000008194 pharmaceutical composition Substances 0.000 claims 10
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 6
• 150000003839 salts Chemical class 0.000 claims 5
• 125000003118 aryl group Chemical group 0.000 claims 4
• 125000001072 heteroaryl group Chemical group 0.000 claims 4
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
• 125000004793 2,2,2-trifluoroethoxy group Chemical group FC(CO*)(F)F 0.000 claims 2
• YXQUGSXUDFTPLL-LURJTMIESA-N 4-amino-1-[[(5s)-2-hydroxy-2-oxo-1,4,2$l^{5}-dioxaphosphinan-5-yl]methyl]pyrimidin-2-one Chemical compound O=C1N=C(N)C=CN1C[C@@H]1OCP(O)(=O)OC1 YXQUGSXUDFTPLL-LURJTMIESA-N 0.000 claims 2
• VWFCHDSQECPREK-LURJTMIESA-N Cidofovir Chemical compound NC=1C=CN(C[C@@H](CO)OCP(O)(O)=O)C(=O)N=1 VWFCHDSQECPREK-LURJTMIESA-N 0.000 claims 2
• 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 2
• 229960000724 cidofovir Drugs 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 150000002148 esters Chemical class 0.000 claims 2
• 239000000651 prodrug Substances 0.000 claims 2
• 229940002612 prodrug Drugs 0.000 claims 2
• 229920006395 saturated elastomer Polymers 0.000 claims 1
• DUIOPKIIICUYRZ-UHFFFAOYSA-N semicarbazide Chemical compound NNC(N)=O DUIOPKIIICUYRZ-UHFFFAOYSA-N 0.000 claims 1